Wilmot: Rising to the Top
Craig T. Jordan, Ph.D.
Monica L. Guzman, Ph.D.
Flowers Lead Scientists Down Path to
New Leukemia Drug
A new, easily ingested form of a compound that has already shown it can attack the roots
of leukemia in Wilmot Cancer Center laboratory studies is moving into human clinical trials.
The Wilmot team has been leading the investigation of this promising therapy on
the deadly blood cancer for nearly ﬁve years. And to bring it from a laboratory concept
to patient studies in that time is very fast progress in the drug development world, says
Craig T. Jordan, Ph.D., senior author of a research study published in Blood and director of
Wilmot’s Translational Research for Hematologic Malignancies.
Clinical trials are expected to begin in England soon. Investigators expect to initially
enroll about a dozen adult volunteers who’ve been diagnosed with acute myeloid leukemia
(AML), acute lymphoblastic leukemia (ALL) or other types of blood or lymph cancers.
Under development is dimethylamino-parthenolide (DMAPT), a form of parthenolide
that is derived from a daisy-like plant known as feverfew or bachelor’s button. DMAPT is a
water-soluble agent that scientists believe will selectively target leukemia at the stem-cell
level, where the malignancy is born. This is signiﬁcant because standard chemotherapy
does not strike deep enough to kill cancer at the roots, thus resulting in relapses. Even the
most progressive new therapies, such as Gleevec, are effective only to a degree because
they do not reach the root of the cancer.
DMAPT appears to be unique. Its mechanism of action is to boost the cancer cell’s
reactive oxygen species – which is like pushing the stress level of the cell over the edge
– to the point where the cell can no long protect itself and dies, says Monica L. Guzman,
Ph.D., the lead researcher on the DMAPT project and a senior instructor at the University of
Rochester Medical Center.
Leukemia is different from most cancers and particularly hard to eradicate because
leukemia stem cells lie dormant. Standard cancer treatments are designed to seek out
actively dividing cells. But in studies so far, DMAPT can kill both dormant cells and cells that
are busy dividing, Guzman says.
Rochester investigators looked at whether DMAPT could eliminate leukemia in donated
human cells, and in mice and dogs. In all cases, DMAPT induced rapid death of AML stem
and progenitor cells, without harming healthy blood cells.
DMAPT also has shown potential as a treatment for breast and prostate cancer,
melanoma, and multiple myeloma, Guzman says, although those studies have only been
conducted in cell cultures to date.
“Once we begin seeing evidence from the clinical trials, it will give us more insight into
the pharmacological properties of DMAPT and it will be easier to ﬁgure out its potential for
other cancers,” Guzman says.
In addition to the studies of DMAPT, Guzman and Jordan also reported in the same
issue of Blood on another new type of leukemia drug known as TDZD-8. Although this agent
is at a much earlier stage of development, it also shows the ability to kill leukemia stem
cells and may some day lead to better forms of treatment.
It May Impact Breast Cancer Recurrence
Women diagnosed with metastatic breast cancer who have also endured previous traumatic
or stressful events see their cancer recur nearly twice as fast as other women, according to
a study written by a Wilmot Cancer Center scientist.
The small, retrospective study showed that women who faced physical or sexual abuse
or life-threatening situations see metastatic tumors return after about 2.5 years, compared
with women who have more peaceful lives who see recurrence at about ﬁve years. The
report was published in this month’s Journal of Psychosomatic Research by scientists from
the University of Rochester Medical Center and Stanford University School of Medicine.
While some of the reported events are less common than others, they all took a toll on
the women and, scientists believe, may have contributed to the recurrence of disease.
“There is such a dramatic difference between women who had experienced traumatic
things and those who didn’t,” says Oxana Palesh, Ph.D., ﬁrst author of the study and
research assistant professor of Radiation Oncology and Psychiatry. “Clearly this study
demonstrates that it’s important to recover from trauma or stressful event for your mental
and physical health.”
The relationship between stress and breast cancer has been heavily studied, however
Oxana Palesh, Ph.D. the results are murky. Studies have shown that stress can alter the immune system’s
function, and that the activity of natural killer cells is related to breast cancer progression.
But scientists have had more difﬁculty showing a link between stress and the development
of breast cancer. Some large-scale studies have shown connections between recent
stressful life events, such as the death of a spouse, and breast cancer risk, while others
Scientists are intrigued by the conﬂicting evidence and research continues. In this most
recent effort, the bi-coastal team interviewed 94 women from the San Francisco Bay area
and categorized their life experiences as either traumatic or stressful, and compared them
with a control group of women who had not faced similar situations.
The participants reported traumatic experiences such as childhood sexual abuse, rape,
suicide of a family member or life-threatening injury. Stressful events included adoption,
parent’s death, living with their mother-in-law, earthquake, divorce or having a family
In the three study groups, 39 women reported traumatic events in their history and
median disease-free interval was 2.5 years, and for 27 women who had experienced
stressful situations, it was 37 months – just over three years. And in the ﬁnal group, 28
women who reported no stress or trauma in their history, the median disease-free interval
was 62 months – just over ﬁve years.
All of the women were diagnosed in their late 40s and 85 percent of them were white.
Demographic analysis showed that 69 percent were married and 19 of the women in the
stressed and traumatic groups were divorced or widowed.
The research also involved analysis of cortisol levels from saliva samples from
participants. Cortisol is produced when the body faces periods of stress and there is
growing evidence that abnormally prolonged cortisol production inhibits the body’s immune
response. This could potentially make the body more susceptible to recurrence of cancer,
“Extended periods of stress and trauma and its resulting cortisol production may
interfere with the body’s ability to ﬁght off cancer progression,” says Palesh. “When there
is consistent, long-term stress in the body, the elevated cortisol level may change the
body’s normal rhythms and potentially reduce resistance to tumor growth.”
Palesh worked on this study as a post-doctoral fellow at Stanford, with principal
investigator David Spiegel, M.D., who is known for his research on support groups and
Wilmot Honors Researcher for Cell Signaling
Discovery at Annual Scientiﬁc Symposium
The James P. Wilmot Cancer Center recently
honored scientist Alan V. Smrcka, Ph.D.,
for his research into the machinations
of proteins and cells that could lead to
development of new therapies for cancer
and heart disease. Smrcka received the
Davey Memorial Award for Outstanding
Cancer Research during the 12th annual
Scientiﬁc Symposium, Oct. 18.
Smrcka, associate professor of
Pharmacology and Physiology, Oncology and
Biochemistry and Biophysics, studies the
function of disease-relevant cell signaling
molecules at atomic resolution with the
aim to develop targeted therapeutic
The Davey Memorial Award for
Outstanding Cancer Research was
established as a tribute to R. Bruce Davey,
who died in 1996. Mr. Davey’s wife, Linda,
is a founding member of the Cancer Center
Board and served as its ﬁrst chair. The
Davey Award is given annually to scientists
who have made outstanding contributions
to cancer research.
Smrcka was recognized for the
discovery of compounds that modulate the
speciﬁcity of cell signaling by G-protein proliferation also drive the contradictory organizations. He was also a patient at
coupled receptors. His ground-breaking pathway of cell suicide. This discovery has the Wilmot Cancer Center. Because of the
work could lead to development of more enlightened scientists’ understanding of excellent care he received, along with his
effective drugs for treating diseases such as molecular mechanisms of cell suicide and longtime association with the University,
cancer, diabetes, depression, arthritis, and opened the doors to development of new the family felt it was appropriate to
heart disease. therapies that target these pathways and establish this lectureship in his memory.
Another highlight of the event was combat cancer. Through the years, this lecture has
the Alan J. Underberg Memorial Lecture, The lectureship was established by brought compelling speakers to Rochester to
delivered by Gerard Evan, Ph.D., of the Joyce Underberg and her children in honor speak about cancer research.
University of California at San Francisco of her late husband, Alan Underberg, a
Cancer Research Institute. prominent attorney in Rochester who was
Evan is credited with discovering a member of the University of Rochester’s
that the mutations that drive cancer cell Board of Trustees and several area health
Above, Scientist Alan Smrcka, Ph.D., center,
received the Davey Memorial Award for Outstanding
Cancer Research. At right are Jeffrey Davey and his
mother, Linda Davey. She established the award in
memory of her husband. At left are Richard Fisher,
M.D., director of the Wilmot Cancer Center, and
Hartmut “Hucky” Land, Ph.D., Chair of Biomedical
At right, Gerard Evan, Ph.D, right, delivered the
Alan J. Underberg Memorial Lecture, a highlight of
the annual symposium. Joyce Underberg, center,
supports this effort each year. Hartmut “Hucky”
Land, Ph.D., left, welcomed Evan, from the University
of California at San Francisco Cancer Research
NEWS & NOTES
NEWS & NOTES Wilmot Doctors Named Best in Nation
Several University of Rochester Medical • Regis O’Keefe, M.D., Ph.D., chair
Center oncologists and surgeons are of Orthopaedics and Rehabilitation,
included in America’s Top Doctors for Cancer, specializes in cancers of the bone,
a valued guide for patients. They are the muscle and soft tissue around the
only Rochester area doctors included in the skeleton. He is director of the Center for
650-page book. Musculoskeletal Research, overseeing
“Clearly this demonstrates the level the research of 16 faculty and two dozen
of skill and expertise available within the graduate students and post-doctoral
University of Rochester Medical Center’s fellows. O’Keefe’s NIH grant support
oncology teams,” said Richard I. Fisher, has consistently placed him among the
Louis Constine, M.D. M.D., director of the Wilmot Cancer Center most highly funded orthopaedic surgeon-
and vice president for clinical services for clinician scientists in the United States.
the Medical Center, who was included in • Kristin Skinner, M.D., chief of
the book. Surgical Oncology and director of the
The guide, considered an authoritative Multidisciplinary Breast Cancer Program,
resource for patients seeking the best is an outstanding breast surgeon. She
cancer care, includes: also leads clinical and translational
• Louis “Sandy” Constine, M.D., research evaluating biologic markers of
professor and vice chair of Radiation breast cancer risk, possible molecular
Oncology, is internationally recognized diagnostic markers in breast cancer, the
for his expertise in acute and chronic application of intraductal approaches to
effects of chemotherapy and radiation breast cancer diagnosis and treatments,
therapy on normal tissues. He specializes and the potential for less invasive forms
Richard I. Fisher, M.D. in lymphomas, sarcomas, brain tumors of treatment for ductal carcinoma in situ
and pediatric malignancies. of the breast.
• Richard I. Fisher, M.D., an • Thomas Watson, M.D., associate
internationally recognized expert in professor of Surgery and chief of
lymphoma care and research. Fisher has Thoracic Surgery, is an expert in foregut
led numerous national and international (esophageal/stomach) and pulmonary
studies in Hodgkin’s disease and non- surgery. He has extensive experience in
Hodgkin’s lymphoma. Patients and open and minimally invasive procedures,
physicians throughout the world seek his including laparoscopic and thoracoscopic
expertise on lymphoma. approaches.
• David Korones, M.D., associate
professor of Pediatrics and Hematology/
Oncology, focuses on brain tumor care
and research for children and adults.
David Korones, M.D.
He leads research into new therapies
for brain tumors and management of
$1.5M NIH Grant Supports Hematology Research Training
The Medical Center “While there is a shortage of hematology
received a $1.46 researchers, science is progressing rapidly
million, ﬁve-year and there is a lot of opportunity for research
grant for training in this ﬁeld,” says Charles W. Francis, M.D.,
in hematology director of the Hemostasis and Thrombosis
research. The goal Program and the training program. “This
of the program is to grant helps us attract researchers with
train physicians and tremendous potential.”
Regis O’Keefe, M.D., Ph.D. scientists for active The training grant will provide support
research careers in each year for four postdoctoral fellows
basic and clinical sciences in nonmalignant and two Ph.D. or M.D./Ph.D. students.
hematology, such as sickle cell anemia and The program was one of the ﬁrst training
hemophilia, and malignant hematology, such grants in hematology ever sponsored by the
as leukemia and lymphoma. National Institutes of Health.
Lymphoma Expert Honored By Gilda’s Club
James P. Wilmot Friedberg, associate professor of
Cancer Center’s Hematology/Oncology, is director of
Jonathan Friedberg, hematological malignancies clinical
Kristin Skinner, M.D. M.D., received research and inpatient hematology
Gilda’s Club’s services at the Wilmot Cancer Center and
2007 Jacob a highly respected clinician specializing in
Gitelman Award lymphoma care.
for outstanding Friedberg coordinates clinical trials for
service to people patients with indolent B-cell malignancies
with cancer in the and Hodgkin’s lymphoma.
Rochester community. Previous recipients of the Jacob
“Dr. Friedberg is a wonderful clinician Gitelman Award include Wilmot Cancer
with a sensitive bedside manner,” says Center oncologists Louis “Sandy” Constine,
Beverly Brooks, executive director for Gilda’s M.D., professor of Radiation Oncology, and
Club. “We are grateful to Dr. Friedberg’s David Korones, M.D., professor of Medicine
time and generosity because he volunteers and Oncology.
to speak at the Clubhouse on various cancer
Thomas Watson, M.D.
NEWS & NOTES 9
with Arnot for
Better Cancer Care
Dear Friends and Colleagues,
The Wilmot Cancer Center believes in a multidisciplinary team approach to treating people
with cancer. Oncologists, pathologists, radiologists, radiation oncologists, nurses, social
workers, and other support staff work together to provide each person with the best chance
for survival and hopefully a cure.
This includes working with others across New York through the James P. Wilmot
Community Oncology Network. Recently we welcomed Arnot Health’s Falck Cancer
Center in Elmira to expand their patients’ access to the newest therapies and cutting-edge
treatments, educational programs, and clinical research by joining the network.
The partnership brings together Wilmot’s expertise to the Southern Tier’s primary
These collaborations are a key part of our strategic plan to grow into a top cancer
center. We’ve outlined plans for the expansion of clinical programs for the major diseases
and our research programs where we can have great impact on cancer care.
The opening of a new cancer center facility, which will be completed in a few short
months, will allow more people from the Rochester and Finger Lakes region to receive
expert care close to home. It will also accommodate the ever-increasing number of people
traveling here from across the state and country seeking expert care.
As we grow in size and reputation, we will continue working in concert with
other clinical oncology groups and institutions to improve cancer care. It is our mission
to beat cancer.
Richard I. Fisher
James P. Wilmot Cancer Center
Cancer Services, Strong Health
Vice President for Clinical Services
University of Rochester Medical Center
Cancer Center Board
Feinblooms Honored for Generosity Members 2007-2008
Bruce Zicari II, Chair
George Abraham, M.D.
Ronald Billitier Jr.
Wilmot Cancer Center Board member Harold Elaine Del Monte
Feinbloom and his wife, Joan, a University Robin DeWind
of Rochester Medical Center board member James Hammer
and Cancer Center art committee member, Robert Kessler
were recently honored as outstanding André Langston
Judy Wilmot Linehan
philanthropists by the Genesee Valley Michael Linehan
Chapter of the Association of Fundraising Ronald Maggio
Professionals. The award recognizes Carol Mullin
exceptional generosity and commitment to Donald Rhoda
helping the community. James T. Rudgers
James Ryan Jr.
Their generosity has touched numerous Stephen Ryan
non-proﬁt organizations in Rochester, but Tim Williams
has perhaps most measurably impacted Paul J. Wilmot
children and adults with disabilities, arts and Ex-Ofﬁcio Board Members
cultural organizations and the improvement Bradford C. Berk, M.D., Ph.D.
of healthcare in the community. Through their Mary Ann Dever
Richard I. Fisher, M.D.
philanthropy they have expanded education Paul Okunieff, M.D.
for children with disabilities, helped revitalize the Rochester Philharmonic Orchestra, and
awarded $2.9 million in grants to youth and community programs through their Supporting Comprehensive Campaign
Foundation at the Rochester Area Community Foundation.
Judy Wilmot Linehan, Co-Chair
The Feinblooms also have a longstanding commitment to supporting cancer care. Jim Ryan Jr., Co-Chair
George Abraham, M.D.
In 2004, the couple put their conﬁdence in the vision and mission of the Cancer Center and Ralph J. Code III
made a $1 million gift to help kick-off the Wilmot Cancer Center Comprehensive Campaign. Jim DeGuzman
“The legacy of giving that the Feinblooms have established in Rochester sets an Harold Feinbloom
outstanding example for others,” says Richard I. Fisher, M.D., director of the Wilmot Cancer Richard I. Fisher, M.D.
Center. “We are proud to receive their support and work closely with them.” Robert Kessler
The Feinblooms were nominated for the award jointly by the Wilmot Cancer Center, Vince Leo
Al Sigl Center, Rochester Philharmonic Orchestra and the Rochester Area Community Stephen McCluski
Foundation. Donald Rhoda
Save the Date May 10, 2008 Paul J. Wilmot
Thomas C. Wilmot
Join us at the Bruce Zicari II
Rochester Riverside 9th annual Dialogue Editor
Convention Center for a Leslie White
spectacular celebration of the of Public Relations
opening of the new James P. Wilmot (585) 273-1119
Cancer Center facility.
To become a sponsor or reserve tables, please call (585) 242-8988.
Supporters Get Sneak Peek of
New Wilmot Cancer Center
The sounds of hammers and drills at the site of the new Wilmot Cancer Center were
silenced brieﬂy on Oct. 17 when major supporters of the James P. Wilmot Comprehensive
Campaign toured the facility and celebrated the progress.
The “Hard Hat Party” gave members of the Wilmot Cancer Center Board and
supporters a sneak peek at the future home of the Finger Lakes region’s top cancer center,
which will open in the spring.
“Rochester is an incredibly philanthropic community. The Wilmot Cancer Center has
truly been blessed with the support from families, individuals, foundations, and corporations
who have supported our campaign,” says Richard I. Fisher, M.D., director of the Wilmot
Cancer Center and vice president of clinical services for the University of Rochester
The Wilmot Cancer Center is raising $42.5 million to fund the Wilmot Cancer Center’s
strategic plan, which includes construction of the new 163,000-square-foot building and Above, leaders of the Wilmot Cancer Center Comprehensive
expanded cancer care and research. So far, almost $34 million has been raised, in part from Campaign welcomed donors to the Hard Hat party in the new
generous donations from Harold and Joan Feinbloom, the Hansen Family, Jack Rowe, M.D., facility under construction. Cancer Center Director Richard
Fisher, M.D., center, is ﬂanked by Campaign Co-Chairs Jim and
the Davenport-Hatch Foundation and the Wilmot family.
Caroline Ryan, left, and Judy and Paul Linehan, right. They have
Guests toured the facility – still in the “dry wall stages” – and were impressed with the raised $ 34 million toward the $42.5 million goal.
progress construction crews have made in the past 18 months. Everyone was excited about
the improvements to come. Right top, the Wilmot Cancer Center Hard Hat party brought
“Our patients will be amazed to see just what a signiﬁcant difference the new some interesting decorations, such as saw-horses for tables
facility will make in providing the best patient care in a modern, private, ultra-comfortable when guests enjoyed a bountiful buffet.
setting,” Fisher says. “The facility is not only beautiful — it has been designed with the
Right middle, Wilmot Cancer Center Director Richard Fisher,
input of patients and staff members who are on the front lines of care everyday and will M.D., left, and Medical Center CEO Bradford C. Berk, M.D.,
accommodate their needs.” Ph.D., discuss plans to create one of the top cancer centers
The new, four-story building will feature a three-story glass atrium, providing natural in the nation during a tour of the new facility. The building
lighting to patients and families. Clinical exam and treatment rooms will offer greater will open in the spring, bringing cancer care to a new level in
privacy, and improvements to the Radiation Oncology treatment area will be dramatic, with
spacious and private waiting and changing areas. Bottom right, Richard Fisher, M.D., director of the Wilmot
When the building opens, there will be twice as much space for outpatient cancer Cancer Center, with Kim and Steve McCluski, a Cancer Center
care, allowing more people from the Rochester and Finger Lakes region access to the best Board member and survivor.
care close to home. Scientists and clinicians will be closer together encouraging greater
collaboration for cures and education of the Wilmot Cancer Research Fellows who are
pursuing careers in cancer research.
If you’d like to support this campaign, please contact the Wilmot Cancer Center
Development Ofﬁce at 585-242-8988 or go to wilmotcancercenter.com.
4th annual Ice Cream Bowl
Help cream cancer by gobbling up Maggie Moo’s ice cream on Sunday,
Jan, 27, at Eastview Mall. This brain-freezing event is open to individuals
and teams who raise lots of “moo-lah” for the Wilmot Cancer Center.
The top fund-raiser wins an ice cream party for 100 people! Top ice-
cream-eaters in various age groups will receive prizes. Norma Holland
from 13 WHAM-TV will host the event. Registration formsorms Thumbs Up
are available at the Gates, Parma/Hilton, Penﬁeld, Henrietta,
nrietta, * To Erin Fennell for organizing
Greece, Ogden, Pittsford, Victor and Webster libraries, the
s, the annual Michael Fennell
Rochester Amerks game Dec. 28, or at Maggie Moo’s from Memorial Golf Tournament, in
11 a.m. to 2 p.m. Saturday, Jan. 5. To download the form,
orm, memory of her husband, and
go to wilmotcancercenter.com. Sponsorship opportunitiesities raising $ 6,530.
are available; please call (585) 242-0725 to inquire. * To Ron Billitier and Paul Tessoni
for organizing a golf tournament
Feb. 27 and raising $1,700.
Cenzi Motorcycle Unveiling * To Brockport Yacht Club for
For the second year, Cenzi Motorcycle Company will hosting a wine tasting and
unveil a custom motorcycle, valued at $30,000, for a drawing to raising $1,300.
support the Wilmot Cancer Center at the 2008 Rochester I t ti l * To Oak Hill Country Club’s
Auto Show. Tickets are $10 or three for $20 and will be available starting Tuesday Night Golf League
Feb. 27. The motorcycle will be on display at a number of locations for hosting the annual Pink
through June 1, when the winner is announced during the second Flamingo Golf Charity Event and
annual Cenzi Ride for Cancer and Bike Show, presented by Regional donating $885.
International. For a list of opportunities to see the motorcycle, go to * The Genesee Valley
wilmotcancercenter.com or call Cenzi Motorcycle at (585) 349-0120 or Conservation Club for raising
the Wilmot Cancer Center at (585) 242-8988. $ 600 during the annual Ed
Gordon Memorial Trap Shoot.
March 20 * To Maureen Graham, melanoma
Hat Day survivor and independent
Sign up your school or business for the 3rd annual Hat Day celebration consultant for Creative
and support the Wilmot Cancer Center. For a small donation you can wear Memories, for hosting a 12-hour
a hat to school or dress down at work to help support local cancer care scrap-booking event, raising
and research. Please call Karen McIntyre (585) 242-0725 for $400.
more information. * To Janine Burge who held cake
rafﬂes during the Hilton Apple
May 10 Festival and raised $200.
Save the date for the 9th annual Discovery Ball! Sponsorships and * To Martha Brown Middle
tickets are available for this signature event at the Rochester Riverside School for hosting their own hat
Convention Center, in support of the Wilmot Cancer Center’s clinical care day and raising $178.
and cancer research programs. Please call (585) 242-8988 to reserve
Awareness Events Staff from through the Medical Center showed
their support for ﬁnding a cure for breast cancer
held in October by wearing pink to work. The effort, organized by
Friends of Strong, raised $ 900 for Wilmot.
Breast Cancer Awareness Month provided
many opportunities to remind women of the
importance of screenings for early detection at the Wilmot Cancer Center. Strong
and to raise money for Wilmot Cancer Memorial Hospital’s Food & Nutrition
Center breast cancer programs. Services generously donated drinks and
Friends of Strong organization held pizza that raised $250 during the event.
Above, breast cancer survivor Paula Bokman,
center, raised $ 3,000 during an afternoon of music,
Wear Pink Day for staff to show their Breast cancer survivor Paula Bokman
wine tasting, and auctions at “Keeping the Hope support for women with breast cancer and colleagues organized Keeping the Hope
Alive” on Oct. 21. She is with Blanche Shearer, left, on Oct. 19 and raised more than $900. Alive, an afternoon of music, rafﬂes, silent
and Sue LoCicero, another breast cancer survivor Similarly, New Life Fellowship Church auction and wine tasting, raising more than
who was honored at the event. collected $2,745 during “Pink Sunday” on $3,000. Kristin Skinner, M.D., director of
Oct. 21 and donated the funds in memory of the Wilmot Multidisciplinary Breast Care
Below, Kristin Skinner, M.D., director of the
Muldisciplinary Breast Care Program, joined Marti Sally K. Majors. Program, was the featured speaker and
Caspar and George “Ace” Acevedo, at right, and WFKL radio (93.3FM) held its annual survivor Susan LoCicero was honored at the
Bob Kirk, at left, from Fickle 93.3FM. The radio Fickled Pink live broadcast at Strong Oct. 21 event.
station helped raise awareness of the importance of Memorial Hospital on Oct. 12, drawing Meliora Restaurant at University of
screenings during Breast Cancer Awareness Month
attention to the expert breast care team Rochester donated a portion of proceeds
from the “Think Pink” luncheon and dinner
Oct. 25. The day’s event raised $800.
James D. Marasco Memorial Golf
Tournament Seventy-ﬁve golfers
participated in the James D. Marasco
Memorial Golf Tournament Sept. 2.
Jim Marasco organized the event to honor
his father, a retired Gates police ofﬁcer
who passed away from cancer in December
2006, and to honor the Wilmot Cancer
Center doctors and nurses who cared for
him. The tournament rasied $2,865 to
support the Samuel E. Durand Bone Marrow
Diane Camelio & Susan Satter receive The Hettie Shumway Award Transplant Unit.
Wilmot Cancer Center volunteers Diane Camelio and Susan Satter received the Hettie
Shumway Award from Friends of Strong for their outstanding commitment to patients.
They have been Strong Memorial Hospital volunteers since the late 1980s and joined
the Wilmot Cancer Center team ﬁve years ago. The “Dynamic Duo” spread their warmth
and joy to patients treated in the Medical Treatment Center every Friday morning and help
prepare new patient handbooks. They are truly special ladies.
Balloon Manor Airigami artist Larry Moss
organized the third annual balloon haunted
house – Re/Max Balloon Manor: Elastic
Concert for Karen On Sept. 16, more than 200 people celebrated the life of Karen
Park. The 100,000-balloon theme park was
Schroeder, a local popular musician who died from melanoma, during the Concert for
constructed at Medley Centre. Balloon
Karen. Several local bands performed, including Rochester Metro Jazz Orchestra,
artists from throughout the country and
Upholstered 6 Strings, Kid Kurry, Random Act, The Taint, Coupe DeVilles, and Dave
across the globe traveled to Rochester to
McGrath. Special thanks to the sponsors: Abbott’s Frozen Custard, Budweiser, EPI
help build it.
Printing, Freetime Magazine, House of Guitars, Lake Beverage, Nola’s BBQ, Thomas
Funeral Chapel and The Rochester Razorsharks. The event raised more than $1,500.
A SEASON OF GIVING
Making the Most of Your Year-End Gifts
Year-end is a great time for giving, to family and friends, and to your favorite charities.
When you make a tax-deductible donation by Dec. 31, to the James P. Wilmot Cancer
Center, you aren’t just giving money. You’re giving hope to the thousands of people who
will need our services in the coming year.
While writing a check is simple and quick, there are other ways to give that could be
best for your ﬁnancial situation. Here are a few thoughts for your consideration:
Appreciated Securities – A popular alternative to cash is gifts of appreciated securities.
These gifts generate a double tax beneﬁt. In addition to receiving a charitable income-tax
deduction for the full fair-market value of the gifted security, the donor also avoids capital-
Cuts for the Cause Tangles Hair Salon gain tax which would occur if the asset was sold. Note: To qualify for the double tax-
and Day Spa in Irondequoit raised $2,800 beneﬁt, the security must have been held for more than one year.
during the Cuts for the Cause event Aug. 26.
Participants enjoyed “new ‘dos,” live music, DEFERRED GIFTS
and a barbecue, and supported the Wilmot Otherwise known as life-income plans, these gifts allow you to make a substantial
Cancer Center. Thanks to the Ridge Culver contribution to the Wilmot Cancer Center while still providing for your and your family’s own
Volunteer Fire Department for bringing a personal ﬁnancial needs.
truck to the salon for children’s tours. The Charitable Gift Annuity, which, in return for a cash or security gift of $5,000
or more, contractually guarantees ﬁxed-amount life income payments to one or more
annuitants, and an immediate charitable income-tax deduction. The payout rate depends on
the number of annuitants and their ages.
The Charitable Remainder Trust, which, in one form, generates a ﬁxed amount of
income, or, in another, provides variable income as the trust value ﬂuctuates. This latter
Dinner & form may provide a hedge against inﬂation. The trust may continue beyond the death of
Theatre Books the donor, and eventually passes to the Wilmot Cancer Center for the donor’s designated
Purchase purpose when all beneﬁciaries have passed away. A charitable income-tax deduction is
your Dinner & available at the creation of the trust.
Coupon Book DONOR ADVISED FUNDS
today to start saving. You can enjoy over 50 Philanthropy Simpliﬁed – This unique vehicle allows the donor to make a gift and receive
restaurants, retail stores (national & local) a tax deduction for the year of the gift, while retaining the right to make decisions in
and the local theatres. Coupons are valid the future as to which charities and in what amounts the gift should be distributed. The
now through December 2008. Each book is University invests the assets and handles all payment and record keeping duties, at
$15 with 50% of the proceeds supporting no charge.
the Wilmot Cancer Center. These books are
small enough to ﬁt in your purse and make All types of gifts can be made in memory or in honor of a loved one, patient, physician,
great holiday gifts! To purchase your book nurse or staff member. To learn more about these and other year-end planned giving
call (585) 242-8988, sale ends Dec. 31. strategies, please contact:
Ofﬁce of Trusts and Estates, 590 Mt Hope Ave., Rochester, NY 14620
(585) 275-7547 or (800) 635-4672
We also invite you to go to: http://rochester.plannedgifts.org
1. Napa Valley-based Auctioneer David Reynolds raises the ﬁnal $ 50,000 toward a $1 million night for the “Toast to Your Health Fine Wine Auction” to support the
James P. Wilmot Cancer Center. Medical Center CEO Bradford C. Berk, M.D., Ph.D., and Danny Wegman, presenting sponsor, applaud his efforts.
2. Diane and Steve Graham, Pamela and Don Rhoda, Mike and Connie Tambe enjoyed the spectacular evening of exquisite wines and a ﬁve-course gourmet meal.
3. Danny and Stency Wegman were presenting sponsors for the seventh annual “Toast to Your Health Fine Wine Auction,” the premier wine event in
continued from back cover
purchased by Jack and Lisa Baron for
$28,000. They will be escorted by
Sherwood Deutsch and Michael Misch to
little-seen Burgundy wineries and private
cellars, including the most renowned estate
in Burgundy: the Domaine de la Romanée-
Steve and Diane Graham bid $21,000
for a Tuscany trip, donated by Constellation
Brands, with a stay at Rufﬁno’ Montemasso
5 Castle. And Melissa Rutherford raised her
paddle with a $15,000 bid for a fashion
week excursion in New York City, with
runway shows featuring Carmen Marc Valvo
designs and two exquisite gowns.
Wines available included a 2004
Switchback Ridge Napa Valley Petite Sirah,
1996 – 2001 Opus One Napa Valley Red
Vertical, 2001, 2002, 2003 Screaming Eagle
Napa Valley Cabernet Sauvignon and a 2003
Rob Fisher of Fisher Vineyards in Napa
Valley, Calif., attended and donated several
vintages as well as an outstanding Wedding
Vineyard Cabernet Sauvignons dinner for 10,
which garnered $12,000.
Bidders also donated $350,000 to
support the addition of the Trilogy Image-
Guided Radiation Therapy System – cutting-
edge technology for high-dose, precision
radiation treatment for cancerous tumors.
This equipment is more versatile and faster
6 than any technology available to patients
and oncologists today in Rochester and
Upstate New York.
Proceeds supported the Wilmot Cancer
Center’s $42.5 million comprehensive
campaign, which includes construction of a
new, four-story facility to expand its local
cancer care and research to help ﬁnd cures.
This comprehensive campaign lays the
foundation to create one of the top cancer
centers in the nation.
Upstate New York. 4. Mariah and Anthony DiMarco were all smiles during the wine auction. 5. Sherwood Deutsch, of Century Liquor, volunteer Tony Gugino,
and Rolla Huff, honorary chair, discuss the ﬁne wines for bid during the live auction. 6. Daan and Lorraine Braveman enjoyed the riveting action during the bidding
for sought-after vintages, exclusive trips to private wine cellars and vacations.
Toast to Your Health
Fine Wine Auction
Raises $1M for Wilmot
The Toast to Your Health Fine Wine
Auction grossed more than $1 million
to support the University of Rochester
Medical Center’s James P. Wilmot Cancer
Center comprehensive campaign to expand
research and clinical care.
“It was an outstanding evening as
the Rochester community came together
to demonstrate their enthusiasm for the
Medical Center’s efforts to build a top
cancer program here,” says Medical Center
CEO Bradford C. Berk, M.D., Ph.D.
The Nov. 16 event attracted 420 wine
connoisseurs for an evening in Tuscany,
courtesy of Wegmans Food Markets, which
provided the location, elegant decorations
and ﬁve-course meal. The evening, chaired
by Rolla Huff, featured a spirited auction of
rare vintages, exclusive wine adventures,
and wonderful wine dinners, led by well
known Napa Valley auctioneer David
Among the top auction lots were an
exclusive trip to Burgundy, France,
continued on page 18 Tom Wilmot is awarded a bottle of champagne for his generous bid on a wine lot.
University of Rochester Medical Center Non-Proﬁt Org.
James P. Wilmot Cancer Center U.S. Postage
601 Elmwood Avenue, Box 704 PAID
Rochester, N.Y. 14642 Permit No. 780