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Exacerbations of Asthma

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Exacerbations of Asthma

Description:    There is growing interest in the pronounced variability in the incidence and severity of chronic
                respiratory diseases such as Asthma, observed to occur in any particular patient over a given
                period of time. It is now known that acute exacerbations are multi-factorial in origin, with pollution,
                allergens and viruses all implicated, and effective treatment requires a similarly complex approach
                that addresses each of the component causes. In this new volume, leading authorities review what
                is known of these causative factors and the mechanisms by which they exacerbate the symptoms
                of pulmonary disease both singly and in combination. The authors evaluate the individual efficacy
                of current treatments in the light of this knowledge and present new recommendations for
                formulating effective therapeutic regimens.

                Short Contents



Contents:       EPIDEMIOLOGY. Acute exacerbations are major unmet needs in asthma therapy. Socio-economic
                costs of acute asthma exacerbations. Seasonal patterns of asthma exacerbations. Aetiology of
                asthma exacerbations in children. Aetiology of asthma exacerbations in adults. Differentiating
                asthma exacerbations from poor asthma control. Do frequent exacerbations lead to accelerated
                long term decline in lung function in asthma? PATHOPHYSIOLOGY. Inflammatory mechanisms of
                asthma exacerbations. Virus induction of neurogenic inflammation and airway responsiveness.
                Antiviral immunity and protection against asthma exacerbations. Lessons from RSV bronchiolitis
                and acute wheezing episodes in infants. Virus induction of steroid resistance. IN-VITRO
                EXPERIMENTAL MODELS OF ASTHMA EXACERBATIONS. In vitro models of bronchial epithelial cell
                infection. In vitro models of macrophage infection. IN-VIVO EXPERIMENTAL MODELS OF ASTHMA
                EXACERBATIONS. Murine models of allergen exposure and virus infection. A murine model of
                rhinovirus infection. A human experimental model of asthma exacerbation induced by rhinovirus
                infection. Lessons from human experimental rhinovirus infection in combination with allergen
                exposure. TREATMENT & PREVENTION OF ASTHMA EXACERBATIONS. Role of established asthma
                therapies in treating acute asthma exacerbations (adults and children). Role of leukotriene
                antagonists in the treating acute asthma exacerbations. How good are inhaled steroids alone at
                preventing asthma exacerbations? (prophylactic and doubling dose). How good are inhaled
                steroids/LABA in combination at preventing asthma exacerbations? New targets for
                treatment/prevention of asthma exacerbations. DELIVERY OF CARE
                Role of self-management in preventing asthma exacerbations. Psychosocial factors in severe
                asthma



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posted:10/10/2011
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