Clinical Trial Recruitment in Cardiovascular Diseases by GBIResearch

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Clinical Trial Recruitment in Cardiovascular Diseases - Average Patient Recruitment per Trial was the Highest in Venous Thromboembolism

Summary

GBI Research, the leading business intelligence provider, has released its latest research, “Clinical Trial Recruitment in Cardiovascular Diseases - Average Patient Recruitment per Trial was the Highest in Venous Thromboembolism”. The report provides a robust idea about patient recruitment status by geography, sponsor companies and year for all the major CVD indications. Furthermore, the report provides prevalence forecast data to 2017 for all the major CVD indications. The major indications covered in the report are hypertension, atrial fibrillation, dyslipidemia and venous thromboembolism. The report was built using data and information sourced from proprietary databases, primary and secondary research and in house analysis by GBI Research’s team of industry experts.

There has been an increase in the number of clinical trials conducted for cardiovascular diseases (CVD) due to the high prevalence of CVD. According to the American Heart Association’s (AHA) 2006 data, around 81.1 million people in the US suffer from CVD and one in every 2.9 deaths in the US is due to CVD. According to the European Heart Network’s 2008 data, CVD caused 4.3 million deaths (48%) in Europe. The high prevalence and mortality rate associated with CVD has led to an increase in research and development (R&D) activity by pharmaceutical companies.

Clinical trials are one of the most critical parts of the drug development process. The various aspects involved in clinical trials, such as the implementation of technology, efficient supply chain management, proper site selection, patient recruitment and database management among others, are crucially important. Clinical trial recruitment is a time intensive process so good strategies must be followed by pharmaceutical companies for proper patient recruitment.

Efficient patient recruitment

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									        Clinical Trial Recruitment in Cardiovascular Diseases -
       Average Patient Recruitment per Trial was the Highest in
                       Venous Thromboembolism
 Reference Code: GBIHC120MR                                                                                                          Publication Date: September 2011


                                      CVD is One of the Four Major Therapeutic Areas for Clinical Trials
    Absence of appropriate            Pharmaceutical companies conduct clinical trials based on factors such as promising therapeutic
    treatment for many heart          areas, unmet needs for a particular indication and the presence of a significant patient population.
    diseases has led to               There are currently a number of indications for which no appropriate treatment is available, where
    increased number of               pharmaceutical companies analyze the scope of launching a new therapy and tapping the potential
    clinical trials for               market. Cardiovascular diseases are an indication for which clinical trials are conducted to try and
    cardiovascular diseases           provide better treatment options. Changing lifestyles, which includes poor diets and reduced
                                      physical activity, is one of the leading causes of CVDs.

                                        Clinical Trial Recruitment in CVD, Global, Ongoing Trials by Therapeutic Area, 2005-2010

                                                                        40



                                                                        35                                                                       34


                                                                        30
                                          Number of Trials (thousand)




                                                                        25



                                                                        20



                                                                        15



                                                                        10                                                                                        9
                                                                                                                                 8

                                                                                                 5                5
                                                                         5       4



                                                                         0
                                                                             Respiratory   Cardiovascular     Infectious   Central Nervous    Oncology          Others
                                                                                                              Diseases        System

                                        Source: GBI Research, ClinicalTrials.gov



                                      The total number of ongoing cardiovascular trials was 5,165 (starting in the period between 2005
                                      and 2010). This count includes all trials (interventional) which were started, ongoing or in the follow-
                                      up phase during this period.




Clinical Trial Recruitment in Cardiovascular Diseases -                                                                                  GBIHC120MR /Published SEP 2011
Average Patient Recruitment per Trial was the Highest in
Venous Thromboembolism                                                                                                                                                   Page 1
                                                                                                      © GBI Research. This is a licensed product and is not to be photocopied
                                      Most CVD Patients Were Recruited For Venous Thromboembolism Clinical Trials, 2000-2009
                                      Patient recruitment for venous thromboembolism (VTE) was the highest of the major indications
                                      under CVD. VTE recruited the most patients but there were more trials conducted for hypertension.
                                      Only patients recruited for clinical trials that were completed, interventional or started between 2000
                                      and 2009 were considered.

                                        Clinical Trial Recruitment in CVD, Global, Number of Patients Recruited for Major
                                                   Indications, 2000-2009

                                                                              300,000


                                                                                                                                                                      258,414
                                                                              250,000

                                                                                                                                                220,275
                                         Total Number of Patients Recruited




                                                                              200,000

                                                                                          168,736


                                                                              150,000




                                                                              100,000




                                                                               50,000                                        38,139

                                                                                                           13,400

                                                                                   0
                                                                                        Hypertension   Atherosclerosis    Dyslipidemia      Atrial Fibrillation       Venous
                                                                                                                                                                  Thromboembolism

                                        Source: GBI Research, ClinicalTrials.gov



                                      The total number of patients recruited for VTE clinical trials was 258,414. The number of patients
                                      recruited for atrial fibrillation was 220,275, followed by hypertension and dyslipidemia with 168,736
                                      and 38,139 patients, respectively.
                                      Most Clinical Trials Were Conducted For Hypertension, 2000-2009
                                      Hypertension leads the way among the sub-indications for which clinical trials were conducted
                                      under CVD. Most clinical trials under CVD were conducted for hypertension, with a total of 334
                                      trials. The total number of trials conducted for atrial fibrillation was 72, followed by dyslipidemia and
                                      VTE with 66 and 60 trials, respectively. 40 clinical trials were conducted for atherosclerosis.




Clinical Trial Recruitment in Cardiovascular Diseases -                                                                                      GBIHC120MR /Published SEP 2011
Average Patient Recruitment per Trial was the Highest in
Venous Thromboembolism                                                                                                                                                          Page 2
                                                                                                          © GBI Research. This is a licensed product and is not to be photocopied
                                      1      Table of Contents
                                      1   Table of Contents ........................................................................................................................ 3
                                          1.1    List of Tables..................................................................................................................... 6
                                          1.2    List of Figures ................................................................................................................... 9
                                      2   Clinical Trial Recruitment in CVD - Introduction......................................................................... 12
                                          2.1    GBI Research Report Guidance ..................................................................................... 13
                                      3   Clinical Trial Recruitment in CVD - Overview ............................................................................ 14
                                          3.1    Clinical Trials Share by Therapeutic Area, 2005-2010 .................................................... 14
                                          3.2    Clinical Trials by Major Pharmaceutical Companies, 2005-2010 .................................... 21
                                          3.3    Clinical Trial and Patient Recruitment for Major Indications, 2000-2009 ......................... 22
                                      4   Clinical Trials and Patient Recruitment for Hypertension........................................................... 24
                                          4.1    Introduction ..................................................................................................................... 24
                                          4.2    Number of Clinical Trials for Hypertension ...................................................................... 25
                                             4.2.1     Number of Clinical Trials by Phase.......................................................................... 25
                                             4.2.2     Number of Clinical Trials for Hypertension by Major Sponsors................................ 26
                                             4.2.3     Number of Clinical Trials for Hypertension by Geography ....................................... 27
                                             4.2.4     Number of Clinical Trials for Hypertension by Year ................................................. 28
                                          4.3    Prevalence Population for Hypertension (2010-2017) .................................................... 29
                                             4.3.1     Brazil ....................................................................................................................... 29
                                             4.3.2     India......................................................................................................................... 30
                                             4.3.3     China ....................................................................................................................... 31
                                          4.4    Patient Recruitment for Hypertension ............................................................................. 32
                                             4.4.1     Number of Patients Recruited by Phase of Clinical Trial ......................................... 32
                                             4.4.2     Number of Patients Recruited by Major Sponsors ................................................... 33
                                             4.4.3     Number of Patients Recruited by Geography .......................................................... 34
                                             4.4.4     Number of Patients Recruited per Year ................................................................... 35
                                          4.5    Average Number of Patients Recruited Per Trial ............................................................ 36
                                             4.5.1     Average Number of Patients Recruited per Trial by Stage of Development ............ 36
                                             4.5.2     Average Number of Patients Recruited per Trial per Year ...................................... 37
                                      5   Clinical Trials and Patient Recruitment for Atherosclerosis ....................................................... 38
                                          5.1    Introduction ..................................................................................................................... 38
                                          5.2    Number of Clinical Trials for Atherosclerosis .................................................................. 38
                                             5.2.1     Number of Clinical Trials by Phase.......................................................................... 38
                                             5.2.2     Number of Clinical Trials by Sponsor ...................................................................... 40
                                             5.2.3     Number of Clinical Trials by Geography .................................................................. 41
                                             5.2.4     Number of Clinical Trials by Year ............................................................................ 42
                                          5.3    Prevalence Population for Atherosclerosis (2010-2017) ................................................. 43
                                             5.3.1     Brazil ....................................................................................................................... 43
                                             5.3.2     India......................................................................................................................... 44
                                             5.3.3     China ....................................................................................................................... 45
                                          5.4    Patient Recruitment for Atherosclerosis .......................................................................... 46
                                             5.4.1     Number of Patients Recruited By Phase of Clinical Trial ......................................... 46
                                             5.4.2     Number of Patients Recruited by Sponsor .............................................................. 47
                                             5.4.3     Number of Patients Recruited by Geography .......................................................... 48
                                             5.4.4     Number of Patients Recruited per Year ................................................................... 49
                                          5.5    Average Number of Patients Recruited per Trial............................................................. 50
                                             5.5.1     Average Number of Patients Recruited per Trial by Stage of Development ............ 50
                                             5.5.2     Average Number of Patients Recruited per Trial per Year ...................................... 51
                                      6   Clinical Trials and Patient Recruitment for Dyslipidemia ........................................................... 52
                                          6.1    Introduction ..................................................................................................................... 52
                                          6.2    Number of Clinical Trials for Dyslipidemia....................................................................... 52
                                             6.2.1     Number of Clinical Trials by Phase.......................................................................... 52
                                             6.2.2     Number of Clinical Trials by Major Sponsor............................................................. 54
                                             6.2.3     Number of Clinical Trials by Geography .................................................................. 55


Clinical Trial Recruitment in Cardiovascular Diseases -                                                                                GBIHC120MR /Published SEP 2011
Average Patient Recruitment per Trial was the Highest in
Venous Thromboembolism                                                                                                                                                        Page 3
                                                                                        © GBI Research. This is a licensed product and is not to be photocopied
                                           6.2.4     Number of Clinical Trials by Year ............................................................................ 56
                                        6.3    Prevalence Population for Dyslipidemia (2010-2017) ..................................................... 57
                                           6.3.1     Brazil ....................................................................................................................... 57
                                           6.3.2     India......................................................................................................................... 58
                                           6.3.3     China ....................................................................................................................... 59
                                        6.4    Patient Recruitment for Dyslipidemia .............................................................................. 60
                                           6.4.1     Number of Patients Recruited by Phase of Clinical Trial ......................................... 60
                                           6.4.2     Number of Patients Recruited by Major Sponsors ................................................... 61
                                           6.4.3     Number of Patients Recruited by Geography .......................................................... 62
                                           6.4.4     Number of Patients Recruited per Year ................................................................... 63
                                        6.5    Average Number of Patients Recruited per Trial............................................................. 64
                                           6.5.1     Average Number of Patients Recruited per Trial by Stage of Development ............ 64
                                           6.5.2     Average Number of Patients Recruited per Trial per Year ...................................... 65
                                      7 Clinical Trials and Patient Recruitment for Atrial Fibrillation ...................................................... 66
                                        7.1    Introduction ..................................................................................................................... 66
                                        7.2    Number of Clinical Trials for Atrial Fibrillation ................................................................. 67
                                           7.2.1     Number of Clinical Trials by Phase.......................................................................... 67
                                           7.2.2     Number of Clinical Trials by Major Sponsors ........................................................... 68
                                           7.2.3     Number of Clinical Trials by Geography .................................................................. 69
                                           7.2.4     Number of Clinical Trials by Year ............................................................................ 70
                                        7.3    Prevalence Population for Atrial Fibrillation (2010-2017) ................................................ 71
                                           7.3.1     Brazil ....................................................................................................................... 71
                                           7.3.2     India......................................................................................................................... 72
                                           7.3.3     China ....................................................................................................................... 73
                                        7.4    Patient Recruitment for Atrial Fibrillation ......................................................................... 74
                                           7.4.1     Number of Patients Recruited by Phase of Clinical Trial ......................................... 74
                                           7.4.2     Number of Patients Recruited by Major Sponsors ................................................... 75
                                           7.4.3     Number of Patients Recruited by Geography .......................................................... 76
                                           7.4.4     Number of Patients Recruited per Year ................................................................... 77
                                        7.5    Average Number of Patients Recruited Per Trial ............................................................ 78
                                           7.5.1     Average Number of Patients Recruited per Trial by Stage of Development ............ 78
                                           7.5.2     Average Number of Patients Recruited per Trial per Year ...................................... 79
                                      8 Clinical Trials and Patient Recruitment for Venous Thromboembolism ..................................... 80
                                        8.1    Introduction ..................................................................................................................... 80
                                        8.2    Number of Clinical Trials for Venous Thromboembolism ................................................ 80
                                           8.2.1     Number of Clinical Trials by Phase.......................................................................... 80
                                           8.2.2     Number of Clinical Trials by Sponsor ...................................................................... 82
                                           8.2.3     Number of Clinical Trials by Geography .................................................................. 83
                                           8.2.4     Number of Clinical Trials by Year ............................................................................ 84
                                        8.3    Prevalence Population for Venous Thromboembolism (2010-2017) ............................... 85
                                           8.3.1     Brazil ....................................................................................................................... 85
                                           8.3.2     India......................................................................................................................... 86
                                           8.3.3     China ....................................................................................................................... 87
                                        8.4    Patient Recruitment for Venous Thromboembolism........................................................ 88
                                           8.4.1     Number of Patients Recruited By Phase of Clinical Trial ......................................... 88
                                           8.4.2     Number of Patients Recruited by Major Sponsors ................................................... 89
                                           8.4.3     Number of Patients Recruited By Geography .......................................................... 90
                                           8.4.4     Number of Patients Recruited Per Year .................................................................. 91
                                        8.5    Average Number of Patients Recruited per Trial............................................................. 92
                                           8.5.1     Average Number of Patients Recruited per Trial by Stage of Development ............ 92
                                           8.5.2     Average Number of Patients Recruited per Trial per Year ...................................... 93
                                      9 Appendix ................................................................................................................................... 94
                                        9.1    Market Definitions ........................................................................................................... 94
                                        9.2    Abbreviations .................................................................................................................. 94
                                        9.3    Research Methodology ................................................................................................... 95

Clinical Trial Recruitment in Cardiovascular Diseases -                                                                                GBIHC120MR /Published SEP 2011
Average Patient Recruitment per Trial was the Highest in
Venous Thromboembolism                                                                                                                                                       Page 4
                                                                                        © GBI Research. This is a licensed product and is not to be photocopied
                                             9.3.1    Clinical Trials Overview ........................................................................................... 95
                                             9.3.2    Number of Clinical Trials ......................................................................................... 95
                                             9.3.3    Patient Recruitment Status ...................................................................................... 96
                                             9.3.4    Prevalence of Disease in India, China and Brazil (2010-2017) ............................... 96
                                          9.4    Coverage ........................................................................................................................ 96
                                          9.5    Secondary Research ...................................................................................................... 96
                                          9.6    Primary Research ........................................................................................................... 97
                                          9.7    Expert Panel Validation................................................................................................... 97
                                          9.8    Contact Us ...................................................................................................................... 97
                                          9.9    Disclaimer ....................................................................................................................... 97
                                          9.10 Sources ........................................................................................................................... 98




Clinical Trial Recruitment in Cardiovascular Diseases -                                                                               GBIHC120MR /Published SEP 2011
Average Patient Recruitment per Trial was the Highest in
Venous Thromboembolism                                                                                                                                                      Page 5
                                                                                        © GBI Research. This is a licensed product and is not to be photocopied
                                      1.1     List of Tables
                                      Table 1:    Clinical Trial Recruitment in CVD, Global, Ongoing Trials by Therapeutic Area, 2005-
                                                  2010 ............................................................................................................................... 14
                                      Table 2:    Clinical Trial Recruitment in CVD, Asia, Ongoing Trials by Therapeutic Area, 2005-2010
                                                  ....................................................................................................................................... 15
                                      Table 3:    Clinical Trial Recruitment in CVD, Europe, Ongoing Trials by Therapeutic Area, 2005-
                                                  2010 ............................................................................................................................... 16
                                      Table 4:    Clinical Trial Recruitment in CVD, Middle East, Ongoing Trials by Therapeutic Area,
                                                  2005-2010 ...................................................................................................................... 17
                                      Table 5:    Clinical Trial Recruitment in CVD, South and Central America, Ongoing Trials by
                                                  Therapeutic Area, 2005-2010 ........................................................................................ 18
                                      Table 6:    Clinical Trial Recruitment in CVD, North America, Ongoing Trials by Therapeutic Area,
                                                  2005-2010 ...................................................................................................................... 19
                                      Table 7:    Clinical Trial Recruitment in CVD, Rest of the World, Ongoing Trials by Therapeutic
                                                  Area, 2005-2010 ............................................................................................................ 20
                                      Table 8:    Clinical Trial Recruitment in CVD, Global, Clinical Trials by Major Pharmaceutical
                                                  Companies, 2005-2010 .................................................................................................. 21
                                      Table 9:    Clinical Trial Recruitment in CVD, Global, Number of Clinical Trials for Major Indications,
                                                  2000-2009 ...................................................................................................................... 22
                                      Table 10:   Clinical Trial Recruitment in CVD, Global, Number of Patients Recruited for Major
                                                  Indications, 2000-2009 ................................................................................................... 23
                                      Table 11:   Clinical Trial Recruitment in CVD, Hypertension, Total Number of Clinical Trials by
                                                  Phase, 2000-2009 .......................................................................................................... 25
                                      Table 12:   Clinical Trial Recruitment in CVD, Hypertension, Total Number of Clinical Trials by Major
                                                  Sponsors, 2000-2009 ..................................................................................................... 26
                                      Table 13:   Clinical Trial Recruitment in CVD, Hypertension, Total Number of Clinical Trials by
                                                  Geography, 2000 - 2009 ................................................................................................ 27
                                      Table 14:   Clinical Trial Recruitment in CVD, Hypertension, Total Number of Clinical Trials per
                                                  Year, 2000 - 2009 .......................................................................................................... 28
                                      Table 15:   Clinical Trial Recruitment in CVD, Hypertension, Brazil, Prevalence Population, million,
                                                  2010 - 2017 .................................................................................................................... 29
                                      Table 16:   Clinical Trial Recruitment in CVD, Hypertension, India, Prevalence Population, million
                                                  2010 - 2017 .................................................................................................................... 30
                                      Table 17:   Clinical Trial Recruitment in CVD, Hypertension, China, Prevalence Population, million
                                                  2010 - 2017 .................................................................................................................... 31
                                      Table 18:   Clinical Trial Recruitment in CVD, Hypertension, Total Number of Patients Recruited by
                                                  Phase, 2000 - 2009 ........................................................................................................ 32
                                      Table 19:   Clinical Trial Recruitment in CVD, Hypertension, Total Number of Patients Recruited by
                                                  Major Sponsors, 2000 - 2009 ......................................................................................... 33
                                      Table 20:   Clinical Trial Recruitment in CVD, Hypertension, Total Number of Patients Recruited by
                                                  Geography, 2000 - 2009 ................................................................................................ 34
                                      Table 21:   Clinical Trial Recruitment in CVD, Hypertension, Total Number of Patients Recruited per
                                                  Year, 2000 - 2009 .......................................................................................................... 35
                                      Table 22:   Clinical Trial Recruitment in CVD, Hypertension, Average Number of Patients Recruited
                                                  per Trial by Stage of Development, 2000 - 2009 ............................................................ 36
                                      Table 23:   Clinical Trial Recruitment in CVD, Hypertension, Average Number of Patients Recruited
                                                  per Trial per Year, 2000 - 2009 ...................................................................................... 37
                                      Table 24:   Clinical Trial Recruitment in CVD, Atherosclerosis, Total Number of Clinical Trials, 2000
                                                  - 2009 ............................................................................................................................. 39
                                      Table 25:   Clinical Trial Recruitment in CVD, Atherosclerosis, Total Number of Clinical Trials by
                                                  Major Sponsors, 2000 - 2009 ......................................................................................... 40
                                      Table 26:   Clinical Trial Recruitment in CVD, Atherosclerosis, Total Number of Clinical Trials by
                                                  Geography, 2000 - 2009 ................................................................................................ 41
                                      Table 27:   Clinical Trial Recruitment in CVD, Atherosclerosis, Total Number of Clinical Trials per
                                                  Year, 2000 - 2009 .......................................................................................................... 42
                                      Table 28:   Clinical Trial Recruitment in CVD, Atherosclerosis, Brazil, Prevalence Population,
                                                  million, 2010 - 2017 ........................................................................................................ 43
                                      Table 29:   Clinical Trial Recruitment in CVD, Atherosclerosis, India, Prevalence Population, million,
                                                  2010 - 2017 .................................................................................................................... 44
                                      Table 30:   Clinical Trial Recruitment in CVD, Atherosclerosis, China, Prevalence Population,
                                                  million, 2010 - 2017 ........................................................................................................ 45


Clinical Trial Recruitment in Cardiovascular Diseases -                                                                                  GBIHC120MR /Published SEP 2011
Average Patient Recruitment per Trial was the Highest in
Venous Thromboembolism                                                                                                                                                           Page 6
                                                                                       © GBI Research. This is a licensed product and is not to be photocopied
                                      Table 31: Clinical Trial Recruitment in CVD, Atherosclerosis, Total Number of Patients Recruited
                                                by Phase, 2000 - 2009 ................................................................................................... 46
                                      Table 32: Clinical Trial Recruitment in CVD, Atherosclerosis, Total Number of Patients Recruited
                                                by Major Sponsors, 2000 - 2009 .................................................................................... 47
                                      Table 33: Clinical Trial Recruitment in CVD, Atherosclerosis, Total Number of Patients Recruited
                                                by Geography, 2000 - 2009 ........................................................................................... 48
                                      Table 34: Clinical Trial Recruitment in CVD, Atherosclerosis, Total Number of Patients Recruited
                                                per Year, 2000 - 2009 .................................................................................................... 49
                                      Table 35: Clinical Trial Recruitment in CVD, Atherosclerosis, Average Number of Patients
                                                Recruited per Trial by Stage of Development, 2000 - 2009 ........................................... 50
                                      Table 36: Clinical Trial Recruitment in CVD, Atherosclerosis, Average Number of Patients
                                                Recruited per Trial per Year, 2000 - 2009 ...................................................................... 51
                                      Table 37: Clinical Trial Recruitment in CVD, Dyslipidemia, Total Number of Clinical Trials by
                                                Phase, 2000 - 2009 ........................................................................................................ 53
                                      Table 38: Clinical Trial Recruitment in CVD, Dyslipidemia, Total Number of Clinical Trials by Major
                                                Sponsors, 2000 - 2009 ................................................................................................... 54
                                      Table 39: Clinical Trial Recruitment in CVD, Dyslipidemia, Total Number of Clinical Trials by
                                                Geography, 2000 - 2009 ................................................................................................ 55
                                      Table 40: Clinical Trial Recruitment in CVD, Dyslipidemia, Total Number of Clinical Trials per Year,
                                                2000 - 2009 .................................................................................................................... 56
                                      Table 41: Clinical Trial Recruitment in CVD, Dyslipidemia, Brazil, Prevalence Population, million,
                                                2010 - 2017 .................................................................................................................... 57
                                      Table 42: Clinical Trial Recruitment in CVD, Dyslipidemia, India, Prevalence Population, million,
                                                2010 - 2017 .................................................................................................................... 58
                                      Table 43: Clinical Trial Recruitment in CVD, Dyslipidemia, China, Prevalence Population, million,
                                                2010 - 2017 .................................................................................................................... 59
                                      Table 44: Clinical Trial Recruitment in CVD, Dyslipidemia, Total Number of Patients Recruited by
                                                Phase, 2000 - 2009 ........................................................................................................ 60
                                      Table 45: Clinical Trial Recruitment in CVD, Dyslipidemia, Total Number of Patients Recruited by
                                                Major Sponsors, 2000 - 2009 ......................................................................................... 61
                                      Table 46: Clinical Trial Recruitment in CVD, Dyslipidemia, Total Number of Patients Recruited by
                                                Geography, 2000 - 2009 ................................................................................................ 62
                                      Table 47: Clinical Trial Recruitment in CVD, Dyslipidemia, Total Number of Patients Recruited per
                                                Year, 2000 - 2009 .......................................................................................................... 63
                                      Table 48: Clinical Trial Recruitment in CVD, Dyslipidemia, Average Number of Patients Recruited
                                                per Trial by Stage of Development, 2000 - 2009 ............................................................ 64
                                      Table 49: Clinical Trial Recruitment in CVD, Dyslipidemia, Average Number of Patients Recruited
                                                per Trial per Year, 2000 - 2009 ...................................................................................... 65
                                      Table 50: Clinical Trial Recruitment in CVD, Atrial Fibrillation, Total Number of Clinical Trials by
                                                Phase, 2000 - 2009 ........................................................................................................ 67
                                      Table 51: Clinical Trial Recruitment in CVD, Atrial Fibrillation, Total Number of Clinical Trials by
                                                Major Sponsors, 2000 - 2009 ......................................................................................... 68
                                      Table 52: Clinical Trial Recruitment in CVD, Atrial Fibrillation, Total Number of Clinical Trials by
                                                Geography, 2000 - 2009 ................................................................................................ 69
                                      Table 53: Clinical Trial Recruitment in CVD, Atrial Fibrillation, Total Number of Clinical Trials per
                                                Year, 2000 - 2009 .......................................................................................................... 70
                                      Table 54: Clinical Trial Recruitment in CVD, Atrial Fibrillation, Brazil, Prevalence Population,
                                                million, 2010 - 2017 ...................
								
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