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Methods in Enzymology, Volume 459

$168.30

$168.30
From:Elsevier

Document Overview:

Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine.Gathers tried and tested methods and techniques from top players in the field.Provides an extremely useful reference for the experienced research scientist.Covers biosynthesis of Polyketides, Tarpenoids, Aminocoumarins and Crabohydrates
The Human Nervous System

$274.50

$274.50
From:Elsevier

Document Overview:

This long-awaited update of the classic, The Human Nervous System, stands as an impressive survey of our knowledge of the brain, spinal cord, and peripheral nervous system. The book has been completely redone and brought up-to-date. An impressive and respected cast of international authors have contributed 37 chapters on topics ranging from Brain Evolution, all phases of Brain Development, to all areas of the adult brain and peripheral pathways, along with careful descriptions of the spinal cord and peripheral nervous system, brainstem and cerebellum. The Human Nervous System, Second Edition will again serve as the gold standard, providing a one-stop source of up-to-date information about our knowledge of the human nervous system.This second edition of the standard reference on the human nervous system is extensively and completely revised and updated from the 1990 first edition. Written by the leading researchers, many chapters have been completely rewritten, new chapters have been added. A new section on Evolution and Development provides a broader perspective, and all chapters include references and perspectives to neurological disease.
Food and Western Disease

$85.49

$85.49
From:John Wiley & Sons, Inc. 0

Document Overview:

Nutrition science is a highly fractionated, contentious field with rapidly changing viewpoints on both minor and major issues impacting on public health. With an evolutionary perspective as its basis, this exciting book provides a framework by which the discipline can finally be coherently explored. By looking at what we know of human evolution and disease in relation to the diets that humans enjoy now and prehistorically, the book allows the reader to begin to truly understand the link between diet and disease in the Western world and move towards a greater knowledge of what can be defined as the optimal human diet. Written by a leading expert Covers all major diseases, including cancer, heart disease, obesity, stroke and dementia Details the benefits and risks associated with the Palaeolithic diet Draws conclusions on key topics including sustainable nutrition and the question of healthy eating This important book provides an exciting and useful insight into this fascinating subject area and will be of great interest to nutritionists, dietitians and other members of the health professions. Evolutionary biologists and anthropologists will also find much of interest within the book. All university and research establishments where nutritional sciences, medicine, food science and biological sciences are studied and taught should have copies of this title.
Dental Practice Transition

$75.59

$75.59
From:John Wiley & Sons, Inc. 0

Document Overview:

Practice management is one of the key elements in the career of a dentist. Most dentists own their own practices and even associateships carry with them the prospect of management, accounting and dealing with health insurance providers. Dental Practice Transition: A Practical Guide to Management helps readers navigate through options such as starting a practice, associateships, and buying an existing practice with helpful information on business systems, marketing, staffing, and money management. With topics applicable to both recently graduated as well as established professionals, Dental Practice Transition is a comprehensive exposition of practice management from a dentist's perspective.
Decision Making in Small Animal Oncology

$74.69

$74.69
From:John Wiley & Sons, Inc. 0

Document Overview:

Decision Making in Small Animal Oncology is a practical manual for the increasing number of veterinarians called upon to treat patients with cancer. This case-based quick reference leads practitioners through diagnosis, treatment, and management decisions, offering reliable guidance for more effective management of cancer care. With easy-to-follow algorithms to assist the reader through the critical thinking process, Decision Making in Small Animal Oncology answers the questions most commonly asked in daily practice to provide the cancer knowledge practitioners and students need in general practice.
Fundamental Neuroscience

$92.70

$92.70
From:Elsevier

Document Overview:

Fundamental Neuroscience, 3rd Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts. A companion web site contains test questions, and an imagebank of the figures for ready use in presentations, slides, and handouts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers!New to this edition:30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and ConsciousnessCompanion website with figures, web links to additional material, and test questionsAdditional text boxes describing key experiments, disorders, methods, and conceptsMultiple model system coverage beyond rats, mice, and monkeysExtensively expanded index for easier referencing
Osteoporosis

$414.00

$414.00
From:Elsevier

Document Overview:

Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year.NEW TO THIS EDITION:Recognizes the critical importance of the Wnt signaling pathway for bone healthIncorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and boneExamines essential updates on estrogen prevention and treatment and the recent results from the WHIDiscusses the controversial topics of screening and clinical trial design for drug registrationIncludes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormoneOffers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere
Progress in Brain Research, Volume 150

$234.00

$234.00
From:Elsevier

Document Overview:

Consciousness is one of the most significant scientific problems today. Renewed interest in the nature of consciousness - a phenomenon long considered not to be scientifically explorable, as well as increasingly widespread availability of multimodal functional brain imaging techniques (EEG, ERP, MEG, fMRI and PET), now offer the possibility of detailed, integrated exploration of the neural, behavioral, and computational correlates of consciousness. The present volume aims to confront the latest theoretical insights in the scientific study of human consciousness with the most recent behavioral, neuroimaging, electrophysiological, pharmacological and neuropathological data on brain function in altered states of consciousness such as: brain death, coma, vegetative state, minimally conscious state, locked-in syndrome, dementia, epilepsy, schizophrenia, hysteria, general anesthesia, sleep, hypnosis, and hallucinations. The interest of this is threefold. First, patients with altered states of consciousness continue to represent a major clinical problem in terms of clinical assessment of consciousness and daily management. Second, the exploration of brain function in altered states of consciousness represents a unique lesional approach to the scientific study of consciousness and adds to the worldwide effort to identify the "neural correlate of consciousness". Third, new scientific insights in this field have major ethical and social implications regarding our care for these patients.
Handbook of Neuro-Oncology Neuroimaging

$162.00

$162.00
From:Elsevier

Document Overview:

Although the field of Neuro-Oncology has grown considerably in the last 10 to 15 years and has a rather extensive literature, there are no comprehensive, "single-source" books that summarize the current literature and future trends of neuroimaging in neuro-oncology. This book covers this topic in more comprehensive fashion, making it an important addition to the armamentarium of physicians that care for patients with brain tumors and other neuro-oncological disorders. Well-founded in basic science, it includes chapters that provide an overview of relevant background material in critical areas such as physics, contrast agents, ultra-high field brain MRI, and molecular imaging.
Elsevier's Dictionary of Medicine and Biology

$360.00

$360.00
From:Elsevier

Document Overview:

Dictionaries are didactic books used as consultation instruments for self-teaching. They are composed by an ordered set of linguistic units which reflects a double structure, the macrostructure which correspond to the word list and the microstructure that refers to the contents of each lemma. The great value of dictionaries nests in the fact that they establish a standard nomenclature and prevent in that way the appearance of new useless synonyms.This dictionary contains a total of about 27.500 main English entries, and over of 130.000 translations that should normally sufficiently cover all fields of life sciences. The basic criteria used to accept a word a part of the dictionary during the development period in order of importance were usage, up-to-dateness, specificity, simplicity and conceptual relationships. The dictionary meets the standards of higher education and covers all main fields of life sciences by setting its primary focus on the vastly developing fields of cell biology, biochemistry, molecular biology, immunology, developmental biology, microbiology, genetics and also the fields of human anatomy, histology, pathology, physiology, zoology and botany.The fields of ecology, paleontology, systematics, evolution, biostatistics, plant physiology, plant anatomy, plant histology, biometry and lab techniques have been sufficiently covered but in a more general manner. The latest Latin international anatomical terminology "Terminologia Anatomica" or "TA" has been fully incorporated and all anatomical entries have been given their international Latin TA synonym. This dictionary will be a valuable and helpful tool for all scientists, teachers, students and generally all those that work within the fields of life sciences.
Functional Neurobiology of Aging

$243.00

$243.00
From:Elsevier

Document Overview:

Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.Key FeaturesOrganized by function, making it easy to find and understand the materialAddresses impairments both associated with diseases and not associated with diseasesWritten by leading researchers in the fieldMost comprehensive source of information on the neurobiology of aging
Heart Physiology and Pathophysiology

$333.00

$333.00
From:Elsevier

Document Overview:

Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved.The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.Key FeaturesThe most comprehensive book available on this topicClear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiologyCompletely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiologyUseful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Foundations of Ethical Practice, Research, and Teaching in Psychology and Counseling

$47.66

$47.66
From:Taylor & Francis Inc; 0

Document Overview:

In Foundations of Ethical Practice, Research, and Teaching in Psychology and Counseling, Kitchener and Anderson lay a conceptual foundation for thinking well about ethical problems.Whereas the first edition focused mainly on ethical reasoning and decision making, this new edition draws more explicitly on all components of James Rest's model of moral/ethical behavior, including moral/ethical sensitivity, moral/ethical decision making, moral/ethical motivation, and the ego strength to follow through on the decision.The book addresses five key principles of ethical decision making and includes updated sections on research, teaching and supervision, and practice. It discusses the relationship of the ethical principles and the model of ethical decision-making to professional ethical codes, while offering discussion questions, case scenarios, and activities to help the reader focus on ethical character and virtue. Foundations of Ethical Practice, Research, and Teaching in Psychology and Counseling gives psychologists, students, and trainees the tools they need to analyze their own ethical quandaries and take the right action.
Veterinary Toxicology

$94.50

$94.50
From:Elsevier

Document Overview:

Veterinary Toxicology is a unique single reference that teaches the basic principles of veterinary toxicology to any student at the DVM, MS or PhD level and will continue to serve as a clinical reference for practicing veterinary toxicologists, poison control centers, marine biologists, environmentalists, and animal scientists. While most comparable texts are primarily directed toward the field of human toxicology, this is the one text needed to thoroughly prepare future veterinarians on the newest approaches for diagnosing poisoning cases in all animals from chemicals and plants of a diverse nature as a result of inadvertent, accidental, or malicious intents. Many chapters are provided on topics not covered in any previous books such as target organ toxicity, radiation and radioactive materials, FDA regulatory issues, and ethics in veterinary toxicology.Problem solving strategies are offered for treatment as well as in-depth knowledge of the basic mechanisms of veterinary toxicology.For the first time the specifics of the effects toxins have on different animals and the resulting condition is discussed. For example, acetaminophen affects dogs by causing liver damage but causes red blood cell damage in cats.Provides a comprehensive coverage of chemical terrorism, epidemiology, regulatory issues and the law making this text extremely timely.
Prostate Cancer

$225.00

$225.00
From:Elsevier

Document Overview:

An important translational book bridging the gap between science and clinical medicine, Prostate Cancer reviews the biological processes that can be implicated in the disease, reviews current treatments, highlighting the pitfalls where relevant and examines the scientific developments that might result in novel treatments in the future.Key FeaturesProvides a translational resource for scientists and clinicians working on prostate cancerReviews current surgical interventions and highlights their related pitfallsPresents the latest laparoscopic techniques with figures and illustrations of step-by-step proceduresOffers insight into the potential for novel approaches to treatment in the futureIncludes personal perspectives from patients

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