Exhibit 10.10 FIRST AMENDMENT TO EMPLOYMENT AGREEMENT THIS FIRST AMENDMENT TO EMPLOYMENT AGREEMENT (this “Amendment”) is entered into effective as of February 27, 2006, by and between BioMed Realty Trust, Inc., a Maryland corporation (the “REIT”), BioMed Realty, L.P., a Maryland limited partnership (the “Operating Partnership” and, together with the REIT, the “Company”), and Matthew G. McDevitt (the “Executive”). WHEREAS, the Company and the Executive desire to amend that certain Employment Agreement dated as of August 6, 2004, between the Company