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312

VIEWS: 4 PAGES: 3

									Author(s): Yeh, YH (Yeh, Yen-Hung); Lee, YT (Lee, Ya-Ting); Hsieh, HS (Hsieh, Hung-Seng);
Hwang, DF (Hwang, Deng-Fwu)

Title: Dietary Caffeic Acid, Ferulic Acid and Coumaric Acid Supplements on Cholesterol
Metabolism and Antioxidant Activity in Rats

Source: JOURNAL OF FOOD AND DRUG ANALYSIS, 17 (2): 123-132 APR 2009

Language: English

Document Type: Article

Author Keywords: caffeic acid; ferulic acid; coumaric acid; HMG-CoA reductase; ACAT; fecal
sterols; antioxidant enzymes

KeyWords Plus: MICROSOMAL GLUTATHIONE TRANSFERASE; HMG-COA
REDUCTASE; HIGH-FAT DIET; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION;
ACYL-COA; OXIDIZED CHOLESTEROL; HYDROGEN-PEROXIDE; TANNIC-ACID;
POLYPHENOLS

Abstract: This study was designed to test the lipid-lowering and antioxidative activities of
three phenolic compounds, caffeic acid, ferulic acid and coumaric acid. Four groups of rats
were given a semisynthetic diet containing 3% of cholesterol for 6 weeks. The control group
only received a high cholesterol diet, whereas the other three groups received a diet including
0.2% of caffeic acid, 0.2% of ferulic acid and 0.2% of coumaric acid. The caffeic acid, ferulic
acid and coumaric acid significantly lowered the plasma lipid and hepatic cholesterol levels
compared to those in the control (p < 0.05). The hepatic HMG-CoA reductase activity was
significantly lower in the caffeic acid group than in the ferulic acid and coumaric acid groups (p
< 0.05), while the hepatic ACAT activity was significantly lower in the caffeic acid, ferulic acid
and coumaric acid groups compared to the control group (p < 0.05). The overall potential of
the antioxidant system was significantly enhanced by the caffeic acid, ferulic acid and
coumaric acid supplements as the plasma and hepatic TBARS levels were lowered while the
hepatic SOD activities and GSH concentration were elevated in the high-cholesterol-fed rats (p
< 0.05). Furthermore, these results indicated that the supplementation of caffeic acid, ferulic
acid and coumaric acid boosted the antioxidant activity in rats and promoted the excretion of
neutral sterol and acidic sterol (p < 0.05), thereby leading to a decreased absorption of dietary
cholesterol as well as lower plasma, hepatic cholesterol and promoted excretion of fecal
sterols.

Addresses: [Yeh, Yen-Hung] Toko Univ, Dept Nutr & Hlth Sci, Chiayi, Taiwan; [Lee, Ya-Ting]
Chien Kuo Technol Univ, Dept Beauty Sci, Changhua, Taiwan; [Hsieh, Hung-Seng] Asia Univ,
Dept Hlth & Nutr Biotechnol, Taichung, Taiwan; [Hwang, Deng-Fwu] Natl Taiwan Ocean Univ,
Dept Food Sci, Chilung, Taiwan

Reprint Address: Yeh, YH, Toko Univ, Dept Nutr & Hlth Sci, Chiayi, Taiwan.
E-mail Address: yhyeh@mail.toko.edu.tw

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Cited Reference Count: 59

Times Cited: 1

Publisher: BUREAU FOOD DRUG ANALYSIS

Publisher Address: 161-2 KUNYANG STREET, NANGANG, TAIPEI, 00000, TAIWAN

ISSN: 1021-9498

29-char Source Abbrev.: J FOOD DRUG ANAL

ISO Source Abbrev.: J. Food Drug Anal.

Source Item Page Count: 10

Subject Category: Food Science & Technology; Pharmacology & Pharmacy

ISI Document Delivery No.: 441IR

								
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