BIO:6973 - Bacterial Pathogenesis
Tues and Thur - 2:00-3.15
Janakiram Seshu, Ph.D.
Office: BSE 3.230
Phone: (210) 458-6578
Office hours: By appointment
Course Description: The purpose of this course is to have a broad understanding of the
molecular mechanisms adopted by bacterial pathogens to establish disease within the
context of a robust anti-bacterial response from the host. Structural and functional aspects
of above molecular interactions will be emphasized along with cutting edge tools and
strategies employed to dissect these interactions. This course will also examine where the
current boundaries of the field are by discussing a seminal paper that establishes a novel
trend in the various topics that will be discussed. This will be a fast moving course.
Significant student participation is a must.
Text: Bacterial Pathogenesis-A Molecular Approach by Abigail A Salyers and Dixie D.
Whitt- 2nd Edition ASM Press. Several online retailers have this book for around $40 –
Course Requirements: This course covers a lot of material and moves quickly. Each
student is expected to attend all classes, study the assigned chapter/review or paper before
it is presented. Class participation is an important component of this course and answers
to several questions are arrived by consensus.
Exams and Grading: Three take-home exams (more like QEs’), one oral presentation
and class participation will be used as a measure to assign grades.
Jan 13: Organizational Meeting
Jan 15: Introduction to Bacterial Infections-Methods and Models
Jan 20: Immune Response and Bacterial Infections
Jan 22: Vaccines and Vaccination Strategies
Jan 27: Evasion Strategies against Host Response
Jan 29: Toxins
Feb 3: Antimicrobial Compounds
Feb 5: Bacterial Secretion Systems-1
Feb 10: Bacterial Secretion Systems-2
Feb 12 Molecular Basis of Resistance to Antimicrobials
Feb 17 EXAM 1
Feb 19: Molecular Basis of Spirochetal Infections
Feb 24: Current Trends in Molecular Pathogenesis of Yersinia
Feb 26: Molecular Basis of Staphylococcal Infections
Mar 3: Molecular Basis of Streptococcal Infections
Mar5: Pseudomonas and Cystic Fibrosis
Mar17: Current Trends in Molecular Pathogenesis of Bordetella
Mar 26: EXAM 2
Mar 31: Current Trends in Anthrax Research
April 2: Biology and Prophylaxis of Chlamydial spp.
April 7: Salmonellosis-Molecular Basis of Persistance
April 9: Legionella and Listeria- Motility and Pathogenesis
April 14: Current Trends in Molecular Pathogenesis of Vibrio cholerae
April 16: Current Trends in Molecular Pathogenesis of Biothreat agents
April 21: Current Trends in Molecular Pathogenesis of Neisseria spp.
April 23: Enteropathogenic E.coli
April 23: Other enteric pathogens
April 29: Post-Genomic Tools for Studying Bacterial Pathogenesis
May 4: FINAL EXAM and Oral Presentations