Interactive Lecture Quiz #3 on Endocrine Chart, syllabus pages - PowerPoint

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					              Interactive Lecture Quiz #3 on
           Endocrine Chart, syllabus pages 39-44,
     gland, hormone, regulation of secretion, chemical structure

                                  Spring, 2008
                         By Patricia L. Mansfield, Ph.D.

 Directions. Take this quiz using your powerpoint viewer to test yourself and to get immediate
                                 feedback on your answer choice.

  I obtained some animations or videos from internet classes or from your textbook author to
     demonstrate the important principles covered in this quiz. Unfortunately, I don’t always
    remember the website address of the figure; and some websites are no longer available.



3/6/2008
                                                                                                 1
1. Which hormone directly stimulates the release of cortisol, a
glucocorticoid?
a. ACTH b. CRH      c. aldosterone d. glucagon
2. Which gland secretes cortisol?
a. hypothalamus      b. posterior pituitary      c. kidneys
d. adrenal cortex   e. adrenal medulla

                                          CAPSULE
                                          --------------------
                                          Z.G.
                                          --------------------

                                          Z.F.


                                          --------------------
                                          Z.R.

                                          --------------------
                                          MEDULLA
3. Which hormone or condition stimulates the release of hGH?
a. GHRH b. ↑[glucose]blood c. ↑ lactic acid production
d. TSH e. somatostatin




Another fact to record
on your LIVER PAGE,
syllabus p.120
  hGH can only act on tissues
  by stimulating the liver to
  produce the IGFs aka
  insulin-like growth factors
  aka somatomedins!
4. Give the chemical structure of hGH.
a. steroid b. catecholamine      c. peptide                d. eicosanoid
 http://en.wikipedia.org/wiki/Growth_hormone
 “Growth hormone (GH) is a hormone that stimulates growth and cell
 reproduction in humans and other animals. It is a 191-amino acid, single chain
 polypeptide hormone which is synthesized, stored, and secreted by the
 somatotroph cells within the lateral wings of the anterior pituitary gland. The
 hormone is also known as somatotrophin when referring to growth hormone
 produced by recombinant DNA technology, and is abbreviated "rhGH".”




                   From http://www.antiagingresearch.com/
5. Which hormone(s) is (are) secreted by the thyroid gland?
a. T3   b. T4   c. calcitonin   d. all of these e. none of these
6. Which of the hormones in #5 is an iodine-containing
amino acid?
a. T3   b. T4 c. calcitonin d. all of these e. T3 and T4
7. Which hormone is stimulated by PTH?
a. calcitriol b. leptin     c. gastrin                                             d. two of these




     Please add the parathyroid gland to the Endocrine Chart, syllabus p.40. It got cut off by mistake.

     PARATHYROID      PTH                Peptide Bone, Kidney,          Increases blood calicum levels by
     GLAND            Stim. by decreased         Small intestine        stimulating bone resorption,
                      blood calcium                                     increasing absorption, and
                      levels                                            decreasing calcium excretion
8. Melatonin is a ________.
a. peptide    b. amine c. steroid   d. prostaglandin
9. What inhibits the secretion of melatonin?
a. light b. food       c. water          d. ↑oxygen




                                      The pineal gland is part of the
                                             diencephalon.
10. Based upon the correct answer in #9, which sensory
organ must communicate with the pineal gland?
a. eye b. ear      c. nose d. muscle spindle        e. skin



  I thought you might be interested in this!
  The visual pathways from the eye –axons from the optic
  tract– send axon collaterals to synapse in a hypothalamic
  nucleus called the suprachiasmatic nucleus (SCM). Axons
  from the SCM synapse in the pineal gland.
11. What event stops the secretion of insulin?
a. eating b. glucose levels return to normal c. hunger
12. How would you describe the relationship between the
hormones, glucagon and insulin?
a. antagonistic         b. additive
c. no relationship: secreted by different endocrine glands
d. dependent: one stimulates the secretion of the other
          Answers
1.    A
2.    D
3.    A
4.    C
5.    D
6.    E
7.    A
8.    B
9.    A
10.   A
11.   B
12.   A
          RELATIONSHIP BETWEEN
 Chemical Structure of Signal Molecule – Signal
 Molecule Behavior at Target – Signaling Pathway
 •Peptides, Amines, Steroids

 •Pull out your SIGNALING PATHWAYS handout
 as you review the next slides.


Review the major facts about the
 different classes of hormones
  Signaling Pathway for Peptides:
Peptide Hormone-Receptor Complex
• Hormone binds to cell surface receptor– can’t enter
  cell, so they need signal amplification and a second
  messenger
• Enzyme activation           •http://highered.mcgraw-
                              hill.com/sites/0072437316/stud
• Second messenger            ent_view0/chapter7/animations.
                              html#
• Cascade of events
• Open channels
• Cellular response
          Peptide Hormone-Receptor Complex
Membrane receptors and signal transduction for peptide hormones




                                                          Figure 7-5
    Steroid Hormones: Features
• Cholesterol-derived
  – Lipophilic and can enter target cell by simple diffusion
• Cytoplasmic or nuclear receptors – Don’t need
  signal amplification and a second messenger
• Activate DNA for protein synthesis
• Slower acting, longer half-life
• Examples
  – Cortisol, estrogen, and testosterone
                            Amines

    •Catecholamines: Epinephrine, Norepinephrine
    •Second messengers– cAMP and Ca++
    •Use with your handout
http://highered.mcgraw-
hill.com/sites/0072437316/student_view0/chapter7/animations.html#
                Steroid Hormones: Structure
     Steroid hormones are derived from cholesterol
•Mechanism of Steroid
Hormone Action at
http://highered.mcgraw-
hill.com/sites/0072437316/stud
ent_view0/chapter47/animation
s.html#




                                                     Figure 7-6
Thyroid hormones– T3 and T4




                                         •Lipophilic hormones
                                         •Mechanism of Thyroxine Action at
                                         http://highered.mcgraw-
                                         hill.com/sites/0072437316/student_
                                         view0/chapter47/animations.html#
    Silverthorn, Figure 23-9: Thyroid hormone synthesis