Resume - Center for Cancer Research - National Cancer Institute by wuxiangyu

VIEWS: 14 PAGES: 4

									                                                          NCI-Frederick/CCR/LMI
                                                          Building 560 Room 31-76
                                                          Frederick, MD 21702
                                                          Phone: 301-846-6867
                                                          e-mail: hurte@ncifcrf.gov



     Elaine M. (Chamberlain) Hurt

Education             Ph.D. Biochemistry, Molecular Biology, and Biophysics, 1999
                      University of Minnesota, Minneapolis, Minnesota


                      B.S.   Biochemistry and Genetics and Cell Biology, 1994
                      University of Minnesota, Minneapolis, Minnesota


Research Experience   2005-present. Staff Scientist
                      National Cancer Institute-Frederick, , Laboratory of Molecular
                      Immunoregulation, Cytokine Molecular Mechanisms Section
                      William L. Farrar., Ph.D., Principal Investigator


                      2004-2005. Scientist I
                      SAIC-Frederick, Inc., National Cancer Institute-Frederick, Laboratory of
                      Molecular Immunoregulation, Cytokine Molecular Mechanisms Section
                      William L. Farrar., Ph.D., Principal Investigator


                      1999-2004. Post-doctoral Fellow
                      NIH/NCI/Metabolism Branch, National Cancer Institute
                      Louis M. Staudt, M.D., Ph.D., Principal Investigator


                      1994-1999. Graduate Research Assistant
                      Department of Biochemistry, Molecular Biology, and Biophysics, University
                      of Minnesota
                      Michel M. Sanders, Ph.D., Research Advisor
                      Dissertation: The Role of the Two-Handed Zinc Finger/Homeodomain protein,
                      EF1, in Estrogen-Triggered Signaling Cascades and in Human Carcinomas.


                      1992-1994. Undergraduate Research Program
                      Department of Plant Biology, University of Minnesota
                      Judith Berman, Ph.D., Research Advisor


Related Experience    2002 Invited Speaker UICC 18th International Cancer Congress. Oslo, Norway.
                      Gene profiling of hematopoietic cells and gene expression in non-Hodgkins
                      Lymphoma. Implications for diagnosis and treatment.


                      2001 Invited Speaker EURESCO B Cells in Health and Disease. Acquafredda
                      di Maratea, Italy. Gaining insights into B cells development and tumorgenesis
                      through genomic scale profiling.


                      1998 Invited Speaker for the Edina Youth Science Forum. Edina, Minnesota.
                    1996 Teaching Assistant and review session leader for the Medical School
                    nutrition course. University of Minnesota.


                    1995 Teaching Assistant and review session leader for the Dental School
                    biochemistry course. University of Minnesota.


                    1995,1996,1997,1998 Mentor/director for graduate students and
                    undergraduate students.


Awards and Honors   1999 Veneziale-Steer Award for Outstanding Research in Cellular Growth
                    Regulation, University of Minnesota


                    October 1998 Young Investigator Award, American Association for Cancer
                    Research


                    October 1998 Travel Grant, Department of Biochemistry


                    March 1998 Travel Grant, Endocrine Society


                    March 1998 Travel Grant, Department of Biochemistry


                    1996 Cyrus P. Barnum, Jr. Memorial Teaching Fellowship Award, University
                    of Minnesota


                    1992-1994 Undergraduate Research Opportunities Grant, University of
                    Minnesota


Publications        Hurt EM, Thomas SB, Peng B, Farrar WL. (In preparation) Epigenetic
                    silencing of SOD2 and molecular consequences in pancreatic carcinoma.
                    Cancer Research.

                    Hurt EM, Thomas SB, Peng B, Farrar WL. (In review) Integrated Molecular
                    Profiling of SOD2 Expression in Epigenetically Silenced Multiple Myeloma.
                    Genome Biology.

                    Hurt EM, Thomas SB, Peng B, Farrar WL. (2006) Reversal of p53 epigenetic
                    silencing in multiple myeloma permits apoptosis by a p53 activator.
                    Cancer Biol Ther 5(9):.

                    Peng B, Hurt EM, Hodge DR, Thomas SB, Farrar WL. (2006) DNA
                    hypermethylation and partial gene silencing of human base excision repair genes
                    in multiple myeloma. Epigenetics 1(3):.

                    Sharifi, N, Kawasaki BT, Hurt EM, FarrarWL. (2006) Stem cells in prostate
                    cancer: Resolving the conundrum and implications for hormonal therapy.
                    Cancer Biol Ther 5(8):.
Hodge DR, Hurt EM, Farrar WL. (2005) The role of STAT3 in inflammation
and cancer . Eur J Cancer 41:2502-12.

Hodge DR, Peng B, Cherry, JC, Munroe DJ, Pompeia C, Hurt EM, Fox SD,
Marquez, VE, Kelley JA, Farrar WL. (2005) IL-6 Supports the maintenance of
p53 tumor suppressor gene promoter methylation. Cancer Research 65: 1-10.

Shaffer AL, Ahapiro-Shelef M, Iwakoshi NN, Lee AH, Qian SB, Zhao H, Yu X,
Tan BK, Rosenwald A, Hurt EM, Petroulakis E, Sonenberg N, Yewdell JW,
Calame K, Glimcher LH, Staudt LM. (2004) XBP1, downstream of Blimp-1,
expands the secretory apparatus and other organelles, and increase protein
synthesis in plasma cell differentiation. Immunity 21(5):81-93.

Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Bergsagel PL,
Kuehl WM, Staudt, LM. (2004) Overexpression of c-maf is a frequent
oncogenic event in multiple myeloma that promotes proliferation and
pathological interactions with bone marrow stroma. Cancer Cell 5(2):191-9.
Commentary: Kienast J, Berdel WE. (2004) c-maf in multiple myeloma: an
oncogene enhancing tumor-stroma interactions. Cancer Cell 5(2):109-10.

Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. (2003) A
gene expression-based method to diagnose clinically distinct subgroups of
diffuse large B cell lymphoma. ProcNatl Acad Sci 100(17): 9991-6.

Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E,
Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M,
Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J,
Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner
TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO,
Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt
LM. (2003) The proliferation gene expression signature is a quantitative
integrator of oncogenic events that predicts survival in mantle cell lymphoma.
Cancer Cell 3(2):185-97. Commentary: Evans WE, Cheok M, Yang W, Sherr
CJ. Expression arrays illuminate a way forward. Cancer Cell3(2):100-2.

Kovanen PE, Rosenwald A, Fu J, Hurt EM, Lam LT, Giltnane JM, Staudt LM,
Leonard WJ. (2003) Analysis of c-family cytokine genes: Identification of
DUSP5 as regulator of MAPK activity in IL-2 signaling. J Biol Chem
278(7):5205-13

Shaffer AL, Lin K-I, Kuo TC , Xin Yu, Hurt EM, Rosenwald A, Giltnane JM,
Yang L, Zhao H, Calame K, Staudt LM. (2002) Blimp-1 orchestrates plasma
cell differentiation by extinguishing the mature B cell gene expression program.
Immunity 17(1):51-62.

Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI,
Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM,
Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD,
Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG,
Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, Lopez-Guillermo A,
Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci
P, Stokke T, Staudt LM. (2002) The use of molcelar profiling to predict
survival after chemotherapy for difuse large-B-cell lymphoma. N Engl J Med
346(25):1937-47.
             Shaffer AL, Rosenwald A, Hurt EM, Giltnane JM, Lam LT, Pickeral OK,
             Staudt LM. (2001) Signatures of the immune response. Immunity 15(3):375-
             85.

             Lam LT, Pickeral OK, Peng AC, Rosenwald A, Hurt EM, Giltnane JM, Averett
             LM, Zhao H, Davis RE, Sathyamoorthy M, Wahl LM, Harris ED, Mikovits JA,
             Monks AP, Hollingshead MG, Sausville EA, Staudt LM. (2001) Genomic-scale
             measurement of mRNA turnover and the mechanisms of action of the anti-
             cancer drug flavopiridol. Genome Biol .2(10):RESEARCH0041.

             Chamberlain, E.M. and Sanders, M.M. Identification of the novel player EF1
             in estrogen transcriptional cascades. (1999) Mol. Cell Biol. 19(5):3600-06.


             Konkel, L.M., Enomoto, S., Chamberlain, E.M., McCune-Zierath, P., Iyadurai,
             S.J., and Berman, J. (1995). A class of single-stranded telomeric-binding
             proteins required for Rap1p localization in yeast nuclei. PNAS 92(2): 5558-62.




References   Available upon request

								
To top