Low Dose Naltrexone (LDN) LDN Not Suitable
Doctors who have trained in LDN can not be taken with immunosuppressive
NaProTECHNOLOGY fertility treatment often drugs such as steroids, methotrexate or interferon. Naltrexone
recommend Low Dose Naltrexone (LDN) as part of In addition, if you mix LDN with OPOID based
the overall treatment programme to help couples pain relieving medications you can become acutely Treatment of Endorphin Deficiency
with infertility or recurrent miscarriage. ill with persistent vomiting lasting up to 48 hours.
Patients that are most likely to benefit from You should stop LDN the day before any surgery
treatment are those with and recommence 24 hours after discontinuing pain
1. Premenstrual symptoms lasting for 4 or relieving medication after surgery. If you have poor
more days each cycle liver or Kidney function you cannot take LDN.
2. Endometriosis or PCOD
3. Persistent Brown menstrual bleeding Finally
4. Persistent fatigue
5. Sleep disturbance Naltrexone is not licensed as a treatment for
6. Low mood infertility or autoimmune conditions. This means
7. Excessive Anxiety that further research is needed to confirm its
8. Personal or Family history of efficacy for these conditions. It is unlikely to be
Autoimmunity – MS, Rheumatoid widely used until proper clinical trials are
Arthritis, Insulin dependent Diabetes, conducted and published in peer reviewed medical
Underactive Thyroid, etc… journals. Until that time the medical community
must regard LDN as an experimental treatment.
The majority of people taking LDN have few or no
side effects. About 5% of patients cannot tolerate
LDN at all and it must be discontinued. 1. Chapter 41, “The Medical and Surgical Practice of
If you do experience mild side effects they usually NaProTECHNOLOGY” Pope Paul VI Press, Omaha,
subside after 2 weeks of treatment. NE, USA.
Typical side effects include 2. Natural Procreative Technology as explained in
“The Medical and Surgical Practice of
· Sleep disturbance NaProTECHNOLOGY” Pope Paul VI Press
· Vivid Dreams 3. Is Endometriosis an Autoimmune Disease? Gleicher
N, El-Roeiy A et al, Obstet Gynecol. 70: 115-121, 1987 www.fertilitycare.net
4. Polycystic Ovary Syndrome as an Autoimmune
· Headache Disease: A New Concept. Ali AFM, Fateen B, et al www.lowdosenaltrexone.org
· Dry mouth Obstet Gynecol 95:48S, 2000
Original Licensed use Naltrexone has been shown to dramatically
improve severe premenstrual symptoms and
Naltrexone is licensed as a treatment for alcoholics increase fertility rates as well as reduce the
and drug addicts. It is an opioid receptor antagonist likelihood of miscarriage, when used as part of a
and blocks endorphin receptors to prevent them comprehensive NaProTECHNOLOGY2
fertility programme as in Dr. Hilgers practice.
If somebody is addicted to alcohol, heroin or Naltrexone has also been given safely during
morphine it is because these substances stimulate pregnancy at a dose of 50mg daily without
the endorphin receptors to give a “Rush, Buzz or causing any adverse effect to either mother or
Kick”. This effect does not occur if a patient has baby.
taken Naltrexone because the receptors are
blocked. In this way patients with addictions can Dr. Bernard Bahari, a Neurologist and
be helped to break their habit. Immunologist based in New York, has found
that Naltrexone can also be used to treat patients
with AUTOIMMUNE diseases such as Multiple
New Unlicensed use – Endorphin Sclerosis, Rheumatoid Arthritis, Crohns Disease,
If you block the endorphin receptors at night
Two doctors working independently of each the body responds by giving an increased natural Dr. Bahari has a group of over 200 patients with
other in the USA have been using Naltrexone as endorphin surge the following day. Dr. Hilgers MS that have not had any progression of their
a treatment to stimulate the body’s endorphin has shown through his research efforts that a disease since commencing Naltrexone. Some
system and cause an increased endorphin surge single night time dose of Naltrexone will patients have been on treatment for 20 years.
to treat a number of different “Endorphin- increase endorphin levels the following day (See Dr. Bahari uses a low dose of Naltrexone (LDN)
Deficiency states”. Below.). – ranging from 1.5 to 4.5mg nightly and has
found this to be very effective to improve
Dr. Thomas Hilgers, a Professor in Obstetrics endorphin levels and halt the autoimmune
and Gynaecology from Creighton University, disease process.
Omaha, Nebraska has used Naltrexone since
1990 to enhance the natural Endorphin surge The Common link
and improve fertility rates in his Infertility Interestingly a number of conditions that cause
Treatment programme. It has been known for infertility have been shown to have a possible
some time that endorphin deficiency will result autoimmune3,4 component. So the positive effect
in reduced fertility and that improving of treating endorphin deficiency related to
endorphin levels can improve fertility1. Beta Endorphin levels following Naltrexone treatment
infertility may be through improving immune
Dr. Hilgers, Ch 29 Med & Surg Principles of NPT.