THOMAS J. MEADE
Eileen M. Foell Professor
Department of Chemistry,
Biochemistry and Molecular & Cell Biology,
Neurobiology & Physiology
Director: Center for Advanced Molecular Imaging
2145 Sheridan Road
Evanston, Illinois 60208-3113
phone: (847) 491-2481 fax: (847) 491-3832
Postdoctoral Research Fellow. California Institute of Technology, 1987-89.
Advisor: Professor Harry B. Gray.
National Institutes of Health Postdoctoral Fellow. Harvard Medical School and the
Massachusetts General Hospital, 1985-1987. Advisor: Professor Thomas J. Brady.
Ph.D. in Inorganic Chemistry, The Ohio State University; Columbus, Ohio, August,
1985. Dissertation Advisor: Professor Daryle H. Busch.
M.S. in Chemistry (Division of Biochemistry), The Ohio State University,
Columbus Ohio, 1982. Thesis Advisor: Professor Perry A. Frey.
B.S. with Honors in Chemistry, Arizona State University; Tempe, Arizona, May, 1980.
Honors Thesis Advisor: Professor Therald Moellar.
Professor of Chemistry; Biochemistry and Molecular and Cell Biology; Neurobiology
and Physiology; and Radiology, Northwestern University (2002-present)
Faculty: Division of Biology and the Beckman Institute, California Institute of
Research Faculty: Div. of Biology, California Institute of Technology, (1991-96).
Honors and Professional Service
National Research Service Award, Harvard Medical School (1985),Cofounder, Clinical
Micro Sensors Inc., Pasadena, CA (1995), Cofounder Clinical MicroSensors,
Pasadena, CA (1995) Watson Lecturer, Caltech (1997), Grubstakes Award, Direct
Detection of Gene Expression via MRI; Caltech (1996), Founder, Metaprobe LLC, San
Diego CA (1998), American College of Neuropharmacology Award (1999), Founder,
Imaging in 2020: Molecular Imaging Conference joint with NCI (1999-), National
Academy of Engineering Award Lecturer, Cleveland, OH (2000), Editorial Advisory
Boards: Bioconjugate Chemistry and Inorganic Chemistry (2001 - present ), Editorial
Advisory Board: Accounts of Chemical Res. and Journal of Molecular Imaging (2002 –
present), Neuroscience Award, Society for NeuroOncology (2002), Frontier Lecturer,
Texas A&M University (2003) Elkin Distinguished Investigators Cancer Award, Emory
University (2003), FMC lecturer, Princeton University (2004), President: Society of
Molecular Imaging (2004), Founder, Ohmx Inc., Evanston IL (2005), , Eileen M.
Meade, Thomas J.
Foell Professor (2005), NIH SBCA study section member (2006-), Allen & Constance
Ford Distinguished Award, Case Western Reserve University (2006), William Beaumont
Award: Wayne County Medical Society (2007), Founder, PreDx Corp., Evanston IL
(2007) Northwestern University Excellence in Teaching Award (2008), Miller Professor,
University of California Berkeley (2009). Illinois Biotechnology Industry Organization
(iBIO) iCON Innovator Award (2009). Editorial Board: World Journal of Radiology
(2009- present), NIH NeXT SEP member (2009- present), ACS National Awards
Selection Committee (2009-present).
Invited/Plenary/Keynote Lectures at National & International Conference:
103 Lectures in the United States, Europe and Asia
Invited Academic and Industrial Presentations
164 invited academic and industrial lectures
Supervised undergraduate and graduate laboratories and led recitation sections (O.S.U.
1980-81). Ohio State University Teaching Award (student selected) 1981.
Codirector and Founder; “Seeing is Believing: A Classroom Tour of the Sciences.”
Pasadena Unified School District and local private schools, 1994-
American Chemical Society, American Association for the Advancement of Science,
International Society for Magnetic Resonance in Medicine, Sigma Chi Honorary
Research Society, Alpha Chi Sigma, New York Academy of Sciences, Society for
Supervised 55 undergraduates, 50 graduate students and 30 post-doctoral fellows, 1992-present.
Selected Publications (from more then 100)
Endres P, Paunesku T, Woloschak GE, Meade TJ, “DNA-TiO2 Nanoconjugates Labeled with MR
Contrast Agents.” J. Am. Chem. Soc., 2007, 129, 15760-15761.
Urbanczyk-Pearson LM, Femia FJ, Smith J, Parigi G, Duimstra JA, Eckermann AL, Luchinat C,
Meade TJ. Mechanistic investigation of beta-galactosidase-activated MR contrast agents. Inorg
Chem. 2008 47:56-68.
Bull SR, Palmer LC, Fry NJ, Greenfield MA, Messmore BW, Meade TJ, Stupp SI. A templating
approach for monodisperse self-assembled organic nanostructures. J Am Chem Soc. 2008
Urbanczyk-Pearson LM, Meade TJ. Preparation of magnetic resonance contrast agents activated by
beta-galactosidase. Nat Protoc. 2008;3(3):341-50.
Chong HS, Song HA, Lim S, Macrenaris K, Ma X, Lee H, Bui P, Meade TJ, “A novel cholic acid-
based contrast enhancement agent for targeted MRI.” Biorg. & Med. Chem. Let., 2008, 18, 2505-
Meade, Thomas J.
Cilliers R, Song Y, Kohlmeir EK, Larson AC, Omary RA, Meade TJ. Modification of embolic-
PVA particles with MR contrast agents. Magn Reson Med. 2008 59(4):898-902.
Song Y, Kohlmeir EK, Meade TJ. Synthesis of multimeric MR contrast agents for cellular imaging.
J Am Chem Soc. 2008 130(21):6662-3.
Bertin PA, Georganopoulou D, Liang T, Eckermann AL, Wunder M, Ahrens MJ, Blackburn GF,
Meade TJ. Electroactive self-assembled monolayers on gold via bipodal dithiazepane anchoring
groups. Langmuir. 2008 24(16):9096-101.
Endres, PJ, Macrenaris KW, Vogt S, Meade TJ. Cell-Permeable MR Contrast Agents with
Increased Intracellular Retention. Bioconjugate Chem., 2008, 19, 2049-2059.
Major J, MeadeTJ, Investigation into the Mechanism of Zn(II)-Activated MR Imaging Contrast
Agents. Inorg Chem. 2009, 47, 10788-10795.
Modo M, Beech JS, Meade TJ, Williams SC, Price J. A chronic 1 year assessment of MRI contrast
agent-labelled neural stem cell transplants in stroke. Neuroimage, 2009, 47, T133-142.
Modo M, Meade TJ, Mitry RR. Liver cell labelling with MRI contrast agents. Methods Mol Biol.
2009 481:207-19. Review.
Lin W, Hyeon T, Lanza G, Miqin MZ, Meade TJ. “Magnetic Nanoparticles for Early Detection of
Cancer by Magnetic Resonance Imaging.” MRS Bulletin 2009, 34, 441-448.
Meade TJ, Aime S. Chemistry of molecular imaging. Acc Chem Res. 2009 42(7):821.
Major JL, Meade TJ. Bioresponsive, cell-penetrating, and multimeric MR contrast agents. Acc
Chem Res. 2009 42(7):893-903.
Harney AS, Lee J, Manus LM, Wang P, Ballweg DM, LaBonne C, Meade TJ. Targeted inhibition
of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate.
Proc Natl Acad Sci U S A. 2009 106(33):13667-72.
Bertin PA, Meade TJ. Novel redox active bifunctional crosslinkers from unsymmetrical 1,1'-
disubstituted ferrocenes. Tetrahedron Letters. 2009, 50(38): 5409-5412.
Barker K, Eckermann AL, Sazinsky M, Hartings M, Abajian C, Georganopoulou D, Ratner M,
Rosenzweig A, Meade TJ. Protein Binding and the Electronic Properties of Iron (II) Complexes: An
Electrochemical and Optical Investigation of Outer Sphere Effects. Bioconjugate Chemistry, 2009,
Joshi, HM, Lin YP, Aslam M, Prasad PV, Schultz-Sikma, EA, Edelman R, Meade TJ, Dravid VP.
Effects of Shape and Size of Cobalt Feritte Nanostructures on Their MRI Contrast and Thermal
Activation. J. Phys. Chem., 2009, 113: 17761-17767.
Meade, Thomas J.
Song Y, Xu X, MacRenaris KW, Zhang X, Mirkin CA, Meade TJ. Multimodal Gadolinium-
Enriched DNA Gold Nanoparticle Conjugates for Cellular Imaging. Angew. Chem Int. Engl., 2009,
Hu F, MacRenaris KW, Waters EA, Liang T, Schultz-Sikma EA, Eckermann AE, Meade TJ.
Ultrasmall, Water-Soluble Magnetite Nanoparticles with High Relaxivity for Magnetic Resonance
Imaging. J. Phys. Chem., 2009, 113(49), 20855-20860.
Eckermann AL, Shaw J, Meade TJ. Kinetic Dispersion in Redox Active Dithiocarbamate
Monolayers. Langmuir, 2010, 26(4), 2904-2913.
Trivedi ER, Harney AS, Olive MB, Podgorski I, Moin K, Sloane BF, Barrett AGM, Meade TJ,
Hoffman BM. Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor
accumulation. PNAS, 2010, 107(4), 1284-1288.
Hu F, MacRenaris K, Waters EA, Schultz-Sikma EA, Eckermann AL, Meade TJ. Highly
Dispersible, Superparamagnetic Magnetite Nanoflowers for Magnetic Resonance Imaging. Chem.
Comm., 2010, 46(1), 73-75.
Manus L, Masterone D, Waters EA, Zhang X, Schultz-Sikma E, MacRenaris K, Ho D, Meade TJ.
Gd(III)-nanodiamond conjugates for MRI contrast enhancement. Nano Letters, 2010, 10(2), 484-
Harney AS, Meade TJ. Molecular imaging of in vivo gene expression. Future Medicinal Chemistry,
2010, 2(3), 503-519.
Eckermann AL, Meade TJ. Electrochemistry of Redox-Active Self Assembled Monolayers, Coord.
Chem Rev., 2010, 254,1769-1802.
Karfeld-Sulzer L, Waters E, Davis N, Meade TJ, Barron A. Multivalent Protein Polymer MRI
Contrast Agents: Controlling Relaxivity via Modulation of Amino Acid Sequence,
Biomacromolecules, 2010, 11(6), 1429-1436.
Potapov A, Song Y, Meade TJ, Goldfarb D, Astashki AV. Distance measurements in model Bis-
Gd(III) complexes with flexible “bridge”: Emulation of biological molecules having flexible
structure with Gd(III) label attached, Journal of Magnetic Resonance, 2010, in press.
Karfeld-Sulzer L, Waters EA, Kohlmeir EK, Kissler H, Zhang X, Kaufman DB, Barron AE, Meade
TJ. Protein Polymer MRI Contrast Agents: Longitudinal Analysis of Biomaterials in Vivo. Magnetic
Resonance in Medicine, 2010, in press.
Hu F, Joshi HM, Dravid VP, Meade TJ. High-performance nanostructured MR contrast probes.
Nanoscale, 2010, in press.
Sukerkar P, Rezvi U, MacRenaris K, Patel P, Wood J, Meade TJ. Polystyrene Microsphere-Ferritin
Conjugates: A Robust Phantom for Correlation of Relaxivity and Size Distribution. Magnetic
Resonance in Medicine, 2010, in press.