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AUSTRALIA
DNA CHARACTER
SILVER JEWELRY
OPERRATION PLAN
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226
AUSTRALIA TABLE OF CONTENTS
1. Operation Overview ------------------------------ 3
2. Organization ------------------------------------ 4
3. DNA Information
3.1 Introduction ----------------------------- 5
3.2 Genome Structure --------------------- 6
3.3 Gene Sequence ----------------------- 7
3.4 DNA Sequence ----------------------- 8
3.5 The DNA Character ---------------- 9
3.6 STR ------------------------------- 10
3.7 HVR ----------------------------- 11
4. Work Process
4.1 Collecting Specimen ------- 12
4.2 Handling Specimen ------- 13
4.3 DNA Testing ------------- 14
4.4 Legal DNA Testing ----- 15
4.5 DNA Preservation ----16
5. Other Concerns --------17
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 2
AUSTRALIA 1. OPERATION OVERVIEW
DNA CHARACTER PRODUCT
Dr. LEE CORPORATION will establish a new business that provides DNA
character products. The concept of the business is to commercialize basic/medium
level of DNA technology as jewelry, accessories, memorials, etc. The proposed
business will provide DNA abstract products, personal identifying DNA products,
DNA photographic products, etc. Major target customers will be consumer group
who is interested in jewelry and personal/family identity.
THE WORK PROCESS
- Collecting orders from clients through DNA Character Shops and Website
- Collecting DNA Samples (Specimen) with orders (Hair, Swab-Cheek etc)
- Post the Specimen to the DNA testing laboratory.
- DNA testing is processed in the laboratory
- Selecting DNA identification from the profile
- Produce the Silver Jewelry with the identification embossed
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 3
AUSTRALIA 2. ORGANIZATION
MANAGING DIRECTOR
FINANCE MARKETING DNA LABORATORY
MANAGEMENT DESIGN/SALES TESTING
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 4
AUSTRALIA 3. DNA INFORMATION
1. INTRODUCTION
Fifty years ago scientists first described the structure of deoxyribonucleic acid (DNA).
Today humans have put DNA to work in a wide variety of applications.
Throughout the body > in cells...
Human body consists of cells with the number of about 50 and 100 trillion cells (a
trillion is a thousand billion, or a thousand, thousand million). These cells are
organized into tissues, such as skin, muscle, and bone. Each cell contains organism's
all of the genetic information stored as DNA. However, each cell uses only the
information from part of the DNA, which is called tissue specific expression. For
example, a muscle cell uses the DNA that specifies the muscle apparatus, whereas a
nerve cell uses DNA that specifies the nervous system. It is as if each cell reads only
that part of a book of instructions that it needs.
Within the cell > in chromosomes...
Each very long DNA molecule is tightly wound and
packaged as a chromosome.
Humans have two copies of 23 chromosomes in every
cell, one set inherited from each parent.
A human cell therefore contains 46 of these
chromosomal DNA molecules.
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 5
AUSTRALIA 3. DNA INFORMATION
2. GENOME STRUCTURE
Within each chromosome > in genes...
Each DNA molecule that forms a chromosome
can be viewed as a set of shorter DNA sequences.
These are the units of DNA function, called
genes, each of which guides the production of
one particular protein of an organism. A set of
human chromosomes contains one copy of each
of the roughly 30,000 genes in the human
"genome" - the term used to refer to the
complete genetic instructions for an organism.
Are People Really Identical?
Even though humans share 100% of the same
genes, the information contained within the
genes are not entirely identical. Each person has
their own unique DNA sequence. People have
different hair colors, facial structures, and other
traits. These differences between individuals
result from very small differences in their DNA
sequence.
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 6
AUSTRALIA 3. DNA INFORMATION
3. GENE SEQUNCE
Two Copies of the Genome
Human Inherits One Copy From Each Parent
A person has two copies of every gene sequence, one inherited from the mother,
and the other inherited from the father. A child thus inherits one copy from each
parent's own pair, and this copy is selected from the parent randomly. In order to
fully understand a person's DNA sequences, both inherited copies of a gene need to
be examined.
These sequences are often not identical. Gene
sequences for so-called "dominant" traits are expressed
over "recessive" traits. Do you have a cleft chin? It is an
indentation at the tip of your chin. If so, you have at
least one copy of the dominant gene for cleft chin. But if
your chin has no indentation, you have two copies of the
recessive gene for this trait.
Inherited Disease
Just as a children may inherit their hair or eye color from
their parents, they can also inherit genetic diseases. In
dominant trait, if a child inherits just one mutated copy
of the gene he or she is a "carrier" of the genetic disease.
If there are two defective copies the child may be
affected by the disease.
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 7
AUSTRALIA 3. DNA INFORMATION
4. DNA SEQUENCE The DNA Sequence
The extremely long DNA molecule is actually made of a long string of chemical
building blocks called “nucleotides.” There are four different nucleotides, which are
labeled adenine A, thymine T, guanine G, and cytosine C. The human genome is
made of a sequence of roughly three billion of these nucleotides.
Although 99% of DNA sequence is identical in each individuals, there are
polymorphic markers, which we call micro-satellite or SNPs. These polymorphic
markers are used for Identification purpose.
What part of DNA sequence is used for DNA Character item?
Functional Sequence
for phenotype and Gene
Polymorphic Sequence for
Identification
DNAtyping
forensic and ID use
STR + HVR : a part of the
Mitochondria DNA Sequence
Engraving the Code on items
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 8
AUSTRALIA 3. DNA INFORMATION
5. THE DNA CHARACTER
The ‘DNA Character’ is a way of creating a DNA identity code named by Dr.
J.I.Lee.
It is a patented formula of combining the number of repeat counted on DNA
Sequencing (STR, Short Tandem Repeat ) and the HVR (Hypervariable
Region) section of the Mitochondria.
Ex) 73-249-263-C1(305)-C2(315)/G-D-G-8-6 DYS385/392/19;10-17/13/15<
Our DNA
In Nuclear In Cytoplasm
Genomic DNA Mitochondrial DNA
STR - Characterized HVR - Characterized
by Numbers by A.T.G.C.
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 9
AUSTRALIA 3. DNA INFORMATION
6. STR
STR Polymorphisms
Most of our DNA is identical to DNA of others. However, there are inherited
regions of our DNA that can vary from person to person. Variations in DNA
sequence between individuals are termed "polymorphisms".
As we will discover in this activity, sequences with the highest degree of
polymorphism are very useful for DNA analysis in forensics cases and
paternity testing. This activity is based on analyzing the inheritance of a
class of DNA polymorphisms known as "Short Tandem Repeats", or simply
STRs.
STRs are short sequences of DNA, normally of length
2-5 base pairs, that are repeated numerous times in
a head-tail manner,
i.e. the 16 bp sequence of "gatagatagatagata" would
represent 4 head-tail copies of the tetramer "gata".
The polymorphisms in STRs are due to the different
number of copies of the repeat element that can
occur in a population of individuals.
Ex) 12-11, 13-11,7-15
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 10
AUSTRALIA 3. DNA INFORMATION
7. HVR The HVR section of the Mitochondria
hypervariable region in mitochondria describes who you are,
The DNA sequence of STR
and is used for personal identification as well as STR.
HVR (Hypervariable Region)
Variation of Mitochondria DNA Sequence
100,000 times
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 11
AUSTRALIA 4. THE WORK PROCESS
1. COLLECTING SPECIMEN
Collecting orders from clients through the „DNA Character Shop‟ and
the Website. The first DNA Character Shop will be open in Victoria
from middle of year 2006” followed by direct order facilitated website.
The client at the shop or website will choose the jewelry product and
agree with the condition of providing the specimen for DNA Testing.
(Consent form will be signed on)
The „Specimen Collecting Kit‟ will be handed out person to person in
the shop. The same kit will be posted out by Australian Post to the
website client with a return envelop.
The kit contains BUCCAL swabs and return envelope (for mail order).
Taking the sample is simple by just wiping the buccal swab inside of
the cheek. A buccal swab looks like a long Q-tip. The head of the
swab is firmer than the head of a regular cotton swab.
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 12
AUSTRALIA 4. THE WORK PROCESS
2. HANDLING SPECIMEN
SHOP : The specimen will be handed in person to person.
The Collected specimen will be sent out to the lab by Australian Post.
When DNA Testing is completed, the specific result data will be returned to the
shop by email or fax.
email
WEBSITE : The „Specimen Collecting Kit‟ will be posted out to the client. Once
the BUCCAL swab is done the client will post it out to the lab with the return
envelop enclosed. This return envelop will go to the lab directly by Australia post.
email
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 13
AUSTRALIA 4. THE WORK PROCESS
3. DNA TESTING
COMPLIANCE
For the nature of our DNA ID data use, the DNA Testing facility does
not have to be a NATA accredited laboratory. (National Association of
Testing Authorities Australia www.nata.com.au )
In the first stage of the business we are going to use a Korea based and well
established existing DNA Testing Laboratory.
To be a recognized and reputable DNA testing company as well as a successful
DNA Character Jewelry business, we plan to extend our business to a DNA Testing
Laboratory Service in full scale at the second stage of the business. This service
will include Paternity, Sibling-ship Analysis and Forensic Test, as well as DNA
Preservation. Legal evidence service will be included.
1st STAGE 2ND STAGE
OUT SOURSED LAB ACCREDITED LAB
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 14
AUSTRALIA 4. THE WORK PROCESS
4. LEGAL DNA TESTING
What is the difference between a Legal Test and Peace of Mind Test?
The difference between a peace of mind case and legal case is the “witnessing” of
the samples and the paper trail that is behind the testing.
As the legal cases are required by the court or immigration authority we need to
make certain that the samples are from the correct person.
The doctor or witnessing party will review photo identification and associated
paperwork before placing into a tamper proof bag.
This assures the appropriate court/authority that the samples are coming from the
correct individuals and is a mandatory requirement.
Court Related Paternity Test
In the 2nd stage of our service will provide court admissible
DNA and paternity tests used for paternity disputes and
immigration cases those often occur in Australia and from
overseas.
Collection kits are sent directly to a recommended practitioner
or GP in your local area. DNA Test results can be used to
amend and change birth certificates.
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 15
AUSTRALIA 4. THE WORK PROCESS
5. DNA PRESERVATION
Due to the accelerated advances made in medical science concerning genetic links
to diseases, DNA preservation after the DNA Test done or, sampling before burial or
cremation is an option.
The information gained from a preserved DNA sample can be of invaluable benefit
to the client and his/her future generations.
Furthermore, because of its world-wide acceptance as the most finite form of
identity, DNA preservation can conclusively resolve future estate, parentage,
immigration and inheritance issues for all.
We already know that some of the biggest killers are inherited genetic disorders.
In fact it has been scientifically proven that 75% of all diseases can be traced to a
family‟s genetic makeup. Some of these include..
- Coronary heart disease
- Numerous cancers but particularly breast,
- ovarian and colonic cancers Cystic fibrosis
- Alzheimer‟s disease
- Liver and kidney diseases
Consent For DNA Preservation
Client who is taking the DNA Test for Jewelries has option to preserve their DNA Test
result data and samples to be reserved. The sample will be stored in a deep freezer
for future use. We need to have a signed consent form for this process.
Otherwise the sample will be terminated but DNA data will be kept in a secured DB.
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 16
AUSTRALIA 5. OTHER CONCERNS
Privacy
Privacy needs to be assured.
The client‟s sample will not be used by the company or its employees for research
or any genetic analyses.
The profiles and any additional tests results are kept in strict confidence.
The information is only available to the next of kin or other legally authorities.
Our privacy policy will be addressed in many forms.
Commonwealth government is currently implementing new policy that states that
an individual can not be unfairly discriminated against on the basis of his or her
genetic characteristics. This covers all insurers and employers too.
Ethics
- National Health and Medical Research Council
- Medical Research Ethics Committee
Any law against us?
Only seriouslyto DB
mindaccess to!file
Not even privacy
No your to Bush
No talk
access
Wevery Dog is allowed
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 17
AUSTRALIA
DNA CHARACTER SILVER JEWELRY
DR LEE CORPORATION PTY LTD
DR LEE CORPORATION PTY LTD
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226
2 Margaret Street, Oakleigh South, Victoria 3167 Australia Tel : 61-3-9544-1191, Fax : 61-3-9543-1226 END
