Yasminelle and asssociated names, INN-Drospirenone - Ethinylestradiol

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ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTH OF THE MEDICINAL PRODUCTS, ROUTE OF ADMINISTRATION, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES 1 Member State Austria Marketing autorisation Holder Bayer Austria GmbH (Schering Austria GmbH) Herbststr. 6 - 10 1160 Wien, Austria Bayer S.A./N.V. 143, Avenue Louise 1050 Brussel, Belgium Bayer Hellas AG 18-20 Sorou Str 15125 Amaroussion Athens, Greece Bayer Schering Pharma AG D-13342 Berlin Germany Bayer Schering Pharma AG D-13342 Berlin Germany Bayer Schering Pharma AG D-13342 Berlin Germany Bayer Schering Pharma Oy Pansiontie 47, FI-20210 Turku Finland Bayer Santé 13, Rue Jean Jaurès 92807 Puteaux Cedex France Invented Name Yasminelle Strength 0.02 mg / 3 mg Pharmaceutical form film-coated tablets Route of administration Oral use Belgium Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Cyprus Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Czech Republic Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Denmark Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Estonia Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Finland Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use France Jasminelle 0.02 mg / 3 mg film-coated tablets Oral use 2 Germany Bayer Vital GmbH 51368 Leverkusen Germany Bayer Hellas AG 18-20 Sorou Str 15125 Amaroussion Athens Greece Bayer Schering Pharma AG D-13342 Berlin Germany Bayer Schering Pharma AG D-13342 Berlin Germany Bayer Ltd. The Atrium, Blackthorn Road Dublin 18 Ireland Bayer S.P.A. Viale Certosa 130 20156 Milano Italy Bayer Schering Pharma AG D-13342 Berlin Germany Bayer Schering Pharma AG D-13342 Berlin Germany Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Greece Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Hungary Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Iceland Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Ireland Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Italy Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Latvia Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Lithuania Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use 3 Luxembourg Bayer S.A./N.V. 143, Avenue Louise 1050 Brussel Belgium Bayer Schering Pharma AG D-13342 Berlin Germany Bayer B.V. Energieweg 1 3641 RT Mijdrecht The Netherlands Bayer Schering Pharma AG D-13342 Berlin Germany Bayer Schering Pharma AG D-13353 Berlin Germany Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Malta Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Netherlands Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Norway Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Poland Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Portugal Berlex, Especialidades Farmacêuticas, Lda. Yasminelle Rua da Quinta do Pinheiro, No. 5 2794-003 Carnaxide Portugal Bayer Schering Pharma AG D-13342 Berlin Germany Bayer Schering Pharma AG D-13342 Berlin Germany Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Slovakia 0.02 mg / 3 mg film-coated tablets Oral use Slovenia Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use 4 Spain Química Farmacéutica Bayer, S.L. Av. Baix Llobregat, 3-5 08970 Sant Joan Despí, Barcelona Spain Bayer Schering Pharma AG D-13342 Berlin Germany Schering Health Care Ltd The Brow Burgess Hill West Sussex RH15 9NE United Kingdom Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use Sweden Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use United Kingdom Yasminelle 0.02 mg / 3 mg film-coated tablets Oral use 5 ANNEX II SCIENTIFIC CONCLUSIONS 6 SCIENTIFIC CONCLUSIONS The Yasminelle blister is glued in a carton which is subsequently folded to a wallet configuration. The wallet with the inserted blister is assembled with a package leaflet (PL) and all components are wrapped together with clear, transparent cellophane wrapping to form the unit pack which prevents the loss of individual components. The product is marketed in pack size of 3 x 21 film-coated tablets. OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF YASMINELLE AND ASSOCIATED NAMES (see Annex I) The required basic information (how to use the product, what to do in case of missed dose, etc.), which ensures the safe use of the product is present on the cardboard wallets and visible through the cellophane wrapping. Once the cellophane wrapping is removed the safe use of the product is still ensured as the cardboard wallets contain the required information. In addition it is not possible to separate blisters from cardboard wallets and therefore the users always have access to the required information. Moreover cardboard wallets protect blisters against damage. The risk resulting from the separation of a package leaflet from cardboard wallets is comparable with the risk resulting from separation of blisters from conventional external packaging (cardboard box). Although different observations in respect to readability of the Braille text through the cellophane wrapping have been made by blind users, it is assumed that before use of the product the cellophane wrapping will be removed and therefore blind person will be in a position to identify the product. It has also been confirmed by blind persons that the Braille text on the cardboard is palpable and readable. Since it is a prescription medicine, the name of the product always will be known to the blind user as during the visit the physicians inform patients about medicinal product they are prescribing, including the name of the product. Therefore blind users will be able to double check the information written on the cardboard wallets (Braille text) with the information obtained from a physician (during the visit). Finally taking into account that the medicinal product is intended for long term use, the possible mistakes and misuse are further minimised. 7 ANNEX III SUMMARY OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET 8 The valid Summary of Product Characteristics, labelling and package leaflet are the final versions achieved during the Coordination group procedure. 9

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