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Cognitive and Behavioral Evaluation of Patients with ALS PI: Hiroshi Mitsumoto, MD Coordinators: Edward Huey, MD, Jennifer Greene Design: The goal of this study is to cognitively characterize amyotrophic lateral sclerosis (ALS) patients seen at the Eleanor and Lou Gehrig MDA/ALS Research Center and Neuromuscular Division at the Neurological Institute of New York and to determine the best method to identify cognitive dysfunction in ALS patients. The study will involve 60 patients with ALS who fulfill the revised El Escorial criteria (Brooks et al., 2000) for probable or definite ALS. Patients who choose to participate in the protocol will come for a single visit to CUMC for a clinical, behavioral, and neuropsychological evaluation for cognitive symptoms associated with ALS, especially frontotemporal dementia associated with ALS (FTD-ALS). The goal is to evaluate experimental neuropsychological tests for the diagnosis of cognitive impairment in ALS. Eligibility: Diagnosis of ALS which fulfills the revised El Escorial criteria for probable or definite ALS. Able to complete a cognitive screen. Other eligibility/exclusion criteria coming soon.
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