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					                                                                                 Georgia Zhuo Chen
                                                                                      July 14, 2008




                  EMORY UNIVERSITY SCHOOL OF MEDICINE
                           CURRICULUM VITAE
Name:                 Georgia Zhuo Chen

Office Address:       Emory University
                      Winship Cancer Institute
                      1365-C Clifton Road
                      Suite C3086
                      Atlanta, GA 30322

Phone:                (404)-778-3977

Fax:                  (404)-778-5520

E-Mail Address:       georgia.chen@emory.org

Citizenship:          USA

Current Titles and Affiliations:

         a.    Academic appointment:

               1.     Primary appointment:

                      Associate Professor (research track)
                      Emory University Winship Cancer Institute, March 1, 2004

               2.     Joint and secondary appointment:

                      Visiting Professor
                      Central South University, XiangYa School of Medicine, Changsha, China,
                      July 14, 2006

                      Visiting Professor
                      Tianjin Medical University, Tianjin, China
                      July 4, 2008

         b.    Clinical appointment:
                      N/A

         c.    Other administrative appointment:
                      N/A

Previous Academic and Professional Appointments:
      2002 – 2004 Research Associate Professor, University of Pittsburgh

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                                                                                 Georgia Zhuo Chen
                                                                                      July 14, 2008


       1998 – 2002    Assistant Biologist and Assistant Professor (tenure track),
                      University of Texas M. D. Anderson Cancer Center
       1992 – 1998    Assistant Professor (research track),
                      University of Texas–Houston Dental Branch
       1982 – 1984    Assistant Professor, Beijing Institute of Chemical Technology



Previous Administrative and/or Clinical Appointments:
            N/A

Licensures/Boards:
             N/A

Specialty Boards:
             N/A

Education:
Beijing Institute of Chemical Technology, B.S.                                   1978-1982
Supervised by Mr. Yao-Wen He

Louisiana State University, Ph.D.,                                               1985-1989
Supervised by Dr. Simon H. Chang

Postgraduate Training:
Louisiana State University, Post-doctor supervised by Dr. Simon H. Chang         1989-1991

Military or Government Service:
             N/A

Committee Membership:

      a.     National and international:

             Member of UICC International fellowship review panel, since 2005.

      b.     Regional and state:
             N/A

      c.     Institutional:

             Institutional Research Committee, U. T. Houston, Dental Branch, 1996-1997.

             Animal Model Core Committee, Emory University Winship Cancer Institute,
                     2005-precent
             Basic Laboratory Research Council, Emory University Winship Cancer Institute,
                     2007-2008

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                                                                             Georgia Zhuo Chen
                                                                                  July 14, 2008


           Emory University Institutional Animal Care and Use Committee
                  2008-precent


Consultantships:
             N/A

Editorships and Editorial Boards:
              N/A

Manuscript Reviewer:

      Cancer Research, since 2000
      Laryngoscope, since 2000
      Clinical Cancer Research, since 2003
      Cellular and Molecular Life Sciences, 2004.
      Journal of the American College of Surgeons, 2004
      Expert Review of Anticancer Therapy, 2004
      Journal of Cellular of Physiology, 2004
      Head and Neck, since 2004
      Molecular Cancer Therapeutics, since 2005
      Journal of Clinical Oncology, since 2005
      Archives of Otolaryngology-Head & Neck Surgery, since 2005
      Molecular Carcinogenesis, since 2005
      Journal of Oral Pathology and Medicine, since 2006
      Cancer, since 2006
      Annals of Surgical Oncology, since 2006
      British Journal of Cancer, since 2008


Honors and Awards

      Sponsored dental student, T. John Parsi, won an award of the best basic research
      presentation (project: anti-EGFR ribozyme in oral SCC) at Hinman Student Research
      Symposium in Memphis, 1996

      NIH Career Development Award, 1998

      Georgia Cancer Coalition Distinguished Cancer Scholar, 2006.


Society Memberships:

      American Society of Biochemistry and Molecular Biology          1992 - present

      American Association for Cancer Research                        1996 - present

      Metastasis Research Society                                     2004 - present
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                                                                                Georgia Zhuo Chen
                                                                                     July 14, 2008



Organizing of National or International Conferences:
             N/A

Research Focus:
      a.    Identification of metastasis-related genes and proteins in head and neck cancer;
      b.    Study of signal transduction pathways in head and neck cancer;
      c.    Development of prognosis or therapeutic biomarkers of cancer;
      d.    Chemoprevention of head and neck cancer;
      e.    Development of anticancer therapeutic drugs.

Patents:
              N/A

Grant Supports:

       a.     Active support:

              1.     Federal funded:

                     P.I.,   DOD, US AMRMC W81XWH-07-1-0306, PROSPECT Project #5
                             (contracted through M.D. Anderson Cancer Center) $800,000;
                             2007-2011
                             Title: Development of a novel multi-biomarker system using
                             quantum dot technology for assessments of prognosis of NSCLC
                             and prediction of outcome of EGFR-targeted therapy

                     P.I.,   Georgia Cancer Coalition, $250,000; 2007- 2012
                             Title: Georgia Cancer Coalition Distinguished Cancer Scholar

                     Co-leader      NIH/NCI Specialized Programs of Research Excellence
                                    (SPORE) in Head and Neck Cancer 1 P50 CA128613-01
                                    $12,200,000; 2007-2012
                                    Project #1: Chemoprevention with Green Tea Polyphenon
                                    E (PPE) and EGFR-TKIs in Head and Neck Cancer

                     Co-Invest.     NIH/NCI Specialized Programs of Research Excellence
                                    (SPORE) in Head and Neck Cancer 1 P50 CA128613-01
                                    $12,200,000; 2007-2012
                                    Project #2: Targeting death receptor-mediatedapoptosis for
                                    head and neck cancer.

                     Co-P.I., NIH/NCI (U01CA101244), $2,255,000; 2004-2009
                            Title: Chemoprevention of head and neck cancer with ZD1839
                            and celecoxib for former smokers.

                     Co-P.I. NIH/NCI (R01 CA112643-01) $1,600,000; 2006-2011

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                                                                        Georgia Zhuo Chen
                                                                             July 14, 2008


                    Title: Second primary tumor prevention with EGFR TKIs and
                    COX-2 inhibitors in head and neck cancer.

            Co-P.I. NIH/NCI (CCNE #5) $2,300,000; 2006-2011
                   Title: Nanotherapeutics: multifunction nanoparticles from drug
                   delivery and targeting

            Co-Invest.     NIH/NCI (P50 CA128301-01), Project 2; $1,250,000;
                           2007-2012
                           Title: Development of PET imaging probes for chemokine
                           receptors for head & neck cancer metastasis.


     2.     Private foundation funded:
            P.I.    Georgia Tech/Emory Fund for Innovative Cancer Technologies
                    (GTE-FICT) $45,000; 2005-2006
                    Title: A novel methodology in detection of biomarkers by an
                    acoustic wave biosensor in head and neck cancer.

     3.     Contracts:

            Co-P.I. Millennium Pharmaceuticals $50,000; 2004-2006
                   Title: In vitro and in vivo studies of PS-341 as a single or in
                   combination with chemo-therapeutic agents, EGFR TKI, or COX-
                   2I in treatment of head and neck cancer.

            Co-P.I. Domantis Limited Inc., $160,000; 2006-2008
                   Title: Determination of the efficacy of dual targeting anti-EGFR,
                   anti-VEGF IgG (DT-IgG)


b.   Previous support:

            P.I.,   NIH/NCI (R29CA72427-01) $522,160; 1996-2002
                    Title: Regulation of human papillomaviruses in oral mucosa.

            P.I.,   NIH/NIDCR (K02 DE00426-01) $279,090; 1998-2004
                    Career Development Award

            P.I.,   NIH/NIDCR (R03 DE11869-01) $50,000; 1996-1998
                    Title: Ribozyme-mediated gene therapy for oral cancer

            P.I.,   M D Anderson PRS Research Fund $50,000; 2001-2002
                    Title: Role of protease-activated receptor in progression invasion,
                    and metastasis of head and neck squamous cell carcinoma.

            P.I.,   UPCI Pilot Fund $25,000; 2003-2005

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                                                                                 Georgia Zhuo Chen
                                                                                      July 14, 2008


                            Title: Possible roles of PAR-1 in metastasis of head and neck
                            cancer.

                    Co-P.I. Aventis Pharmaceuticals $70,000; 2003-2005
                           Title: In vitro and in vivo studies of taxotere and other cytotoxic
                           agents with a combination of ZD1839 in head and neck cancer.

                    P.I.,   NIH/ NIDCR (R21 DE014767-01), $200,000; 2003-2006
                            Title: Identification of metastasis-related genes in oral cancer

      c.     Pending support:


                    P.I.    NIH/NCI (R21 CA125062-0A1) $270,000; 2008-2010
                            Title: Identifying high risk cells in primary SCCHN to predict
                            lymph node metastasis

                    P.I.    NIH/NCI (R33 CACA134392-01) $401,660; 2008-2011
                            Title: Development of a multiplexed biomarker platform for
                                    metastasis assessment

                    Co-P.I. at Emory Site, NIH (PAR01023) $1,066,953; 2006-2011
                                  Title: A MicroSystems Platform for Analyzing Tumor
                                  Heterogeneity and Response to Therapy

                    Co-P.I. at Emory Site, NIH/NIC R01 $ 415,722 (total)/ $80,901(Total at
                                  Emory), 2007 - 2010
                                  Title: Microsystem Platform for Quantifying Tumor
                                  Heterogeneity

                    Co-Invest. NIH/NCI (RO1 CA) $1,125,000; 2006-2011
                                  Title: Molecular determinants of perifosine-induced
                                  apoptosis

                    Co-Invest.     NIH/NCI R01 $77,727.00 at Emory, 2007 - 2012
                                   Title: Role of ALDH1A1 in prevention and therapy of
                                   oral cancer

Clinical Service Contributions:
              N/A

Formal Teaching:

      a.     Medical student teaching

             Block Program for medical students, residents, and fellows,
                    The University of Pittsburgh Medical School, 2002-2004


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                                                                                 Georgia Zhuo Chen
                                                                                      July 14, 2008


            Oral Biology I and Biochemistry 1521 for dental student,
                   UT- Houston Dental Branch, 1997-1998

      b.    Graduate program

            Advanced Technology of Molecular Biology Laboratory for graduate student,
                   Louisiana State University, 1991.
            Physical Chemistry for undergraduate student,
                   Louisiana State University, 1986
            Chemical Engineering Thermodynamics for graduate student,
                   Beijing Institute of Chemical Technology, 1982-1984.

Supervisory Teaching:

      a.    Ph.D. student directly supervised:

            Member, thesis advisory committee, Ryan Von Lindern, 9/97- 3/2002, Graduate
                 School of Biomedical Sciences
            Member, examining committee, Weimin Bi, 10/1998, Graduate School of
                 Biomedical Sciences
            Member, examining committee, Eileen D. Moss, 6/2006, Georgia Institute of
                 Technology

      b.    Post-doctoral fellow directly supervised:

            Dr. T. John Parsi, Dental Student, 1996. Project: Anti-EGFR ribozyme in oral
                    cancer. Dr. Parsi is currently practice in San Antonio and is one of the
                    Board Directors of University Health System, The University of Texas
                    Health Science Center at San Antonio.
            Dr. Junzhi Li, Postdoctor, 6/1996-1/1998. Project: Regulation of HPV E6 and E7
                    expression in oral cancer cells. Dr. Li is currently President of Jinke Group
                    USA, Inc.
            Dr. Li Dao Ke, Postdoctor, 7/1996-4/1998. Project: Development of quantitative
                    RT-PCR for oncogene expression. Dr. Ke has retired from University of
                    Texas M.D Anderson Cancer Center
            Dr. Ying-lin Lu, Research Scientist, 12/1998-6/1999. Project: Development of an
                    animal model for metastasis. Dr. Lu is currently Professor and Director of
                    Molecular Pathology Laboratory, Institute of Basic Medical Science in
                    Beijing, China.
            Dr. Yaan Kang, Research Scientist, 12/1999-12/2000. Project: Study of
                    metastatic related genes in HNSCC. Dr. Kang is currently a Research
                    Associate in M. D. Anderson Cancer Center.
            Dr. Xin Zhang, Postdoctor, 2/2001-2/2004. Project: Study of metastatic related
                    genes, including PAR-1, uPAR and MMPs, in HNSCC. Dr. Zhang is
                    currently Professor and Director for Research in Xiangya Hospital, Central
                    South University, Changsha, China



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                                                                                  Georgia Zhuo Chen
                                                                                       July 14, 2008


              Dr. Misun Choe, Postdoctor, 5/ 2003-2/2005. Project: Study of targeted therapies
                     in HNSCC. Dr. Choe is currently performing service and teaching of
                     tumor pathology in Korea.
              Dr. Kathryn Sun, Postdoctor, 3/2004-6/2004. Project: Identification of metastatic
                     related genes by cDNA microarray analysis. Dr. Sun is currently a
                     Research Scientist in pharmaceutical company.
              Dr. Carmen Klass, Medical Fellow, 1/2005-8/2006, Project: Antitumor effects of
                     combined therapy using bortezomib and other targeted molecules on
                     HNSCC. Dr. Klass joined a private medical oncology service in Marietta,
                     Georgia.
              Dr. Hongzheng Zhang, Postdoctor, 10/2004-10/2006, Project: Study of metastatic
                     related genes, including E-cadherin and Caveolin-1 in HNSCC. Dr Zhang
                     is currently Research Associate in Emory Winship Cancer Institute.
              Dr. Kwang Jae Cho, Postdoctor, 7/2005-2/2007, Project: Applications of
                     nonatherapeutic drugs in treatment HNSCC. Dr. Cho is currently
                     Associate Professor in Department of Otolaryngology - Head & Neck
                     Surgery, The Catholic University of Korea, College of Medicine
                     Uijeongbu St. Mary's Hospital, Uijeongbu City, Korea.
              Dr. Sujin Yun, Postdoctor, 7/2006-precent, Project: Determination of the efficacy
                     of dual targeting anti-EGFR, anti-VEGF IgG (DT-IgG)
              Dr. Donghai Huang, Postdoctor, 6/2007-precent, Project: Development of a novel
                     multi-biomarker system using quantum dot technology for lung and head
                     and neck cancer


       c.     Residency Program

              N/A

       d.     Other

              Served as a mentor in WCI Summer Research Program for high school student in
              2004 and 2005.


Lectureships, Seminar Invitations, and Visiting Professorships:

       a.     Departmental seminar, Title: Expression of human papillomavirus oncogene in
              oral epithelial cells. UT Dental Branch, 4/97.
       b.     Departmental seminar, Title: PAR-1: good, bad, or ugly? UT M. D. Anderson
              Cancer Center, 8/01.
       c.     Invited seminar, Title: Identification of metastasis-related genes in human head
              and neck squamous cell carcinoma (HNSCC) using a lymph node metastatic
              mouse model. Oral Cancer Center Meeting, University of Pittsburgh, 10/18/02.
       d.     Invited seminar, Title: Identification of metastasis-related genes in human head
              and neck squamous cell carcinoma (HNSCC) using a lymph node metastatic
              mouse model. Tumor Board, Department of Otolaryngology, University of
              Pittsburgh, 01/07/03.
                                                                                                  8
                                                                                 Georgia Zhuo Chen
                                                                                      July 14, 2008


       e.     UPCI Research Seminar, Title: Identification of metastasis-related genes in
              human head and neck squamous cell carcinoma (HNSCC) using a lymph node
              metastatic mouse model. University of Pittsburgh Cancer Institute, 03/18/03.
       f.     Invited seminar, Title: A metastatic xenograft mouse model: what we have
              learned from it. Emory University Winship Cancer Institute, 10/22/03.
       g.     WCI Grand Round Basic Research Seminar, Title: Simultaneously targeting
              EGFR tyrosine kinase and cyclooxygenase-2: A potential approach for
              chemoprevention of head and neck cancer. Emory University Winship Cancer
              Institute, 04/30/04.
       h.     Invited seminar, Title: A metastatic xenograft mouse model: what we have
              learned from it. ENT fellow Grand Round, Emory University School of Medicine,
              09/03/04.
       i.     Invited seminar, Title: A Metastatic mouse model of the head and neck cancer
              and its implication in human disease. Department of Biology, Georgia State
              University, 11/11/05.
       j.     WCI Grand Round Clinical Research Seminar, Title: Recent Advances in
              Chemoprevention for Head and Neck Cancer. Emory University Winship Cancer
              Institute, 02/22/06.
       k.     Invited presentation in fellow’s orientation, Title: Research on Head and Neck
              Cancer. Emory University Winshipn Cancer Institute, 07/07/06.
       l.     WCI Elkin Lecture, Title, A Metastatic Mouse Model and its Implications for
              Head and Neck Cancer. Emory University Winship Cancer Institute, 08/25/06.
       m.     CCNE Nanotechnology workshop 2006. Title: Cancer Nanotherapuetics,
              12/13/06.
       n.     Presentation in 2007 Frontiers of Cancer Nanotechnology Symposium, Title:
              Recent Advances in Cancer Nanotherapeutics, 4/2/2007.
       o.     Presentation in Molecular Oncology Journal Club, Title: Applying stem cell
              concept to solid tumor, 11/2/2007.


Invitation to National or International Conferences:

       a.     Invited oral presentation, Title: Human papillomaviruses as targets for cancer
              gene therapy. First International Symposium on Gene Therapy (Beijing, China),
              7/97.
       b.     Invited oral presentation, Title: Hammerhead ribozymes as unique tools for gene
              therapy of HPV-related cancers. First International Symposium on Gene Therapy
              (Beijing, China), 7/97.
       c.     Invited lecture, Title: Transcriptional regulation of oncogene expression: what
              shall we learn from an HPV story? Beijing Institute of Basic Medical Research,
              Beijing, China, 6/99.
       d.     Invited lecture, Title: Study of ribozyme targeting mRNA of human epidermal
              growth factor receptor. Beijing Institute of Basic Medical Research, Beijing,
              China, 6/99.
       e.     Oral presentation, Title: Expression of metastasis-related genes in sub-cell lines
              with different metastatic potential selected in nude mice from human oral
              squamous cell carcinoma. International Conference of Anticancer Research
              (Greece), 6/01.
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                                                                                  Georgia Zhuo Chen
                                                                                       July 14, 2008


       f.       Selected oral presentation, Title: Identification of metastasis-related genes in
                human head and neck squamous cell carcinoma (HNSCC) using a lymph node
                metastatic mouse model. 6th International Research Workshop on Biology,
                Prevention, and Treatment of Head and Neck Cancer. McLean, VA, 10/9/02-
                10/13/02.
       g.       Selected oral presentation, Title: Selection of Metastasis-related Genes from a
                Lymph Node Metastatic Mouse Model of the Head and Neck Cancer.
                International Conference of Metastasis Research. Genova, Italy, 9/04.
       h.       Invited lecture, Title: Metastatic Mouse Models and Their Implications in
                HNSCC. Xiangya Hospital Central South University, Changsha, China, 07/25/06.
       i.       Invited oral presentation, Title: Understanding Metastatic Head and Neck Cancer
                at Molecular Level using a Unique Animal Model and Exploring Early Detection
                and Treatment of Metastatic Disease. World Cancer Congress 2008, Shanghai,
                China, 6/11/08-6/15/08.
       j.       Invited lecture, Title: Understanding and Exploring Early Detection and
                Treatment of Metastatic Head and Neck Cancer using a Unique Animal Model
                Xiangya Hospital Central South University, Changsha, China, 06/20/08.
       k.       Invited lecture, Title: Understanding and Exploring Early Detection and
                Treatment of Metastatic Head and Neck Cancer using a Unique Animal Model.
                Tianjin Medical University, Tianjin, China, 07/04/08.



Other Activities:

                Organizing Multi-Lab Research Progress Meeting since 2004.

Bibliography:

       a.       Published and accepted research articles:

                1.     Chen, Z., and He Y.-W., (1983) Available energy analysis of large olefine
                       plant. Petrochemical Industry (Chinese).
                2.     Chen, Z., Lee, W. R., and Chang, S. H. (1988) Construction and
                       expression of Drosophila alcohol dehydrogenase full-length cDNA. ICSU
                       Short Reports 8:155.
                3.     Valdez, B. C., Chen, Z., Sosa, M. G., Younathan, E. S., and Chang, S. H.
                       (1989) Human 6-phosphofructo-1-kinase gene has an additional intron
                       upstream of start codon. Gene 76(1):167-169.
                4.     Chen, Z., Lu, L., Shirley, M., Lee, W. R., and Chang, S. H. (1990) Site-
                       directed mutagenesis of glycine-14 and two critical cysteinyl residues in
                       Drosophila alcohol dehydrogenase. Biochemistry. 29:1112-1118.
                5.     Li, J., Chen, Z., Lu, L., Bynes, M., and Chang, S. H. (1990) Sequence
                       diversity in the 5' untranslated region of rabbit muscle
                       phosphofructokinase mRNA. BBRC. 170(3):1056-1060.
                6.     Chen, Z., Lee, W. R., and Chang, H. S. Role of aspartic acid-38 in the
                       cofactor specificity of Drosophila alcohol dehydrogenase. (1991) Eur. J.
                       Biochem. 202:263-267.
                                                                                                10
                                                                   Georgia Zhuo Chen
                                                                        July 14, 2008


7.    Chen, Z., Jiang, J. C., Lin, Z-G., Lee, W. R., Baker, M. E., and Chang, S.
      H. (1993) Site-specific mutagenesis of Drosophila alcohol
      dehydrogenase: Evidence for involvement of tyrosine-152 and lysine-156
      in catalysis. Biochemistry. 32: 3342-3346.
8.    Chen, Z., Lee, W. R., Baker, M. E., and Chang, S. H. (1994) Adding a
      positive charge at residue 45 of drosophila alcohol dehydrogenase
      increases cofactor specificity for NADP. FEBS Letters, 365:81-85.
9.    Chen, Z., Kamath, P., Zhang, S., Weil, M., and Shillitoe, E. J. (1995)
      Effectiveness of three ribozymes for cleavage of an RNA transcript from
      human papillomavirus Type-18. Cancer Gene Therapy. 2(4): 263-271.
10.   Chen, Z.*, Kamath, P., Zhang, S., St.John, L., Adler-Storthz, K., and
      Shillitoe, E. J. (1996) Effect on tumor cells of three ribozymes that cleave
      the RNA transcript of HPV-18. Cancer Gene Therapy, 3(1): 18-23.
11.   Arany, I., Adler-Storthz, K., Chen, Z., Tyring, S. K., Brysk, H., and
      Brysk, M. M., (1997) Differentiation markers in oral carcinoma cell lines
      and tumors. Anticancer Research, 17:4607-4610.
12.   Chen, Z.*, Storthz, K.A., and Shillitoe, E.J. (1997) Mutations in the long
      control region of human papilloma virus DNA in oral cancer cells, and
      their functional consequences. Cancer Research, 57:1614-1619.
13.   Btysk, M.M., Lei G., Adler-Storthz, K., Chen, Z., Horikoshi, T., Brysk,
      H, Tyring, S. K. Arany, I. (1998) Differentiation and cathepsin D
      expression in human oral tumors. Laryngoscope, 108:1234-1237.
14.   Arany, I, Adler-Storthz, K. Chen, Z., Tyring, S. K., and Brysk, M. M.
      (1998) Tumor differentiation-dependent local immunity in human head
      and neck cancer, Cancer Letter, 123:173-176.
15.   Ke, L-D., Adler-Storthz, K., Clayman, G.L., Yung, A.W.K., and Chen,
      Z.* (1998) Differential expression of epidermal growth factor receptor in
      human head and neck cancers. Head & Neck, 20:320-327.
16.   Arany, I., Brysk, M. M., Chen, Z., Adler-Storthz, K., Tyring, S. K. (1999)
      Differentiation-dependent expression of growth regulatory cytokines and
      their receptors in squamous cell carcinomas of the head and neck.
      Anticancer Res. 19:3623-3626.
17.   Brysk, M. M., Lei, G., Adler-Storthz, K., Chen, Z., Brysk, H., Tyring, S.
      K., Arany, I. (1999) Zinc-2-glycoprotein expression as a marker of
      differentiation in human oral tumors. Cancer letters, 137:117-120.
18.   Arany, I, Adler-Storthz, K, Chen, Z., Tyring, S. K., Brysk, H., Lei, G.,
      and Brysk, M. M. (1999) Local inflammation may influence oral tumor
      cell differentiation. Anticancer Research, 19:1065-1068.
19.   Ke, L-D., Adler-Storthz, K., Michell M. F., Clayman, G. L., and Chen,
      Z.* (1999) Expression of human papillomavirus E7 mRNA in human oral
      and cervical neoplasia and cell lines. Oral Oncology, 35:415-420.
20.   Ke, L-D., Chen, Z., and Yung W.K.A. (2000) A reliability test of
      standard-based quantitative PCR: exogenous vs endogenous standards.
      Mol. Cellu. Probes, 14:127-135.
21.   Chen, Z.*, Ke, L-D., Yuan, X. H., and Adler-Storthz, K. (2000)
      Correlation of cisplatin sensitivity with differential alteration of EGFR
      expression in head and neck cancer cells. Anticancer Res., 20:899-902.

                                                                                 11
                                                                  Georgia Zhuo Chen
                                                                       July 14, 2008


22.   Liu, Y., Gilcrese, M.Z., Henderson, Y., Yuan, X.H., Clayman, G.L., and
      Chen, Z.* (2001) Expression of protease-activated receptor 1 in oral
      squamous cell carcinoma. Cancer Letters, 169:173-180.
23.   Liu, Y., Li, J.Z., Yuan, X.H., and Adler-Storthz, K., and Chen Z.* (2002)
      An AP-1 binding site mutation in HPV-16 LCR enhances E6/E7 promoter
      activity in human oral epithelial cells. Virus Genes, 24:29-37.
24.   Zhang, X., Liu, Y., Gilcrease, M.Z., Yuan, X.H., Clayman, G.L., Adler-
      Storthz, K., and Chen Z.* (2002) A lymph node Metastatic mouse model
      reveals alteration of Metastasis-related gene expression in metastatic
      human oral cancer sublines selected from a poorly metastatic parental cell
      line. Cancer, 95:1663-1672.
25.   Chen Z.* Zhang K., Zhang, X, Yuan, X.H., Yuan Z, Jin, L, and Xiong M.
      (2003) Comparison of gene expression between metastatic derivatives and
      their poorly metastatic parental cells implicates curial tumor-environment
      interaction in metastasis of head and neck squamous cell carcinoma. Clin
      Exp Metastasis, 20:335-342.
26.   Wang, J., Xi, L., Hunt, J. L., Gooding, W., Whiteside, T. L., Chen Z (G).,
      Godfrey, T. E., and Ferris, R. L. (2004) Expression pattern of chemokine
      receptors 6 (CCR6) and 7 (CCR7) in Squamous cell carcinoma of the head
      and neck identifies a novel metastatic phenotype. Cancer Res. 64:1861-
      1866.
27.   Zhang, X., Hunt, J. L., Landsittel, D., J. R., Susan Muller, Adler-Storthz,
      K., Ferris, R. L., Shin, D. M., and Chen, Z (G).* (2004) Correlation of
      protease-activated receptor-1 (PAR-1) with differentiation markers in
      squamous cell carcinoma of the head and neck and its implication in
      lymph node metastasis Clin Cancer Res., 10:8451-8459.
28.   Chen, Z (G)., Zhang, X., Li, M., Wang, Z., Wieand, S., Grandis J. R., and
      Shin, D. M. (2004) Simultaneously targeting EGFR tyrosine kinase and
      cyclooxygenase-2, an efficient approach to inhibition of squamous cell
      carcinoma of the head and neck. Clin. Cancer Res., 10:5930-5939.
29.   Wang, J., Zhang, X., Thomas, S. M., Grandis, J. R., Wells, A., Chen, Z
      (G)., and Ferris, R. L. (2005) Chemokine receptor 7 activates
      phosphoinositide-3 kinase-mediated invasion and prosurvival pathways in
      of head and neck cancer cells independent of EGFR. Oncogene, 24:5897-
      5904.
30.   Scheurer, M., Tortolero-Luna, G., Guillaud, M., Follen, M., Chen, Z.,
      Dillon, L. M., and Adler-Storthz, K. (2005) Correlation of HPV 16 and
      HPV 18 E7 mRNA levels with degree of cervical dysplasia. Cancer
      Epidemiology. Biomarker & Prevention, 14:1948-1952.
31.   Zhang, X., Chen Z., Choe, M. Sun., Lin, Y., Sun, S.-Y., Wieand, S., Shin,
      Shin, H. J. C., H. J., Chen, A., Khuri, F. R., and Shin, D. M. (2005) Tumor
      growth inhibition by simultaneously blocking epidermal growth factor
      receptor and cyclooxygenase-2 xenograft model. Clin. Cancer Res,
      11:6261-6269.
32.   Zhang, X., Su, L., Pirani, A., Zhang, H., Shin, D. M., Gernert, K.M.,
      Chen, Z(G).* (2006) Understanding metastatic SCCHN cells from unique
      genotypes to phenotypes with the aid of an animal model and DNA
      microarray analysis. Clin Exp Metastasis, 23:209-222.
                                                                                12
                                                                        Georgia Zhuo Chen
                                                                             July 14, 2008


     33.    Zhang, X., Hunt, J., Shin, D. M., Chen, Z (G).* (2007) Down Regulation
            of S100A2 in Lymph Node Metastases as Compared to Non-metastatic
            Primary Tumors in Head and Neck Cancer. Head and Neck, 29:236-243.
     34.    Zhang, X., Chen, Z (G)., Y., Wieand, S., Shin, D. M. (2007) A combined
            treatment with 13-Cis-Retinoid Acid, Interferon-2a and -Tocopherol
            induces cell cycle arrest and apoptosis in squamous carcinoma cells of the
            head and neck cancer. Head and Neck, 29:351-361.
     35.    Choe, M. S., Chen, Z(G)., Carmen Klass, Zhang, X., Lee, J., Shin, D. M.
            (2007) Enhancement of docetaxel-induced cytotoxicity by blocking EGFR
            and COX-2 pathways in squamous cell carcinoma of the head and neck.
            Clinical Cancer Res, 13:3015-3023.
     36.    Scheurer, M. E., Dillon, L. M., Chen, Z., Follen, M., Adler-Storthz, K.
            (2007) Absolute quantitative real-time polymerase chain reaction for the
            measurement of human papillomavirus E7 mRNA in cervical cytobrush
            specimens. Infect Agents Cancer, 2:8.
     37.    Yoon, Y., Liang, Z., Zhang, X., Choe, M., Cho, H. T., Shin, D. M.,
            Goodman, M., Chen, Z(G)., Shim, H.(2007) CXCR4 antagonist blocks
            both growth of primary tumor and metastasis of head and neck cancer in
            xenograft mouse models. Cancer Res. 67:7518-7529.
     38.    Qian, X., Peng X-H., Ansari, D. O., Yin-Goen, Q., Chen, Z(G)., Shin, D.
            M., Yang, L., Young, A. N., Wang, M. D., Nie, S. (2008) In vivo tumor
            targeting and spectroscopic detection with surface-enhanced Raman
            nanoparticle tags, Nat Biotech 26:83-90.
     39.    Zhang , X., Tighiouart, M., Lee, J.E., Shin, H. J., Khuri F. R., Yang, C.S.,
            Chen, Z(G)., Shin, D. M. (2008) Synergistic tumor growth inhibition by
            combined treatment with green tea epigallocatechin-3-gallate and an
            epidermal growth factor receptor tyrosine kinase inhibitor (erlotinib) in
            squamous cell carcinoma of the head and neck (SCCHN). Int. J Cancer, in
            press.
     40.    Muller, S., Su, L., Tighiouart, M., Saba, N., Zhang, H., Shin, D. M. Chen,
            Z(G)*. (2008) Distinctive E-cadherin and epidermal growth factor
            receptor expression in metastatic and non-metastatic head and neck
            squamous cell carcinoma: Predictive and prognostic correlation. Cancer,
            113:97-107.
     41.


b.   Review articles and book chapters:

     1.     Shillitoe, E. J., Kamath, P., and Chen, Z. (1994) Papillomaviruses as
            targets for cancer gene therapy. Cancer Gene Therapy. 1(3): 193-204.
     2.     Choi, M., Zhang, X, Shin, H. J., Shin, D. M., Chen, Z.* (2005) Interaction
            between EGFR signaling and COX-2 pathways and its therapeutic
            implication. Molecular Therapeutics, 4:1448-1455.
     3.     Saba, N. F., Chen, Z (G), Shin, D. M. (2006).Vascular targeting and
            therapeutics for head and neck cancer. Am J Cancer, 5:7-18.


                                                                                      13
                                                                          Georgia Zhuo Chen
                                                                               July 14, 2008


     4.       Chen, Z(G).* (2007) Exploration of Metastasis-related Proteins as
              Biomarkers and Therapeutic Targets in the Treatment of Head and Neck
              Cancer. An invited review for Current Cancer Drug Targets, 7:613-622.
     5.       Wang, X., Yang, L., Chen, Z (G)., Shin, D. M. (2008) Application of
              Nanotechnology in Cancer Therapy and Imaging. CA J Cancer, 58:97-110.
     6.       Cho, K., Wang, X., Nie, S., Chen, Z (G)., Shin, D. M. (2008) Therapeutic
              Nanoparticles for Drug Delivery in Cancer. Clin Cancer Res, 14:1310-
              1316.
     7.       Chen, Z(G)., Ramalingam, S., Shin, D.M. (2008) Biological principles
              and clinical application of EGFR inhibitors in cancer. A book chapter in
              Molecular Basis of Human Cancer, in press.
     8.       Peng, X.-H., Qian, X. Mao, H., Wang, A. Y., Chen, Z(G)., Nie, S., Shin,
              D. M. (2008) Targeted magnetic iron oxide nanoparticles for tumor
              imaging and therapy. Int J Nanomed, in press.
     9.       Davis, M. E., Chen, Z(G)., Shin, D. M. (2008) Nanoparticle therapeutics:
              An emerging treatment modality for cancer. Nat Rev Drug Discovery, in
              press.


     *
          Indicated the corresponding publications, n = 15


c.   Manuscript submitted:

     1.       Zhang, H., Su, L., Shin, H. J. C., Muller, S., Tighiouart, M., Zhang, X.,
              Shin, D. M., Chen, Z(G). Suppressing Growth and Metastasis of Head
              and Neck Squamous Cell Carcinoma by Caveolin-1 through Interaction
              with Integrin β1 and β-Catenin, Cancer Res. Submitted, 2007.
     2.       Chen, Z(G). Metastatic mouse models of HNSCC and their implications
              in human disease. A book chapter in Cancer Growth and Progression, 8:
              Metastasis/Dissemination, Edit by E Gorelik, Submitted, 2007.
     3.       Klass, K, Choe, M. S., Hurwitz, S. J., Zhang, X., Chen, Z(G), Shin, D. M.
              The Sequence Dependence of Cell Growth Inhibition by EGFR-Tyrosine
              Kinase Inhibitor ZD1839, Docetaxel and Cisplatin in Head and Neck
              Cancer, Eur J. Cancer, Submitted, 2008.


d.   Symposium contributions:

     1.       Chang, S. H., Valdez, B. C., Chen, Z., Sosa, M. G., Kao, M-C., Lee, C-P,
              and Younathan, E. S. Human Phosphofructokinase gene has an additional
              intron up stream of initiation codon. The American Society for Cell
              Biology and the American Society for Biochemistry and Molecular
              Biology Joint Meeting. FASEB J. 2(2) A4095, 1988.
     2.       Chen, Z., Lee, W. R., and Chang, S. H. Construction and expression of
              drosophila alcohol dehydrogenase full-length cDNA. The 1988 Miami
              Bio/Technology Winter Symposium, Miami Florida. Abstract No. 155.
              February 8-12, 1988.
                                                                                        14
                                                                  Georgia Zhuo Chen
                                                                       July 14, 2008


3.    Chen, Z., Lu, L., Lee, W. R., and Chang, S. H. The coenzyme and
      substrate binding site of alcohol dehydrogenase from drosophila
      melanogaster. The American Society for Cell Biology and the American
      Society for Biochemistry and Molecular Biology Joint Meeting, San
      Francisco, California. FASEB J. 3:A4738, 1989.
4.    Li, J-Y., Chen, Z., Byrnes, M., and Chang, S. H. Polymorphism in rabbit
      muscle phosphofructokinase (RMPFK) mRNA. The American society for
      Cell Biology and American Society for Biochemistry and Molecular
      Biology Joint Meeting. FASEB J. 4(7): A1342, 1990.
5.    Chen, Z., Lee, W. R., and Chang, S. H. Role of aspartic acid-38 and
      alanine-45 in the cofactor specificity of drosophila alcohol dehydrogenase.
      The American Society for Cell biology and the American Society for
      Biochemistry and Molecular Biology Joint Meeting, Atlanta, Georgia.
      FASEB J. 5(6):A2407, 1991.
6.    Chen, Z., Lin, Z. G., Lee, W. R., and Chang, S. H. Tyrosine-152 of
      drosophila alcohol dehydrogenase is an essential residue for activity. The
      American Society for Biochemistry and Molecular Biology and the
      American Society for Biophysics Joint Meeting, Houston, Texas. FASEB
      J. 6(3):A2643, 1992.
7.    Xiao, S., Chen, Z., and Chang, S. H. Transcription of rabbit muscle
      phoshofructokinase gene is TATA-governed as well as TATA-
      independent. The American Society for Biochemistry and Molecular
      Biology and American Society for Biophysics Joint Meeting, Houston,
      Texas. FASEB J. 6(3):A2798, 1992.
8.    Chen, Z., and Shillitoe, E. J. Ribozymes as potential antiviral agents for
      HPV. 12th International Papilloma virus Conference, Baltimore,
      Maryland. Abstract No. 84. September 26 - October 1, 1993.
9.    Chen, Z., Kamath, P., and Shillitoe, E.J. Hammerhead ribozyme as
      potential antiviral agents for human papilloma virus Type 18. FASEB J.
      8(7):A1446. 1994.
10.   Chen, Z., Shillitoe, E. J., and Aldler-Storthz, K. Mutations in the long
      control region of human papilloma virus Type 16 and 18 and their effects
      on E6 and E7 gene promoters. 48th Annual Symposium on Fundamental
      Cancer Research, Houston Texas, Abstract No.B-9. October 17-20, 1995.
11.   Chen, Z.,Shillitoe, E. J., Murrah, V. A., Gilchrist, E. P., and Chen, Z.
      Inhibition of tumorigenicity of HeLa cells by ribozyme directed against
      human papilloma virus Type 18. Cancer Gene Therapy. 2(4): O-100.
      1995.
12.   Chen, Z., Shillitoe, E. J., and Adler-Storthz, K. Effects of mutations in
      the human papilloma virus LCR cloned from oral cancer cell lines. J.
      Dent. Res. 75:1071, 1996.
13.   Ke, L-D., Adler-Storthz, K., Yung, W. K. A., and Chen, Z., Using a
      quantitative assay to detect differential expression of epidermal growth
      factor receptor in human head and neck cancer. Proceedings: AACR.
      38:330, 1997.
14.   Chen, Z., Li, J-Z., Adler-Storthz, K., Interactions between NF-IL6 and
      other regulatory proteins with E6 promoter of HPV-16 in oral cancer cells.
      Abstract No. 2052, FASEB J. 11(9):A1208, 1997.
                                                                                15
                                                                  Georgia Zhuo Chen
                                                                       July 14, 2008


15.   Parsi, T. J., Chen, Z., Adler-Storthz, K., Construction of an inducible
      vector for ribozyme expression and its potential in gene therapy for oral
      cancer. J. Dent. Res. 77:252, 1998.
16.   Li, J.-Z., Adler-Storthz, K., Chen, Z., Examining interaction between NF-
      IL6 and other regulatory proteins with the E6 promoter of HPV-16 in head
      and neck cancer cells by site-directed mutagenesis. Proceedings: AACR
      39:446, 1998.
17.   Li, J.-Z., Adler-Storthz, K., Chen, Z., Examining interaction between NF-
      IL6 and other regulatory proteins with the E6 promoter of HPV-16 in head
      and neck cancer cells by site-directed mutagenesis. Proceedings: AACR
      39:446, 1998.
18.   Lu, Y-L., Chen, Z., Ge, X-M., Fu, S-F., Fan, W-H., Wang, S-Q., Chen,
      K., Liu, S., A novel human DNA fragment containing a metastatic
      suppression function. Proceedings: AACR 40:105, 1999.
19.   Yuan, X-H., Liu, Y., Clayman, G.L., Chen, Z., NF-IL6 and its complex
      regulate E6 promoter function in oral and cervical squamous cell
      carcinomas. Proceedings: AACR 40: 634, 1999.
20.   Chen, Z., Liu, Y., Li, J.Z., Yuan, X.H., Clayman, G.L., Adler-Storthz, K.,
      Role of AP-1 and C/EBP in regulation of HPV-16 E6/E7 promoter
      activity. Abstract No. 747, FASEB J. 14(8): A1442, 2000.
21.   Chen, Z., Liu, Y., Gilcrease, M. Z., Yuan, X. H., Clayman, G. L. A
      potential role of protease-activated receptor 1 in oral squamous cell
      carcinoma. Proceedings: AACR 42:710, 2001.
22.   Chen, Z., Liu, Y., Zhang, X., Gilcrese, M. Z., Yuan, X. H. Expression of
      metastasis-related genes in sub-cell lines with different metastatic
      potentials selected in nude mice from human oral squamous cell
      carcinoma. Anticancer Res. 21:1628, 2001.
23.   Lu, X., Chen, Z., Chiao P. J., Hunt, K. K., Feig B. W. Metastasis-
      associated differences in gene expression in a human extra-osseous
      osteosarcoma cell line with spontaneous lung metastasis in mice.
      Preceedings: AACR 43: #4478, 2002.
24.   Chen, Z., Zhang, K., Zhang, X., Yuan, X. H., Jin, L., Xiong, M.
      Differential expression analysis of metastasis-related genes in metstatic
      human head and neck cancer sublines selected from a novel xenograft
      mouse model. Proceedings: AACR 43: #4484, 2002.
25.   Zhang, X., Yuan, X. H., Chen, Z. Two phase activity of protease-
      activated receptor-1 (PAR-1) in human head and neck cancer.
      Proceedings: AACR 43: #3613, 2002.
26.   Shin, D. M., Zhang, X., Wang, Z., Li, M., Grandis J. R., Chen, Z.
      Simultaneously targeting epidermal growth factor receptor (EGFR) and
      cyclooxygenase-2 (COX-2) as a potential novel approach for
      chemoprevention of squamous cell carcinoma of the head and neck
      (SCCHN). Proceedings: Frontiers in Cancer Prevention Research, B158,
      2003.
27.   Zhang, X., Hunt, J. L., Landsittel, D. P., Shin, D. M., Chen, Z. Expression
      of protease-activated receptor-1 (PAR-1): a differential marker for
      metastasis of squamous cell carcinoma of the head and neck (SCCHN).
      Proceedings: Frontiers in Cancer Prevention Research, B124, 2003.
                                                                                16
                                                                 Georgia Zhuo Chen
                                                                      July 14, 2008


28.   Shin, D. M., Wang, Z., Zhang, X., Li, M., Graham, S. H., Grandis, R. J.,
      Chen, Z. ZD1839, an epidermal growth factor receptor (EGFR) tyrosine
      kinase inhibitor (TKI), inhibits cell growth synergistically with a
      cyclooxygenase-2 (COX-2) inhibitor, celecoxib, in squamous cell
      carcinoma of the head and neck (SCCHN). Proceedins: AACR 44: #4729,
      2003.
29.   Chen, Z., Zhang, X., Wang, Z., Li, M., Grandis, J. R., Shin, D. M. A
      possible interaction between epidermal growth factor receptor (EGFR) and
      cyclooxygenase-2 (COX-2) mediated pathway in squamous cell
      carcinoma of the head and neck (SCCHN). Proceedins: AACR 44: #2242,
      2003.
30.   Zhang, X., Hunt, J., Landsittel, D., Wang, Z., Shin, D. M., Chen, Z.
      Analyzing expression of a potential metastasis-related protein, protease-
      activated receptor-1 (PAR-1), in human squamous cell carcinoma of the
      head and neck (SCCHN). Proceedings: AACR 44: #293, 2003.
31.   Zhang, X., Chen, Z., Choe, M. S., Lin, Y., Wieand, S., Shin, D. M.
      Significant delay of tumor progression by ZD1839, an epidermal growth
      factor receptor tyrosine kinase inhibitor (EGFR-TKI), in combination with
      a cyclooxygenase-2 (COX-2) inhibitor, Celecoxib, in a xengraft model for
      squamous cell carcinoma of the head and neck (SCCHN). Proceedings:
      AACR 45: #3136, 2004.
32.   Choe, M. S., Chen, Z., Zhang, X., Lin, Y., Wieand, S., Shin, D. M.
      Inhibitory effect of a combined treatment of docetaxel with an epidermal
      growth factor receptor tryrosine kinase inhibitor (EGFR-TKI), ZD1839,
      and cyclooxygenase-2 (Cox-2) inhibitor, celecoxib on head and neck
      squamous cell carcinoma (HNSCC) cells. Proceedings: AACR 45: #541,
      2004.
33.   Chen, Z., Zhang, X., Hunt, J., Shin, D. M. Expression of S100A2 and its
      regulation in lymph node metastasis as compared with primary squamous
      cell carcinoma of the head and neck (SCCHN). Proceedings: AACR 45:
      #3315, 2004.
34.   Chen, Z (G)., Sun, W., Zhang, X., Choe, M., Shin, D. M. Selection of
      metastasis-related genes from a lymph node metastasis mouse model of
      the head and neck cancer. Clin & Exp Metastasis 21:638, 2005.
35.   Chen, Z (G)., Wu, H., Zhang, X., Choe, M. S., Pirani A. A., Gernert K.
      M., Shin, D. M. Identification of metastasis-related genes by DNA
      microarray analyses on samples generated from a metastatic mouse model
      of head and neck cancer. Proceedings: AACR 46:#204, 2005.
36.   Yoon, Y., Liang, Z., Kang, S., Zhang, X., Choe, M. S., Chen, Z (G).,
      Shin, D. M., Shim, H. CXCR4 antagonist blocks both primary tumor and
      metastasis in head and neck cancer animal models. Proceedings: AACR
      46:#2327, 2005.
37.   Zhang, X., Chen, Z (G)., Choe M. S., Lee, J. E., Khuri, F. R., Shin, D. M.
      Groth inhibitory effect of a combined treatment of 13-cis-retinoic acid,
      interferon-2a and -tocopherol on squamous cell carcinoma of the head
      and neck. Proceedings: AACR 46:#2466, 2005.


                                                                               17
                                                                  Georgia Zhuo Chen
                                                                       July 14, 2008


38.   Choe M. S, Chen, Z (G)., Zhang, X., Lee, J. E., Shin, D. M. Sequence
      dependent effect of epidermal growth factor receptor-tyrosine kinase
      inhibitor (EGFR-TKI), ZD1839 or Iressa in combination with docetaxel
      and cisplatin in squamous cell carcinoma of the head and neck (SCCHN).
      Proceedings: AACR 46:#5931, 2005.
39.   Zhang, X. Mi Sun Choe, M. S., Lee, J. E., Muller, M., Tighiouart, M.,
      Rogatko, A., Glisson, B. S., Chen, Z (G)., Khuri, F., Shin, D. M. GRIM-
      19 expression and its correlation with clinical outcomes of an induction
      chemotherapy for patients with locally advanced squamous cell carcinoma
      of the head and neck (SCCHN). Proceedings: ASCO 23: #5519, 2005.
40.   Mi Sun Choe, M. S., Rogatko, A., Tighiouart, M., Muller, M., Shin, H. J.,
      Hong, W. K., Papadimitrakopoulou, V. A., Glisson, B. S., Francisco, M.,
      Chen, Z (G)., Shin, D. M. Role of cyclooxygenase-2 (Cox-2) expression
      in tumor progression and survival in the squamous cell carcinoma of the
      head and neck (HNSCC). Proceedings: ASCO 23: #5508, 2005.
41.   Wang, J., Zhang, X., Thomas, S., Grandis, J., Wells, A., Chen, Z (G).,
      Ferris, R. L. PI3K-dependent chemokine receptor 7 mediated survival and
      invasion of head and neck cancer cells are independent of EGFR.
      Proceedings: AACR 46:#143, 2005.
42.   Zhang, X., Lee, J., Tighiouart, M., Shin, H. J., Khuri, F. R., Chen, Z(G).,
      Shin, D. M. Synergistic tumor growth inhibition by combined treatment
      with green tea epigallocatechin-3-gallate (EGCG) and an epidermal
      growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), erlotinib in
      squamous cell carcinoma of the head and neck (SCCHN). Proceedings:
      AACR 47:#4892, 2006.
43.   Zhang, H., Su, L., Shin, H. J., Muller, S., Tighiouart, M., Xu, Z., Zhang,
      X., Hunt, J., Shin, D. M., Chen, Z(G). The role of caveolin-1 on lymph
      node metastasis of the head and neck cancer. Proceedings: AACR
      47:#5140, 2006.
44.   Klass, C. Chen, Z(G), Zhang, X., Lonial, S., Khuri, F. R., Shin, D. M.
      Antitumor effects of combined bortezomib and tipifarnib in head and neck
      squamous cell carcinoma (HNSCC) cells. Proceedings: ASCO 42:#5581,
      2006.
45.   Chen, Z (G)., Shin, D. M., Su, L., Zhang, X., Yoon, Y., Zhang, H., Shim,
      H. Exploring cancer stem cell like feature and potential treatment of
      metastatic SCCHN. Abstract #PD-5-8. The 11th International Congress of
      Metastasis Research Society. Tokushima, Japan, 2006.
46.   Su, L., Muller, S., Tighiouart, M., Rogatko, A., Saba, N., Shin, D. M.,
      Chen, Z. G. Correlation of expression and localization of E-caherin and
      EGFR in metastatic and non-metastatic head and neck cancer.
      Proceedings: AACR: Volume 48: Abs#3021, 2007.
47.   Wang. X., Cho, K.J., Chen, Z.G., Arbiser, J., Shin, D.M. Honokiol
      reduces drug resistance by inhibition of P-glycoprotein expression in
      multidrug resistant (MDR) squamous cell carcinoma of the head and neck
      (SCCHN). Proceedings: AACR: Volume 48: Abs #2776, 2007.
48.   Cho, K.J., Wang, X., Kim, G.J., Gjyrezi, A., Giannakakou, P., Nie, S.,
      Chen, Z.G., Shin, D.M. Investigation of taxol-resistance using folate-

                                                                                18
                                                                 Georgia Zhuo Chen
                                                                      July 14, 2008


      targeted ternary therapeutic nanoparticle Proceedings AACR, 48:Abstract
      #2311, 2007.
49.   Saba, N.F., Wang, X., Tighiouart, M., Muller, S., Cho, K.J., Chen, Z.G.,
      Yang, L., Khuri, F.R,. Nie, S., Shin, D.M. Examining expression of folate
      receptors in squamous cell carcinoma of the head and neck (SCCHN) as a
      target for a novel nanotherapeutic drug. Proceedings AACR, 48: Abstract
      #LB-174, 2007.
50.   Zhang, H., Su, L., Xu, Z., Shin, D. M., Chen, Z.G. Overexpression of
      caveolin-1 suppresses tumor growth and lung metastasis of head and neck
      squamous cell carcinoma. Proceedings AACR, 48: Abstract #4685, 2007.
51.   Lin, Y., Liu, X., Chen, Z.G., Yue, P., Lonial, S., Shin, D.M., Khuri, F.,
      Sun, S. Therapeutic potential of the Akt inhibitor perifosine in
      combination with tumor necrosis factor-related apoptosis-inducing ligand
      (TRAIL) for metastatic head and neck cancer. Proceedings AACR, 48:
      Abstract #2405, 2007.
52.   Yoon, Y., Zhu, A., Yu, W., Chang, Y.S., Jeong, J. M., Liang, Z., Voll, R.,
      Pohl, J., Chen, Z. G., Goodman, M., Shim, S. Development of 18F-
      labeled CXCR4 PET tracer. Proceedings AACR, 48: Abstract #4715,
      2007.
53.   Zhang, H., Yun, S., Nannapaneni, S., Batuwangala, T., Steward, M., Shin,
      D. M., Chen, Z(G). A novel dual targeting antibody against EGFR and
      VEGF (DMS3008) in lung and head and neck cancer cell lines.
      Proceedings AACR, 49:Abstract #2400, 2008.
54.   Yun, S., Zhang, H., Nannapaneni, S., Steward, M., Batuwangala, T.,
      Tighiouart, M., Hurwitz, S., Chen, Z(G)., Shin, D. M.. A dual antibody
      against EGFR and VEGF as a therapeutic agent for cancer treatment.
      Proceedings AACR, 49:Abstract #2401, 2008.
55.   Amin, A.R.M. R., Zhang, X., Khuri, F. R., Chen, Z(G)., Shin, D. M.
      Inhibition of Erlotinib-induced checkpoint but not apoptotic targets by
      EGCG: Implication for their anti-tumor synergism in squamous cell
      carcinoma of the head and neck Proceedings AACR, 49:Abstract #2123,
      2008.
56.   Peng, X., Wang, A. Y., Mao, H., Chen, Z(G)., Nie, S., Shin, D. M.
      Epidermal growth factor receptor (EGFR) targeted iron oxide
      nanoparticles for imaging of head and neck cancer Proceedings AACR,
      49:Abstract #3163, 2008.
57.   Huang, D., Su, L., Peng, X., Zhang, H., Khuri, F. R., Shin, D. M., Chen,
      Z(G). Using quantum dots to examine dynamic relocalization of EGFR, E-
      cadherin, and β-catenin in lung cancer cells upon treatment with EGFR-
      TKI Proceedings AACR, 49:Abstract #3737, 2008.
58.   Wang, X., Li, J., Cho, K. J., Nannapaneni, S., Tighiouart, M., Chen, Z(G),
      Nie, S., Shin, D. M. Efficacy of a novel folate receptor-targeted ternary
      nanoparticle in human cancer model Proceedings AACR, 49:Abstract
      #5730, 2008.
59.   Su, L., Wang, D., Zhang, H., Shin, D. M., Chen, Z(G). Loss of E-cadherin
      induces proliferation of head and neck cancer through EGFR signaling
      pathway Proceedings AACR, 49:Abstract #5355, 2008.

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