Name Stephen O’Rahilly, MD, FRS, FMedSci
Date of Birth 1st April 1958
Place of Birth Dublin, Ireland
Director 2007- Institute of Metabolic Science
Metabolic Research Laboratory
Addenbrooke’s Hospital, Cambridge
Professor of Clinical Biochemistry Oct 2002 - University of Cambridge
& Medicine present Department of Clinical Biochemistry
Honorary Consultant 1994 - Addenbrooke’s Hospital NHS Trust
Physician present Cambridge.
Director, MRC Centre for 2007- Institute of Metabolic Science,
Translational Research in Obesity present Cambridge
& Related Metabolic Diseases
Service Centre Director for Clinical 2002 - Addenbrooke’s Hospital NHS Trust
Biochemistry & Immunology present Cambridge.
Deputy Director of the Oct 2002 - Addenbrooke’s Centre for Clinical
Wellcome Trust Clinical present Investigation.
Honorary Senior Scientist 1999 - Medical Research Council Resource
present Centre for Human Nutrition Research
1998-2002 Director of the Wellcome Trust Clinical Research Facility, Addenbrooke’s
Centre for Clinical Investigation.
1996-2002 Professor of Metabolic Medicine, University of Cambridge.
1991-1996 Wellcome Trust Senior Clinical Fellow, University of Cambridge.
1989-1991 MRC Travelling Fellow, Harvard University, Boston, MA, USA.
1987-1989 Registrar in Diabetes, Endocrinology and General medicine, Oxford Regional
1984-1987 Research Fellow, Nuffield Dept of `Medicine, Diabetes Research Laboratories,
University of Oxford.
1983-1984 Senior House Officer in Medicine, Hammersmith Hospital, London.
1982-1983 Senior House Officer in Medicine, St Bartholomew’s Hospital London.
1981-1982 Pre-registration House Officer, Mater Misericordiae Hospital, Dublin, Ireland.
MB BCh BAO 1981 (National University of Ireland)
MD 1987 (National University of Ireland)
MRCPI (1983); MRCP (UK) (1984), FRCPI (1996); FRCP (UK) (1996), FRCPath (2002)
Academic distinctions (Awards, Prizes, Named Lectureships)
1975 Department of Education Scholarship to UCD.
Irish Institute of Chemistry, Gold Medal for First Place in Chemistry in Ireland at Leaving
1981 DK O’Donovan Medal in Medicine.
Mater Hospital Gold Medal in Medicine.
Mater Hospital Gold Medal in Surgery.
Coleman Saunder’s Medal in Paediatrics.
1984 Dr John Keenan Travelling Studentship in Medicine from University College Dublin.
1986 William Stokes Award of Royal College of Physicians of Ireland.
Travelling Studentship in Medicine from the National University of Ireland.
1987 Charles & Maggie Green Jnr. Research Fellowship at Green College, Oxford.
Awarded the “Golden Stethoscope” by the Oxford clinical students for best clinical
1992 Senior Research Fellowship, Churchill College, Cambridge.
1995 SmithKline Beecham Visiting Professor, SKB, Philadelphia, PA, USA.
1996 RD Lawrence Lecturer of the British Diabetic Association.
Visiting Professorship, University of Witwatersrand, Johannesburg, South Africa.
Professorial Fellowship, Churchill College, Cambridge.
Member of the Association of Physicians.
1997 Bayer Lecturer of the Biochemical Society, University College Dublin.
1998 Visiting Professorship, SEMDSA, South Africa.
1999 Clinical Endocrinology Trust Lecturer, U.K.
Kroc Lecturer, University of Washington, Seattle.
2000 Archibald Byron Macallum Lecturer, University of Toronto.
Rufus Cole Lecturer, Rockefeller University, New York.
Society for Endocrinology Medal, U.K.
Bristol-Myers Squibb Unrestricted Grant for Metabolic Research.
Graham Bull Prize in Clinical Medicine, Royal College of Physicians of England.
Fellow of Academy of Medical Sciences UK.
Honorary Fellowship, Faculty of Medicine, University College Dublin.
2001 Visiting Professor to University of California San Francisco.
David Pyke & Peter Watkins Visiting Professor, King’s College Hospital, London.
Alexander Marble Lectureship, Joslin Diabetes Centre, Harvard University.
European Journal of Endocrinology Prize.
Novartis International Award for Clinical Research in Diabetes.
Pfizer Visiting Professorship, Yale University, USA.
Physiological Society Annual Review Prize Lecturer, UK.
Robert Turner Memorial Lecturer, EASD meeting, Glasgow.
2002 Gordon Cumming Memorial Lecturer, Medical Research Society, London.
Peter Baker Memorial Lecturer, King’s College, London.
Heinrich Wieland Prize, Munich, Germany.
2003 Fellowship of the Royal Society.
Carl Gottschalk Award, University of North Carolina.
Lydia Roberts Memorial Lecturer, University of Chicago.
Harry Bostrum Lecturer, Swedish Society of Internal Medicine.
2004 Julia McFarlane Diabetes Research Centre Special Lectureship, University of Calgary.
Honorary Membership of the Association of Physicians.
Foreign Membership of the Association of American Physicians.
Lilly Lecturer, Queen’s University, Belfast.
Pfizer Visiting Lecturer, SUNY Stony Brook.
Linacre Lecturer, St John’s College, University of Cambridge.
2005 Visiting Professor, University of Sussex Medical School.
H.C. Jacobaeus Lecturer & Novo-Nordic Award, University of Oslo.
Hadassah Horn Memorial Lecturer, Weizmann Institute, Rehovot, Israel.
Rolf Luft Award, Karolinska Institute, Stockholm.
Middlesex Hospital Medical School Commemorative Visiting Professor at UCH, London.
2006 Biolink USA-Ireland Lifescience Award.
2007 Feldberg Prize
George Frederic Still Memorial Lecturer, Royal College of Paediatrics and Child Health
Solomon Berson Award, Mount Sinai Medical School, New York
Kroc Lecturer, University of Massachusetts.
Clinical Investigator Award, The Endocrine Society, USA
2008 Lambertsen Lecturer, University of Pennsylvania
Current Major Grant Support
Grants held as Principal Investigator
MRC Programme Grant
Title: Molecular Mechanisms in Human Obesity
Wellcome Programme grant
Title: Molecular Mechanisms in Human Insulin Resistance.
Co-Investigator: Dr A Vidal-Puig
Wellcome Trust Consortium Grant (Integrative Physiology Initiative)
Title: Integrative Physiology of Common Metabolic Disease
Co-investigators: 11 other PIs from Cambridge and Oxford.
Translational Research in Obesity and Related Metabolic Diseases
Amount: £2.7 million
Co-investigators: 17 other PIs from Cambridge and Oxford.
Grants held as co- investigator
MRC Research Grant
Title: Targeting therapy to molecular mechanism of disease in obesity & related metabolic
Duration 2006 - 2009
EU 6th FrameworkProgramme
EUGENE 2 “Functional genomics of type 2 diabetes”.
Principal Investigator: Prof. Ulf Smith, Gothenburg University, Sweden.
Amount for SOR lab: Euros 390,000
EU FP6 Programme
Principal Investigator: Dr S Dickson, Gothenburg University
Amount for SOR lab: £452,180
Duration: 2004 -2008
Wellcome Trust Consortium Grant (Functional Genomics Initiative)
Title: Biological Atlas of Insulin Resistance
Principal Investigator: James Scott, Imperial College London
Amount for SOR lab: £488,301
Contributions to Research Infrastructure in Cambridge
Wellcome Trust Clinical Research Facility, Addenbrooke’s NHS Trust
Principal scientist co-ordinating the scientific case to the Wellcome Trust.
As its first Director, responsible for co-ordinating the design of the facility and the establishment
of its operating procedures.
Institute of Metabolic Science, Cambridge (IMS)
Principal scientist responsible for fund-raising from Atlantic Philanthropies, Wolfson Foundation
and Garfield Weston Trust.
Principal scientist responsible for design of facility, which will open in 2007.
Chair of IMS Management Committee.
1. Anna Krook (Oct 1992-Oct 1995) Elmore Prize PhD Student, Gonville & Caius College.
Now: Principal Investigator Karolinska Institute, Stockholm.
2. Philippa Humphreys (Oct 1992-Oct 1995) MRC PhD
Now: Clinical Scientist GSK, UK.
3. Heidi Kalloo-Hosein (Oct 1994-Oct 1997) Wellcome Prize PhD Student.
Now Biotechnology Industry, UK.
4. Carl Montague (Oct 1994-Oct 1997) MRC PhD
Now Research Group Leader, Boehringer-Ingelheim Pharmaceuticals, Germany.
5. Kevin Baynes (1996-1999) Wellcome Trust Clinical Training Fellow, PhD
Now Consultant Physician London.
6. Claire Baker (Oct 1996-2001) BDA PhD
7. Sadaf Farooqi (Jan 1997-2001) Wellcome Trust Clinical Training Fellow. PhD
Now Wellcome Trust Clinician Scientist, Cambridge.
8. George Millington (April 97-March 01) Wellcome Trust Clinical Training Fellow PhD
Now dermatology Specialist Registrar East Anglia .
9. Ciaran Sewter (Sept 1997-Aug 2001), BDA PhD
Now Sales Executive, Upstate Biotechnology UK.
10. Claire Mulligan (Oct 1998-2002)
Now Post-Doctoral scientist, QMW London.
10. Ben Challis (Oct 1998-2001 ) Canada Cambridge Scholarship, ORS, Dept of Clinical
Biochemistry PhD. Now Medical Student, University of Cambridge.
11. Christopher Lelliot (Oct 1999 - 2003 ) MRC PhD
Now Post Doctoral scientist AstraZeneca, Sweden.
13 David Savage (1999-2003) Wellcome Clinical Training Fellow MD, Capetown
Now Wellcome Trust Clinician Scientist, University of Cambridge
13. Vivion Crowley MRC Clinical training Fellow MD Nat Univ Ireland
Now Consultant Chemical Pathologist, Dublin
14 Stella George (Oct 2000-2003 ) MRC Clinical Training Fellow. PhD
Now Endocrinology Specialist Registrar, East Anglia
15 Bill Gibson (Jan 2001-2004) Canadian MRC Clinical Training Fellow.
Now Post Doctoral fellow UBC, Vancouver.
16 Connie Hung, (2002-2005) Cambridge Overseas Trust, ORS, privately funded PhD.
Now Project Manager, Medigen Biotechnology Corp (Taiwan).
17. Andrew Powlson (Jan 2002-present ), MBPhD student.
18. Robert Semple (April 2002-2005), Wellcome Trust Clinical Training Fellow. PhD.
Now Specialist Registrar in Diabetes, Endocrinology & General Medicine.
19. Anthony Coll (July 2002 -2006) MRC Clinical Training Fellow. PhD.
Now MRC Clinician Scientist, University of Cambridge.
20. Karen Tan, (2003-present) Singapore Agency for Science & Technology Research
Scholarship. MBPhD student.
21. Juliette Gray (Oct 2003-present), MRC PhD studentship. Now translator of scientific
manuscripts in Paris.
22. Wo-Shing Au (2004-present), Dorothy Hodgkin International studentship. PhD student.
23. Rebecca Sanders (Oct 2005- present), MRC MSc studentship. Now in biotech industry.
24. Zorica Jovanovic (Oct 2005-present), MPhil student, Cambridge European Trust, German
Academic Exchange Service, Kurt Hahn Trust.
25. Satya Dash (Oct 2006-present), MRC Clinical Training Fellowship, PhD student.
Diabetes Clinic (1 per week) Endocrine Clinic (1 per week)
Specialist referral service for patients with severe insulin resistance
Service Centre Director in Clinical Biochemistry and Immunology (2003-)
Undergraduate and Medical Student Teaching
Part II Cambridge Natural Sciences. Medical Biochemistry Option (1 lecture).
Medical Sciences Tripos, Pathology.: Molecular Mechanisms of Disease (2 lectures).
Lectures to clinical students in Medicine, Pathology & Therapeutics (approx. 3 per year).
Teaching to clinical students (15-20 sessions per year).
Associate Editor of Diabetologia (1995-2001)
Scientific Editor of the Journal of Endocrinology (1996-2003)
Editorial Board Quarterly Journal of Medicine.(1999-2003)
Editorial Board Diabetic Medicine (2001-2005)
Editorial Board Journal of Clinical Endocrinology & Metabolism (2002-)
Editorial Board Reviews in Endocrinology & Metabolism (2000-)
Editorial Board PLOS Biology (2003-)
Associate Editor Cell Metabolism (2004-)
Member, BDA/Diabetes UK Research Committee (1996-2001)
Member, Wellcome Trust Clinical Interest Group (1996-2002)
Chairman, Wellcome Trust Clinical Interest Group (1999-2002)
Chairman, Awards Panel, Bristol Myers Squibb Foundation Award for Metabolic Diseases (2001-
Member, Research Advisory Council of Research into Ageing (2002-2004)
Member, Scientific Advisory Council of the Dublin Molecular Medicine Centre (2002-)
Chairman, Medical Research Society (UK) (2004- )
Member, SAB of Dublin Centre for Human Proteomics (2004.-)
Member, Academy of Medical Sciences Council (2004 - 2007)
Member, Royal Society Sectional Committee 10 (2004-2007) and the Biological Sciences
Awards Committee (2005-2007)
Member, Council of the Society for Endocrinology (2006 - )
Panel member, Foresight Tackling Obesities Project, Department of Trade & Industry (2006)
Scientific member, Ernst Klenk Foundation (2008- )
Member, SAB of the MRC Clinical Sciences Centre, Hammersmith Hospital (2008 -)
Chairman, MRC Translational Research Overview Group (2008- 2010)
Chairman of SAB and co-founder Cambridge Clinical Research (UK) (2001-)
SAB member Biovitrum (Sweden) (2001- 2007)
SAB member Paradigm Ltd (UK) (2002-)
SAB member of OSI/Prosidion (UK) (2003-)
SAB member Cambridge Antibody Technology (UK) (2004-)
Public Understanding of Science
Multiple contributions on national and international television and radio regarding the science of
obesity and diabetes.
Public lectures in schools and lay organisations.
Public Lecture in the Royal Institution Lecture Series 2003.