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THE UNIVERSITY OF WARWICK

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					                                      JOB DESCRIPTION

POST TITLE:                           Associate Clinical Professor / Senior Clinical Teaching
                                      Fellow in Implant Dentistry

DEPARTMENT:                           Warwick Medical School

SUB-DEPARTMENT:                       Institute of Clinical Education, Postgraduate Dental
                                      Education Unit (PGDEU)

POST RESPONSIBLE TO:                  Head of PGDEU, Professor Jeremy Dale

REFERENCE NUMBER:                     34576-119

CLOSING DATE:                         15th December 2009


JOB PURPOSE:
The Postgraduate Dental Education (PGDEU) Unit was established in 2003 with the aim of
becoming a centre of excellence in dental education. The Unit now runs several Masters
courses for general dental practitioners in the UK and internationally and currently has
almost 200 registered students. The current course portfolio includes Masters and diploma
courses in implant dentistry, orthodontics, lingual orthodontics and endodontics. The Unit‟s
five year plan anticipates considerable further growth and development of the course
portfolio, with several new courses being launched and the emergence of a major stream of
activity associated with dental research.

The PGDEU is now seeking to employ an exceptional individual to play a major role in
delivering this vision. The appointment will be made at either Associate Clinical Professor or
Senior Clinical Teaching Fellow level, according to experience and expertise. To be
considered for appointment as an Associate Clinical Professor, you will have an established
reputation in dental education and research in a field that relates to restorative implant
dentistry. Responsibilities of the role will include becoming the Course Director for the MSc
in Implant Dentistry, and developing a major stream of research. The Unit does not have a
fixed view of the how this role should be undertaken and will welcome applications from
individuals who are interested to take on this role.

At least 4 sessions per week based at Warwick are required to meet the needs of course
directorship and associated educational activity. The remaining sessions, up to 4 per week,
are for research and/or other educational activity.

It is assumed that you will wish to spend at least two sessions (one day per week) in clinical
practice at a clinical setting of your choice. However, this will be outside the contract for this
post. If you do not already have a contract with the NHS you will be expected to accept an
honorary contract, as required for all clinical academic appointments. Arrangements for this
will be made on a case-by-case basis in negotiation with you and appropriate NHS
organisations.

As Course Director for the MSc in Implant Dentistry, you will lead the development and
delivery of all aspects of teaching related to the MSc in Implant Dentistry, including chairing
the Course Committee and leading at least one module. The MSc in Implant Dentistry is a
training pathway which provides general dental practitioners with in-depth knowledge and
understanding of restorative implant dentistry. Its overall aim is to provide general dental
surgeons with the knowledge and core skills for the provision of predictable, safe and ethical
implant treatment. Designed with flexibility in mind, the course can be studied in stages
(Postgraduate Diploma and MSc) over a period of up to eight years, suited to individual
requirements. It is delivered in part at Warwick and in part at regional clinical training
centres run by our partner organisation GIFT (www.gift.org.gg). GIFT operates clinical
training centres throughout the United Kingdom and in Singapore and Dubai. Full details of
the course and its structure can be found at: www.warwick.ac.uk/go/implantdentistry.

DUTIES AND RESPONSIBILITIES:

As Course Director for the MSc in Implant Dentistry, the main duties are:

Teaching and Learning Support

   1. Engage in teaching at all levels using relevant teaching methods, e.g. lectures,
      seminars, tutorials, etc, working as part of the teaching team.

   2. Develop and apply appropriate teaching techniques and materials, which may be
      novel or innovative, to create interest, understanding and enthusiasm amongst
      students.

   3. Undertake curriculum design and deliver material across programmes of study at
      various levels, using appropriate teaching, learning support and assessment
      methods, reviewing and improving as required.

   4. Liaise with GIFT and other external partners over all matters relating to the clinically-
      based elements of teaching.

   5. Supervise student projects (PhD, MPhil, MSc).

   6. Take responsibility for academic duties (i.e. setting examination questions, marking,
      invigilation and pastoral support of students) required to sustain the delivery of high
      quality teaching.

   7. Co-ordinate and undertake pastoral support for students within the programme,
      course or modules for which you are responsible, liaising where necessary with other
      University agencies such as the Senior Tutor's Office.

   8. Provide first line support for colleagues, referring them to sources of further help if
      required.

Applicable to an appointee as Associate Clinical Professor only

You will be expected to develop an externally funded programme of research related to oral
health that is relevant to the research strategy of the Medical School in collaboration with
academic       staff   in    the      Health     Sciences     Research      Institute   (HSRI)
(www2.warwick.ac.uk/fac/med/research/hsri) and / or the Clinical Sciences Research
Institute (CSRI) (www2.warwick.ac.uk/fac/med/research/csri). There is no fixed view on the
focus of this research, provided it fits with and adds to the research profile and strengths of
the Medical School and is relevant to the academic programme of the PGDEU.

In addition to directing the MSc in Implant Dentistry you will be a member of the PGDEU
strategic board and will be expected to contribute to the overall management of PGDEU, as
well as contributing to the development of new courses and programmes and, if appropriate,
leading a research programme.

Research

   1. To establish a sound research base in order to pursue individual and collaborative
      research of high quality in line with the objectives of WMS.
   2. To secure, in collaboration with colleagues as appropriate, external funding through
      research grants or contracts to support a research agenda.

   3. To manage research projects within the University, including their financial control
      and to supervise post-doctoral research assistants, research students, clinical
      trainees and other support staff engaged in research.

   4. To consider the value of research achievements within their potential commercial
      context and where appropriate, with the assistance of the Research Support
      Services, take appropriate action to protect such research results by patent
      application or copyright to the potential benefit of the University.

   5. Where appropriate and expedient, to secure contract work to the benefit of your
      research activity and to provide resources to underpin this activity.

   6. To publish research outcomes in appropriate journals of international standing and to
      publish and disseminate the results of research and scholarship in other outlets.

   7. To identify and explore with WMS and the University of Warwick any entrepreneurial
      opportunities which may arise and to ensure that intellectual property rights are
      protected for the benefit of the University and the researcher.

   8. To attend and present research findings and papers at academic and professional
      conferences, and to contribute to the external visibility of PGDEU, WMS, and the
      University of Warwick.

   9. To contribute fully to the research plans developed by WMS, including providing such
      information as may be required to monitor the progress of each member of staff‟s
      research programme and to support WMS fully in the preparation of material required
      for the RAE / REF or similar activities.

Administration and Other Activities (applicable to both Associate Clinical Professor and
Senior Clinical Teaching Fellow appointments)

   1. To undertake such specific roles and management functions as may be reasonably
      required by the Head of PGDEU.

   2. To attend departmental meetings at WMS, and to participate in other committees and
      working groups.

   3. To participate in relevant professional activities.

   4. To engage in continuous professional development.

   5. To undertake external commitments, which reflect and enhance the reputation of the
      University.

   6. To ensure compliance with health and safety in all aspects of work.

The duties and responsibilities outlined are not intended to be an exhaustive list but provide
guidance on the main aspects of the job. You will be required to be flexible in your duties.
                                   PERSON SPECIFICATION

POST TITLE:                     Associate Clinical Professor in Implant Dentistry

DEPARTMENT:                     Warwick Medical School, Institute of Clinical Education

The Person Specification focuses on the knowledge, skills, experience and qualifications
required to undertake the role effectively.

REQUIREMENTS                                         ESSENTIAL (E) or        MEASURED BY:
The postholder must be able                          DESIRABLE (D)           a) Application
to demonstrate:                                      REQUIREMENTS            Form
                                                                             b) Test/Exercise
                                                                             c) Interview
                                                                             d) Presentation
A high level of expertise in implant dentistry as    E                       a) c)
evidenced by, for example, membership of the
GDC specialist list for oral surgery /
periodontology / prosthodontics / restorative
dentistry; or of the GMC specialist list for oral
and maxillo-facial surgery, with full registration
with the GDC/GMC as applicable
Relevant specialist qualification                    E                       a)

Higher academic qualification                        E                       a)
(PhD or equivalent)

Postgraduate teaching qualification                  D                       a)

Demonstrable experience in restorative implant       E                       a)
dentistry or related field

Experience of teaching health care                   E                       a), c)
professionals, including dentists

Substantial track record of research of              E                       a), c)
international quality, including excellence in
gaining external research funding and achieving
publication
Evidence of continuing professional                  E                       a), c)
development

Experience of developing educational                 E                       a), c)
programmes with evidence of creative thinking

Understanding of the specialist educational          E                       c), d)
needs of dentists

Familiarity with current research related to         E                       c)
implant dentistry

Excellent communication skills, oral written and     E                       a), c), d)
electronic
Proven leadership skills and the ability to         E                        a)
motivate others

Effective team working                              E                        a), c)

Ability to work on own initiative                   E                        d)

Membership of an appropriate professional           E                        a)
indemnity organisation


Short-listed candidates will be required to give a short presentation as part of the interview
process. Further details will be provided once the short-listing has been completed.

Please note: Due to the nature of this role, the successful applicant will be required to
undergo enhanced level Criminal Records Bureau clearance before commencing work with
the University. Clearance obtained via another institution or body cannot be transferred. The
successful applicant will also be required to undergo a Pre Employment Medical Check
before commencing work with the University. This will involve a medical history
questionnaire and may also require an appointment with a member of the University‟s
Occupational Health team.
POST TITLE:                    Senior Clinical Teaching Fellow in Implant Dentistry

DEPARTMENT:                    Warwick Medical School, Institute of Clinical Education

The Person Specification focuses on the knowledge, skills, experience and qualifications
required to undertake the role effectively.

REQUIREMENTS                                         ESSENTIAL (E) or      MEASURED BY:
The postholder must be able                          DESIRABLE (D)         a) Application
to demonstrate:                                      REQUIREMENTS          Form
                                                                           b) Test/Exercise
                                                                           c) Interview
                                                                           d) Presentation
A high level of expertise in implant dentistry as    E                     a) c)
evidenced by, for example, membership of the
GDC specialist list for oral surgery /
periodontology / prosthodontics / restorative
dentistry; or of the GMC specialist list for oral
and maxillo-facial surgery, with full registration
with the GDC/GMC as applicable

Relevant specialist qualification                    E                     a)

Postgraduate teaching qualification                  D                     a)

Demonstrable experience in restorative implant       E                     a)
dentistry or related field

Experience of teaching health care                   E                     a), c)
professionals, including dentists

Evidence of continuing professional                  E                     a), c)
development

Experience of developing educational                 E                     a), c)
programmes with evidence of creative thinking

Understanding of the specialist educational          E                     c)
needs of dentists

Familiarity with current research related to         E                     c)
implant dentistry

Excellent communication skills, oral written and     E                     a), c), d)
electronic

Proven leadership skills and the ability to          E                     a)
motivate others

Effective team working                               E                     a), c)

Ability to work on own initiative                    E                     d)
Membership of an appropriate professional           E                        a)
indemnity organisation


Short-listed candidates will be required to give a short presentation as part of the interview
process. Further details will be provided once the short-listing has been completed.

Please note: Due to the nature of this role, the successful applicant will be required to
undergo enhanced level Criminal Records Bureau clearance before commencing work with
the University. Clearance obtained via another institution or body cannot be transferred. The
successful applicant will also be required to undergo a Pre Employment Medical Check
before commencing work with the University. This will involve a medical history
questionnaire and may also require an appointment with a member of the University‟s
Occupational Health team.
                                  FURTHER PARTICULARS

In accordance with the national agenda in higher education to modernise pay and grading
structures, the University of Warwick has completed a significant programme of change that
has seen the introduction of a new pay spine and single job evaluation scheme. The work
commenced in September 2004 and was communicated and implemented across the
University in August 2006.

All salaries detailed within this recruitment document are post implementation and will be
subject to normal salary progression as defined by the relevant terms and conditions of
service.

In conjunction with this, the University has now concluded discussions with trade unions and
is now implementing harmonised terms and conditions.

The University

The University of Warwick is arguably the most successful of UK universities founded within
the past half-century, and has earned an outstanding reputation both for research and
teaching. Warwick is comfortably ranked within the top ten of all UK university league
tables. The latest national UK newspaper tables (Times, Guardian, Independent, December
2008) all ranked Warwick in 7th place overall for research based on its performance in the
Research Assessment Exercise.

Founded in 1965 Warwick has been a unique and uniquely successful British university
combining a “can-do” entrepreneurial spirit with a commitment to absolute academic
excellence. Professor Nigel Thrift, Warwick‟s 5th Vice-Chancellor, was appointed in 2006 to
transform the University from a leading university within the UK to become one of the world‟s
top 50 universities by 2015. A new university strategy was launched as a result of extensive
consultation with staff, students and Warwick‟s many external stakeholders, and is making
good progress.

Warwick employs over 5,000 members of staff, of whom 2,400 are academic and research
staff spread across 28 academic departments and 30 research centres; The University's
most recent QAA Institutional Audit in November 2008 resulted in findings of "confidence" in
our management of academic standards and the quality of the learning experience, and a
very positive report. The results of the 2008 Research Assessment Exercise (RAE) again
reiterated Warwick‟s position as one of the UK‟s leading research universities, being ranked
7th overall in the UK (based on multi-faculty institutions). 65% of Warwick‟s research is
„world-leading‟ or „internationally excellent‟, with a quality level of either 3* or 4*. 19 Warwick
Departments were ranked in the top 10 in the UK in their units of assessment and Warwick
achieved a 35% increase in the number of staff selected in RAE 2008, with almost 90% of
staff submitted.

The University of Warwick has a total student population of 17,000 (full-time equivalent) of
whom approximately 11,000 are undergraduates and 7,000 are postgraduates. The
University is an international and cosmopolitan body which is committed to tackling major
global problems through research and teaching. Many of Warwick‟s staff originate or were
educated overseas and almost a third of the total student population comes from over 120
countries outside of the UK.

The University‟s main campus, located on a 400-acre site spanning the south west boundary
of Coventry and the county of Warwickshire has an open and pleasant outlook. The campus
offers excellent sporting facilities, including a swimming pool, a newly refurbished gym, a
climbing wall, an all weather running track and acres of football and rugby pitches. An
indoor tennis centre has recently been opened. The renowned Warwick Arts Centre is one
of the largest outside London with the Mead Gallery showing visiting collections of
contemporary art, a concert hall, two theatres and a cinema. The 1,500 seat Butterworth
Hall reopened in Autumn 2009 following a £6.9 million redevelopment.

The University of Warwick is ideally placed for easy access to London (just over one hour on
the train), close to the picturesque towns of Warwick, Kenilworth and Leamington Spa and
about 45 minutes from the centre of Birmingham. Immediately to the south of the main
campus is rural Warwickshire and both Shakespeare‟s Stratford and the Cotswolds are just
30 minutes away.

The University of Warwick has a turnover approaching £350 million. The University
continues to invest heavily in its campus infrastructure and environment and current
developments include a multi million pound extension and redevelopment of the Students‟
Union building, a new Clinical Trials Unit for Warwick Medical School and a £2 million refit of
our Chemistry teaching labs.

The state-of-the-art £50 million Warwick Digital Laboratory‟s foundation stone was laid by
Prime Minister Gordon Brown in May 2007 and he returned to formally open the building in
2008.

Further details about the University of Warwick can be found at http://www.warwick.ac.uk

The Managerial and Administrative Structure of the University

The University‟s administrative and managerial structure is headed by the Vice-Chancellor,
supported by the Deputy Vice-Chancellor (this position is vacant at the present time), the
Registrar, the Deputy Registrar and the Finance Director. However, as with all such
structures, the informal lines of decision making and the sharing of responsibility for planning
and strategy flatten the hierarchy. Institutional level decisions are initially made by a group
comprising academics and administrators who form the Senate Steering Committee which
operates much along the lines of a weekly cabinet for the University.

The Registrar, Mr Jon Baldwin, is responsible for the administration of the University and is
supported in this task by a team of Senior Officers, each of whom is responsible for a key
area and associated offices of University administration: the Academic Registrar, the Estates
Director, the Director of Human Resources and Commercial Activities, the Director of IT
Services, the Director of Development, Communication and Strategy, and the University
Librarian. A number of office heads and directors report in turn to these Senior Officers. To
ensure overall co-ordination between and across the University‟s administration, all
administrative posts within academic departments have a “dotted line” reporting to the
University Registrar as well as the Department in which they are based.

Warwick Medical School (WMS)

Acting Dean WMS: Professor Martin Underwood, MD FRCGP

The Medical School at Warwick was established in 2000 as part of an expansion in the
number of Medical School‟s nationally to deliver the additional capacity needed to support
the Government‟s plan to increase the number of UK trained medical graduate‟s joining the
NHS.

In its first RAE submission WMS was ranked 10th for Health Services Research and 19th for
Other Hospital Clinical Subjects. This is an excellent result for a new medical school. Our
aim is to be rate in the top 5-10 in each unit of assessment in the forthcoming Research
Excellence Framework.

The School is organised in three Institutes, the Institute of Clinical Education (ICE) which is
the base for all the School‟s educational programmes, the Clinical Sciences Research
Institute (CSRI), home for our biomedical and acute hospital-based research groups, and
Health Sciences Research Institute (HSRI) which focuses on research in the community-
based clinical disciplines.

The School‟s principal clinical partners are University Hospitals Coventry and Warwickshire
NHS Trust (UHCW), the George Eliot Hospital NHS Trust, South Warwickshire General
Hospitals NHS Trust, Coventry Teaching Primary Care Trust and the other Primary Care
Trusts within Warwickshire. Additional clinical placements are provided by Worcestershire
Acute Hospitals NHS Trust, Worcestershire Mental Health Partnership NHS Trust and by a
number of general practices throughout the West Midlands. At UHCW, a state of the art PFI
hospital provides an optimal environment to support both research and education at the
Trust. The Clinical Sciences Building and the Clinical Sciences Research Institute are based
on the UHCW site and provide a base for education and laboratory research for the Medical
School.

The Medical School‟s research is focused around a number of multi-disciplinary and cross-
specialty teams; collaboration within and outside School and University is encouraged and
investigators are encouraged to work across traditional disciplinary boundaries in innovative
ways.

WMS works closely with many departments across the University for both our research and
education programmes; these include the Department of Biological Sciences, the School of
Health and Social Studies, the Department of Sociology, the Department of Statistics,
Warwick Business School, Warwick Manufacturing Group, Complexity Science, Centre for
Systems Biology, the Law School and the Department of Mathematics.

Institute of Clinical Education (ICE)

The Institute of Clinical Education has three core functions delivering undergraduate medical
education, postgraduate education including research degrees, and research on
clinical/health professional education. Professor Jill Thistlethwaite, the Director of the
Institute, leads a team comprising three directorates covering specific portfolios. These are
the Directorate for Masters-level Accredited Courses and continuing professional
development (Director: Dr Adrian Stokes); the Directorate for MBChB Graduate-entry course
(Director: Dr Jane Kidd), and the Directorate for Research Degrees (Director: Dr Frances
Griffiths). The Director of Quality Assurance, Dr Paul O‟Hare, has a remit across all areas of
the Institute. Professor Neil Johnson, as Associate Dean for teaching, has an overarching
role across this Institute.

WMS is very active in the provision of postgraduate and continuing professional
development programmes. The university has a long history of involvement in postgraduate
medical education and CPD for health professionals, particularly in the fields of diabetes
(Warwick Diabetes Care), community child health, health information science and sexual
health. Postgraduate provision has been consolidated, strengthened and expanded through
the formation of the medical school.

The school provides a number of entry routes into postgraduate study. Students can initially
register for our flexible master‟s programme in health sciences which allows students to
select their own combination of modules from the wide range on offer to build sufficient credit
for the award of a master‟s degree. We also offer masters programmes in diabetes, public
health, implant dentistry, child health, sexual and reproductive health, orthopaedics,
philosophy and ethics of mental health, palliative care, medical education, and health
services management. We offer short courses both accredited and non-accredited in areas
such as diabetes care, occupational health, and clinical systems improvement.
Collaborations with other departments include the Postgraduate Diploma in Regulatory
Occupational Health and Safety for HSE Inspectors.

The Institute is developing a number of strands of research in clinical education. Particular
areas of interest are clinical and communication skills education, values-based practice,
interprofessional education, patient involvement and service improvement, professionalism
and the professional development experiences of health professionals.

The undergraduate MB ChB course at Warwick is a four-year graduate entry programme
which requires entrants to already have a first degree in biological sciences or a similar
subject. The initial element of the course (Phase 1) lasts for 18 months and provides a
foundation in the clinical and social sciences with some elements of clinical experience. This
is followed by Phase 2 which is organised as a series of clinical placements in local NHS
organisations, including four local hospitals and 30 local practices, lasting for 36 months.
The annual intake to the MB ChB programme is 164 home students and 14 overseas
students and the vast majority of our students‟ progress to foundation training posts in local
West Midlands NHS Trusts following their graduation.

The MB ChB course is based in the purpose-designed medical teaching building. Dr Jane
Kidd is Reader in Communication Studies, and Director of Undergraduate Education,
working closely with Dr Philip McTernan, who co-ordinates Phase 1 teaching, and Dr Colin
MacDougall, the Phase 2 co-ordinator. Dr Vinod Patel is Reader in Clinical Skills: the
curriculum places emphasis on the horizontal integration of clinical skills teaching with
communication skills as well as the vertical integration of early learning and patient contact
with later Phase 2 teaching (it is for this reason that clinicians are involved in the Phase 1
teaching alongside their basic scientist colleagues). Ms Deborah Markham (FRCS), and Dr
Mandy Barnett are Associate Clinical Professors in Medical Education, and Dr Ann Jackson
is Associate Professor in Interprofessional Education. Professor Peter Abrahams as
Professor of Clinical Anatomy is developing integrated clinical anatomy teaching across
clinical specialities. Dr David Davies is Reader in E-Learning. The School is very active in
the International Virtual Medical School (IVIMeds) collaboration.

At Warwick Medical School particular emphasis is placed on developing professionalism in
medical education. Professor Bill Fulford and colleagues in Philosophy of Mental Health
have been developing the concepts of values-based practice, working to provide doctors and
medical students with a system of decision support which considers the values of patients
and colleagues and which works in a way complementary to evidence-based practice.

Community education comprises learning in general practices across Coventry and
Warwickshire PCTs and beyond. An active network of practices, GP tutors, and practice
teachers is involved with undergraduate students throughout their course. There are 10 GP
Senior or Principal Clinical Fellows in Medical Education employed at WMS and three GP
Associate Clinical Professors. Interprofessional learning is an active partnership with
University of Coventry and Faculty Development is led by a learning and teaching specialist.

A recent collaboration sees Best Evidence Medical Education (BEME) establishing on the
Warwick Medical School site under the leadership of Professor Marilyn Hammick.

The Health Sciences Research Institute

Director – Professor Sarah Stewart-Brown

The Health Sciences Research Institute comprises the disciplines of public health, primary
care, statistics, health economics and rehabilitation as well as the medical specialities of
general practice, psychiatry, emergency medicine and community child health. It includes
Warwick Clinical Trials Unit (CTU) which supports intervention trials throughout the Medical
School. Warwick CTU has recently relocated to a new building on the Gibbet Hill campus;
the building received funds from the Science City Initiative.

The Institute has strong links with the NHS through the local Primary Care Trusts, the West
Midlands Deanery and the Regional Public Health Office. It also has strong links with the
Clinical Sciences Research Institute and Institute of Clinical Education, with other Warwick
University Departments, particularly the School of Health and Social Studies, and with local
Universities including Leicester, Coventry and Birmingham.

The Institute‟s research programme covers new and emerging areas of health research and
key health priorities. At present there are three main research groups: - one of which covers
public health, epidemiology, psychiatry, child health, knowledge management evidence and
e-health, particularly the role of the internet in healthcare; the second primary care, primary
secondary care interface and health care systems; and the third clinical trials with a focus on
emergency care, rehabilitation and cancer. The three groups are closely integrated and
members work collaboratively across all three groups. Key research topics include:

      Cardiovascular disease and diabetes risk factors and preventive programmes
       including promotion of physical activity and healthy eating, prevention of obesity in
       children and adults, prevention of hypertension and screening for
       hypercholesterolemia and the emerging and the burden of cardiovascular disease in
       developing countries.
      Public mental health including the impact of life course determinants, social
       inequalities and the built environment, aetiology and risk factors, links with physical
       health and preventive interventions.
      Emergency care, rehabilitation and prevention of injury and musculoskeletal
       problems.
      Management of chronic illness with a focus on decision making and patient
       involvement.
      Cancer prevention and management.
      Applied and health services research
       E- Health: the use of electronic media to promote and monitor health
      Knowledge management; technology assessment and appraisals for NICE as part
       of Warwick‟s new Technology Appraisals Review (TAR) Team, evidence production,
       diffusion and use in health care

Warwick Clinical Trials Unit (WCTU)
Director: Professor Sallie Lamb

Currently within the Health Sciences Research Institute, the Warwick Clinical Trials Unit
(WCTU) was formally established in 2005, and provides support to randomised clinical trials
undertaken in Warwick Medical School as well as working with a range of internationally
excellent external collaborators. The unit received full registration status from the UKCRC in
November 2007 and has been awarded research grants in excess of £20m since 2005.

WCTU has an interdisciplinary, collaborative approach, with expertise in trial design and
methods, including design of trials in complex interventions, sequential trials, longitudinal
data analysis, missing data and questionnaire design and analysis. WCTU has excellent
links to academic networks in diabetes, emergency care, intensive care, rehabilitation,
stroke, primary care, mental health and cancer. The staff are multi-disciplinary, and include
several internationally recognised investigators. Standard Operating Procedures cover the
full range of activities associated with managing clinical trials from inception to publication.

Our internal research programme covers three areas emergency/critical care, rehabilitation
and cancer. The trials are generally Phase III studies of either complex or pharmacological
interventions, and most have a parallel and substantial economic evaluations running
alongside them. The main funder is the National Institute of Health Research Health
Technology Assessment Programme. In addition members of the CTU have been involved
in economic modelling and systematic reviewing, and have provided substantial input and
support to the recently secured Technology Appraisal Review contract from the NIHR HTA.
There is a strong commitment to methodological research in statistics, trial design and
economics.

Clinical Sciences Research Institute (CSRI)

The Clinical Sciences Research Institute (CSRI) of WMS is a centre for research into
strategic areas of human health. Professor John Davey, the Director of the CSRI, oversees a
research strategy that ranges from molecular and cellular biology to patient-orientated
physiological approaches and is based around the major research themes of Metabolic
Health (including diabetes, obesity, cardiovascular medicine and endocrinology),
Reproduction (reproductive biology and reproductive medicine), Orthopaedics and Clinical
Effectiveness. CSRI has 35 full-time academics, ~20 research fellows, ~15 postdoctoral
fellows and ~45 postgraduate students working in new, purpose-built laboratories equipped
with the latest instrumentation. There are more than 60 externally-funded projects external
currently underway at CSRI, with a total value exceeding £8.7 million. WMS signed a
strategic partnership agreement with the Medical Research Council in 2007, the first new
medical school to do so. This has already resulted in a Strategic Chair appointment and a
new Doctoral Training Centre with the Department of Biological Sciences.

CSRI is sited at the recently completed University Hospital of Coventry and Warwickshire
(UHCW), providing an interface for patient-orientated research. Translational Medicine is a
key element in our research approach and we have recently developed a major collaboration
with the University of Birmingham under the Science City initiative and funded by the
Advantage West Midlands.

Further     information     about    research         at     CSRI      is     available     at
http://www2.warwick.ac.uk/fac/med/research/csri

Metabolic Health
Obesity, Type-2 diabetes and hyperglycaemic damage
The mechanisms relating obesity to the major associated pathologies (type-2 diabetes,
cardiovascular disease) are being studied using multi-disciplinary approaches. The neural
circuits involved in the regulation of body weight and satiety are being studied by the
neurophysiology group (led by Prof D Spanswick). The work of Prof S Kumar is aimed at
discovering the mechanisms that link sub-clinical inflammation, the development of obesity
and the aetiology of tye-2 diabetes. The effects of insulin on adipose tissue function are
being studied to elucidate mechanisms through which the hyperinsulinaemia of the pro-
diabetic state affects adipokine secretion (Dr P McTernan and Dr G Tripathy). The
enzymology of the pathways of fatty acid metabolism in the aetiology of insulin resistance is
being studied by the group of Prof V A Zammit. The effects of the hyperglycaemia that
accompanies poorly controlled diabetes on protein modification are studied by Prof P
Thornalley and his group, which specialises in the use of mass spectrometry in the study of
protein damage and impaired insulin signalling in a programme of research shared with
Systems Biology.

Clinical studies are being conducted into the molecular basis of the monogenic forms of
diabetes, the phenotype of LADA in Indo-Asian type-2 diabetic patients, and the effects of
different treatments for type-2 diabetes on clinical outcomes, and the role of ethnicity in
determining these outcomes. The UK Asian Diabetes Study investigates novel approaches
to delivering care for Indo-Asian diabetic patients. There are links to several NHS partners,
clinical and academic centres worldwide. A Centre of Excellence in Diabetes Research and
Education (WISDEM) has been established within the new hospital.

Cardiovascular Medicine and Epidemiology
The main research interests of CSRI in this field are the prevention, detection and
management of hypertension and its complications, and the epidemiology of cardiovascular
disease and stroke. The relationships between nutrition, metabolic abnormalities and
cardiovascular risk, including risk assessment in ethnic minorities, both in developed and
developing countries are being studied by the group led by Prof F P Cappuccio, with
particular emphasis on the role of inflammation and immunity in cardiovascular disease in
entire populations. Work leading to the identification of novel biochemical markers for
cardiovascular risk are being led by Dr M Miller, as part of large studies (e.g. Whitehall II,
Olivetti). Epidemiological studies are performed locally within the Midlands, and
internationally. International cardiovascular health studies on the role of high salt- intake in
raised blood pressure in rural communities are being performed on cohorts in Western
Africa. There are close interactions with epidemiological and public health research
performed within the Health Sciences Research Institute (HSRI) of the School.

Prof Cappuccio‟s group also has a major interest in the interaction between sleep and the
development of obesity and cardiovascular disease, particularly as they impinge on other
metabolically active factors such as sub-clinical chronic inflammation.

Microvascular research (led by Prof D R Singer) is exploring why patients with high blood
pressure and other cardiovascular risk factors have impaired function of small arteries and
fewer capillaries than normal (rarefaction). Recent imaging and protein- characterization
studies have shown how oxidant stress can prevent normal activity. Protein-carbohydrate
and protein-protein interactions that underpin immune function and virus-host interactions as
they relate to the oligosaccharide binding properties of specific endothelial cell surface
proteins are studied by Dr D Mitchell (RCUK Fellow).

Molecular Medicine and Endocrinology
The major interests in endocrinology within the CSRI are centred on the structure-function
relationships of hormone receptors, and mechanisms of signal transduction. The role of
central and peripheral orexin, adiponectin and ghrelin action in body weight regulation and
insulin sensitivity are studied by the group led by Dr H Randeva. The signal transduction
mechanisms, and particularly the activation and subcellular localisation of the protein
kinases, involved in the action of corticotropin releasing hormone (CRH) are studied by Prof
D Grammatopoulos. These studies have strong links with those being performed on the
regulation of G-protein signalling as part of the Reproductive Health programme.

Clinical studies are being performed into the pathogenesis of endocrine tumours and the
relevance of the expression of the telomeric complex as an indicator of malignancy
particularly of endocrine tumours.

Reproductive Health
Within this programme, which is under the overall leadership of Prof S Thornton, two major
lines of research are followed; Obstetrics and Reproductive Medicine.

Obstetrics
Obstetrics research at CSRI predominantly aims at understanding the fundamental principles
controlling myometrial (uterine) contractility and the associated pathologies of pre-term labour,
pre-eclampsia and dystocia. Members of the preterm labour group have research interests
that range from basic science through translational medicine to clinical trials. Micro-genomic
strategies are used to correlate differential patterns of gene expression in different cells and
regions of the uterus with myometrial physiology, with particular reference to the spatial
expression of proteins within myocytes.          Using cells isolated by laser-capture micro
dissection (LCM) from frozen sections of human myometrium followed by single-cell PCR
analysis, the heterogeneity of the uterine cell population with respect to the expression of the
oxytocin receptor and different ion channels and transporters within individual cell-types have
been studied. These experimental data are used to generate mathematical models of the
contractile function of the uterus under conditions associated to pre-term labour (Prof S
Thornton and Dr A Blanks). The role of voltage-gated L-type Ca2+ channels in uterine
contractility in human uterus is being delineated by Dr A Shmygol who is also interested in the
physiology of uterine interstitial cells.
The interactions with the Molecular Medicine and Endocrinology group focus on the study of
the role of Urocortin II (UCN II) and its interaction with type-2 corticotropin-releasing
hormone-receptor (CRH-R2) in myometrial contractility by Prof D Grammatopoulos. In
addition, using a yeast model system to study G-protein coupled receptors (as exemplified
by CRH) combined with mathematical modelling, Dr G Ladds is studying dimerisation of G-
protein-coupled receptors (GPCRs), and the specificity of GPCR-G and G-RGS
interactions.      The pathogenesis of placental dysfunction, with reference to intrauterine
growth retardation (IUGR) and pre-eclampsia, is studied by the group of Dr M Vatish, using
human tissue, cell lines and a transgenic mouse model of pre-eclampsia. The work aims to
identify GPCRs involved in determining placental vascularisation, and the relationship with
foetal nutrition and maternal hypertension.

Clinical studies include on the use of Electromyography (EMG) in the diagnosis and
management of term and preterm labour, and the role of drugs to prevent premature
delivery. This has included the setting up by Prof S Thornton of the national Preterm Labour
Network, which includes most UK teaching hospitals, and assesses clinical trial proposals
for submission to major national funding bodies including the MRC. Other clinical trials are
being conducted with the pharmaceutical industry.

Reproductive Medicine
This research investigates mechanisms underlying human infertility. There is an extensive
programme of work aimed at understanding egg- and sperm-formation, fertilisation and
embryo development (Dr G Hartshorne and Dr S Keay). In particular, a programme of work
aimed at identifying competent embryos is being pursued with the aim of establishing
procedures that will allow fewer embryos to be transferred during IVF treatment, so
minimising the possibility of multiple pregnancies. A particular area of investigation involves
quantifying the control of male- and female-derived genes at fertilisation which is important in
understanding genetic diseases arising from „imprinting disorders‟ that may possibly arise
from abnormal sperm- or egg-formation. Other research into reproductive genetics is aimed
at understanding the impairment of fertility and poor pregnancy-outcomes. For example, an
EC-funded network of 52 research groups, co-ordinated from Warwick, is developing
methods for detecting chromosome disorders, such as Downs Syndrome, using blood from
mothers in early pregnancy.

Trauma and Orthopaedics
Prof D Griffin leads a multidisciplinary orthopaedic team at CSRI, comprising scientists and
surgeons who collaborate with statisticians, methodologists, health economists and trial
managers. They have particular expertise in the design of large national and international
studies that investigate the clinical effectiveness of particular interventions e.g. in the
treatment of heel fracture and Achilles tendon rupture.         The development of new
orthopaedic technologies is coupled with clinical and cost-effectiveness assessment to
ensure health- and socio-economic gains from these new developments.

Professors at Warwick Medical School

Clinical Professors
The current clinical professors at the University of Warwick are Martin Underwood [Primary
Care Research & Acting Dean of WMS], Neil Johnson [Medical Education & Associate Dean
(Teaching)], Sudhesh Kumar [Medicine, Diabetes and Metabolism & Associate Dean
(External Affairs)], Steve Thornton [Obstetrics & Associate Dean (Clinical Research)], Sarah
Stewart-Brown [Public Health & Director of the Health Sciences Research Institute], Jill
Thistlethwaite [Clinical Education and Research & Director of ICE], Francesco Cappuccio
[Cardiovascular Medicine and Epidemiology], Matthew Cooke [Emergency Medicine &
Clinical Systems Improvement], Jeremy Dale [Primary Care], Bill Fulford [Philosophy &
Mental Health], Fang Gao-Smith [Anaesthesia Critical Care & Pain], Damian Griffin [Trauma
& Orthopaedic Surgery], Simon Murch [Paediatrics & Child Health], Chris Poole [Oncology],
Donald Singer [Clinical Pharmacology], Swaran Singh [Social and Community Psychiatry]
and Scott Weich [Psychiatry].
Professor Siobhan Quenby [Obstetrics] is due to join WMS on 1st February 2010.

Non-Clinical Professors
The non-clinical professors are John Davey [Cell Biology, Associate Dean (Biomedical
Research) & Director of CSRI], Peter Abrahams [Anatomy], Jane Barlow (Public Health in
the Early Years], Colin Blakemore, Janet Dunn [Cancer Clinical Trials], Martin Feelisch
[Experimental Medicine], Dimitris Grammatopoulos [Molecular Medicine], Geraldine
Hartshorne [Professorial Fellow], Sallie Lamb [Rehabilitation & Clinical Trials], David
Spanswick [Molecular Neurosciences], Peter Spurgeon [Health Services Management],
Nigel Stallard [Medical Statistics], Ala Szczepura [Health Services Research], Paul
Thornalley [Systems Biology], Margaret Thorogood [Epidemiology], and Victor Zammit
[Molecular Biochemistry].

We are currently recruiting to a Professor of Pathology, Professor of Surgery and Professor
of Clinical Imaging (all Clinical Professorships).
Recruitment of Ex-Offenders Policy
(Developed in line with the CRB Disclosure information pack, part DIP011)

This Policy applies to all staff recruitment at the University of Warwick.

As an organisation using the Criminal Records Bureau (CRB) Disclosure service to assess applicants‟
suitability for positions of trust, the University of Warwick complies fully with the CRB Code of Practice
and undertakes to treat all applicants for positions fairly. It undertakes not to discriminate unfairly
against any subject of a Disclosure on the basis of a conviction or other information revealed.

The University of Warwick is committed to the fair treatment of its staff, potential staff or users of its
services, regardless of race, gender, religion, sexual orientation, responsibilities for dependants, age,
physical/mental disability or offending background.

Our written policy on the recruitment of ex-offenders is made available to all applicants at the outset of
the recruitment process.

We actively promote equality of opportunity for all with the right mix of talent, skills and potential and
welcome applications from a wide range of candidates, including those with criminal records. We
select all candidates for interview based on their skills, qualifications and experience.

A Disclosure is only requested after a thorough risk assessment has indicated that one is both
proportionate and relevant to the position concerned. For those positions where a Disclosure is
required, all application forms, job adverts and recruitment briefs will contain a statement that a
Disclosure will be requested in the event of the individual being offered the position.

Where a Disclosure is to form part of the recruitment process, we encourage all applicants called for
interview to provide details of their criminal record at an early stage in the application process. We
request that this information is sent under separate, confidential cover, to a designated person within
the University of Warwick and we guarantee that this information will only be seen by those who need
to see it as part of the recruitment process.

Unless the nature of the position allows the University of Warwick to ask questions about the
applicants entire criminal record, we only ask about „unspent‟ convictions as defined in the
Rehabilitation of Offenders Act 1974.

We ensure that all appropriate staff in Personnel Services at the University of Warwick who are
involved in the recruitment process have been suitably trained to identify and assess the relevance
and circumstances of offences. We also ensure that they have received appropriate guidance in the
relevant legislation relating to the employment of ex-offenders, e.g. the Rehabilitation of Offenders Act
1974. Line managers are advised who to approach for support on these issues.

At interview, or in a separate discussion, we ensure that an open and measured discussion takes
place on the subject of any offences or other matter that might be relevant to the position. Failure on
the part of the applicant to reveal information that is directly relevant to the position sought could lead
to withdrawal of an offer of employment.

We make every subject of a CRB Disclosure aware of the existence of the CRB Code of Practice and
make a copy available on request.

We undertake to discuss any matter revealed in a Disclosure with the person seeking the position
before withdrawing a conditional offer of employment.

We do not accept Disclosures transferred from other organisations and do not supply Disclosures
requested by us to any external organisations.

				
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