CURRICULUM VITAE NAME: Caroline Elizabeth Brain NATIONALITY: British DEGREES, DIPLOMAS: M.B. B.S. London Hospital Medical College (1979) M.R.C.P. U.K. (1983) MD. University of London (1993) MRCP FRCPCH PRESENT APPOINTMENT: Consultant Paediatric Endocrinologist Great Ormond Street Hospital for Children & The Middlesex Hospital (2000) PREVIOUS 3 APPOINTMENTS: 1991 – 92 Paediatrics Paediatric Endocrinology St Bartholomew's Hospital London 1992 – 93 Paediatric Endocrinology and Special Paediatrics Great Ormond Street London 1993 – 94 Paediatric Endocrinology and Metabolism Great Ormond Street London RECENT PUBLICATIONS (10 in total) Lau L, Wu S, Kudo M, Hsueh AJW, Cutler GB Jr, Griffin JE, Wilson JD, Brain CE, Berry AC, Grant DB, Chan W. A nonsense mutation of the human luteinizing hormone receptor gene in Leydig cell hypoplasia. Human Molecular Genetics 1995;4(8):1429-1433 Davenport M, Brain C, Vandenberg S, Zappala P, Duffy P, Ransley P, Grant D. The use of the hCG stimulation test in the endocrine evaluation of cryptorchidism. British Journal of Urology 1995;76:790-794 Richards A, Brain C, Dillon MJ, Bailey CM. Craniometaphyseal and craniodiaphyseal dysplasia, head and neck manifestations and management. The Journal of Laryngology and Otology 1996;110:328-338 Patel L. Clayton PE. Brain C. Pelekouda E. Addison GM. Price DA. Mughal MZ. Acute biochemical effects of growth hormone treatment compared with conventional treatment in familial hypophosphataemic rickets. Clinical Endocrinology. 44(6):687-96, 1996 Jun. Street ME. Weber A. Camacho-Hubner C. Perry LA. Brain CE. Cotterill AM. Savage MO. Girls with virilisation in childhood: a diagnostic protocol for investigation. Journal of Clinical Pathology. 50(5):379-83, 1997 May. Brain CE. Hubbard M. Preece MA. Savage MO. Aynsley-Green A. Metabolic status of children with growth hormone insensitivity syndrome and responses to treatment with IGF-I. Hormone Research. 50(2):61-70, 1998. Wu SM. Hallermeier KM. Laue L. Brain C. Berry AC. Grant DB. Griffin JE. Wilson JD. Cutler GB Jr. Chan WY. Inactivation of the luteinizing hormone/chorionic gonadotropin receptor by an insertional mutation in Leydig cell hypoplasia. Molecular Endocrinology. 12(11):1651-60, 1998 Nov. Jackson RS. O'Rahilly S. Brain C. Nussey SS. Proopiomelanocortin products and human early-onset obesity [letter]. Journal of Clinical Endocrinology & Metabolism. 84(2):819-20, 1999 Feb. Wu SM. Leschek EW. Brain C. Chan WY. A novel luteinizing hormone receptor mutation in a patient with familial -limited precocious puberty: effect of the size of a critical amino acid on receptor activity. Molecular Genetics & Metabolism. 66(1):68-73, 1999 Jan. Kirk JM. Brain CE. Carson DJ. Hyde JC. Grant DB. Cushing's syndrome caused by nodular adrenal hyperplasia in children with McCune-Albright syndrome. Journal of Pediatrics. 134(6):789-92, 1999 Jun. Craig F. Leiper AD. Stanhope R. Brain C. Meller ST. Nussey SS. Sexually dimorphic and radiation dose dependent effect of cranial irradiation on body mass index. Archives of Diseases of Childhood 81(6): 500-504 1999 De LIST OF TEACHING ACTIVITIES In sub-specialty clinics..(see below) Participation in various post-graduate teaching programs at GOS & Middlesex Hospitals. Lecture as an invited speaker at post-grad meetings in UK trusts Committee member for South Thames Paediatric Endocrine Group & Trans Channel Endocrine group Academic meetings organized bi-annually SUB-SPECIALTY CLINICS Joint Urology-Endocrinology clinic (multidisciplinary clinic for the diagnosis and management of conditions of intersex. Monthly Calcium & Metabolic bone clinic. Monthly Joint Endocrine/gender identity clinic. Endocrine assessment & management of children & adolescents with Gender Dysphoria.