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					- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Elanco
RUMENSIN(R) 60 AF0360 RUMENSIN(R) 60 is a tradename from monensin sodium. RUMENSIN(R) 60 is fed to feedlot cattle for improved feed efficiency and for the prevention and control of coccidiosis; to reproducing beef cows to improve feed efficiency; and to pasture cattle to improve average daily gain. ----------------------------------------------------------I. MANUFACTURER/EMERGENCY INFORMATION ----------------------------------------------------------A. MANUFACTURER: ELANCO ANIMAL HEALTH A DIVISION OF ELI LILLY AND COMPANY LILLY CORPORATE CENTER INDIANAPOLIS, INDIANA 46285 B. EMERGENCY TELEPHONE NUMBERS: ELI LILLY AND COMPANY (317) 276-2000 CHEMTREC (800) 424-9300 C. GENERAL INFORMATION TELEPHONE NUMBER: ELANCO ANIMAL HEALTH (317) 276-3000 D. ISSUED: 2/80; REVISED: 5/82, 10/83, 10/86, 2/89, 7/90, 1/91, 10/91 ----------------------------------------------------------II. MATERIAL IDENTIFICATION ----------------------------------------------------------A. GENERIC NAME: monensin sodium (an ionophore) 13.2% 1. CHEMICAL ABSTRACT REGISTRY NUMBER (CAS#): 22373-78-0 B. OTHER INGREDIENTS: diluent (e.g.: rice hulls, limestone, 84.8% soybean mill run) antidusting oil 2.0% ----------------------------------------------------------III. PHYSICAL AND CHEMICAL PROPERTIES ----------------------------------------------------------A. NORMAL PHYSICAL STATE, ODOR, APPEARANCE: Dark brown free-flowing granular meal. Detectable odor of amyl alcohol may be present. B. pH (aqueous 50/50): 5.2 C. SOLUBILITY IN WATER: Insoluble. D. MELTING POINT: Not applicable. ----------------------------------------------------------IV. FIRE AND EXPLOSION HAZARD DATA ----------------------------------------------------------A. MINIMUM IGNITION TEMPERATURE (Dust Layer): 374 deg. F (190 deg. C) B. FLASHPOINT: No ignition up to 150 deg. F (65.6 deg. C). C. EXPLOSIVE LIMIT: 1. LOWER EXPLOSIVE LIMIT (LEL): No ignition up to 2.0 oz/cu.ft. 2. UPPER EXPLOSIVE LIMIT (UEL): Not applicable. D. UNUSUAL FIRE AND EXPLOSION HAZARDS: Relatively noncombustible; requires continuous ignition source to support flames. Dust explosion potential less than that of various grain dusts tested individually. E. FIRE FIGHTING INFORMATION: Extinguish with water. Wear protective clothing. ----------------------------------------------------------V. NATIONAL FIRE PROTECTION ASSOCIATION (NFPA 704) ----------------------------------------------------------(4 = Extreme; 3 = High; 2 = Moderate; 1 = Slight; 0 = Insignificant) A. HEALTH: 2 B. FLAMMABILITY: 1 C. REACTIVITY: 0 ----------------------------------------------------------VI. SHIPPING REQUIREMENTS ----------------------------------------------------------A. DOT HAZARD CLASS: Not regulated.

----------------------------------------------------------VII. REACTIVITY DATA ----------------------------------------------------------A. STABILITY AND STORAGE: Store in a cool, dry place. Protect from moisture and heat. Product should not be used after the date printed on the bottom or side of the bag. A dating of 24 months is noted on the bag. B. HAZARDOUS DECOMPOSITION: None known. C. HAZARDOUS POLYMERIZATION: None known. D. INCOMPATIBILITY: None known. ----------------------------------------------------------VIII. HEALTH HAZARD DATA ----------------------------------------------------------A. TOXICOLOGY (Animal Toxicity Data): 1. ACUTE EXPOSURE (RUMENSIN 60): a. EYES: Rabbit, corrosive; permanent damage prevented by immediate rinsing. b. SKIN: Rabbit, 2000 mg/kg, no deaths or toxicity, slight irritant. c. INHALATION: Rat, 0.37 mg/L for one hour, no deaths (mycelial monensin sodium). d. INGESTION: Rat, median lethal dose 314 mg/kg, leg weakness, diarrhea, soft stools, hypoactivity, lethargy, ataxia, and coma. Monkey, 1000 mg/kg, no deaths, vomiting. e. SENSITIZATION: Guinea pig, not a contact sensitizer. 2. CHRONIC EXPOSURE (crystalline monensin sodium): The following effects were reported in chronic, teratogenic, and reproductive toxicity studies in laboratory animals where experimental dosage levels and durations of exposure were in excess of those likely to occur in humans. a. CHRONIC TOXICITY: Heart and skeletal muscle lesions (degenerative and regenerative). Decreased body weight gains. Increased kidney, heart, thyroid, adrenal, prostrate, testes, liver, and spleen weights. Electrocardiogram effects, congestive heart failure. Elevated blood enzymes, increased blood cell counts. b. TERATOLOGY & REPRODUCTION: Not teratogenic or fetotoxic. No impairment of reproductive capacity through four generations of exposure in rats. c. MUTAGENICITY: Not mutagenic in bacterial cells. d. CARCINOGENICITY: Not listed as a carcinogen or as a potential carcinogen by IARC, NCI/NTP, OSHA, or ACGIH. Not considered to be carcinogenic in lifetime feeding studies conducted by Lilly. B. EFFECTS OF EXPOSURE: While there are laboratory animal studies that indicate monensin sodium may be cardiotoxic at exaggerated levels of exposure, Elanco Animal health and U.S. Government regulatory agencies have concluded that the product does not present a hazard when recommended handling procedures are followed. 1. SIGNS AND SYMPTOMS OF EXPOSURE: Skin rash and irritation may occur. Nausea, dizziness, nasal congestion/irritation, diarrhea, muscular discomfort, chest heaviness or pain, and difficulty breathing have occurred infrequently. Rare or singular events reported include: headache, puffiness of face, abdominal pain/cramps, coughing up blood, nosebleed, eye swelling/irritation/redness, allergic reactions, nervousness, and increased pulse rate.

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- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Elanco
2. MEDICAL CONDITIONS GENERALLY AGGRAVATED BY EXPOSURE: When laboratory animals receive a bolus injection of monensin, there are cardiovascular changes such as increased heart rate and elevated blood pressure. In human experience with exposure, however, there is no corroborative information available that would establish the aggravation of a medical condition by exposure to RUMENSIN (monensin). Persons with a history of allergies, contact dermatitis, or chronic rashes should use special precautions to avoid skin contact with RUMENSIN or exposure to dust. NOTE: Prolonged exposure to high concentrations of grain dust or limestone dust may cause irritation of the respiratory tract and mucous membranes. C. EXPOSURE GUIDELINES*: 1. MONENSIN SODIUM: PEL: Not established; TLV: Not established; LEG: 0.015 mg/m3, TWA per 12 hr. 2. GRAIN DUST: PEL: Not established; TLV: 4 mg/m3. Aerosol exposure to rice hulls should be no greater than the grain dust TLV of 4 mg/m3. Users should restrict dust levels to the grain dust TLV of 4 mg/m3 which should be achievable under normal operating conditions. The oil emulsifier reduces potential exposure under normal conditions of use or in a foreseeable emergency. 3. LIMESTONE DUST: PEL: Not established; TLV: 10 mg/m3 Aerosol exposure to limestone should be no greater than the nuisance dust TLV of 10 mg/m3. Users should restrict dust levels to the limestone dust TLV of 10 mg/m3 which should be achievable under normal operating conditions. The oil emulsifier reduces potential exposure under normal conditions of use or in a foreseeable emergency. D. PRIMARY ROUTES OF ENTRY: Skin contact and inhalation. ----------------------------------------------------------IX. FIRST AID (Statement of Practical Treatment) ----------------------------------------------------------A. EYES: Hold eyelids open and flush with a steady, gentle stream of water for 15 minutes. See an ophthalmologist (eye doctor) immediately. Failure to rinse the eyes could result in possible damage. B. SKIN: Wash all exposed areas with plenty of soap and water. Wash all contaminated clothing before reuse. If irritation occurs or is severe or persistent, contact a physician. C. INHALATION: RUMENSIN 60 is not expected to present a hazard by inhalation due to the coarse granular nature of the product. If inhalation does occur, remove individual to fresh air. If not breathing, provide cardiopulmonary resuscitation assistance and get medical attention. D. INGESTION: Call a physician or Poison Control Center. Drink promptly a large quantity of milk, egg white, gelatin solution, or if these are not available, large quantities of water. Avoid alcohol. Induce vomiting by touching back of throat with finger. Do not induce vomiting or give anything by mouth to an unconscious person. ----------------------------------------------------------X. PRECAUTIONS FOR SAFE HANDLING AND USE ----------------------------------------------------------A. SPILL HANDLING INFORMATION: Sweep or clean with vacuum. Control the dust by use of oils or water during cleanup. Residues may be flushed with water. Large spills due to traffic accidents, etc., should be reported immediately to CHEMTREC and Elanco Animal Health for assistance. Prevent spilled material from flowing onto adjacent land or into streams, ponds or lakes. B. HANDLING AND MIXING INFORMATION: (See Section VIII, Paragraphs C.2 and 3.) C. CONTAINER DISPOSAL: Bags may be burned or buried in accordance with approved safety and environmental standards.

D. WARNING: 1. HUMAN: When mixing and handling RUMENSIN 60, use protective clothing, impervious gloves, and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. E. CAUTION: 1. ANIMAL: Do not feed undiluted. Do not allow horses or other equines access to feeds containing monensin. Ingestion of monensin by horses has been fatal. The feeding of undiluted premix or feeds containing high concentration of RUMENSIN (mixing errors) could be fatal to cattle. Monensin medicated feed is safe at approved dosages for use in approved species only. Consumption by unapproved species may result in toxic reactions. Do not feed to lactating dairy cows. F. STORAGE: (See Section VII, Paragraph A) ----------------------------------------------------------XI. PROTECTIVE EQUIPMENT REQUIREMENTS ----------------------------------------------------------During manufacture, wear goggles to protect eyes, wear impermeable gloves and protective equipment to avoid direct contact with skin. use NIOSH(1) approved dust respirator. ----------------------------------------------------------XII. OTHER INFORMATION ----------------------------------------------------------A. NADA NUMBER: 95-735 B. REFERENCES: (1)NIOSH Certified Equipment Guide *PEL: Permissible Exposure Limit TLV: Threshold Limit Value LEG: Lilly Exposure Guideline C. RUMENSIN(R) (monensin sodium, Elanco) D. NOTE: This information applies only to RUMENSIN 60 which is sold in the U.S. All information contained herein is offered in good faith and with the belief that it is accurate. As of the date of issuance or revision, we are providing all information that we have or are aware of relevant to the anticipated use or handling of the material. However, in the event of an adverse incident associated with this material, this Material Safety Data Sheet is not, and is not intended to be, a substitute for consultation with appropriately trained personnel. ----------------------------------------------------------DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES: Although reasonable care has been taken in the preparation of this document, we extend no warranties and make no representation as to the accuracy or completeness of the information contained therein, and assume no responsibility regarding the suitability of this information for the user's intended purposes or for the consequences of its use. Each individual should make a determination as to the suitability of the information for their particular purpose(s). A request has been made to the manufacturer to approve the contents of this material safety data sheet. Upon receipt a new MSDS will be made available. ----------------------------------------------------------COMPAS Code: 31000010

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