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					Chapter 19 Questions: Eukaryotic Genomes

MULTIPLE CHOICE. Choose the one alternative that best completes the statement or
answers the question.


1) The compacted chromosomes observed in mitosis are due to
A) coiling, looping, and folding of DNA.
B) coiling of chromatin.
C) tandemly repetitive DNA.
D) DNA winding around histones.
E) looped domains

2) The fundamental form of chromatin is
A) repeating, noncoding sequences of DNA.
B) cleavage.
C) successive levels of DNA packing.
D) four "beads" consisting of DNA wrapped around eight histone molecules.
E) degradation of unnecessary proteins.

3) In a nucleosome, what is the DNA wrapped around?
A) ribosomes
B) histones
C) nucleolus protein
D) polymerase molecules
E) mRNA

4) All of the following statements concerning the eukaryotic chromosome are true except
that
A) it is composed of DNA and protein.
B) the nucleosome is the structural subunit.
C) it consists of a single molecule of DNA wound around nucleosomes.
D) active transcription occurs on euchromatin.
E) gene expression is controlled by the histones.

5) If a cell were unable to produce histone proteins, which of the following would be
expected?
A) Spindle fibers would not form during prophase.
B) Pseudogenes would be transcribed to compensate for the decreased protein in the cell.
C) The cell's DNA couldn't be packed into its nucleus.
D) The amplification of other protein genes would compensate for the lack of histones.
E) There would be an increase in the amount of "satellite" DNA produced during
centrifugation.

6) Which of the following represents an order of increasingly higher levels of
organization?
A) looped domain, 30-nanometer chromatin fiber, nucleosome
B) nucleosome, 30-nanometer chromatin fiber, looped domain
C) looped domain, nucleosome, 30-nanometer chromatin fiber
D) nucleosome, looped domain, 30-nanometer chromatin fiber
E) 30-nanometer chromatin fiber, nucleosome, looped domain

7) Which of the following statements is true?
A) Both heterochromatin and euchromatin are found in the nucleus.
B) Heterochromatin is composed of DNA, while euchromatin is made of DNA and RNA.
C) Only euchromatin is visible under the light microscope.
D) Euchromatin is not transcribed while heterochromatin is transcribed.
E) Heterochromatin is highly condensed, while euchromatin is less compact.

8) Approximately what proportion of the DNA in humans does not produce a protein or a
functional RNA?
A) 17% B) 68% C) 54% D) 97% E) 87%

9) Most of the DNA in eukaryotic chromosomes is
A) organized into operons.
B) transposons.
C) tandemly repetitive DNA.
D) Alu elements.
E) moderately interspersed.

10) Which of the following is not a characteristic of triplet-repeat disorders like
Huntington's disease?
A) Extra repeat disorders have all been shown to operate by the same mechanism.
B) In general, these disorders affect the nervous system.
C) The number of repeats tends to correlate with the severity of the disease.
D) The triplet is actually translated.
E) The resulting protein has a string of adjacent glutamines.

11) Artificial chromosomes have been made in the laboratory. A cell will be able to
replicate these chromosomes if
A) an origin of replication is included.
B) the artificial chromosome has two telomeres.
C) the artificial chromosome has a centromere.
D) A and B are correct.
E) A, B, and C are correct.

12) Which of the following would you not expect to be part of a multigene family?
A) rRNA genes
B) genes coding for the enzymes used in glycolysis
C) tRNA genes
D) genes for histone proteins
E) genes for globin subunits
13) The numerous copies of rRNA genes in a salamander are an example of
A) satellite DNA.
B) prokaryotic multigene families.
C) a highly repetitive sequence.
D) enhanced promoter regions.
E) eukaryotic multigene families.

14) In humans, the embryonic and fetal forms of hemoglobin have a higher affinity for
oxygen than that of adults. This is due to
A) histone proteins changing shape during embryonic development.
B) nonidentical genes that produce different versions of globins during development.
C) the attachment of methyl groups to cytosine following birth, which changes the type
of hemoglobin produced.
D) pseudogenes, which interfere with gene expression in adults.
E) identical genes that generate many copies of the ribosomes needed for fetal globin
production.

15) Which of the following is least related to the others?
A) nucleosomes
B) pseudogenes
C) 30 nm chromatin fiber
D) histones
E) looped domains

				
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