Wilmot Rising to the Top - University of Rochester Medical Center by siwoyxrzafiawzzy


									WINTER 2007/08

Wilmot: Rising to the Top

Craig T. Jordan, Ph.D.

                         Monica L. Guzman, Ph.D.

Flowers Lead Scientists Down Path to
New Leukemia Drug
A new, easily ingested form of a compound that has already shown it can attack the roots
of leukemia in Wilmot Cancer Center laboratory studies is moving into human clinical trials.
      The Wilmot team has been leading the investigation of this promising therapy on
the deadly blood cancer for nearly five years. And to bring it from a laboratory concept
to patient studies in that time is very fast progress in the drug development world, says
Craig T. Jordan, Ph.D., senior author of a research study published in Blood and director of
Wilmot’s Translational Research for Hematologic Malignancies.
      Clinical trials are expected to begin in England soon. Investigators expect to initially
enroll about a dozen adult volunteers who’ve been diagnosed with acute myeloid leukemia
(AML), acute lymphoblastic leukemia (ALL) or other types of blood or lymph cancers.
      Under development is dimethylamino-parthenolide (DMAPT), a form of parthenolide
that is derived from a daisy-like plant known as feverfew or bachelor’s button. DMAPT is a
water-soluble agent that scientists believe will selectively target leukemia at the stem-cell
level, where the malignancy is born. This is significant because standard chemotherapy
does not strike deep enough to kill cancer at the roots, thus resulting in relapses. Even the
most progressive new therapies, such as Gleevec, are effective only to a degree because
they do not reach the root of the cancer.
      DMAPT appears to be unique. Its mechanism of action is to boost the cancer cell’s
reactive oxygen species – which is like pushing the stress level of the cell over the edge
– to the point where the cell can no long protect itself and dies, says Monica L. Guzman,
Ph.D., the lead researcher on the DMAPT project and a senior instructor at the University of
Rochester Medical Center.
      Leukemia is different from most cancers and particularly hard to eradicate because
leukemia stem cells lie dormant. Standard cancer treatments are designed to seek out
actively dividing cells. But in studies so far, DMAPT can kill both dormant cells and cells that
are busy dividing, Guzman says.
      Rochester investigators looked at whether DMAPT could eliminate leukemia in donated
human cells, and in mice and dogs. In all cases, DMAPT induced rapid death of AML stem
and progenitor cells, without harming healthy blood cells.
      DMAPT also has shown potential as a treatment for breast and prostate cancer,
melanoma, and multiple myeloma, Guzman says, although those studies have only been
conducted in cell cultures to date.
      “Once we begin seeing evidence from the clinical trials, it will give us more insight into
the pharmacological properties of DMAPT and it will be easier to figure out its potential for
other cancers,” Guzman says.
      In addition to the studies of DMAPT, Guzman and Jordan also reported in the same
issue of Blood on another new type of leukemia drug known as TDZD-8. Although this agent
is at a much earlier stage of development, it also shows the ability to kill leukemia stem
cells and may some day lead to better forms of treatment.


                                 Got Stress?
                                 It May Impact Breast Cancer Recurrence

                                 Women diagnosed with metastatic breast cancer who have also endured previous traumatic
                                 or stressful events see their cancer recur nearly twice as fast as other women, according to
                                 a study written by a Wilmot Cancer Center scientist.
                                       The small, retrospective study showed that women who faced physical or sexual abuse
                                 or life-threatening situations see metastatic tumors return after about 2.5 years, compared
                                 with women who have more peaceful lives who see recurrence at about five years. The
                                 report was published in this month’s Journal of Psychosomatic Research by scientists from
                                 the University of Rochester Medical Center and Stanford University School of Medicine.
                                       While some of the reported events are less common than others, they all took a toll on
                                 the women and, scientists believe, may have contributed to the recurrence of disease.
                                       “There is such a dramatic difference between women who had experienced traumatic
                                 things and those who didn’t,” says Oxana Palesh, Ph.D., first author of the study and
                                 research assistant professor of Radiation Oncology and Psychiatry. “Clearly this study
                                 demonstrates that it’s important to recover from trauma or stressful event for your mental
                                 and physical health.”
                                       The relationship between stress and breast cancer has been heavily studied, however
           Oxana Palesh, Ph.D.   the results are murky. Studies have shown that stress can alter the immune system’s
                                 function, and that the activity of natural killer cells is related to breast cancer progression.
                                 But scientists have had more difficulty showing a link between stress and the development
                                 of breast cancer. Some large-scale studies have shown connections between recent
                                 stressful life events, such as the death of a spouse, and breast cancer risk, while others
                                 have not.
                                       Scientists are intrigued by the conflicting evidence and research continues. In this most
                                 recent effort, the bi-coastal team interviewed 94 women from the San Francisco Bay area
                                 and categorized their life experiences as either traumatic or stressful, and compared them
                                 with a control group of women who had not faced similar situations.
                                       The participants reported traumatic experiences such as childhood sexual abuse, rape,
                                 suicide of a family member or life-threatening injury. Stressful events included adoption,
                                 parent’s death, living with their mother-in-law, earthquake, divorce or having a family
                                 member imprisoned.
                                       In the three study groups, 39 women reported traumatic events in their history and
                                 median disease-free interval was 2.5 years, and for 27 women who had experienced
                                 stressful situations, it was 37 months – just over three years. And in the final group, 28
                                 women who reported no stress or trauma in their history, the median disease-free interval
                                 was 62 months – just over five years.
                                       All of the women were diagnosed in their late 40s and 85 percent of them were white.
                                 Demographic analysis showed that 69 percent were married and 19 of the women in the
                                 stressed and traumatic groups were divorced or widowed.
                                       The research also involved analysis of cortisol levels from saliva samples from

participants. Cortisol is produced when the body faces periods of stress and there is
growing evidence that abnormally prolonged cortisol production inhibits the body’s immune
response. This could potentially make the body more susceptible to recurrence of cancer,
Palesh says.
     “Extended periods of stress and trauma and its resulting cortisol production may
interfere with the body’s ability to fight off cancer progression,” says Palesh. “When there
is consistent, long-term stress in the body, the elevated cortisol level may change the
body’s normal rhythms and potentially reduce resistance to tumor growth.”
     Palesh worked on this study as a post-doctoral fellow at Stanford, with principal
investigator David Spiegel, M.D., who is known for his research on support groups and
cancer patients.


                                                  Wilmot Honors Researcher for Cell Signaling
                                                  Discovery at Annual Scientific Symposium

The James P. Wilmot Cancer Center recently
honored scientist Alan V. Smrcka, Ph.D.,
for his research into the machinations
of proteins and cells that could lead to
development of new therapies for cancer
and heart disease. Smrcka received the
Davey Memorial Award for Outstanding
Cancer Research during the 12th annual
Scientific Symposium, Oct. 18.
      Smrcka, associate professor of
Pharmacology and Physiology, Oncology and
Biochemistry and Biophysics, studies the
function of disease-relevant cell signaling
molecules at atomic resolution with the
aim to develop targeted therapeutic
      The Davey Memorial Award for
Outstanding Cancer Research was
established as a tribute to R. Bruce Davey,
who died in 1996. Mr. Davey’s wife, Linda,
is a founding member of the Cancer Center
Board and served as its first chair. The
Davey Award is given annually to scientists
who have made outstanding contributions
to cancer research.
      Smrcka was recognized for the
discovery of compounds that modulate the
specificity of cell signaling by G-protein       proliferation also drive the contradictory    organizations. He was also a patient at
coupled receptors. His ground-breaking          pathway of cell suicide. This discovery has   the Wilmot Cancer Center. Because of the
work could lead to development of more          enlightened scientists’ understanding of      excellent care he received, along with his
effective drugs for treating diseases such as   molecular mechanisms of cell suicide and      longtime association with the University,
cancer, diabetes, depression, arthritis, and    opened the doors to development of new        the family felt it was appropriate to
heart disease.                                  therapies that target these pathways and      establish this lectureship in his memory.
      Another highlight of the event was        combat cancer.                                     Through the years, this lecture has
the Alan J. Underberg Memorial Lecture,              The lectureship was established by       brought compelling speakers to Rochester to
delivered by Gerard Evan, Ph.D., of the         Joyce Underberg and her children in honor     speak about cancer research.
University of California at San Francisco       of her late husband, Alan Underberg, a
Cancer Research Institute.                      prominent attorney in Rochester who was
      Evan is credited with discovering         a member of the University of Rochester’s
that the mutations that drive cancer cell       Board of Trustees and several area health

Above, Scientist Alan Smrcka, Ph.D., center,
received the Davey Memorial Award for Outstanding
Cancer Research. At right are Jeffrey Davey and his
mother, Linda Davey. She established the award in
memory of her husband. At left are Richard Fisher,
M.D., director of the Wilmot Cancer Center, and
Hartmut “Hucky” Land, Ph.D., Chair of Biomedical

At right, Gerard Evan, Ph.D, right, delivered the
Alan J. Underberg Memorial Lecture, a highlight of
the annual symposium. Joyce Underberg, center,
supports this effort each year. Hartmut “Hucky”
Land, Ph.D., left, welcomed Evan, from the University
of California at San Francisco Cancer Research


      NEWS & NOTES                 Wilmot Doctors Named Best in Nation

                                   Several University of Rochester Medical         • Regis O’Keefe, M.D., Ph.D., chair
                                   Center oncologists and surgeons are               of Orthopaedics and Rehabilitation,
                                   included in America’s Top Doctors for Cancer,     specializes in cancers of the bone,
                                   a valued guide for patients. They are the         muscle and soft tissue around the
                                   only Rochester area doctors included in the       skeleton. He is director of the Center for
                                   650-page book.                                    Musculoskeletal Research, overseeing
                                        “Clearly this demonstrates the level         the research of 16 faculty and two dozen
                                   of skill and expertise available within the       graduate students and post-doctoral
                                   University of Rochester Medical Center’s          fellows. O’Keefe’s NIH grant support
                                   oncology teams,” said Richard I. Fisher,          has consistently placed him among the
         Louis Constine, M.D.      M.D., director of the Wilmot Cancer Center        most highly funded orthopaedic surgeon-
                                   and vice president for clinical services for      clinician scientists in the United States.
                                   the Medical Center, who was included in         • Kristin Skinner, M.D., chief of
                                   the book.                                         Surgical Oncology and director of the
                                        The guide, considered an authoritative       Multidisciplinary Breast Cancer Program,
                                   resource for patients seeking the best            is an outstanding breast surgeon. She
                                   cancer care, includes:                            also leads clinical and translational
                                   • Louis “Sandy” Constine, M.D.,                   research evaluating biologic markers of
                                      professor and vice chair of Radiation          breast cancer risk, possible molecular
                                      Oncology, is internationally recognized        diagnostic markers in breast cancer, the
                                      for his expertise in acute and chronic         application of intraductal approaches to
                                      effects of chemotherapy and radiation          breast cancer diagnosis and treatments,
                                      therapy on normal tissues. He specializes      and the potential for less invasive forms
         Richard I. Fisher, M.D.      in lymphomas, sarcomas, brain tumors           of treatment for ductal carcinoma in situ
                                      and pediatric malignancies.                    of the breast.
                                   • Richard I. Fisher, M.D., an                   • Thomas Watson, M.D., associate
                                      internationally recognized expert in           professor of Surgery and chief of
                                      lymphoma care and research. Fisher has         Thoracic Surgery, is an expert in foregut
                                      led numerous national and international        (esophageal/stomach) and pulmonary
                                      studies in Hodgkin’s disease and non-          surgery. He has extensive experience in
                                      Hodgkin’s lymphoma. Patients and               open and minimally invasive procedures,
                                      physicians throughout the world seek his       including laparoscopic and thoracoscopic
                                      expertise on lymphoma.                         approaches.
                                   • David Korones, M.D., associate
                                      professor of Pediatrics and Hematology/
                                      Oncology, focuses on brain tumor care
                                      and research for children and adults.
         David Korones, M.D.
                                      He leads research into new therapies
                                      for brain tumors and management of
                                      side effects.

                             $1.5M NIH Grant Supports Hematology Research Training
                                                      The Medical Center      “While there is a shortage of hematology
                                                      received a $1.46        researchers, science is progressing rapidly
                                                      million, five-year       and there is a lot of opportunity for research
                                                      grant for training      in this field,” says Charles W. Francis, M.D.,
                                                      in hematology           director of the Hemostasis and Thrombosis
                                                      research. The goal      Program and the training program. “This
                                                      of the program is to    grant helps us attract researchers with
                                                      train physicians and    tremendous potential.”
Regis O’Keefe, M.D., Ph.D.                            scientists for active        The training grant will provide support
                                                      research careers in     each year for four postdoctoral fellows
                             basic and clinical sciences in nonmalignant      and two Ph.D. or M.D./Ph.D. students.
                             hematology, such as sickle cell anemia and       The program was one of the first training
                             hemophilia, and malignant hematology, such       grants in hematology ever sponsored by the
                             as leukemia and lymphoma.                        National Institutes of Health.

                             Lymphoma Expert Honored By Gilda’s Club

                                                       James P. Wilmot             Friedberg, associate professor of
                                                       Cancer Center’s        Hematology/Oncology, is director of
                                                       Jonathan Friedberg,    hematological malignancies clinical
Kristin Skinner, M.D.                                  M.D., received         research and inpatient hematology
                                                       Gilda’s Club’s         services at the Wilmot Cancer Center and
                                                       2007 Jacob             a highly respected clinician specializing in
                                                       Gitelman Award         lymphoma care.
                                                       for outstanding             Friedberg coordinates clinical trials for
                                                       service to people      patients with indolent B-cell malignancies
                                                       with cancer in the     and Hodgkin’s lymphoma.
                             Rochester community.                                  Previous recipients of the Jacob
                                  “Dr. Friedberg is a wonderful clinician     Gitelman Award include Wilmot Cancer
                             with a sensitive bedside manner,” says           Center oncologists Louis “Sandy” Constine,
                             Beverly Brooks, executive director for Gilda’s   M.D., professor of Radiation Oncology, and
                             Club. “We are grateful to Dr. Friedberg’s        David Korones, M.D., professor of Medicine
                             time and generosity because he volunteers        and Oncology.
                             to speak at the Clubhouse on various cancer
Thomas Watson, M.D.
                             related topics.”

                             NEWS & NOTES          9

Wilmot Partners
with Arnot for
Better Cancer Care
                     Dear Friends and Colleagues,

                     The Wilmot Cancer Center believes in a multidisciplinary team approach to treating people
                     with cancer. Oncologists, pathologists, radiologists, radiation oncologists, nurses, social
                     workers, and other support staff work together to provide each person with the best chance
                     for survival and hopefully a cure.
                          This includes working with others across New York through the James P. Wilmot
                     Community Oncology Network. Recently we welcomed Arnot Health’s Falck Cancer
                     Center in Elmira to expand their patients’ access to the newest therapies and cutting-edge
                     treatments, educational programs, and clinical research by joining the network.
                          The partnership brings together Wilmot’s expertise to the Southern Tier’s primary
                     cancer center.
                          These collaborations are a key part of our strategic plan to grow into a top cancer
                     center. We’ve outlined plans for the expansion of clinical programs for the major diseases
                     and our research programs where we can have great impact on cancer care.
                          The opening of a new cancer center facility, which will be completed in a few short
                     months, will allow more people from the Rochester and Finger Lakes region to receive
                     expert care close to home. It will also accommodate the ever-increasing number of people
                     traveling here from across the state and country seeking expert care.
                          As we grow in size and reputation, we will continue working in concert with
                     other clinical oncology groups and institutions to improve cancer care. It is our mission
                     to beat cancer.


                     Richard I. Fisher
                     James P. Wilmot Cancer Center
                     Cancer Services, Strong Health
                     Vice President for Clinical Services
                     University of Rochester Medical Center

                                                                                                   Cancer Center Board
Feinblooms Honored for Generosity                                                                  Members 2007-2008
                                                                                                   Bruce Zicari II, Chair
                                                                                                   George Abraham, M.D.
                                                                                                   Ronald Billitier Jr.
                                                                                                   Phyllis Brault
                                                                                                   Michael Buckley
                                                                                                   Rina Chessin
                                                                                                   Olivia Cornell
                                                 Wilmot Cancer Center Board member Harold          Elaine Del Monte
                                                 Feinbloom and his wife, Joan, a University        Robin DeWind
                                                                                                   Harold Feinbloom
                                                 of Rochester Medical Center board member          James Hammer
                                                                                                   John Holtz
                                                 and Cancer Center art committee member,           Robert Kessler
                                                 were recently honored as outstanding              André Langston
                                                                                                   Judy Wilmot Linehan
                                                 philanthropists by the Genesee Valley             Michael Linehan
                                                 Chapter of the Association of Fundraising         Ronald Maggio
                                                                                                   Stephen McCluski
                                                 Professionals. The award recognizes               Carol Mullin
                                                                                                   Samuel Reeder
                                                 exceptional generosity and commitment to          Donald Rhoda
                                                 helping the community.                            James T. Rudgers
                                                                                                   James Ryan Jr.
                                                     Their generosity has touched numerous         Stephen Ryan
                                                                                                   David Vigren
                                                 non-profit organizations in Rochester, but         Tim Williams
                                                 has perhaps most measurably impacted              Paul J. Wilmot
                                                 children and adults with disabilities, arts and   Ex-Officio Board Members
                                                 cultural organizations and the improvement        Bradford C. Berk, M.D., Ph.D.
                                                 of healthcare in the community. Through their     Mary Ann Dever
                                                                                                   Richard I. Fisher, M.D.
                                                 philanthropy they have expanded education         Paul Okunieff, M.D.
                                                                                                   Glen Smiley
for children with disabilities, helped revitalize the Rochester Philharmonic Orchestra, and
awarded $2.9 million in grants to youth and community programs through their Supporting            Comprehensive Campaign
                                                                                                   Steering Committee
Foundation at the Rochester Area Community Foundation.
                                                                                                   Judy Wilmot Linehan, Co-Chair
     The Feinblooms also have a longstanding commitment to supporting cancer care.                 Jim Ryan Jr., Co-Chair
                                                                                                   George Abraham, M.D.
In 2004, the couple put their confidence in the vision and mission of the Cancer Center and         Ralph J. Code III
made a $1 million gift to help kick-off the Wilmot Cancer Center Comprehensive Campaign.           Jim DeGuzman
                                                                                                   Michael Donnelly
     “The legacy of giving that the Feinblooms have established in Rochester sets an               Harold Feinbloom
outstanding example for others,” says Richard I. Fisher, M.D., director of the Wilmot Cancer       Richard I. Fisher, M.D.
                                                                                                   John Gorsline
Center. “We are proud to receive their support and work closely with them.”                        Robert Kessler
                                                                                                   Diana Lauria
     The Feinblooms were nominated for the award jointly by the Wilmot Cancer Center,              Vince Leo
Al Sigl Center, Rochester Philharmonic Orchestra and the Rochester Area Community                  Stephen McCluski
                                                                                                   Michael Norris
Foundation.                                                                                        Donald Rhoda
                                                                                                   Stephen Ryan
                                                                                                   Avi Seidmann
                                                                                                   Tim Williams
                                                                                                   Colleen Wilmot
     Save the Date May 10, 2008                                                                    Paul J. Wilmot
                                                                                                   Thomas C. Wilmot
                                                                                                   Timothy Wilmot
     Join us at the                                                                                Bruce Zicari II
     Rochester Riverside                                                           9th annual      Dialogue Editor
     Convention Center for a                                                                       Leslie White
                                                                                                   Assistant Director
     spectacular celebration of the                                                                of Public Relations
     opening of the new James P. Wilmot                                                            (585) 273-1119
     Cancer Center facility.

     To become a sponsor or reserve tables, please call (585) 242-8988.


Supporters Get Sneak Peek of
New Wilmot Cancer Center

The sounds of hammers and drills at the site of the new Wilmot Cancer Center were
silenced briefly on Oct. 17 when major supporters of the James P. Wilmot Comprehensive
Campaign toured the facility and celebrated the progress.
      The “Hard Hat Party” gave members of the Wilmot Cancer Center Board and
supporters a sneak peek at the future home of the Finger Lakes region’s top cancer center,
which will open in the spring.
      “Rochester is an incredibly philanthropic community. The Wilmot Cancer Center has
truly been blessed with the support from families, individuals, foundations, and corporations
who have supported our campaign,” says Richard I. Fisher, M.D., director of the Wilmot
Cancer Center and vice president of clinical services for the University of Rochester
Medical Center.
      The Wilmot Cancer Center is raising $42.5 million to fund the Wilmot Cancer Center’s
strategic plan, which includes construction of the new 163,000-square-foot building and           Above, leaders of the Wilmot Cancer Center Comprehensive
expanded cancer care and research. So far, almost $34 million has been raised, in part from       Campaign welcomed donors to the Hard Hat party in the new
generous donations from Harold and Joan Feinbloom, the Hansen Family, Jack Rowe, M.D.,            facility under construction. Cancer Center Director Richard
                                                                                                  Fisher, M.D., center, is flanked by Campaign Co-Chairs Jim and
the Davenport-Hatch Foundation and the Wilmot family.
                                                                                                  Caroline Ryan, left, and Judy and Paul Linehan, right. They have
      Guests toured the facility – still in the “dry wall stages” – and were impressed with the   raised $ 34 million toward the $42.5 million goal.
progress construction crews have made in the past 18 months. Everyone was excited about
the improvements to come.                                                                         Right top, the Wilmot Cancer Center Hard Hat party brought
      “Our patients will be amazed to see just what a significant difference the new               some interesting decorations, such as saw-horses for tables
facility will make in providing the best patient care in a modern, private, ultra-comfortable     when guests enjoyed a bountiful buffet.

setting,” Fisher says. “The facility is not only beautiful — it has been designed with the
                                                                                                  Right middle, Wilmot Cancer Center Director Richard Fisher,
input of patients and staff members who are on the front lines of care everyday and will          M.D., left, and Medical Center CEO Bradford C. Berk, M.D.,
accommodate their needs.”                                                                         Ph.D., discuss plans to create one of the top cancer centers
      The new, four-story building will feature a three-story glass atrium, providing natural     in the nation during a tour of the new facility. The building
lighting to patients and families. Clinical exam and treatment rooms will offer greater           will open in the spring, bringing cancer care to a new level in
privacy, and improvements to the Radiation Oncology treatment area will be dramatic, with
spacious and private waiting and changing areas.                                                  Bottom right, Richard Fisher, M.D., director of the Wilmot
      When the building opens, there will be twice as much space for outpatient cancer            Cancer Center, with Kim and Steve McCluski, a Cancer Center
care, allowing more people from the Rochester and Finger Lakes region access to the best          Board member and survivor.
care close to home. Scientists and clinicians will be closer together encouraging greater
collaboration for cures and education of the Wilmot Cancer Research Fellows who are
pursuing careers in cancer research.
      If you’d like to support this campaign, please contact the Wilmot Cancer Center
Development Office at 585-242-8988 or go to wilmotcancercenter.com.


                        Jan. 27
Winter/Spring 2007-08
                        4th annual Ice Cream Bowl
                        Help cream cancer by gobbling up Maggie Moo’s ice cream on Sunday,
                        Jan, 27, at Eastview Mall. This brain-freezing event is open to individuals
                        and teams who raise lots of “moo-lah” for the Wilmot Cancer Center.
                        The top fund-raiser wins an ice cream party for 100 people! Top ice-
                        cream-eaters in various age groups will receive prizes. Norma Holland
                        from 13 WHAM-TV will host the event. Registration formsorms                   Thumbs Up
                        are available at the Gates, Parma/Hilton, Penfield, Henrietta,
                                                                               nrietta,               * To Erin Fennell for organizing
                        Greece, Ogden, Pittsford, Victor and Webster libraries, the
                                                                              s,                        the annual Michael Fennell
                        Rochester Amerks game Dec. 28, or at Maggie Moo’s from                          Memorial Golf Tournament, in
                        11 a.m. to 2 p.m. Saturday, Jan. 5. To download the form,
                                                                              orm,                      memory of her husband, and
                        go to wilmotcancercenter.com. Sponsorship opportunitiesities                    raising $ 6,530.
                        are available; please call (585) 242-0725 to inquire.                         * To Ron Billitier and Paul Tessoni
                                                                                                        for organizing a golf tournament
                        Feb. 27                                                                         and raising $1,700.
                        Cenzi Motorcycle Unveiling                                                    * To Brockport Yacht Club for
                        For the second year, Cenzi Motorcycle Company will                              hosting a wine tasting and
                        unveil a custom motorcycle, valued at $30,000, for a drawing to                 raising $1,300.
                                                                                 t International
                        support the Wilmot Cancer Center at the 2008 Rochester I t          ti l      * To Oak Hill Country Club’s
                        Auto Show. Tickets are $10 or three for $20 and will be available starting      Tuesday Night Golf League
                        Feb. 27. The motorcycle will be on display at a number of locations             for hosting the annual Pink
                        through June 1, when the winner is announced during the second                  Flamingo Golf Charity Event and
                        annual Cenzi Ride for Cancer and Bike Show, presented by Regional               donating $885.
                        International. For a list of opportunities to see the motorcycle, go to       * The Genesee Valley
                        wilmotcancercenter.com or call Cenzi Motorcycle at (585) 349-0120 or            Conservation Club for raising
                        the Wilmot Cancer Center at (585) 242-8988.                                     $ 600 during the annual Ed
                                                                                                        Gordon Memorial Trap Shoot.
                        March 20                                                                      * To Maureen Graham, melanoma
                        Hat Day                                                                         survivor and independent
                        Sign up your school or business for the 3rd annual Hat Day celebration          consultant for Creative
                        and support the Wilmot Cancer Center. For a small donation you can wear         Memories, for hosting a 12-hour
                        a hat to school or dress down at work to help support local cancer care         scrap-booking event, raising
                        and research. Please call Karen McIntyre (585) 242-0725 for                     $400.
                        more information.                                                             * To Janine Burge who held cake
                                                                                                        raffles during the Hilton Apple
                        May 10                                                                          Festival and raised $200.
                        Save the date for the 9th annual Discovery Ball! Sponsorships and             * To Martha Brown Middle
                        tickets are available for this signature event at the Rochester Riverside       School for hosting their own hat
                        Convention Center, in support of the Wilmot Cancer Center’s clinical care       day and raising $178.
                        and cancer research programs. Please call (585) 242-8988 to reserve
                        your tickets.

                                                        Breast Cancer
                                                        Awareness Events                               Staff from through the Medical Center showed
                                                                                                       their support for finding a cure for breast cancer
                                                        held in October                                by wearing pink to work. The effort, organized by
                                                                                                       Friends of Strong, raised $ 900 for Wilmot.
                                                        Breast Cancer Awareness Month provided
                                                        many opportunities to remind women of the
                                                        importance of screenings for early detection   at the Wilmot Cancer Center. Strong
                                                        and to raise money for Wilmot Cancer           Memorial Hospital’s Food & Nutrition
                                                        Center breast cancer programs.                 Services generously donated drinks and
                                                             Friends of Strong organization held       pizza that raised $250 during the event.
Above, breast cancer survivor Paula Bokman,
center, raised $ 3,000 during an afternoon of music,
                                                        Wear Pink Day for staff to show their               Breast cancer survivor Paula Bokman
wine tasting, and auctions at “Keeping the Hope         support for women with breast cancer           and colleagues organized Keeping the Hope
Alive” on Oct. 21. She is with Blanche Shearer, left,   on Oct. 19 and raised more than $900.          Alive, an afternoon of music, raffles, silent
and Sue LoCicero, another breast cancer survivor        Similarly, New Life Fellowship Church          auction and wine tasting, raising more than
who was honored at the event.                           collected $2,745 during “Pink Sunday” on       $3,000. Kristin Skinner, M.D., director of
                                                        Oct. 21 and donated the funds in memory of     the Wilmot Multidisciplinary Breast Care
Below, Kristin Skinner, M.D., director of the
Muldisciplinary Breast Care Program, joined Marti       Sally K. Majors.                               Program, was the featured speaker and
Caspar and George “Ace” Acevedo, at right, and               WFKL radio (93.3FM) held its annual       survivor Susan LoCicero was honored at the
Bob Kirk, at left, from Fickle 93.3FM. The radio        Fickled Pink live broadcast at Strong          Oct. 21 event.
station helped raise awareness of the importance of     Memorial Hospital on Oct. 12, drawing               Meliora Restaurant at University of
screenings during Breast Cancer Awareness Month
                                                        attention to the expert breast care team       Rochester donated a portion of proceeds
in October.
                                                                                                       from the “Think Pink” luncheon and dinner
                                                                                                       Oct. 25. The day’s event raised $800.


                                                                                            James D. Marasco Memorial Golf
                                                                                            Tournament Seventy-five golfers
                                                                                            participated in the James D. Marasco
                                                                                            Memorial Golf Tournament Sept. 2.
                                                                                            Jim Marasco organized the event to honor
                                                                                            his father, a retired Gates police officer
                                                                                            who passed away from cancer in December
                                                                                            2006, and to honor the Wilmot Cancer
                                                                                            Center doctors and nurses who cared for
                                                                                            him. The tournament rasied $2,865 to
                                                                                            support the Samuel E. Durand Bone Marrow
Diane Camelio & Susan Satter receive The Hettie Shumway Award                               Transplant Unit.
Wilmot Cancer Center volunteers Diane Camelio and Susan Satter received the Hettie
Shumway Award from Friends of Strong for their outstanding commitment to patients.
     They have been Strong Memorial Hospital volunteers since the late 1980s and joined
the Wilmot Cancer Center team five years ago. The “Dynamic Duo” spread their warmth
and joy to patients treated in the Medical Treatment Center every Friday morning and help
prepare new patient handbooks. They are truly special ladies.

                                                                                            Balloon Manor Airigami artist Larry Moss
                                                                                            organized the third annual balloon haunted
                                                                                            house – Re/Max Balloon Manor: Elastic
Concert for Karen On Sept. 16, more than 200 people celebrated the life of Karen
                                                                                            Park. The 100,000-balloon theme park was
Schroeder, a local popular musician who died from melanoma, during the Concert for
                                                                                            constructed at Medley Centre. Balloon
Karen. Several local bands performed, including Rochester Metro Jazz Orchestra,
                                                                                            artists from throughout the country and
Upholstered 6 Strings, Kid Kurry, Random Act, The Taint, Coupe DeVilles, and Dave
                                                                                            across the globe traveled to Rochester to
McGrath. Special thanks to the sponsors: Abbott’s Frozen Custard, Budweiser, EPI
                                                                                            help build it.
Printing, Freetime Magazine, House of Guitars, Lake Beverage, Nola’s BBQ, Thomas
Funeral Chapel and The Rochester Razorsharks. The event raised more than $1,500.

                                                A SEASON OF GIVING
                                                Making the Most of Your Year-End Gifts
                                                Year-end is a great time for giving, to family and friends, and to your favorite charities.
                                                When you make a tax-deductible donation by Dec. 31, to the James P. Wilmot Cancer
                                                Center, you aren’t just giving money. You’re giving hope to the thousands of people who
                                                will need our services in the coming year.
                                                     While writing a check is simple and quick, there are other ways to give that could be
                                                best for your financial situation. Here are a few thoughts for your consideration:

                                                OUTRIGHT GIFTS
                                                Appreciated Securities – A popular alternative to cash is gifts of appreciated securities.
                                                These gifts generate a double tax benefit. In addition to receiving a charitable income-tax
                                                deduction for the full fair-market value of the gifted security, the donor also avoids capital-
Cuts for the Cause Tangles Hair Salon           gain tax which would occur if the asset was sold. Note: To qualify for the double tax-
and Day Spa in Irondequoit raised $2,800        benefit, the security must have been held for more than one year.
during the Cuts for the Cause event Aug. 26.
Participants enjoyed “new ‘dos,” live music,    DEFERRED GIFTS
and a barbecue, and supported the Wilmot        Otherwise known as life-income plans, these gifts allow you to make a substantial
Cancer Center. Thanks to the Ridge Culver       contribution to the Wilmot Cancer Center while still providing for your and your family’s own
Volunteer Fire Department for bringing a        personal financial needs.
truck to the salon for children’s tours.             The Charitable Gift Annuity, which, in return for a cash or security gift of $5,000
                                                or more, contractually guarantees fixed-amount life income payments to one or more
                                                annuitants, and an immediate charitable income-tax deduction. The payout rate depends on
                                                the number of annuitants and their ages.
                                                     The Charitable Remainder Trust, which, in one form, generates a fixed amount of
                                                income, or, in another, provides variable income as the trust value fluctuates. This latter
                           Dinner &             form may provide a hedge against inflation. The trust may continue beyond the death of
                           Theatre Books        the donor, and eventually passes to the Wilmot Cancer Center for the donor’s designated
                           Purchase             purpose when all beneficiaries have passed away. A charitable income-tax deduction is
                           your Dinner &        available at the creation of the trust.
                           Coupon Book          DONOR ADVISED FUNDS
today to start saving. You can enjoy over 50    Philanthropy Simplified – This unique vehicle allows the donor to make a gift and receive
restaurants, retail stores (national & local)   a tax deduction for the year of the gift, while retaining the right to make decisions in
and the local theatres. Coupons are valid       the future as to which charities and in what amounts the gift should be distributed. The
now through December 2008. Each book is         University invests the assets and handles all payment and record keeping duties, at
$15 with 50% of the proceeds supporting         no charge.
the Wilmot Cancer Center. These books are
small enough to fit in your purse and make       All types of gifts can be made in memory or in honor of a loved one, patient, physician,
great holiday gifts! To purchase your book      nurse or staff member. To learn more about these and other year-end planned giving
call (585) 242-8988, sale ends Dec. 31.         strategies, please contact:
                                                     Office of Trusts and Estates, 590 Mt Hope Ave., Rochester, NY 14620
                                                     (585) 275-7547 or (800) 635-4672
                                                     We also invite you to go to: http://rochester.plannedgifts.org



1. Napa Valley-based Auctioneer David Reynolds raises the final $ 50,000 toward a $1 million night for the “Toast to Your Health Fine Wine Auction” to support the
James P. Wilmot Cancer Center. Medical Center CEO Bradford C. Berk, M.D., Ph.D., and Danny Wegman, presenting sponsor, applaud his efforts.
2. Diane and Steve Graham, Pamela and Don Rhoda, Mike and Connie Tambe enjoyed the spectacular evening of exquisite wines and a five-course gourmet meal.
3. Danny and Stency Wegman were presenting sponsors for the seventh annual “Toast to Your Health Fine Wine Auction,” the premier wine event in

3                                                        4

                                                                                                                  continued from back cover
                                                                                                                  purchased by Jack and Lisa Baron for
                                                                                                                  $28,000. They will be escorted by
                                                                                                                  Sherwood Deutsch and Michael Misch to
                                                                                                                  little-seen Burgundy wineries and private
                                                                                                                  cellars, including the most renowned estate
                                                                                                                  in Burgundy: the Domaine de la Romanée-
                                                                                                                        Steve and Diane Graham bid $21,000
                                                                                                                  for a Tuscany trip, donated by Constellation
                                                                                                                  Brands, with a stay at Ruffino’ Montemasso
5                                                                                                                 Castle. And Melissa Rutherford raised her
                                                                                                                  paddle with a $15,000 bid for a fashion
                                                                                                                  week excursion in New York City, with
                                                                                                                  runway shows featuring Carmen Marc Valvo
                                                                                                                  designs and two exquisite gowns.
                                                                                                                        Wines available included a 2004
                                                                                                                  Switchback Ridge Napa Valley Petite Sirah,
                                                                                                                  1996 – 2001 Opus One Napa Valley Red
                                                                                                                  Vertical, 2001, 2002, 2003 Screaming Eagle
                                                                                                                  Napa Valley Cabernet Sauvignon and a 2003
                                                                                                                  Chateau Mouton-Rothschild.
                                                                                                                        Rob Fisher of Fisher Vineyards in Napa
                                                                                                                  Valley, Calif., attended and donated several
                                                                                                                  vintages as well as an outstanding Wedding
                                                                                                                  Vineyard Cabernet Sauvignons dinner for 10,
                                                                                                                  which garnered $12,000.
                                                                                                                        Bidders also donated $350,000 to
                                                                                                                  support the addition of the Trilogy Image-
                                                                                                                  Guided Radiation Therapy System – cutting-
                                                                                                                  edge technology for high-dose, precision
                                                                                                                  radiation treatment for cancerous tumors.
                                                                                                                  This equipment is more versatile and faster
                                                          6                                                       than any technology available to patients
                                                                                                                  and oncologists today in Rochester and
                                                                                                                  Upstate New York.
                                                                                                                        Proceeds supported the Wilmot Cancer
                                                                                                                  Center’s $42.5 million comprehensive
                                                                                                                  campaign, which includes construction of a
                                                                                                                  new, four-story facility to expand its local
                                                                                                                  cancer care and research to help find cures.
                                                                                                                  This comprehensive campaign lays the
                                                                                                                  foundation to create one of the top cancer
                                                                                                                  centers in the nation.

    Upstate New York.       4. Mariah and Anthony DiMarco were all smiles during the wine auction.     5. Sherwood Deutsch, of Century Liquor, volunteer Tony Gugino,
    and Rolla Huff, honorary chair, discuss the fine wines for bid during the live auction. 6. Daan and Lorraine Braveman enjoyed the riveting action during the bidding
    for sought-after vintages, exclusive trips to private wine cellars and vacations.

Toast to Your Health
Fine Wine Auction
Raises $1M for Wilmot
The Toast to Your Health Fine Wine
Auction grossed more than $1 million
to support the University of Rochester
Medical Center’s James P. Wilmot Cancer
Center comprehensive campaign to expand
research and clinical care.
     “It was an outstanding evening as
the Rochester community came together
to demonstrate their enthusiasm for the
Medical Center’s efforts to build a top
cancer program here,” says Medical Center
CEO Bradford C. Berk, M.D., Ph.D.
     The Nov. 16 event attracted 420 wine
connoisseurs for an evening in Tuscany,
courtesy of Wegmans Food Markets, which
provided the location, elegant decorations
and five-course meal. The evening, chaired
by Rolla Huff, featured a spirited auction of
rare vintages, exclusive wine adventures,
and wonderful wine dinners, led by well
known Napa Valley auctioneer David
     Among the top auction lots were an
exclusive trip to Burgundy, France,
                        continued on page 18    Tom Wilmot is awarded a bottle of champagne for his generous bid on a wine lot.

University of Rochester Medical Center                                                                          Non-Profit Org.
James P. Wilmot Cancer Center                                                                                    U.S. Postage
601 Elmwood Avenue, Box 704                                                                                         PAID
Rochester, N.Y. 14642                                                                                           Permit No. 780
                                                                                                                Rochester, NY

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