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               Australasian Society for Immunology Incorporated
 PP 341403100035                                               ISSN 1442-8725                                        December 2002

                    A remarkable legacy: Ian MacKenzie and the ARI
                                                                  Mark Hogarth

Ian McKenzie (MD, PhD, FRACP, FRACPath)                                                              and his own swimming, and for being highly
has recently retired as the Founding Director                                                        reliable, dependable and honest. Ian took on
of The Austin Research Institute, the                                                                the position as coach in the swimming
culmination of 40 years of clinical practice                                                         association’s Training Panel, which was
and medical research. Ian’s long and                                                                 designed to develop the younger swimmers.
illustrious career has been built on high                                                            The elite swimmers of the day acknowledged
quality basic research and its translation into                                                      Ian’s mentoring as being the single essential
applied useful therapeutics, centred largely
around the immunology of transplantation,                                                                                               Cont. p.4
cancer, infection and inflammation. Indeed,
there would be few better examples of the                                                                 2003 Membership
“bench to bedside” approach to research
that is all the more remarkable for its breadth                                                           Renewal enclosed
and consistent quality across such a diversity                                                             Please complete Update
of research activities. The outcomes are                                                                   Questionnaire and return
reflected in Ian’s 650 publications and the                                                                  with renewal form and
Institute’s 120 granted patents over 26                                                                       payment to the ASI
families. Those of Ian’s peers who know his                                                                 Secretariat as soon as
prodigious organisational skills and his                                                                   possible. Please indicate
capacity for work, his clear thinking and          the world in butterfly and was the Victorian
                                                                                                            on renewal whether you
dedication to research and his qualities of        team captain on a number of occasions.
                                                   Michael Hunt who was also a Victorian                   wish to have your contact
perseverance, integrity and most of all his
appreciation for the potential of others based     champion swimmer (later becoming famous                  details published in the
on ability rather than status, understand how      as the referee on World Championship                        2003 Membership
it was possible for Ian to be a highly active      Wrestling and who has since gone on to                           Directory.
researcher in many areas, the ASI President        establish a major successful interstate
(1984), TSANZ President (1991 - 1992) and          business) recalled that Ian was the most
founding Institute director.                       organised and dedicated swimmer of his
                                                   peers. He knew exactly what training
Ian’s values, qualities and capabilities are       schedules he was doing and had planned his
evident in all aspects of his life and can be
traced back to his early days as a competitive
                                                   training and events 12 months ahead which
                                                   in the late ’50s/early ’60s was highly unusual
                                                                                                                Contents
swimmer. As is often the case, achievement         for amateur sports. He was succeeding at his
in elite sport often translates into achievement   medical studies at the same time, receiving           Ian McKenzie & the ARI               1
in other walks of life. At the age of five, Ian    several Honours.
                                                                                                         Editorial                            3
joined the Brunswick Swimming Club which,
according to the local newspaper, was “in the      One of the major characteristics of Ian’s             A new search – Bede's emu            6
hope it would develop his rather frail body”.      career, apparent in his time as a champion
                                                   swimmer, is his ability to mentor others. Ian’s
                                                                                                         ASI Councillors' News                7
(It must have worked!) By his late teens and
early twenties, Ian had won a number of            swimming peers remember him as extremely
Victorian freestyle, backstroke and butterfly      generous with his time for others, despite his
championships, was ranked number one in            heavy commitments to his medical studies
ASI Inc. Newsletter December 2002



                             ASI Inc. COUNCIL
    President                                 Vice President                           Non-Voting Councillors:
    Professor James McCluskey                 Professor Chris Parish
    Dept of Microbiology & Immunology         Division of Immunology & Cell Biology    Newsletter Editorial Board
    The University of Melbourne               JCSMR, ANU                               A/Professor Nicholas King
    Parkville Vic 3010                        PO Box 334                               Email: nickk@pathology.usyd.edu.au
    Ph: 03-9344 5709 Fax: 03-9347 3226        Canberra ACT 2601                        Dr Margaret Cooley
    Email: jamesm1@unimelb.edu.au             Ph: 02-6125 2604 Fax: 02-6125 2595       Email: m.cooley@unsw.edu.au
                                              Email: christopher.parish@anu.edu.au
                                                                                       Dr Philip Hodgkin
    Honorary Secretary                        Honorary Treasurer                       Email: hodgkin@wehi.edu.au
    Dr Geeta Chaudhri                         A/Professor Nikolai Petrovsky            Dr Gunasegaran Karupiah
    Division of Immunology & Cell Biology     University of Canberra                   Email: gunak@med.usyd.edu.au
    JCSMR, ANU                                Department of Endocrinology
    PO Box 334                                Canberra Hospital                        Journal Editor
    Canberra ACT 2601                         PO Box 11, Woden ACT 2606                Dr Chris Parish
    Ph: 02-6125 0174 Fax: 02-6125 2595        Ph: 02-6244 2595 Fax: 02-6282 5179       Ph: 02-6125 2604 Fax: 02-6125 2595
    Email: geeta.chaudhri@anu.edu.au          Email: Nikolai.Petrovsky@act.gov.au      Email: christopher.parish@anu.edu.au
                                                                                       Overseas Speakers Correspondence
                                       State Councillors                               Committee of ASI Councillors chaired by:
    New South Wales                            Victoria & Tasmania                     Professor James McCluskey
    Dr Chris Jolly                             Dr Mark Smyth                           Dept of Microbiology & Immunology
    Ph: 02-9565 6188 Fax: 02-9565 6105         Ph: 03-9656 1411 Fax: 03-9656 3728      The University of Melbourne
    Email: c.jolly@centenary.usyd.edu.au       Email: m.smyth@pmci.unimelb.edu.au      Parkville Vic 3010
                                                                                       Ph: 03-9344 5709 Fax: 03-9347 3226
    Queensland                                South Australia & Northern Territory     Email:
    Dr Norbert Kienzle                        Dr Su Heinzel                            j.mccluskey@microbiology.unimelb.edu.au
    Ph: 07-3362 0379 Fax: 07-3362 0105        Ph: 08-8161 6337 Fax: 08-8239 0267
    Email: norbertK@qimr.edu.au               Email: susanne.heinzel@adelaide.edu.au   Council Member of IUIS
                                                                                       Dr Lindsay Dent
    Western Australia                         Australian Capital Territory             Ph: 08-8303 4155 Fax: 08-8303 7532
    Dr Tony Scalzo                            A/Professor Jennelle Kyd                 Email: lindsay.dent@adelaide.edu.au
    Ph: 08-9346 2514 Fax: 08-9346 2912        Ph: 02-6201 2160 Fax: 02-6201 2461
    E-mail: scals@cyllene.uwa.edu.au          Email: kyd@scides.canberra.edu.au        Honorary Archivist & Webmaster:
                                                                                       Dr Judith Greer
    New Zealand                                                                        Ph: 07-3365 5133 Fax: 07-3365 5462
    Dr Glenn Buchan                                                                    Email: j.greer@medicine.herston.uq.edu.au
    Ph: +64-3-479 7708 Fax: +64-3-479 8540
    Email: glen.buchan@stonebow.otago.ac.nz                                            Administrative Correspondence
                                                                                       Ms Judi Anderson
                                                                                       ASI Inc. Secretariat
    FIMSA Councillor                          Contact for Tasmania                     PO Box 7108
    A/Professor Nicholas King                 Dr Greg Woods                            Upper Ferntree Gully Vic 3156
    Ph: 02-9351 4553 Fax: 02-9351 3429        Tel: 03-6226 4830 Fax: 03-6226 4833      Ph: 03-9756 0128 Fax: 03-9753 6372
    Email: nickk@med.su.oz.au                 Email: g.m.woods@utas.edu.au             Email: asi@21century.com.au




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2
                                                                                                ASI Inc. Newsletter December 2002


                                                            EDITORIAL
Rituximab from IDEC pharmaceuticals                  ones of being innately curious and persistent        lymphoma. According to IDEC
currently is one of the hottest biotech drugs        in approaching a problem. This diversity of          Pharmaceuticals, they have a slew of
on the market, earning already $1 billion (US)       skills brought to science by each individual         promising monoclonal antibodies
in annual sales only a few years after release       is very enriching for the community, and one         currently in development. So in a
in the US. Why mention that here? Bear with          of the joys of working in science.                   remarkably short time the CRC committee
me for a moment.                                                                                          have proved to be spectacularly wrong in
                                                     Given that ability at science is inherited in an     their expert assessment. Do we search
You will have seen already Mark Hogarth’s            unpredictable way it is particularly important       out the constitution of the committee that
tribute to Ian McKenzie upon his retirement          the skills and methods of the excellent and          told Ian there was no future in monoclonal
as Director of the Austin Research Institute         most successful are noted and passed down            antibody therapy of cancer and give them
in Melbourne. Mark’s article is broad ranging        from generation of scientist to the next. There      demotions for a job poorly done? While
and gives an excellent insight into the qualities    is little formal way of doing this except by the     individuals are mercilessly evaluated on
that form the backbone of Ian’s remarkable           apprenticeship PhD system and the                    performance, no such retrospective is
success. While reading Mark’s article I was          circulation of stories and examples. Often a         visited on committees, in my experience.
surprised to learn that Ian McKenzie was a           way of thinking or approaching a problem is          Increasingly our science is run and
number one world rated swimmer. I’m not              communicated in some witty or succinct form.         influenced by committees which serve an
surprised in the sense that I can’t believe Ian      Kevin Lafferty would persistently challenge          important purpose but can also defer and
was capable of such an achievement, rather           anyone with his famous “whats your f….ing            dilute responsibility and may have the
that many scientists have another life, before       hypothesis”, or on hearing some dubious              opposite effect of their intention. I know
or parallel with their scientific career, that       piece of student logic would say dismissively        committees are well intentioned and do
usually goes unnoticed. Despite attempts to          “Yeah well, if your Aunt Mary had balls she          excellent work, however, we must never
categorise and parody the scientist in the           would be your Uncle Harry”. In this regard I         imagine they can do the job of predicting
popular imagination, as a group they seem to         often wonder about Burnet and how many of            the future. Only the visionary individual
be as diverse and mixed in skills as any other       his methods and sayings, attitudes and               is capable of that, and even then maybe
slice of society. The source of scientific ability   approaches are still circulating in our scientific   once in a lifetime.
is one of the great mysteries of life, along with    community and contributing to the
artistic temperament. It seems we are as likely      successful pursuit of science here. How could        This brings the year to a close, thanks to
to find athletes, singers, antique collectors,       we tell? Did he invent or adopt favourite            all who contributed articles to our
optimists and naysayers as you are in any            aphorisms or sayings that helped summarise           newsletter and hope to hear from you all
other group. Apart from a few famous                 his opinions?                                        again next year as we continue to pursue
examples, skill at science seems not to be                                                                our common fellowship and bond that is
inherited and there is no particular trait that      I would like to hear from any reader who             Australian and New Zealand immunology.
seems to be essential apart from the obvious         worked with Burnet directly who might
                                                     provide some light on the Burnet method and                                      Phil Hodgkin
                                                     whether there were any such aphorisms that
        An invitation and a                          we might find still in circulation. In fact, let’s
         request to all ASI                          not restrict the search to Burnet - I would like
                                                     to collect a set of Australian and New Zealand
             members                                 ‘aphorisms’ and publish them here
   to contribute copy that they think
      might be interesting, useful,
                                                     occasionally and store then as a repository of
                                                     our history. Let me know if you have any
                                                                                                                      Merry
    historical, humorous or thought                  favourites, and their source.                                  Christmas
                provoking.
                                                                                                                      and a
                                                     But to return to Mark’s article on Ian
  •    Our Student Page is specifi-                  McKenzie, you will also notice a few remarks                    Happy
       cally designed for our student                that may require teasing out. Mark mentions                    New Year
       membership to voice their views
       on issues that interest or di-
                                                     a decision in the early ’90s not to support a
                                                     CRC in monoclonal antibody development
                                                                                                                    to all ASI
       rectly concern them.                          and therapy for cancer in Melbourne. Mark                      members
  •    It’s our newsletter, so let’s sup-            recalls the application failed on the basis the
       port it and strive to make it even            Committee thought that there was no future
       better.                                       for monoclonal antibodies as therapeutics”.
  •    The ASI newsletter comes out                  Which in turn brings me back to the opening
       4 times a year and we welcome                 of this essay. You may have guessed by now               The ASI Secretariat will be
       your contributions.                           that Rituximab is a monoclonal antibody,                  closed from 20 December
                                                     against a common garden variety B cell marker                until 6 January 2003.
                           The Editors               CD20 that is effective in many cases of

                                                                                                                                                       3
ASI Inc. Newsletter December 2002

    Ian McKenzie retires (cont. from p.1)

    component of their success. Ian’s capacity    Director of the Ludwig Institute) and Ted          reaction (MLR), IA antibodies, rapid graft
    to mentor, or take on the interests of        Boyse, described the first mouse lymphocyte        rejection (H-2I) and immune regulation
    younger people, was clearly seen in his       antigens detected by antibodies. This work         (suppression): but were these 4 separate loci
    research life where he has been responsible   showed that the selective expression of            or were they the same? Ian’s description of
    very directly for the research career         surface molecules defined subsets of               the bm12 mutant mouse with colleagues in
    development of 138 post-graduate              lymphocytes. Since this original work there        the USA (Henry Kohn and Roger Melvold)
    students – PhD, MD, MS, Masters and so        have been over 109,000 publications                where all these functions were simultaneously
    on. A large number of these have come         identifying, studying, targeting and               altered (Class II mutation) demonstrated they
    from non-traditional backgrounds –            manipulating these molecules and the cells         were one phenomenon and the variously
    nurses, school leavers, other people who      that bear them, for both basic science and         named Ir genes, LAD, H-2I and I-A were
    have entered medical research from            applied use. Where would we immunologists          essentially abandoned as they were the same.
    different professions, e.g., the building     be without the CD45+ memory cell, the CD38+        Transplantation mechanisms were also
    industry – a large number of whom have        stem cell, the CD2 + T cell or the CD11b           tackled using Jacques Miller’s thymectomy
    ultimately become NH&MRC Research             dendritic cell!?                                   method to investigate effector cells in mouse
    Fellows, Wellcome Fellows, Hughes                                                                skin allograft rejection, and a distinct role for
    Fellows, QEII, NIH and so on or have          Ian’s return in 1974 to Australia to the Austin    Ly1+2- (now CD4) T cells, distinct from Ly2+
    become attorneys and company                  Hospital’s Department of Medicine led him          (CD8) cytotoxic T cells, was identified during
    executives.                                   to expand his transplantation and Ly/CD cell       Bruce Loveland’s PhD project research.
                                                  surface molecule work and apply this by
    Ian’s research career is of course tied to    being one of the principal developers of           A move to the Parkville campus at the
    his early life as a physician (MB BS 1961,    monoclonal antibodies in Australia. Not only       University of Melbourne in the Pathology
    MD 1966) with a number of accolades and       did this basic research into cell surface          school (1981) led to the development of the
    prizes in his medical training. His PhD at    proteins expand but it led to the development      Research Centre for Cancer &
    the University of Melbourne (1970) was        of diagnostic tests for ovarian and breast         Transplantation, one of the 10 Special
    based on the antibody mediated                cancer and ultimately to the first human trials    Research Centres (then called Centres of
    destruction of transplants, a research        of monoclonal antibody:drug conjugates and         Excellence which ultimately evolved into the
    theme that was to recur throughout his        antibody:radioisotope conjugates in cancer.        CRC program). This centre was based around
    career and culminated in the mid 1990s        In addition to the host of new Ly and CD           the use of monoclonal antibodies for the
    with his observations jointly with Mauro      antigens, the first altered cancer cell antigens   diagnosis and treatment of cancer, the
    Sandrin that the target for antibody          were also described. His laboratory’s first        isolation of cell surface molecules for protein
    induced destruction of xenografts was a       monoclonal antibodies were produced as             sequencing and gene cloning, for the
    carbohydrate epitope. This of course          early as 1978 [by Hogarth and others, Editor’s     modification of transplant rejection processes
    paved the way for a myriad of strategies      insert] and indeed many of the people who          and for analysis and description of functional
    around engineering animal organs as           set up monoclonal antibody laboratories in         lymphocyte subsets in immunity. This period
    potential organ donors.                       this country were trained by Ian.                  at the Centre (1981-1991) led to the first cloning
                                                                                                     of immunologically relevant genes in the Ly
    His work at the Royal Melbourne Hospital      Transplantation work at the Austin initially       and human CD antigen families including
    was followed by six years research in the     involved the description of the function of        CD4, CD8, Fc receptors, and complement
    USA at the Massachusetts General              Class I and Class II molecules in the mouse.       regulatory proteins. It was also characterised
    Hospital with Paul Russell and Henry Winn     The important studies here were firstly the        by some of the first immunologically related
    and at the Jackson Laboratories in Bar        demonstration that mutation of Class I             genes to be patented in Australia. The
    Harbour, Maine. It was at the Jackson         molecules altered antigen presentation, using      development of cancer diagnostic assays,
    Laboratories, though, that he teamed up       the bm and other mouse strains. Although           which eventually were to be used in the
    with George Snell (later to receive a Nobel   forgotten now, in 1974/5 the demonstration         diagnosis of breast and ovarian cancer, and
    Prize for Medicine) not only to explore       by Doherty and Zinkernagel of Class I virus        the first use of monoclonal antibodies in
    aspects of transplantation genetics using     antigen presentation was fiercely argued:          human trials for the treatment of disease
    the remarkable collection of recombinant      i.e., were these observations due to Class I       initiated a stronger human immunology
    inbred and congenic mouse strains but to      molecules or to associated molecules               program. Indeed, Ian with Geoff Pietersz
    develop work that formed one of the           encoded by linked genes? The demonstration         pioneered the conjugation of radioisotopes,
    cornerstones of modern immunology: the        by Ian that a single mutation simultaneously       drugs and toxins to antibodies through the
    development of reliable polyclonal            altered both a histocompatibility locus (H-2)      then unique combination of organic chemistry
    antibodies reacting with lymphocyte           and antigen presentation clearly                   and protein chemistry and indicates Ian’s
    antigens for the identification and           demonstrated that the Doherty and                  eye for the application of new technologies
    characterisation of cell surface receptors    Zinkernagel phenomenon was due to a single,        to the treatment of human disease. In the mid
    and the manipulation of leukocyte subsets     Class I H-2 molecule. Secondly, a number of        1980s these were radically new approaches
    – the so called Ly antigens later to become   disparate immunological phenomena were             to disease diagnosis and treatment and many
    the CD antigens. Ian and George Snell,        linked to an indeterminate number of putative      of these principles we today take for granted.
    simultaneously with Lloyd Old (now            Ir genes, such as the mixed lymphocyte

4
                                                                                            ASI Inc. Newsletter December 2002

The price of “excellence” was that the              to commercialise the Institute’s intellectual     what they could be applied to. The
NH&MRC froze all of Ian’s grants and banned         property.                                         research centre and its emphasis on gene
applications for new ones; the ARC declared                                                           cloning and protein chemistry and the
all such research ineligible for ARC support        In reflecting on the last ten years of Ian’s      strategic combination of basic medical
- so in a rare moment NH&MRC and ARC                career, the ARI is clearly a testament to his     research with clinical research and organic
shared the same vision! Finally, in a classic       vision, drive and love of medical research.       chemistry in the early ’80s also generated
example of the Australian approach to               The Institute and its various predecessors        some of the best scientific achievements
excellence, it was decided to terminate the         under Ian’s directorship had the longest          in this country. The vision extended to
Special Research Centre program, transfer           running, largest and arguably the most            the practical and the aggressive
those monies from the Prime Minister’s              successful NH&MRC program grant. It               protection of intellectual property, dating
Department into the ARC and make medical            attracted substantial foreign grant support,      back to the early ’80s. So commercially
research applications ineligible. Caught up in      grew a portfolio of 128 patents in 28 families    aware and practical has Ian been that the
this Interdepartmental bureaucratic vortex,         (all Australian intellectual property),           ARI appointed its own patent attorney in
the future of the group despite all its             developed a range of potential therapeutics       the late 1990s to manage its patent
achievements was bleak. Fortunately, the            and has grown in number from that original 20     portfolio. I know of no such similar
opportunity to establish the Austin Research        staff to over 100. Gordon Ada, one of             appointment elsewhere.
Institute (ARI) arose and Ian and a group of        Australia’s great immunologists, commented
30 researchers and students moved in 1991           that a remarkable feature of Ian’s achievements   Ian can be also characterised as an
into the renovated 19th century Kronheimer          is to have taken less than a decade to build      independent thinker who adhered to the
Building at the Austin & Repatriation Medical       such a successful research institute in           basic principles of quality research. Were
Centre in Heidelberg.                               Melbourne that reliably achieves in such a        the experiments controlled? Are there
                                                    wide range of disciplines in the face of some     alternative explanations to the results?
The decade of development at the Austin             of the most intense competition for the limited   Never accept the dogma as immutable.
Research Institute has seen a greater               research pie. Ian’s career has been               (Aren’t these echoes of Ian asking
emphasis on the translation of basic research       characterised by a visionary approach to          questions at seminars and conferences?
to patients with the development of potential       research. The introduction and development        – a pity that so few imitate him!) In fact,
cancer vaccine therapies, which are now about       of monoclonal antibodies when they were in        Ian’s fundamental belief has always been
to enter a Phase II clinical trial; the discovery   their embryonic phase globally must rank as       that if the experiment was well controlled
of the target of xenograft rejection and the        a major achievement. Indeed it was so             and clear and did not fit the dogma, the
engineering of complement regulator                 visionary that attempts to establish a CRC in     dogma and not the experiment was wrong.
expressing transgenic pigs; the X-ray               the early 1990s around the use of monoclonal      The controversy around the mucin cancer
crystallographic studies of human Fc                antibodies failed on the basis the Committee      vaccine antigen is diffusing now that the
receptors (the first structures of their type       thought that there was no future for              once immutable rules of peptide:MHC
leading to novel functional studies); a series      monoclonal antibodies as therapeutics! Ian        anchoring have proven much too limited
of platform technologies for vaccine                was never interested in the latest fashionable    for reality and Vasso Apostolopolous
development in infectious disease and the           research technology for its own sake but          with Ian Wilson (Scripps Institute) have
development of a suite of biotech enterprises       rather in the quality of key experiments and      produced definitive crystallographic
                                                                                                      evidence of MHC bound non-canonical
                                                                                                      peptides, showing the original
                                                                                                      experimental data were correct. A new set
                                                                                                      of peptide binding rules has emerged
                                                                                                      along with a flurry of publications from a
                                                                                                      surprising number of groups! The vaccine
                                                                                                      developed from these studies will soon
                                                                                                      be in a Phase II clinical immunotherapy
                                                                                                      trial.

                                                                                                      Finally, Ian has genuinely provided
                                                                                                      exemplary research opportunities for
                                                                                                      others, especially amongst developing
                                                                                                      investigators. Perhaps what Ian is not
                                                                                                      best known for is the extent to which he
                                                                                                      provides support behind the scenes. He
                                                                                                      has actively promoted other people,
                                                                                                      nominated many for awards and I am sure
                                                                                                      many recipients have never been aware
                                                                                                      of this. It is perhaps one of the mysteries
                                                                                                      of Australian research why Ian has never
                                                                                                      been admitted to the august bodies such
                                                                                                      as the Academy of Sciences in Australia
                                Austin Research Institute staff

                                                                                                                                                    5
ASI Inc. Newsletter December 2002

    or never been given the high profile
    recognition by his peers. However Ian’s
                                                                      A new search – Bede’s emu
    legacy to research is clearly embodied by
    the ARI, by the more than 600 peer-           In reference to your touching article on the      tation Ethics Committee would never permit
    reviewed publications, by the patents         long search for the appropriately phallic Bursa   such an experiment these days, but that was
    and by the people he has employed and         Limerick Trophy: there is another ASI relic       Bede for you.*
    mentored in research, in sport and in         which is an even greater treasure.
    academia over the last 40 years.                                                                This film was shown at the ASI meeting in
                                                  In the 1970s, Professor Bede Morris was still     December 1973, then in 1974 at the
    Ian’s research interests continue and he      maintaining that B and T lymphocytes were         International Congress of Immunology in
    is actively developing research programs      only distinguished by being the first and last    Brighton. The Brits first looked worried about
    that are aligned with the need to develop     letters of “Bullshit”. Of course, history has     the Science, then shocked and unsure of
    new treatments for cancer and                 shown him to be wrong, but at the time he         themselves as it descended into ribaldry. The
    transplantation. He maintains an active       made a hilarious film to prove his point. It      Australians were helpless with laughter.
    interest in his sailing and swimming (three   started, as I remember, with two identical
    shoulder reconstructions later), in his       electron micrographs of lymphocytes, one          So who knows where this film is? Can we find
    friends and regrettably, in the               labelled “B” and the other “T”. This, he said,    a copy to be shown, next time in Canberra
    Collingwood Football Club. In his typical     showed conclusively there was no difference       maybe, to a new generation of immunologists
    way, Ian refused to have any fuss             between them. He then proposed to search          who believe there have always been two
    associated with his retirement, content to    for the bursa. India ink was dropped on a         populations of lymphocytes?
    accept a signed football jumper from the      bird’s bottom, which responded by taking it
    Collingwood Football Club and the warm        in enthusiastically by a process that looked      *I have no doubt that anaesthetising the emu
    recognition of his peers and younger          like reverse peristalsis. Then came the rectal    was part of a perfectly legitimate experiment,
    colleagues who know him well and realise      examination of an emu. Of course this involved    carried out for some valid reason quite
    what an outstanding and visionary             anaesthetising the hapless bird. It was the       unrelated to Bede’s film.
    scientist he has been and continues to be.    recovery process which had ’em rolling in the
                                                  aisles. If you haven’t seen an emu coming out     Christina Cheers
                                                  of anaesthetic and staggering away on legs        Department of Microbiology and Immunology
                                                  flailing… Of course an Animal Experimen-          University of Melbourne




6
                                                                                           ASI Inc. Newsletter December 2002



        ASI Councillors’ News
Victorian News                                     S.A./N.T. News
Recently we had annual IgV meeting at              Most of the South Australian activities           The annual student meeting of the SA
Beechworth, for the first time after several       centred on visiting speakers. August was          Branch will be held in December. Students
years successively running at Mt. Buffalo.         quite busy with Mark Smyth from the Peter         (members and non-members) who wish
The Scientific Program was once again strong       McCallum Cancer Institute coming over from        to present and compete for the annual
and the new venue proved very popular with         Melbourne and giving two excellent talks,         prize (valued at $200) should submit the
half the attendance from new people. Special       then Nilabh Shastri from Berkley University       title of their talk and a short CV to me by
thanks to all the invited speakers, particularly   stopped by in Adelaide before he went on to       the end of November. Members are
Professor Ian McKenzie for his contribution        the BIG meeting in Queensland and we were         encouraged to come along and hear about
to the meeting. It is great for our students to    delighted to hear about his findings on           the research interests of our local post-
get to interact with so many of our leading        antigen processing. Bernadette Scott from         graduate students at this important
immunologists in this informal setting and         the Monash Institute of Reproduction &            Branch function.
this year students represented half the            Development in Melbourne and Richard Lake
attendees. Winners of student prizes included      from the Tumour Immunology Group, WA              Finally, congratulations to all those South
Mark Chong, Morag Milton, Melissa Martyn,          Institute for Medical Research in Perth gave      Australian ASI members who were
Judith Field, and Marie-Claude Gouel –             a combined seminar on the ‘Biology and            successful with their NH&MRC grant
congratulations to you all. Again, thank you       Immune Response to Mesothelioma”.                 applications!
to all the attendees who supported the meeting
and to the members of IgV committee who            Tom Braciale from the Beirne B. Carter Centre     Su Heinzel
worked behind the scenes to make the meeting       for Immunology Research at the University         Councillor
another success. Your ASI funds are well           of Virginia came over to Adelaide in October
spent by supporting the running of our annual      after his attendance at the Fenner Conference
meeting.                                           on Vaccines in Canberra to give us a great talk
                                                   and some insight in his work on T-
We are now looking for feedback concerning         Lymphocytes Function in RSV Infection.
the venue and time of year for our 2003 IgV                                                          Queensland News
meeting. A questionaire handed out at this         We are also delighted that Pat Holt from the      Queensland ASI’s activities had a little
year’s meeting in Beechworth asked attendees       Division of Cell Biology at the TVW Telethon      rest during the last couple of months (still
to compare Mt Buffalo and Beechworth. Most         Institute for Child Health Research in Perth is   digesting the successful annual BIG
people rated the 2002 meeting very good and        coming to Adelaide later in November.             meeting in August), but gearing up now
value for money. There was an evenly split                                                           with new strength for the upcoming ASI
vote for Beechworth versus Mt Buffalo as a         Almost all of these seminars have been co-        conference in Brisbane. The conference
venue, with some nostalgic voting from             hosted and (most importantly) co-sponsored        committee, which consists of
previous Mt Buffalo attendees. Everyone            by ASI and various other institutions, namely     representatives of the major immunology
attending was happy to go to another IgV           the Department of Molecular Biosciences,          research institutes in Brisbane, has
outside of Melbourne. So what about you            University of Adelaide, the Flinders Medical      entered the final lap in their organization
folk who have failed to make one of our recent     Centre, The Hanson Institute and the Child        frenzy and is adding the finishing touches
meetings? We are really looking to increase        Health Research Institute. I would like to take   to a beautiful conference program (which
our attendance from WEHI and Melbourne             this opportunity to thank everybody involved      you can judge, soon). A recent
University immunologists. What can we do           for the excellent and easy co-operation.          immunological highlight was the QIMR
to make this a meeting you can not afford to                                                         institute seminar given by Prof. Thomas
miss?                                                                                                Braciale, director of the Beirne B. Carter
                                                                                                     Center for Immunology Research in
The IgV committee is happy to receive your                                                           Charlottesville USA. Tom gave a gripping
feedback: m.smyth@pmci.unimelb.edu.au                                                                example how the G-protein of Respitory
                                                              Sustaining                             Syncitia Virus, RSV, can fool the immune
Mark Smyth
Councillor                                                    Membership                             system by deviating a potentially
                                                                                                     effective RSV-specific CD8 T cell
                                                         ASI Inc acknowledges the
                                                                                                     response into oblivion, and how these
                                                          support of the following
                                                                                                     mechanisms can contribute to the high
                                                           sustaining members:
                                                                                                     morbidity in the young and elderly.
                                                            • Bioquest Limited
                                                               • Dynal Pty Ltd
                                                                                                     Norbert Kienzle
                                                                                                     Councillor



                                                                                                                                                    7
ASI Inc. Newsletter December 2002

    W.A. News                                                                                         N.Z. News
    WA ASI has enjoyed some great                    Immunology, Zurich, Switzerland) has made        A scientific consortium, including Drs Mike
    immunological presentations from invited         a commitment to attend the meeting as Burnet     Berridge and Jacquie Harper from the
    interstate speakers over the past few            Orator.                                          Malaghan Institute have won an NZ$8.5
    month or so. On 2 October, Assoc. Prof.                                                           million contract to look for extracts from marine
    Frank Carbone from the Department of             Other major international speakers who will      sponges and New Zealand plants that have
    Microbiology and Immunology at the               be attending the meeting include:                anti-inflammatory properties that may be
    University of Melbourne gave an excellent        Dr David Cosman (Amgen, Seattle, USA)            useful as therapeutics for immune-mediated
    seminar titled: “Antigen presenting cells        Prof. Ruslan Medzhitov (Yale University,         diseases such as asthma and arthritis.
    and cytotoxic T cells in herpes simplex          USA)
    virus infection” which was well attended         Prof. Giorgio Trinchieri (Schering-Plough,       Dr Patrizia Stoitzner from the Department of
    and generated significant interest. ASI          France)                                          Dermatology at the University of Innsbruck
    WA thanks Invitrogen who provided                Prof. Jonathon Yewdell (NIH, Bethesda, USA)      in Austria is currently on study leave in
    support for this seminar. During his 2-day       Prof. Laurence Zitvogel (Institut Gustave        Christchurch Clinical School. Patti is working
    visit to Perth, Frank held numerous              Roussy, France)                                  in the laboratory of Drs Judy McKenzie and
    discussions with a range of local                                                                 Alex McLellan. She has a busy schedule
    immunology groups and in some cases              We look forward to seeing you all in sunny       organised to visit each centre before
    this led to new collaborations.                  Perth in December 2003.                          Christmas to present her work on skin
                                                                                                      dendritic cells and their migration. The title of
    On 28 October, Prof. Anne Kelso from the         Finally, I would to thank local ASI members      her talk is “Tracking leukocyte movement
    Cooperative Research Centre for Vaccine          for their support and interest during my         from the skin into the lymph nodes”.
    Technology at The Queensland Institute           enjoyable 2-year term as WA ASI Councillor
    of Medical Research presented a                  and would like to wish the incoming Councillor   Thought for the month: Basic science is like
    fascinating seminar on recent work from          a successful and enjoyable term.                 shooting an arrow in the air and where it
    her group in a talk entitled: “The secret life                                                    lands, painting a target. – H. Adkins.
    of CTL: unexpected diversity in                  Tony Scalzo
    phenotype and function”. Anne also took          Councillor                                       Best joke of the month: On wall in ladies room:
    time out of her busy schedule to do a tour                                                        “My husband follows me everywhere...”
    of Perth labs, which was greatly                                                                  Written just below it: “I do not!”
    appreciated.
                                                                                                      Glenn Buchan
    Plans for Perth ASI 2003 are moving along                   ASI Secretariat                       Councillor
    well and we hope to have an exciting and                     PO Box 7108,
    stimulating meeting lined up for you next               Upper Ferntree Gully,
    year that you will all want to attend. The              Vic. 3156. Australia
    theme for the meeting will be “Immune                  Tel: +61 3 9756 0128
    regulation, infectious disease and tumour              Fax: +61 3 9753 6372
    control”. The meeting will be held on the            Email: asi@21century.com.au
    beautiful University of Western Australia

                                                                                                          Contributions
    campus from 7–11 December. Prof. Rolf
    Zinkernagel (Institute of Experimental

                                                                                                         sought for the
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                                                                                                            asi@21century.com.au


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