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					MOREHEAD STATE
  UNIVERSITY
KBRIN – INBRE Summary
 May - December, 2007
      Administrative Changes
New Provost – July, 2007
    Dr. Karla Hughes

New Biology Chair – January, 2008
    Dr. Douglas Dennis
Molecular Biology Core Research Laboratory




              October, 2007
Molecular Research Laboratory October, 2007
            Current Investments

  *Instruments             $521,339
  Demo/Renovation          $135,000
  Lab Bench/Cabinetry      $106,802
  Generator                $ 43,355
  Overall total in Lab     $806,496


*See complete instrumentation list
        MSU-KBRIN Supported Researchers

Bruce Mattingly – Lead
Wesley White – Core Project - Neuroscience
Darrin DeMoss – Core Project - Physiology
David Peyton – co-PI – Molecular Biology
Mike Fultz – KBRIN-AREA grant – Physiology
Janelle Hare – Summer Fellowship- Molecular Biology
                                           Darrin DeMoss
                                   Progress Update from May, 2007

Project Title: Molecular Mechanisms of Estrogen-Regulated Bone Resorption

Grants Submitted:
Regulatory Activity of Estrogen and the Impact of Calcium Channel Antagonist Exposure on Bone Resorption.
   NIH-R15, in preparation for resubmission Feb. 2008.

Publications:
Ashley, Laura; Sourik Ganguly; Ryan Grey; Michael Fultz; David Peyton; and Darrin DeMoss. Characterization of
    Osteoblastic Properties of 7F2 and UMR-106 Cultures after Acclimation to Reduced Levels of Fetal Bovine
    Serum, Submitted June 2007, currently under revision

Published Abstract
Ashley, L.A., G.C. Howard, A.J. Auxier, B.D. Kidd, E.D. Nickel, M.J. Harmon and D. L. DeMoss. The Effect of
    Calcium Channel Antagonists on Bone Metabolism in Aged Male and Female Brown Norway Rats. Journal
    Bone Mineral Research. 22(S1): SA139, 2007.

Presentations:
Ashley, L.A., G.C. Howard, A.J. Auxier, B.D. Kidd, E.D. Nickel, M.J. Harmon and D. L. DeMoss. The Effect of
    Calcium Channel Antagonists on Bone Metabolism in Aged Male and Female Brown Norway Rats. 29th
    Annual Meeting of the American Society of Bone and Mineral Research, Honolulu Hawaii, September 2007.
Ashley, L.A., G.C. Howard, A.J. Auxier, B.D. Kidd, E.D. Nickel, M.J. Harmon and D. L. DeMoss. The Effect of
    Calcium Channel Antagonists on Bone Metabolism in Aged Male and Female Brown Norway Rats. 93rd
    Annual Meeting of the Kentucky Academy of Science, Louisville Kentucky, November 2007.
                                  Darrin DeMoss,
                             Progress Update Continued

Current Students Involved in Research

Andrew Auxier                   Junior Biology Major
Courtney Forbis                 Junior Biology Major
Rebecca Green                   Junior Biology Major
Mirissa Harmon                  Senior Biology Major
Gregory Howard                  Junior Biology Major
Savannah Slone                  Junior Biology Major

Additional Student Items

Gregory Howard      Participated in the University of Kentucky Undergraduate Research
   Summer Program 2007.
Rebecca Green       Participated in the University of Texas Undergraduate Pre-
   professional & Research Summer Program 2007.

Interaction with Mentor

Corresponded multiple times with Dr. William Pierce at the University of Louisville via
    email over the summer and met with him, Dr. John Fleming, and Dr. Nigel Cooper in
    Louisville in August 2007. Dr. Pierce and Dr, Fleming have agreed to review the grant
    that I will be resubmitting in February 2008.
                                         Wesley White
                                Progress Update from May, 2007

1. Grants submitted/Awarded

Grant Number: 2R15DA015351-02A1
Project Title: Mechanisms of Amphetamine Withdrawal and Recovery
Budget Period: 09/01/2007 – 08/31/2010
Amount of Award: $191,100.00

2. Publications

White W, Sherrill LK, White IM (2007). Time-dependent effects of amphetamine on feeding in rats. Brain
    Research, 1171:75-82.

3. Papers/posters presented

White W, Hackney RC, Peyton DK, White IM. Dopamine D1 and D2 receptor gene expression in the
    dopaminergic system following amphetamine treatment in rats. Annual Meeting of the Society for
    Neuroscience, November 2007, San Diego, CA.

Beyer J, White W. The effects of selective D1-like and D2-like receptor agonists on circadian patterns of food
    intake in rats. Annual Meeting of the Kentucky Academy of Science, November 2007, Louisville, KY.

Bowen J, White W. Effects of D1 and D2 receptor antagonists on amphetamine-induced changes in activity
   patterns. Annual Meeting of the Kentucky Academy of Science, November 2007, Louisville, KY.

Hundley M, White W. The effects of doses of amphetamine on circadian patterns of food intake in rats.
   Annual Meeting of the Kentucky Academy of Science, November 2007, Louisville, KY
                                       Wesley White
                                 Progress Update Continued
4. Interaction with mentor:

   I have not interacted with my mentor, Dr. Michael Bardo at the University of Kentucky,
   since the last EAC meeting. I am conducting some research regarding the effects of
   dopamine D1 and D2 agonists and antagonists on food intake. Preparing the animals for
   tests takes a considerable time, and I want to maximize the information we get from each
   group of animals. I will be consulting with Dr. Bardo regarding the selection of agonists,
   antagonists, doses, and designs that will maximize information but limit carryover effects
   due to tolerance and sensitization. I will also ask him about brain regions and receptors that
   might be contributing to the phenomena we have obtained, in order to prepare for some
   more gene expression work. I have consulted with Dr. George Rebec at Indiana University
   who is an expert on dopamine and related compounds.

5. Student Awards:

   J. Byer: 3rd Place, KAS Graduate Student Paper Competition, Psychology Section
   J. Bowen: 3rd Place (tie), KAS Undergraduate Student Paper Competition, Psychology Section
   M. Hundley: 1st place, KAS Undergraduate Student Paper Competition, Psychology Section
                                          Mike Fultz
                                     KBRIN-AREA Grant
                                Progress Update from May, 2007

Grants Submitted:

Kinase Regulation of Cytoskeletal Remodeling in the Contracting A7r5 Smooth Muscle.
NIH-R15 resubmitted October, 2007

Publications:

MLCK/Actin Interaction in the Contracting A7r5 Cell (under revision)
Characterization of Osteoblastic Properties of 7F2 and UMR-106 Cultures after Acclimation to
      Reduced Levels of Fetal Bovine Serum (under revision)

Students:

Suzette Pike         Graduate Student       Smooth Muscle Project
Rebecca Green        Undergrad Fellow       Smooth Muscle Project
                                           Janelle Hare
                                 MSU-KBRIN Summer Fellowship
                                 Progress Update from May, 2007

Grants submitted:

Mechanisms of Action of UmuD in regulating DNA damage-induced genes in a umuC- deficient bacterium.
   150,000. NIH AREA R15, Ocotober, 2007

Presentations:

E-J. Lee, J. M. Hare, T. Latifi, and E. A. Groisman. 2007. Regulation of the mgtC Virulence Gene of
     Salmonella typhimurium. Poster presented at the 107th General Meeting of the American Society for
     Microbiology, Toronto, Canada.
Undergraduate Student researchers:

Tyler Elam
Timothy J. Evans

Interaction with Mentor:

  Conferences, e-mail and phone, with Dr. Leslie Gregg-Jolly, Department of Biology, Grinnell College,
   about manuscripts in progress and AREA R15 granted applied for. E-mail correspondence with Dr. Penny
   Beuning, Department of Biology, Northeastern University, about ongoing research on UmuD in E. coli
   and Acinetobacter.

				
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