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CURRICULUM VITAE of IAN JAMES MACKIE - DOC

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					                                      CURRICULUM VITAE

NAME:                                        Caroline Elizabeth Brain

NATIONALITY:                                 British

DEGREES, DIPLOMAS:                           M.B. B.S.       London Hospital Medical College (1979)
                                             M.R.C.P.        U.K. (1983)
                                             MD.             University of London (1993)
                                             MRCP
                                             FRCPCH


PRESENT APPOINTMENT:                         Consultant Paediatric Endocrinologist
                                             Great Ormond Street Hospital for Children
                                             & The Middlesex Hospital (2000)


PREVIOUS 3 APPOINTMENTS:                     1991 – 92 Paediatrics Paediatric Endocrinology
                                             St Bartholomew's Hospital London


                                             1992 – 93 Paediatric Endocrinology and Special Paediatrics
                                             Great Ormond Street London

                                             1993 – 94 Paediatric Endocrinology and Metabolism
                                             Great Ormond Street London


RECENT PUBLICATIONS (10 in total)

Lau L, Wu S, Kudo M, Hsueh AJW, Cutler GB Jr, Griffin JE, Wilson JD, Brain CE, Berry AC,
Grant DB, Chan W. A nonsense mutation of the human luteinizing hormone receptor gene in
Leydig cell hypoplasia. Human Molecular Genetics 1995;4(8):1429-1433

Davenport M, Brain C, Vandenberg S, Zappala P, Duffy P, Ransley P, Grant D. The use of the
hCG stimulation test in the endocrine evaluation of cryptorchidism. British Journal of Urology
1995;76:790-794

Richards A, Brain C, Dillon MJ, Bailey CM. Craniometaphyseal and craniodiaphyseal dysplasia,
head and neck manifestations and management. The Journal of Laryngology and Otology
1996;110:328-338

Patel L. Clayton PE. Brain C. Pelekouda E. Addison GM. Price DA. Mughal MZ. Acute biochemical
   effects of growth hormone treatment compared with conventional treatment in familial
   hypophosphataemic rickets. Clinical Endocrinology. 44(6):687-96, 1996 Jun.

Street ME. Weber A. Camacho-Hubner C. Perry LA. Brain CE. Cotterill AM. Savage MO. Girls
   with virilisation in childhood: a diagnostic protocol for investigation. Journal of Clinical Pathology.
   50(5):379-83, 1997 May.
Brain CE. Hubbard M. Preece MA. Savage MO. Aynsley-Green A. Metabolic status of children with
  growth hormone insensitivity syndrome and responses to treatment with IGF-I. Hormone Research.
  50(2):61-70, 1998.

Wu SM. Hallermeier KM. Laue L. Brain C. Berry AC. Grant DB. Griffin JE. Wilson JD. Cutler GB
  Jr. Chan WY. Inactivation of the luteinizing hormone/chorionic gonadotropin receptor by an
  insertional mutation in Leydig cell hypoplasia. Molecular Endocrinology. 12(11):1651-60, 1998 Nov.

Jackson RS. O'Rahilly S. Brain C. Nussey SS. Proopiomelanocortin products and human early-onset
obesity [letter]. Journal of Clinical Endocrinology & Metabolism. 84(2):819-20, 1999 Feb.

Wu SM. Leschek EW. Brain C. Chan WY. A novel luteinizing hormone receptor mutation in a patient
with familial -limited precocious puberty: effect of the size of a critical amino acid on receptor activity.
Molecular Genetics & Metabolism. 66(1):68-73, 1999 Jan.

Kirk JM. Brain CE. Carson DJ. Hyde JC. Grant DB. Cushing's syndrome caused by nodular adrenal
   hyperplasia in children with McCune-Albright syndrome. Journal of Pediatrics. 134(6):789-92, 1999
   Jun.

Craig F. Leiper AD. Stanhope R. Brain C. Meller ST. Nussey SS. Sexually dimorphic and radiation dose
   dependent effect of cranial irradiation on body mass index. Archives of Diseases of Childhood 81(6):
   500-504 1999 De

LIST OF TEACHING ACTIVITIES

      In sub-specialty clinics..(see below)
      Participation in various post-graduate teaching programs at GOS & Middlesex Hospitals.
      Lecture as an invited speaker at post-grad meetings in UK trusts
      Committee member for South Thames Paediatric Endocrine Group & Trans Channel Endocrine
       group
               Academic meetings organized bi-annually

SUB-SPECIALTY CLINICS

      Joint Urology-Endocrinology clinic (multidisciplinary clinic for the diagnosis and management of
       conditions of intersex. Monthly

      Calcium & Metabolic bone clinic. Monthly

      Joint Endocrine/gender identity clinic. Endocrine assessment & management of children &
       adolescents with Gender Dysphoria.

				
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