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					- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - American Cyanamid
MANUFACTURER: AMERICAN CYANAMID COMPANY WAYNE, NEW JERSEY 07470 EMERGENCY TELEPHONE NO.: (201) 835-3100 MSDS NO.: 5043-01 CAS NO.: 57-68-1 DATE: March 24, 1986 ----------------------------------------------------------I. PRODUCT IDENTIFICATION ----------------------------------------------------------PRODUCT NAME: Sulfamethazine WARNING STATEMENT: SYNONYMS: Sulfadimerazine, sulfadimidine, Sulmet CHEMICAL FAMILY: Sulfonamides MOLECULAR FORMULA: C12H14N4O2S MOLECULAR WGT.: 278.3 ----------------------------------------------------------II. HAZARDOUS COMPONENTS OF MATERIALS ----------------------------------------------------------COMPONENT CAS. NO. % TWA/ REFERENCE CEILING ----------------------------------------------------------Sulfamethazine 57-68-1 10 mg/m3 ACCO PEL ----------------------------------------------------------III. PHYSICAL PROPERTIES ----------------------------------------------------------APPEARANCE AND ODOR: White to yellowish-white powder, odorless BOILING POINT: Not applicable MELTING POINT: 197 - 200 deg C VAPOR PRESSURE: Not applicable SPECIFIC GRAVITY: Not applicable VAPOR DENSITY: Not applicable PERCENT VOLATILE: Not applicable OCTANOL/H2O PARTITION COEF.: Not applicable pH: Not applicable SATURATION IN AIR (BY VOL.): Not applicable EVAPORATION RATE: Not applicable SOLUBILITY IN WATER: Very slightly LIPID SOLUBILITY: Slightly ----------------------------------------------------------IV. FIRE AND EXPLOSION HAZARD DATA ----------------------------------------------------------FLASH POINT (METHOD): Not applicable FLAMMABLE LIMITS: Not applicable LOWER: UPPER: AUTOIGNITION TEMP.: Not applicable DECOMPOSITION TEMP.: Not applicable ----------------------------------------------------------V. NFPA HAZARD RATING ----------------------------------------------------------Not applicable ----------------------------------------------------------VI. REACTIVITY DATA ----------------------------------------------------------STABILITY: Stable CONDITIONS TO AVOID: Not applicable POLYMERIZATION: Will Not Occur CONDITIONS TO AVOID: Not applicable INCOMPATIBLE MATERIALS: Not applicable HAZARDOUS DECOMPOSITION PRODUCTS: Not applicable

SULFAMETHAZINE
----------------------------------------------------------VII. SUMMARY OF TOXICITY AND HEALTH HAZARD INFORMATION ----------------------------------------------------------EFFECTS OF ACCIDENTAL OVEREXPOSURE AND TOXICITY DATA: EFFECTS OF ACCIDENTAL OVEREXPOSURE: MEDIAN LETHAL DOSE (LD50, LC50) (SPECIES): ORAL: Mouse - 1.9 g/kg INHALATION: Not determined DERMAL: Not determined OTHER: SUBCUTANEOUS: Mouse - 1.1 g/kg INTRAVENOUS: Mouse - 1.77 g/kg ACUTE: EYE: Not determined SKIN: Not determined ORAL: Overexposure can produce nausea, vomiting, skin rash and leukopenia. INHALATION: Not determined SENSITIZATION POTENTIAL: Allergic reactions have been reported. OTHER TOXICITY DATA: Administration of sulfonamides can result in kidney damage. Studies to assess the carcinogenic, mutagenic and teratogenic potential of sulfamethazine have not been reported. HAZARD EVALUATION: Sulfamethazine is considered to have slight potential to induce adverse effects under foreseeable occupational exposure conditions. As with all pharmaceuticals, exposure should be kept to a minimum through Good Manufacturing and Industrial Hygiene Practices. ----------------------------------------------------------VIII. FIRST AID MEDICAL TREATMENT ----------------------------------------------------------EYES: Flush eyes with clear water. Obtain medical attention. Avoid eye contact. SKIN: Remove contaminated clothing. Wash affected area with soap and water. Obtain medical attention. Avoid skin contact. INGESTION: Obtain medical attention. Avoid ingestion. INHALATION: Remove to fresh air. Obtain medical attention. Avoid inhalation. ----------------------------------------------------------IX. EXPOSURE CONTROL METHODS ----------------------------------------------------------Dust and mist producing procedures should be performed in a laboratory bench hood or using local exhaust ventilation to minimize excessive dust or mist generation. Gloves should be worn to prevent contact with the skin. In excessively dusty areas wear an approved air-purifying full-face respirator with high efficiency cartridges, full Tyvek coveralls, and gloves (plastic or rubber). Wash hands, face and any exposed body parts before breaks, lunch and end of shift. ----------------------------------------------------------X. SPILL OR LEAK PROCEDURES ----------------------------------------------------------STEPS TO BE TAKEN IN CASE MATERIAL IS RELEASED OR SPILLED: Contain and collect all spill residue. WASTE DISPOSAL: Dispose of in accordance with all federal, state and local regulations. Biological degradation or incineration is recommended. This is not considered a RCRA hazardous waste.

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- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - American Cyanamid
----------------------------------------------------------XI. SPECIAL PRECAUTIONS ----------------------------------------------------------STORAGE AND HANDLING: Store in a closed container. Minimize excessive handling. Maintain good housekeeping and personal hygiene procedures. ----------------------------------------------------------XII. APPENDIX ----------------------------------------------------------The information and statements herein are believed to be reliable but are not to be construed as a warranty or representation for which we assume legal responsibility. User should undertake sufficient verification and testing to determine the suitability for his own particular purpose of any information or products referred to herein. NO WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE IS MADE. ----------------------------------------------------------DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES: Although reasonable care has been taken in the preparation of this document, we extend no warranties and make no representation as to the accuracy or completeness of the information contained therein, and assume no responsibility regarding the suitability of this information for the user's intended purposes or for the consequences of its use. Each individual should make a determination as to the suitability of the information for their particular purpose(s). A request has been made to the manufacturer to approve the contents of this material safety data sheet. Upon receipt a new MSDS will be made available. ----------------------------------------------------------COMPAS Code: 15300400

SULFAMETHAZINE

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