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JOB DESCRIPTION POST TITLE: Associate Clinical Professor / Senior Clinical Teaching Fellow in Implant Dentistry DEPARTMENT: Warwick Medical School SUB-DEPARTMENT: Institute of Clinical Education, Postgraduate Dental Education Unit (PGDEU) POST RESPONSIBLE TO: Head of PGDEU, Professor Jeremy Dale REFERENCE NUMBER: 34576-119 CLOSING DATE: 15th December 2009 JOB PURPOSE: The Postgraduate Dental Education (PGDEU) Unit was established in 2003 with the aim of becoming a centre of excellence in dental education. The Unit now runs several Masters courses for general dental practitioners in the UK and internationally and currently has almost 200 registered students. The current course portfolio includes Masters and diploma courses in implant dentistry, orthodontics, lingual orthodontics and endodontics. The Unit‟s five year plan anticipates considerable further growth and development of the course portfolio, with several new courses being launched and the emergence of a major stream of activity associated with dental research. The PGDEU is now seeking to employ an exceptional individual to play a major role in delivering this vision. The appointment will be made at either Associate Clinical Professor or Senior Clinical Teaching Fellow level, according to experience and expertise. To be considered for appointment as an Associate Clinical Professor, you will have an established reputation in dental education and research in a field that relates to restorative implant dentistry. Responsibilities of the role will include becoming the Course Director for the MSc in Implant Dentistry, and developing a major stream of research. The Unit does not have a fixed view of the how this role should be undertaken and will welcome applications from individuals who are interested to take on this role. At least 4 sessions per week based at Warwick are required to meet the needs of course directorship and associated educational activity. The remaining sessions, up to 4 per week, are for research and/or other educational activity. It is assumed that you will wish to spend at least two sessions (one day per week) in clinical practice at a clinical setting of your choice. However, this will be outside the contract for this post. If you do not already have a contract with the NHS you will be expected to accept an honorary contract, as required for all clinical academic appointments. Arrangements for this will be made on a case-by-case basis in negotiation with you and appropriate NHS organisations. As Course Director for the MSc in Implant Dentistry, you will lead the development and delivery of all aspects of teaching related to the MSc in Implant Dentistry, including chairing the Course Committee and leading at least one module. The MSc in Implant Dentistry is a training pathway which provides general dental practitioners with in-depth knowledge and understanding of restorative implant dentistry. Its overall aim is to provide general dental surgeons with the knowledge and core skills for the provision of predictable, safe and ethical implant treatment. Designed with flexibility in mind, the course can be studied in stages (Postgraduate Diploma and MSc) over a period of up to eight years, suited to individual requirements. It is delivered in part at Warwick and in part at regional clinical training centres run by our partner organisation GIFT (www.gift.org.gg). GIFT operates clinical training centres throughout the United Kingdom and in Singapore and Dubai. Full details of the course and its structure can be found at: www.warwick.ac.uk/go/implantdentistry. DUTIES AND RESPONSIBILITIES: As Course Director for the MSc in Implant Dentistry, the main duties are: Teaching and Learning Support 1. Engage in teaching at all levels using relevant teaching methods, e.g. lectures, seminars, tutorials, etc, working as part of the teaching team. 2. Develop and apply appropriate teaching techniques and materials, which may be novel or innovative, to create interest, understanding and enthusiasm amongst students. 3. Undertake curriculum design and deliver material across programmes of study at various levels, using appropriate teaching, learning support and assessment methods, reviewing and improving as required. 4. Liaise with GIFT and other external partners over all matters relating to the clinically- based elements of teaching. 5. Supervise student projects (PhD, MPhil, MSc). 6. Take responsibility for academic duties (i.e. setting examination questions, marking, invigilation and pastoral support of students) required to sustain the delivery of high quality teaching. 7. Co-ordinate and undertake pastoral support for students within the programme, course or modules for which you are responsible, liaising where necessary with other University agencies such as the Senior Tutor's Office. 8. Provide first line support for colleagues, referring them to sources of further help if required. Applicable to an appointee as Associate Clinical Professor only You will be expected to develop an externally funded programme of research related to oral health that is relevant to the research strategy of the Medical School in collaboration with academic staff in the Health Sciences Research Institute (HSRI) (www2.warwick.ac.uk/fac/med/research/hsri) and / or the Clinical Sciences Research Institute (CSRI) (www2.warwick.ac.uk/fac/med/research/csri). There is no fixed view on the focus of this research, provided it fits with and adds to the research profile and strengths of the Medical School and is relevant to the academic programme of the PGDEU. In addition to directing the MSc in Implant Dentistry you will be a member of the PGDEU strategic board and will be expected to contribute to the overall management of PGDEU, as well as contributing to the development of new courses and programmes and, if appropriate, leading a research programme. Research 1. To establish a sound research base in order to pursue individual and collaborative research of high quality in line with the objectives of WMS. 2. To secure, in collaboration with colleagues as appropriate, external funding through research grants or contracts to support a research agenda. 3. To manage research projects within the University, including their financial control and to supervise post-doctoral research assistants, research students, clinical trainees and other support staff engaged in research. 4. To consider the value of research achievements within their potential commercial context and where appropriate, with the assistance of the Research Support Services, take appropriate action to protect such research results by patent application or copyright to the potential benefit of the University. 5. Where appropriate and expedient, to secure contract work to the benefit of your research activity and to provide resources to underpin this activity. 6. To publish research outcomes in appropriate journals of international standing and to publish and disseminate the results of research and scholarship in other outlets. 7. To identify and explore with WMS and the University of Warwick any entrepreneurial opportunities which may arise and to ensure that intellectual property rights are protected for the benefit of the University and the researcher. 8. To attend and present research findings and papers at academic and professional conferences, and to contribute to the external visibility of PGDEU, WMS, and the University of Warwick. 9. To contribute fully to the research plans developed by WMS, including providing such information as may be required to monitor the progress of each member of staff‟s research programme and to support WMS fully in the preparation of material required for the RAE / REF or similar activities. Administration and Other Activities (applicable to both Associate Clinical Professor and Senior Clinical Teaching Fellow appointments) 1. To undertake such specific roles and management functions as may be reasonably required by the Head of PGDEU. 2. To attend departmental meetings at WMS, and to participate in other committees and working groups. 3. To participate in relevant professional activities. 4. To engage in continuous professional development. 5. To undertake external commitments, which reflect and enhance the reputation of the University. 6. To ensure compliance with health and safety in all aspects of work. The duties and responsibilities outlined are not intended to be an exhaustive list but provide guidance on the main aspects of the job. You will be required to be flexible in your duties. PERSON SPECIFICATION POST TITLE: Associate Clinical Professor in Implant Dentistry DEPARTMENT: Warwick Medical School, Institute of Clinical Education The Person Specification focuses on the knowledge, skills, experience and qualifications required to undertake the role effectively. REQUIREMENTS ESSENTIAL (E) or MEASURED BY: The postholder must be able DESIRABLE (D) a) Application to demonstrate: REQUIREMENTS Form b) Test/Exercise c) Interview d) Presentation A high level of expertise in implant dentistry as E a) c) evidenced by, for example, membership of the GDC specialist list for oral surgery / periodontology / prosthodontics / restorative dentistry; or of the GMC specialist list for oral and maxillo-facial surgery, with full registration with the GDC/GMC as applicable Relevant specialist qualification E a) Higher academic qualification E a) (PhD or equivalent) Postgraduate teaching qualification D a) Demonstrable experience in restorative implant E a) dentistry or related field Experience of teaching health care E a), c) professionals, including dentists Substantial track record of research of E a), c) international quality, including excellence in gaining external research funding and achieving publication Evidence of continuing professional E a), c) development Experience of developing educational E a), c) programmes with evidence of creative thinking Understanding of the specialist educational E c), d) needs of dentists Familiarity with current research related to E c) implant dentistry Excellent communication skills, oral written and E a), c), d) electronic Proven leadership skills and the ability to E a) motivate others Effective team working E a), c) Ability to work on own initiative E d) Membership of an appropriate professional E a) indemnity organisation Short-listed candidates will be required to give a short presentation as part of the interview process. Further details will be provided once the short-listing has been completed. Please note: Due to the nature of this role, the successful applicant will be required to undergo enhanced level Criminal Records Bureau clearance before commencing work with the University. Clearance obtained via another institution or body cannot be transferred. The successful applicant will also be required to undergo a Pre Employment Medical Check before commencing work with the University. This will involve a medical history questionnaire and may also require an appointment with a member of the University‟s Occupational Health team. POST TITLE: Senior Clinical Teaching Fellow in Implant Dentistry DEPARTMENT: Warwick Medical School, Institute of Clinical Education The Person Specification focuses on the knowledge, skills, experience and qualifications required to undertake the role effectively. REQUIREMENTS ESSENTIAL (E) or MEASURED BY: The postholder must be able DESIRABLE (D) a) Application to demonstrate: REQUIREMENTS Form b) Test/Exercise c) Interview d) Presentation A high level of expertise in implant dentistry as E a) c) evidenced by, for example, membership of the GDC specialist list for oral surgery / periodontology / prosthodontics / restorative dentistry; or of the GMC specialist list for oral and maxillo-facial surgery, with full registration with the GDC/GMC as applicable Relevant specialist qualification E a) Postgraduate teaching qualification D a) Demonstrable experience in restorative implant E a) dentistry or related field Experience of teaching health care E a), c) professionals, including dentists Evidence of continuing professional E a), c) development Experience of developing educational E a), c) programmes with evidence of creative thinking Understanding of the specialist educational E c) needs of dentists Familiarity with current research related to E c) implant dentistry Excellent communication skills, oral written and E a), c), d) electronic Proven leadership skills and the ability to E a) motivate others Effective team working E a), c) Ability to work on own initiative E d) Membership of an appropriate professional E a) indemnity organisation Short-listed candidates will be required to give a short presentation as part of the interview process. Further details will be provided once the short-listing has been completed. Please note: Due to the nature of this role, the successful applicant will be required to undergo enhanced level Criminal Records Bureau clearance before commencing work with the University. Clearance obtained via another institution or body cannot be transferred. The successful applicant will also be required to undergo a Pre Employment Medical Check before commencing work with the University. This will involve a medical history questionnaire and may also require an appointment with a member of the University‟s Occupational Health team. FURTHER PARTICULARS In accordance with the national agenda in higher education to modernise pay and grading structures, the University of Warwick has completed a significant programme of change that has seen the introduction of a new pay spine and single job evaluation scheme. The work commenced in September 2004 and was communicated and implemented across the University in August 2006. All salaries detailed within this recruitment document are post implementation and will be subject to normal salary progression as defined by the relevant terms and conditions of service. In conjunction with this, the University has now concluded discussions with trade unions and is now implementing harmonised terms and conditions. The University The University of Warwick is arguably the most successful of UK universities founded within the past half-century, and has earned an outstanding reputation both for research and teaching. Warwick is comfortably ranked within the top ten of all UK university league tables. The latest national UK newspaper tables (Times, Guardian, Independent, December 2008) all ranked Warwick in 7th place overall for research based on its performance in the Research Assessment Exercise. Founded in 1965 Warwick has been a unique and uniquely successful British university combining a “can-do” entrepreneurial spirit with a commitment to absolute academic excellence. Professor Nigel Thrift, Warwick‟s 5th Vice-Chancellor, was appointed in 2006 to transform the University from a leading university within the UK to become one of the world‟s top 50 universities by 2015. A new university strategy was launched as a result of extensive consultation with staff, students and Warwick‟s many external stakeholders, and is making good progress. Warwick employs over 5,000 members of staff, of whom 2,400 are academic and research staff spread across 28 academic departments and 30 research centres; The University's most recent QAA Institutional Audit in November 2008 resulted in findings of "confidence" in our management of academic standards and the quality of the learning experience, and a very positive report. The results of the 2008 Research Assessment Exercise (RAE) again reiterated Warwick‟s position as one of the UK‟s leading research universities, being ranked 7th overall in the UK (based on multi-faculty institutions). 65% of Warwick‟s research is „world-leading‟ or „internationally excellent‟, with a quality level of either 3* or 4*. 19 Warwick Departments were ranked in the top 10 in the UK in their units of assessment and Warwick achieved a 35% increase in the number of staff selected in RAE 2008, with almost 90% of staff submitted. The University of Warwick has a total student population of 17,000 (full-time equivalent) of whom approximately 11,000 are undergraduates and 7,000 are postgraduates. The University is an international and cosmopolitan body which is committed to tackling major global problems through research and teaching. Many of Warwick‟s staff originate or were educated overseas and almost a third of the total student population comes from over 120 countries outside of the UK. The University‟s main campus, located on a 400-acre site spanning the south west boundary of Coventry and the county of Warwickshire has an open and pleasant outlook. The campus offers excellent sporting facilities, including a swimming pool, a newly refurbished gym, a climbing wall, an all weather running track and acres of football and rugby pitches. An indoor tennis centre has recently been opened. The renowned Warwick Arts Centre is one of the largest outside London with the Mead Gallery showing visiting collections of contemporary art, a concert hall, two theatres and a cinema. The 1,500 seat Butterworth Hall reopened in Autumn 2009 following a £6.9 million redevelopment. The University of Warwick is ideally placed for easy access to London (just over one hour on the train), close to the picturesque towns of Warwick, Kenilworth and Leamington Spa and about 45 minutes from the centre of Birmingham. Immediately to the south of the main campus is rural Warwickshire and both Shakespeare‟s Stratford and the Cotswolds are just 30 minutes away. The University of Warwick has a turnover approaching £350 million. The University continues to invest heavily in its campus infrastructure and environment and current developments include a multi million pound extension and redevelopment of the Students‟ Union building, a new Clinical Trials Unit for Warwick Medical School and a £2 million refit of our Chemistry teaching labs. The state-of-the-art £50 million Warwick Digital Laboratory‟s foundation stone was laid by Prime Minister Gordon Brown in May 2007 and he returned to formally open the building in 2008. Further details about the University of Warwick can be found at http://www.warwick.ac.uk The Managerial and Administrative Structure of the University The University‟s administrative and managerial structure is headed by the Vice-Chancellor, supported by the Deputy Vice-Chancellor (this position is vacant at the present time), the Registrar, the Deputy Registrar and the Finance Director. However, as with all such structures, the informal lines of decision making and the sharing of responsibility for planning and strategy flatten the hierarchy. Institutional level decisions are initially made by a group comprising academics and administrators who form the Senate Steering Committee which operates much along the lines of a weekly cabinet for the University. The Registrar, Mr Jon Baldwin, is responsible for the administration of the University and is supported in this task by a team of Senior Officers, each of whom is responsible for a key area and associated offices of University administration: the Academic Registrar, the Estates Director, the Director of Human Resources and Commercial Activities, the Director of IT Services, the Director of Development, Communication and Strategy, and the University Librarian. A number of office heads and directors report in turn to these Senior Officers. To ensure overall co-ordination between and across the University‟s administration, all administrative posts within academic departments have a “dotted line” reporting to the University Registrar as well as the Department in which they are based. Warwick Medical School (WMS) Acting Dean WMS: Professor Martin Underwood, MD FRCGP The Medical School at Warwick was established in 2000 as part of an expansion in the number of Medical School‟s nationally to deliver the additional capacity needed to support the Government‟s plan to increase the number of UK trained medical graduate‟s joining the NHS. In its first RAE submission WMS was ranked 10th for Health Services Research and 19th for Other Hospital Clinical Subjects. This is an excellent result for a new medical school. Our aim is to be rate in the top 5-10 in each unit of assessment in the forthcoming Research Excellence Framework. The School is organised in three Institutes, the Institute of Clinical Education (ICE) which is the base for all the School‟s educational programmes, the Clinical Sciences Research Institute (CSRI), home for our biomedical and acute hospital-based research groups, and Health Sciences Research Institute (HSRI) which focuses on research in the community- based clinical disciplines. The School‟s principal clinical partners are University Hospitals Coventry and Warwickshire NHS Trust (UHCW), the George Eliot Hospital NHS Trust, South Warwickshire General Hospitals NHS Trust, Coventry Teaching Primary Care Trust and the other Primary Care Trusts within Warwickshire. Additional clinical placements are provided by Worcestershire Acute Hospitals NHS Trust, Worcestershire Mental Health Partnership NHS Trust and by a number of general practices throughout the West Midlands. At UHCW, a state of the art PFI hospital provides an optimal environment to support both research and education at the Trust. The Clinical Sciences Building and the Clinical Sciences Research Institute are based on the UHCW site and provide a base for education and laboratory research for the Medical School. The Medical School‟s research is focused around a number of multi-disciplinary and cross- specialty teams; collaboration within and outside School and University is encouraged and investigators are encouraged to work across traditional disciplinary boundaries in innovative ways. WMS works closely with many departments across the University for both our research and education programmes; these include the Department of Biological Sciences, the School of Health and Social Studies, the Department of Sociology, the Department of Statistics, Warwick Business School, Warwick Manufacturing Group, Complexity Science, Centre for Systems Biology, the Law School and the Department of Mathematics. Institute of Clinical Education (ICE) The Institute of Clinical Education has three core functions delivering undergraduate medical education, postgraduate education including research degrees, and research on clinical/health professional education. Professor Jill Thistlethwaite, the Director of the Institute, leads a team comprising three directorates covering specific portfolios. These are the Directorate for Masters-level Accredited Courses and continuing professional development (Director: Dr Adrian Stokes); the Directorate for MBChB Graduate-entry course (Director: Dr Jane Kidd), and the Directorate for Research Degrees (Director: Dr Frances Griffiths). The Director of Quality Assurance, Dr Paul O‟Hare, has a remit across all areas of the Institute. Professor Neil Johnson, as Associate Dean for teaching, has an overarching role across this Institute. WMS is very active in the provision of postgraduate and continuing professional development programmes. The university has a long history of involvement in postgraduate medical education and CPD for health professionals, particularly in the fields of diabetes (Warwick Diabetes Care), community child health, health information science and sexual health. Postgraduate provision has been consolidated, strengthened and expanded through the formation of the medical school. The school provides a number of entry routes into postgraduate study. Students can initially register for our flexible master‟s programme in health sciences which allows students to select their own combination of modules from the wide range on offer to build sufficient credit for the award of a master‟s degree. We also offer masters programmes in diabetes, public health, implant dentistry, child health, sexual and reproductive health, orthopaedics, philosophy and ethics of mental health, palliative care, medical education, and health services management. We offer short courses both accredited and non-accredited in areas such as diabetes care, occupational health, and clinical systems improvement. Collaborations with other departments include the Postgraduate Diploma in Regulatory Occupational Health and Safety for HSE Inspectors. The Institute is developing a number of strands of research in clinical education. Particular areas of interest are clinical and communication skills education, values-based practice, interprofessional education, patient involvement and service improvement, professionalism and the professional development experiences of health professionals. The undergraduate MB ChB course at Warwick is a four-year graduate entry programme which requires entrants to already have a first degree in biological sciences or a similar subject. The initial element of the course (Phase 1) lasts for 18 months and provides a foundation in the clinical and social sciences with some elements of clinical experience. This is followed by Phase 2 which is organised as a series of clinical placements in local NHS organisations, including four local hospitals and 30 local practices, lasting for 36 months. The annual intake to the MB ChB programme is 164 home students and 14 overseas students and the vast majority of our students‟ progress to foundation training posts in local West Midlands NHS Trusts following their graduation. The MB ChB course is based in the purpose-designed medical teaching building. Dr Jane Kidd is Reader in Communication Studies, and Director of Undergraduate Education, working closely with Dr Philip McTernan, who co-ordinates Phase 1 teaching, and Dr Colin MacDougall, the Phase 2 co-ordinator. Dr Vinod Patel is Reader in Clinical Skills: the curriculum places emphasis on the horizontal integration of clinical skills teaching with communication skills as well as the vertical integration of early learning and patient contact with later Phase 2 teaching (it is for this reason that clinicians are involved in the Phase 1 teaching alongside their basic scientist colleagues). Ms Deborah Markham (FRCS), and Dr Mandy Barnett are Associate Clinical Professors in Medical Education, and Dr Ann Jackson is Associate Professor in Interprofessional Education. Professor Peter Abrahams as Professor of Clinical Anatomy is developing integrated clinical anatomy teaching across clinical specialities. Dr David Davies is Reader in E-Learning. The School is very active in the International Virtual Medical School (IVIMeds) collaboration. At Warwick Medical School particular emphasis is placed on developing professionalism in medical education. Professor Bill Fulford and colleagues in Philosophy of Mental Health have been developing the concepts of values-based practice, working to provide doctors and medical students with a system of decision support which considers the values of patients and colleagues and which works in a way complementary to evidence-based practice. Community education comprises learning in general practices across Coventry and Warwickshire PCTs and beyond. An active network of practices, GP tutors, and practice teachers is involved with undergraduate students throughout their course. There are 10 GP Senior or Principal Clinical Fellows in Medical Education employed at WMS and three GP Associate Clinical Professors. Interprofessional learning is an active partnership with University of Coventry and Faculty Development is led by a learning and teaching specialist. A recent collaboration sees Best Evidence Medical Education (BEME) establishing on the Warwick Medical School site under the leadership of Professor Marilyn Hammick. The Health Sciences Research Institute Director – Professor Sarah Stewart-Brown The Health Sciences Research Institute comprises the disciplines of public health, primary care, statistics, health economics and rehabilitation as well as the medical specialities of general practice, psychiatry, emergency medicine and community child health. It includes Warwick Clinical Trials Unit (CTU) which supports intervention trials throughout the Medical School. Warwick CTU has recently relocated to a new building on the Gibbet Hill campus; the building received funds from the Science City Initiative. The Institute has strong links with the NHS through the local Primary Care Trusts, the West Midlands Deanery and the Regional Public Health Office. It also has strong links with the Clinical Sciences Research Institute and Institute of Clinical Education, with other Warwick University Departments, particularly the School of Health and Social Studies, and with local Universities including Leicester, Coventry and Birmingham. The Institute‟s research programme covers new and emerging areas of health research and key health priorities. At present there are three main research groups: - one of which covers public health, epidemiology, psychiatry, child health, knowledge management evidence and e-health, particularly the role of the internet in healthcare; the second primary care, primary secondary care interface and health care systems; and the third clinical trials with a focus on emergency care, rehabilitation and cancer. The three groups are closely integrated and members work collaboratively across all three groups. Key research topics include: Cardiovascular disease and diabetes risk factors and preventive programmes including promotion of physical activity and healthy eating, prevention of obesity in children and adults, prevention of hypertension and screening for hypercholesterolemia and the emerging and the burden of cardiovascular disease in developing countries. Public mental health including the impact of life course determinants, social inequalities and the built environment, aetiology and risk factors, links with physical health and preventive interventions. Emergency care, rehabilitation and prevention of injury and musculoskeletal problems. Management of chronic illness with a focus on decision making and patient involvement. Cancer prevention and management. Applied and health services research E- Health: the use of electronic media to promote and monitor health Knowledge management; technology assessment and appraisals for NICE as part of Warwick‟s new Technology Appraisals Review (TAR) Team, evidence production, diffusion and use in health care Warwick Clinical Trials Unit (WCTU) Director: Professor Sallie Lamb Currently within the Health Sciences Research Institute, the Warwick Clinical Trials Unit (WCTU) was formally established in 2005, and provides support to randomised clinical trials undertaken in Warwick Medical School as well as working with a range of internationally excellent external collaborators. The unit received full registration status from the UKCRC in November 2007 and has been awarded research grants in excess of £20m since 2005. WCTU has an interdisciplinary, collaborative approach, with expertise in trial design and methods, including design of trials in complex interventions, sequential trials, longitudinal data analysis, missing data and questionnaire design and analysis. WCTU has excellent links to academic networks in diabetes, emergency care, intensive care, rehabilitation, stroke, primary care, mental health and cancer. The staff are multi-disciplinary, and include several internationally recognised investigators. Standard Operating Procedures cover the full range of activities associated with managing clinical trials from inception to publication. Our internal research programme covers three areas emergency/critical care, rehabilitation and cancer. The trials are generally Phase III studies of either complex or pharmacological interventions, and most have a parallel and substantial economic evaluations running alongside them. The main funder is the National Institute of Health Research Health Technology Assessment Programme. In addition members of the CTU have been involved in economic modelling and systematic reviewing, and have provided substantial input and support to the recently secured Technology Appraisal Review contract from the NIHR HTA. There is a strong commitment to methodological research in statistics, trial design and economics. Clinical Sciences Research Institute (CSRI) The Clinical Sciences Research Institute (CSRI) of WMS is a centre for research into strategic areas of human health. Professor John Davey, the Director of the CSRI, oversees a research strategy that ranges from molecular and cellular biology to patient-orientated physiological approaches and is based around the major research themes of Metabolic Health (including diabetes, obesity, cardiovascular medicine and endocrinology), Reproduction (reproductive biology and reproductive medicine), Orthopaedics and Clinical Effectiveness. CSRI has 35 full-time academics, ~20 research fellows, ~15 postdoctoral fellows and ~45 postgraduate students working in new, purpose-built laboratories equipped with the latest instrumentation. There are more than 60 externally-funded projects external currently underway at CSRI, with a total value exceeding £8.7 million. WMS signed a strategic partnership agreement with the Medical Research Council in 2007, the first new medical school to do so. This has already resulted in a Strategic Chair appointment and a new Doctoral Training Centre with the Department of Biological Sciences. CSRI is sited at the recently completed University Hospital of Coventry and Warwickshire (UHCW), providing an interface for patient-orientated research. Translational Medicine is a key element in our research approach and we have recently developed a major collaboration with the University of Birmingham under the Science City initiative and funded by the Advantage West Midlands. Further information about research at CSRI is available at http://www2.warwick.ac.uk/fac/med/research/csri Metabolic Health Obesity, Type-2 diabetes and hyperglycaemic damage The mechanisms relating obesity to the major associated pathologies (type-2 diabetes, cardiovascular disease) are being studied using multi-disciplinary approaches. The neural circuits involved in the regulation of body weight and satiety are being studied by the neurophysiology group (led by Prof D Spanswick). The work of Prof S Kumar is aimed at discovering the mechanisms that link sub-clinical inflammation, the development of obesity and the aetiology of tye-2 diabetes. The effects of insulin on adipose tissue function are being studied to elucidate mechanisms through which the hyperinsulinaemia of the pro- diabetic state affects adipokine secretion (Dr P McTernan and Dr G Tripathy). The enzymology of the pathways of fatty acid metabolism in the aetiology of insulin resistance is being studied by the group of Prof V A Zammit. The effects of the hyperglycaemia that accompanies poorly controlled diabetes on protein modification are studied by Prof P Thornalley and his group, which specialises in the use of mass spectrometry in the study of protein damage and impaired insulin signalling in a programme of research shared with Systems Biology. Clinical studies are being conducted into the molecular basis of the monogenic forms of diabetes, the phenotype of LADA in Indo-Asian type-2 diabetic patients, and the effects of different treatments for type-2 diabetes on clinical outcomes, and the role of ethnicity in determining these outcomes. The UK Asian Diabetes Study investigates novel approaches to delivering care for Indo-Asian diabetic patients. There are links to several NHS partners, clinical and academic centres worldwide. A Centre of Excellence in Diabetes Research and Education (WISDEM) has been established within the new hospital. Cardiovascular Medicine and Epidemiology The main research interests of CSRI in this field are the prevention, detection and management of hypertension and its complications, and the epidemiology of cardiovascular disease and stroke. The relationships between nutrition, metabolic abnormalities and cardiovascular risk, including risk assessment in ethnic minorities, both in developed and developing countries are being studied by the group led by Prof F P Cappuccio, with particular emphasis on the role of inflammation and immunity in cardiovascular disease in entire populations. Work leading to the identification of novel biochemical markers for cardiovascular risk are being led by Dr M Miller, as part of large studies (e.g. Whitehall II, Olivetti). Epidemiological studies are performed locally within the Midlands, and internationally. International cardiovascular health studies on the role of high salt- intake in raised blood pressure in rural communities are being performed on cohorts in Western Africa. There are close interactions with epidemiological and public health research performed within the Health Sciences Research Institute (HSRI) of the School. Prof Cappuccio‟s group also has a major interest in the interaction between sleep and the development of obesity and cardiovascular disease, particularly as they impinge on other metabolically active factors such as sub-clinical chronic inflammation. Microvascular research (led by Prof D R Singer) is exploring why patients with high blood pressure and other cardiovascular risk factors have impaired function of small arteries and fewer capillaries than normal (rarefaction). Recent imaging and protein- characterization studies have shown how oxidant stress can prevent normal activity. Protein-carbohydrate and protein-protein interactions that underpin immune function and virus-host interactions as they relate to the oligosaccharide binding properties of specific endothelial cell surface proteins are studied by Dr D Mitchell (RCUK Fellow). Molecular Medicine and Endocrinology The major interests in endocrinology within the CSRI are centred on the structure-function relationships of hormone receptors, and mechanisms of signal transduction. The role of central and peripheral orexin, adiponectin and ghrelin action in body weight regulation and insulin sensitivity are studied by the group led by Dr H Randeva. The signal transduction mechanisms, and particularly the activation and subcellular localisation of the protein kinases, involved in the action of corticotropin releasing hormone (CRH) are studied by Prof D Grammatopoulos. These studies have strong links with those being performed on the regulation of G-protein signalling as part of the Reproductive Health programme. Clinical studies are being performed into the pathogenesis of endocrine tumours and the relevance of the expression of the telomeric complex as an indicator of malignancy particularly of endocrine tumours. Reproductive Health Within this programme, which is under the overall leadership of Prof S Thornton, two major lines of research are followed; Obstetrics and Reproductive Medicine. Obstetrics Obstetrics research at CSRI predominantly aims at understanding the fundamental principles controlling myometrial (uterine) contractility and the associated pathologies of pre-term labour, pre-eclampsia and dystocia. Members of the preterm labour group have research interests that range from basic science through translational medicine to clinical trials. Micro-genomic strategies are used to correlate differential patterns of gene expression in different cells and regions of the uterus with myometrial physiology, with particular reference to the spatial expression of proteins within myocytes. Using cells isolated by laser-capture micro dissection (LCM) from frozen sections of human myometrium followed by single-cell PCR analysis, the heterogeneity of the uterine cell population with respect to the expression of the oxytocin receptor and different ion channels and transporters within individual cell-types have been studied. These experimental data are used to generate mathematical models of the contractile function of the uterus under conditions associated to pre-term labour (Prof S Thornton and Dr A Blanks). The role of voltage-gated L-type Ca2+ channels in uterine contractility in human uterus is being delineated by Dr A Shmygol who is also interested in the physiology of uterine interstitial cells. The interactions with the Molecular Medicine and Endocrinology group focus on the study of the role of Urocortin II (UCN II) and its interaction with type-2 corticotropin-releasing hormone-receptor (CRH-R2) in myometrial contractility by Prof D Grammatopoulos. In addition, using a yeast model system to study G-protein coupled receptors (as exemplified by CRH) combined with mathematical modelling, Dr G Ladds is studying dimerisation of G- protein-coupled receptors (GPCRs), and the specificity of GPCR-G and G-RGS interactions. The pathogenesis of placental dysfunction, with reference to intrauterine growth retardation (IUGR) and pre-eclampsia, is studied by the group of Dr M Vatish, using human tissue, cell lines and a transgenic mouse model of pre-eclampsia. The work aims to identify GPCRs involved in determining placental vascularisation, and the relationship with foetal nutrition and maternal hypertension. Clinical studies include on the use of Electromyography (EMG) in the diagnosis and management of term and preterm labour, and the role of drugs to prevent premature delivery. This has included the setting up by Prof S Thornton of the national Preterm Labour Network, which includes most UK teaching hospitals, and assesses clinical trial proposals for submission to major national funding bodies including the MRC. Other clinical trials are being conducted with the pharmaceutical industry. Reproductive Medicine This research investigates mechanisms underlying human infertility. There is an extensive programme of work aimed at understanding egg- and sperm-formation, fertilisation and embryo development (Dr G Hartshorne and Dr S Keay). In particular, a programme of work aimed at identifying competent embryos is being pursued with the aim of establishing procedures that will allow fewer embryos to be transferred during IVF treatment, so minimising the possibility of multiple pregnancies. A particular area of investigation involves quantifying the control of male- and female-derived genes at fertilisation which is important in understanding genetic diseases arising from „imprinting disorders‟ that may possibly arise from abnormal sperm- or egg-formation. Other research into reproductive genetics is aimed at understanding the impairment of fertility and poor pregnancy-outcomes. For example, an EC-funded network of 52 research groups, co-ordinated from Warwick, is developing methods for detecting chromosome disorders, such as Downs Syndrome, using blood from mothers in early pregnancy. Trauma and Orthopaedics Prof D Griffin leads a multidisciplinary orthopaedic team at CSRI, comprising scientists and surgeons who collaborate with statisticians, methodologists, health economists and trial managers. They have particular expertise in the design of large national and international studies that investigate the clinical effectiveness of particular interventions e.g. in the treatment of heel fracture and Achilles tendon rupture. The development of new orthopaedic technologies is coupled with clinical and cost-effectiveness assessment to ensure health- and socio-economic gains from these new developments. Professors at Warwick Medical School Clinical Professors The current clinical professors at the University of Warwick are Martin Underwood [Primary Care Research & Acting Dean of WMS], Neil Johnson [Medical Education & Associate Dean (Teaching)], Sudhesh Kumar [Medicine, Diabetes and Metabolism & Associate Dean (External Affairs)], Steve Thornton [Obstetrics & Associate Dean (Clinical Research)], Sarah Stewart-Brown [Public Health & Director of the Health Sciences Research Institute], Jill Thistlethwaite [Clinical Education and Research & Director of ICE], Francesco Cappuccio [Cardiovascular Medicine and Epidemiology], Matthew Cooke [Emergency Medicine & Clinical Systems Improvement], Jeremy Dale [Primary Care], Bill Fulford [Philosophy & Mental Health], Fang Gao-Smith [Anaesthesia Critical Care & Pain], Damian Griffin [Trauma & Orthopaedic Surgery], Simon Murch [Paediatrics & Child Health], Chris Poole [Oncology], Donald Singer [Clinical Pharmacology], Swaran Singh [Social and Community Psychiatry] and Scott Weich [Psychiatry]. Professor Siobhan Quenby [Obstetrics] is due to join WMS on 1st February 2010. Non-Clinical Professors The non-clinical professors are John Davey [Cell Biology, Associate Dean (Biomedical Research) & Director of CSRI], Peter Abrahams [Anatomy], Jane Barlow (Public Health in the Early Years], Colin Blakemore, Janet Dunn [Cancer Clinical Trials], Martin Feelisch [Experimental Medicine], Dimitris Grammatopoulos [Molecular Medicine], Geraldine Hartshorne [Professorial Fellow], Sallie Lamb [Rehabilitation & Clinical Trials], David Spanswick [Molecular Neurosciences], Peter Spurgeon [Health Services Management], Nigel Stallard [Medical Statistics], Ala Szczepura [Health Services Research], Paul Thornalley [Systems Biology], Margaret Thorogood [Epidemiology], and Victor Zammit [Molecular Biochemistry]. We are currently recruiting to a Professor of Pathology, Professor of Surgery and Professor of Clinical Imaging (all Clinical Professorships). Recruitment of Ex-Offenders Policy (Developed in line with the CRB Disclosure information pack, part DIP011) This Policy applies to all staff recruitment at the University of Warwick. As an organisation using the Criminal Records Bureau (CRB) Disclosure service to assess applicants‟ suitability for positions of trust, the University of Warwick complies fully with the CRB Code of Practice and undertakes to treat all applicants for positions fairly. It undertakes not to discriminate unfairly against any subject of a Disclosure on the basis of a conviction or other information revealed. The University of Warwick is committed to the fair treatment of its staff, potential staff or users of its services, regardless of race, gender, religion, sexual orientation, responsibilities for dependants, age, physical/mental disability or offending background. Our written policy on the recruitment of ex-offenders is made available to all applicants at the outset of the recruitment process. We actively promote equality of opportunity for all with the right mix of talent, skills and potential and welcome applications from a wide range of candidates, including those with criminal records. We select all candidates for interview based on their skills, qualifications and experience. A Disclosure is only requested after a thorough risk assessment has indicated that one is both proportionate and relevant to the position concerned. For those positions where a Disclosure is required, all application forms, job adverts and recruitment briefs will contain a statement that a Disclosure will be requested in the event of the individual being offered the position. Where a Disclosure is to form part of the recruitment process, we encourage all applicants called for interview to provide details of their criminal record at an early stage in the application process. We request that this information is sent under separate, confidential cover, to a designated person within the University of Warwick and we guarantee that this information will only be seen by those who need to see it as part of the recruitment process. Unless the nature of the position allows the University of Warwick to ask questions about the applicants entire criminal record, we only ask about „unspent‟ convictions as defined in the Rehabilitation of Offenders Act 1974. We ensure that all appropriate staff in Personnel Services at the University of Warwick who are involved in the recruitment process have been suitably trained to identify and assess the relevance and circumstances of offences. We also ensure that they have received appropriate guidance in the relevant legislation relating to the employment of ex-offenders, e.g. the Rehabilitation of Offenders Act 1974. Line managers are advised who to approach for support on these issues. At interview, or in a separate discussion, we ensure that an open and measured discussion takes place on the subject of any offences or other matter that might be relevant to the position. Failure on the part of the applicant to reveal information that is directly relevant to the position sought could lead to withdrawal of an offer of employment. We make every subject of a CRB Disclosure aware of the existence of the CRB Code of Practice and make a copy available on request. We undertake to discuss any matter revealed in a Disclosure with the person seeking the position before withdrawing a conditional offer of employment. We do not accept Disclosures transferred from other organisations and do not supply Disclosures requested by us to any external organisations.
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