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Outline of Medical Immunology basic immunology

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					      Outline of Medical Immunology (basic immunology)

                             (Applied to foreign students)
                                         Preface

     Medical Immunology is the study of the cellular and molecular events that
occur after an organism encounters microbes and other foreign macromolecules. It has
developed rapidly over the last 40 years, and particularly during the last 10 years with
the advent of molecular techniques. It is now a rapidly moving field that is
contributing critical tools for research and diagnosis, and therapeutics for treatment of
a wide range of human diseases. Thus it is an integral part of college life science
courses and medical studies.
      Generally, medical immunology can be divided into basic and clinical
immunology. This outline is applied to foreign students to learn basic immunology.
It will request students to grasp cardinal concepts, theories and principles of
immunological diagnosis, prevention and treatment. For concrete content of each part,
the aims and requests will be divided into three parts: grasped contents, familiar
contents and understanded contents.
     It takes 40 hours to study this course. The study of theory for basic
immunology needs 30 hours, the study of experimental skill needs 10 hours.

Textbook:《医学免疫学》
Original Editos:Tristram G . Parslow Daniel P. Stites AbbaI. TerrJohnB . Imboden
Chief Editors of Adaptation Edition:TanJinquan(谭锦泉) Y ao K un(姚堃)
科学出版社,2006 年出版

                      Table 1 The study of Immunological theory
                                       (30 hours in all)

        Teaching sequences                Contents                       Time
 1     General introduction of     1
 2           Immunology            3
 3             Antigen             3
 4         Immunoglubulin          3
 5      Complement system          2
 6             Cytokine            2
 7              MHC                2
 8   CD and adhesion molecules     3
 9          Immune cells           4
10        Immune response          1
11        Immune tolerance         1
12       Immune regulation         3
13         Hypersensitivity        2
     Prevention and treatment of
             Immunology
                    Part 1 General introduction of Immunology

[Aims and requestions]
      Grasp mordern concept of immunity and function of immunity,make clear the essence of
immunity and composition of immune system.
[Contents]
      Grasp mordern concept of immunity and function of immunity;Grasp the characteristics of
innate immunity and adptive immunity;the composition and functions of immune system.
      Understand the history of Immunology and effect of Immunology in medicine.Understand
the present situation and advance of Immunology.
[Time] 1 hours




                                    Part 2 Antigen(Ag)

[Aims and requestions]
      Grasp several associated concepts with antigen.Understand the significance of antigen in
medicine.
[Contents]
      Grasp concepts of antigen,hapten,antigenic determinant,comman antigen,cross-reaction,
TD-Ag,TI-Ag, heterophilic antigen and superantigen.Grasp the specificities of antigen.Grasp the
important antigens in medicine.Be familiar with decided factors of antigen.Understand the
types,characteristics and functions of superantigen;Understand the concept,types and function of
adjuvant.
[Time] 3 hours




                                Part 3 Immunolglubulin

[Aims and requestions]
       Grast the molecular structure of antibody and its hydrolyzed fragments, functional region
and its function. Grast the major characteristics of the five classes of antibody. Grast the discipline
of antibody production and the biological function of antibody. Grast the concept of polyclonal
antibody and monoclonal antibody. Grasp the relationship of the molecular structure of antibody
and its function.
[Teaching content]
     1.Grast the molecular structure of antibody, its hydrolyzed fragments and their function.
     2.Grast the functional region of antibody and the biological effect of each function region.
     3.Grast the major characteristics of five classes of antibody .
    4.Grast the discipline of antibody production and the biological function of antibody.
    5.Be familiar with the concept of antibody and immunoglubulin.
    6.Understand the serum type, biosynthesis and genetic control of antibody production.
[Time] 3hours

                            Part 4 Complement System

[Aims and requestions]
      Grast the concept of complement system, the activated pathway and biological function of
complement system.
[Teaching content]
    1.Grast the concept, components and activated pathway of complement system.
    2.Grast the biological function of the degraded products.
    3.Grast the biological function of complement system.
    4 . Understand the physical and chemical property of complement, the regulation of
complement activation and the clinical significance of the serum level of complement.
[Time] 3 hours




                                    Part 5 Cytokine

[Aims and requestions]
      Grast the concept ,common characteristics and classification of cytokine.
[Teaching content]
    1.Grast the concept, common characteristics and classification of cytokine.
    2.Be familiar with the function of cytokine.
    3.Understand the application of cytokine.
[Time] 2 hours




                     Part 6 Major Histocompatibility System

[Aims and requestions]
    Grast the concept of MHS,MHC and HLA. Grast the distribution, molecular structure,
function and medical significance of HLA. Understand the intracellular activation depends on the
interaction of surface molecule and genetic control.
[Teaching content]
    1.Mster the concept of MHS,MHC and HLA.
    2.Grast the distribution, molecular structure, function and medical significance of HLA.
    3.Be familiar with the function of HLA in the immune recognition.
    4.Understand the discovery of MHS, nomination and genetic property of HLA.
    5.Understand the appraisal principle of HLA antigen.
[Time] 2 hours
                     Part 7 CD antigen and adhesion molecule

[Aims and requestions]
    Grast the concept, classification of CD antigen and adhesion molecules. Grast the molecular
structure and function of commonly used CD antigens and adhesion molecules.
[Teaching content]
    1.Grast the concept and classification of CD antigens and adhesion molecules.
    2.Grast the structure and function of commonly used CD antigens and adhesion molecules.
    3.Understand the medical significance of comely used CD antigens and adhesion molecules.
[Time] 2 hours



                                  Part 8 Immunocyte

[purpose and request]
    Lay emphases on the surface markers of T and B lymphocytes, and characteristics and
functions of their subunits; lay emphases on the process of antigen presenting; understand the
characteristics and functions of NK cells and others lymphocytes;understand the characteristics
and functions of APC.
[teaching contents]
    The composition of immune system, the functions of immune organs, the distribution,
differentiation, surface markers, subunits and functions of T and B cells; the characteristics and
functions of NK cells and others lymphocytes;the characteristics and functions of APC.
[Time] 3 hours



                             Part 9 Immune Response

[Aims and requestions]
    Grast the process of immune response;Grast the processes, features and biologic functions of
humoral immunity and cellular immunity.
[teaching contents]
    Concept and types of immune response, the relation between the types of immune response
and TD antigens or TI antigens; the processes, features and functions of humoral immunity and
cellular immunity.
[Time] 4 hours



                            Part 10 Immune Tolerance

[Aims and requestions]
    Grast definitions and characteristics of immune tolerance and immune inhibition;Understand
the mechanism of immune tolerance.
[teaching contents]
     The definitions and characteristics of immune tolerance, immune inhibition. The mechanism
of immune tolerance. The phenomenon, forming conditions and significance of immune tolerance.
[Time] 1 hours


                             Part 11 Immune Regulation

[Aims and requestions]
     Grast concept of immune regulation;Grast the regulating functions of immune cells and
cytokines, Grast the theory of Id network.
[teaching contents]
     The concept of immune regulation; the regulating functions of immune cells and cytokines,
Grast the theory of Id network. The interaction of neural systems, incretion system and immune
system.
[Time] 1 hours


                               Part 12 Hypersensitivity

[purposes and requests]
     Grast the concepts, mechanisms and common diseases of all types of hypersensitivity.
[teaching contents]
     The concept of hypersensitivity;the characteristics, mechanisms and common diseases.
Detection method of hypersensitivity.
[teaching method] relate hypersensitivity to immune response and its essence.
[Time] 3 hours


            Part 13 Prevention and Treatment of Immunology

[purposes and requests]
     Grast the concept of immune prevention;Grast the characteristics of artificial positive
vaccination and artificial negative vaccination.   Understand the types and preparation mechanism
of new vaccines. Understand the concept of immunotherapy.
[teaching contents]
     The concept of immune prevention, the preparation of immune prevention. The
characteristics of artificial positive vaccination and artificial negative vaccination. The concepts,
types and features of new vaccines. The types and functions of immunoregulation reagents .
[Time] 2 hours
                         Experimental part(10 hours)
Experiment 1 Non-specified immunity and Agglutination Reaction

[Aims]
    1. Familiar well with Laboratory rules and regulations
    2. Grasp the common cells participated the non-specified immunity.
    3. Familiar well with the methods of phagocytosis function measurement.
    4. Grasp the principle, features and classifications of the agglutination reaction.
    5. Familiar well with the principle of indirect agglutination inhibition test.
    6. Complete the operation and analysis the results by oneself.
[Contents]
    1. Laboratory rules and regulations
    2. Phagocytosis of of neutrophil and macrophage
    3. Lysozyme test
    4. Slide Agglutination Test (human ABO blood type assay)
    5. Latex Agglutination Inhibition Test
[Time] 3 hours


                       Experiment 2 Precipitation Reaction
[Aims]
    1. Grasp the principle, features of the precipitation reaction
    2. Grasp the mechnism of counter electrophoresis.
    3. Familiar well with interfacial ring precipitation, single diffusion and double diffusion.
    4. Complete the analysis the results by oneself.
[Contents]
    1.Interfacial ring precipitation
    2.Single diffusion
    3.Double diffusion
    4.Counter electrophoresis
[Time] 3 hours


         Experiment 3            Complement Fixing Test and T cell assay
[Aims]
    1.Grasp the principle, methods, results judgment of the complement fixing test.
    2.Understand the significant of each control tubes.
    3.Familiar well withthe rosette test and Lymphocyte transformation.
    4.Complete the analysis the results by oneself.
[Contents]
    1.Complement Fixing Test
    2.Rosette test
    3.Lymphocyte transformation
[Time] 3 hours
[Discussion] 1 hour




                               Department of medical microbiology and immunology
                                                      2007.1

				
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