Stem Cells_ Cancer and Metastasis

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					                           Announcing Keystone symposiA’s meeting on:                 \




                                Stem Cells, Cancer and Metastasis
cutting-edge science • cross-disciplinary collaboration • networking opportunities • peer-reviewed meeting program

 S   everal concepts regarding the origins of cancer and metastasis have converged in recent years. In particular, special interest has focused on the possibility
     that tissue specific stem cells and cancer cells displaying the properties of these cells play fundamental roles in the malignant process. These concepts
 have been supported by studies of mouse models in which predictable patterns of tumor spread and access to both primary and metastatic lesions has
 allowed molecular analyses. With regard to primary tumors, emerging evidence suggests that important cancers, including those in the colon and brain,
 may arise directly from mutated progenitor cells that display deviant differentiation within “stem cell-niches.” Tumors appear also to contain stem-like cancer
 cells that are both necessary and required to propagate the disease. These findings overlap with observations of metastasis that suggest tumor dissemination
 may be driven by critical changes in tumor cell differentiation, including epithelial to mesenchymal transition (EMT), and the migration of malignant stem
 cells to “pre-metastatic niches.” We believe the time is ripe for a joint conference that will bring together scientists and clinicians with interests in stem cell
 biology, cancer and metastasis. The meeting will provide a forum for exchange of information and insights between these rapidly moving fields. In addition
 to increasing the sharing of key scientific approaches we believe this conference will galvanize collaborative efforts among disparate research communities to
 address several key outstanding questions: (i) What is the relationship between normal and malignant tissue stem cells? (ii) What is the relationship between
 cancer stem cells and the so-called “metastatic precursor,” that is capable of indefinite proliferation at the new metastatic site? (iii) What are the interactions
 between stromal and stem-like cancer cells in primary and metastatic disease sites? How do these interactions facilitate disease propagation and metastatic
 spread? (iv) How should we monitor in vivo the biology of stem-like cells in primary tumors and metastasis? (v) What are the optimal approaches to target
 therapeutically stem-like cancer cells in primary and metastatic disease? By focusing on these questions, we aim to elicit exciting fundamental biological
 discussions with significant translational application.

                                                         March 6–11, 2011
                                             Keystone Resort • Keystone, Colorado • USA
                                                                Scientific Organizers:
                                                     Richard J. Gilbertson and Daniel A. Haber

                                                       Keynote Speakers:
                              Robert A. Weinberg, Whitehead Institute for Biomedical Research, USA
                                      Sean J. Morrison, HHMI/University of Michigan, USA
                                                                    Plenary Session Topics:
                                 • Stem Cells in Cancer Pathogenesis I: The Controversy of Cancer Origins
                                • Stem Cells in Cancer Pathogenesis II: Niches and the Metastatic Cascade
                                   • Genomic Analyses: Reading the Genome in Cancer Stem Cells and
                                                          Metastatic Precursors
                                                             • Breast Cancer
                                          • Cancer Stem Cells, Metastasis and Cancer Therapy
                                   • Imaging and Tracking Cancer Stem Cells and Metastatic Precursors
                                                   • Epithelial Cancers and Stem Cells
                                • Roundtable: Cancer Stem Cells in Metastasis – Insights and Controversies
                                                       Abstract & Scholarship Deadline – Nov 4, 2010
                                                       Late-Breaking Abstract Deadline – Dec 9, 2010
                                                          Early Registration Deadline – Jan 6, 2011

                                                         www.keystonesymposia.org/11C4




  Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA that is directed and supported by the scientific community.
                                            www.keystonesymposia.org • 1-800-253-0685 • 1-970-262-1230
Stem Cells, Cancer and Metastasis
March 6 – 11, 2011 • Keystone Resort • Keystone, Colorado • USA
Scientific Organizers: Richard J. Gilbertson and Daniel A. Haber
Sponsored by Astellas Pharma Inc., Celgene Corporation and Takeda Pharmaceutical Company Limited

Abstract & Scholarship Deadline: November 4, 2010 / Late-Breaking Abstract Deadline: December 9, 2010 / Early Registration Deadline: January 6, 2011

SUNDAY, MARCH 6                                                               WEDNESDAY, MARCH 9
KEYNOTE ADDRESS                                                               CANCER STEM CELLS, METASTASIS AND CANCER THERAPY
 Robert A. Weinberg, Whitehead Institute for Biomedical Research, USA          Max S. Wicha, University of Michigan, USA
                                                                               Therapeutic Implication of Stem Cells in Breast Cancer
MONDAY, MARCH 7
                                                                               Margaret Read, Infinity Pharmaecuticals, Inc., USA
STEM CELLS IN CANCER PATHOGENESIS I: THE CONTROVERSY                           Drug Discovery in the Cancer Stem Cell Era
OF CANCER ORIGINS                                                              Frederic J. de Sauvage, Genentech, Inc., USA
 John E. Dick, Toronto General Research Institute, University Health           Developmental Regulatory Pathways and Cancer Drug Discovery
 Network, Canada                                                               Joan S. Brugge, Harvard Medical School, USA
 Stem Cells in Leukemia                                                        Genes that Regulate Migration and Invasion
 Robert J. Wechsler-Reya, Duke University Medical Center, USA                  Short Talk(s) to be Chosen from Abstracts
 The Road from Stem Cell to Cancer Progenitor:
                                                                              IMAGING AND TRACKING CANCER STEM CELLS AND METASTATIC
 A Study in Medulloblastoma
                                                                              PRECURSORS
 Michael A. Dyer, St. Jude Children’s Research Hospital, USA
                                                                               Peter Kuhn, The Scripps Research Institute, USA
 Mature Cells: A Hotbed of Cancer Susceptibility?
                                                                               High-Definition Circulating Tumor Cells in Carcinoma Patients
 Richard J. Gilbertson, St. Jude Children’s Research Hospital, USA
                                                                               Daniel A. Haber, Massachusetts General Hospital, USA
 Adult Tissue Stem Cells: A Hotbed of Cancer Susceptibility?
                                                                               Molecular Analysis of Circulating Tumor Cells Using Microfluidic Chip
 Short Talk(s) to be Chosen from Abstracts
                                                                               Michael R.H. White, University of Liverpool, UK
STEM CELLS IN CANCER PATHOGENESIS II: NICHES AND THE                           Systems Analysis in Single Cells
METASTATIC CASCADE                                                             Short Talk to be Chosen from Abstracts
 Richard O. Hynes, Massachusetts Institute of Technology, USA
 Extracellular Matrix Niches in Cancer Progression                            THURSDAY, MARCH 10
 Dorothy A. Sipkins, The University of Chicago, USA                           EPITHELIAL CANCERS AND STEM CELLS
 The Leukemic Stem Cell Niche                                                  Hans C. Clevers, Hubrecht Institute, The Netherlands
 David C. Lyden, Weill Cornell Medical College, USA                            Intestinal Stem Cells and Cancer
 Priming the Soil: The Pre-Metastatic Niche                                    Elaine Fuchs, HHMI/Rockefeller University, USA
 Short Talk to be Chosen from Abstracts                                        Stem Cells and Cancer in the Skin
TUESDAY, MARCH 8                                                               Courtney W. Houchen, University of Oklahoma Health Sciences
                                                                               Center, USA
GENOMIC ANALYSES: READING THE GENOME IN CANCER STEM                            Skin Stem Cells and Colon Cancer
CELLS AND METASTATIC PRECURSORS
                                                                               Carla Kim, Children’s Hospital, Boston, USA
 Charles G. Mullighan, St. Jude Children’s Research Hospital, USA              Stem Cells in Normal Lung and Lung Cancer
 Unmasking the Origins of Leukemia with Genomics                               Short Talk(s) to be Chosen from Abstracts
 Robert H. Blelloch, University of California, San Francisco, USA
                                                                              CLOSING KEYNOTE ADDRESS
 miRNAS and the Regulation of Stem Cell Differentiation in Normal
 and Cancerous Tissues                                                         Sean J. Morrison, HHMI/University of Michigan, USA
 Joan Massagué, Memorial Sloan-Kettering Cancer Center, USA                    Stem Cells and Cancer: Where Are We Now?
 Mechanisms of the Metastatic Process                                         ROUNDTABLE: CANCER STEM CELLS IN METASTASIS:
 Sridhar Ramaswamy, Massachusetts General Hospital,                           INSIGHTS AND CONTROVERSIES
 Harvard Medical School, USA                                                   Richard J. Gilbertson*, St. Jude Children’s Research Hospital, USA
 Tumor versus Stromal Microarray Signatures                                    Daniel A. Haber*, Massachusetts General Hospital, USA
 Short Talk(s) to be Chosen from Abstracts                                     Sean J. Morrison, HHMI/University of Michigan, USA
BREAST CANCER                                                                  Robert A. Weinberg, Whitehead Institute for Biomedical Research, USA
 Jane E. Visvader, Walter and Eliza Hall Institute                             Hans C. Clevers, Hubrecht Institute, The Netherlands
 of Medical Research, Australia                                                Elaine Fuchs, HHMI/Rockefeller University, USA
 Stem Cells in Breast and Breast Cancer
                                                                              * Session Chair
 Rama Khokha, Ontario Cancer Institute, Canada
 Regulation of the Mammary Stem Cell Niche
 Charlotte Kuperwasser, Tufts University School of Medicine,
 New England, USA
 Normal and Cancer Stem Cell Heterogeneity and Metastasis                     Program current as of October 20, 2010. Program subject to change. For the
 Short Talk to be Chosen from Abstracts                                       most up-to-date information, visit www.keystonesymposia.org/11C4.




                          PO Box 1630 • Silverthorne, CO 80498 • www.keystonesymposia.org • 1-800-253-0685 • 1-970-262-1230

				
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