SUPERPRO DESIGNER EXAMPLE by yaoyufang

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									SUPERPRO DESIGNER
     EXAMPLE
SYNTHETIC PHARMACEUTICAL
         SPhr6-0f
PFD – PRODUCT SYNTHESIS
        SECTION




• INCLUDES 2 CSTRs AND ONE
  NUTSCHE FILTER
    PFD – ISOLATION AND
   PURIFICATION SECTION




• INCLUDES ONE MORE CSTR AND
  REUSES THE FIRST NUTSCHE FILTER
 PFD – FINAL PURIFICATION
 AND PRODUCT FINISHING
          SECTION




• INCLUDES ONE MORE NUTSCHE
  FILTER AND A TRAY DRYER
   FIRST REACTION STEP
         P-1/R-101
• GAS Cl2 REACTS WITH QUINALDINE
  (Q) IN CCl4 SOLUTION TO FORM
  CHLOROQUINALDINE (ClQ)
• HCl REACTS WITH SODIUM
  CARBONATE TO FORM NaCl AND
  THEN WITH ClQ TO FORM A SALT
  (ClQ.HCl)
• RESULTING ORGANIC AND WATER
  PHASES ARE SEPARATED
FIRST REACTION STEP
      P-1/R-101
  SECOND REACTION STEP
        P-3/R-102
• TAKES PLACE IN 2nd REACTOR USING
  AQUEOUS STREAM
• NaOH IS ADDED TO RECOVER THE ClQ
  FROM THE ClQ.HCl
• HYDROQUINONE (HQ) IS ADDED TO
  FORM A SALT WITH THE NaOH (HQ.Na)
• THIS SALT REACTS WITH THE ClQ TO
  FORM THE PRODUCT
SECOND REACTION STEP
      P-3/R-102
  FIRST FILTRATION STEP
• PRODUCT AND IMPURITY ARE SOLIDS
  THAT ARE 90% RECOVERED WITH THE
  NUTSCHE FILTER.
• PROCESS TAKES 5.4 HR USING A
  FILTRATE FLUX OF 200 L/m2-HR
THIRD REACTION STEP
 SECOND FILTRATION STEP
• IMPURITY SOLIDS ARE REMOVED
  WITH THE NUTSCHE FILTER.
• PROCESS TAKES 3.5 HR USING A
  FILTRATE FLUX OF 200 L/m2-HR
FOURTH REACTION STEP
  THIRD FILTRATION STEP
• SOLID PRODUCT IS 90% RECOVERED
  WITH THE NUTSCHE FILTER.
• PROCESS TAKES 4.8 HR USING A
  FILTRATE FLUX OF 200 L/m2-HR
   FIFTH REACTION STEP
• THIS STEP PUTS THE PRODUCT INTO
  A SOLUTION WITH ISOPROPANOL AND
  THEN USES ACTIVATED CARBON TO
  DISCOLOR THE SOLUTION
• PROCESS TAKES 17.6 HR
 FOURTH FILTRATION STEP
• LIQUID PRODUCT IS SEPARATED
  FROM THE CARBON WITH THE
  NUTSCHE FILTER.
• PROCESS TAKES 14.8 HR USING A
  FILTRATE FLUX OF 200 L/m2-HR,
  WHICH INCLUDES A HOLD TIME OF
  10.4 HR
   SIXTH REACTION STEP
• THIS STEP CRYSTALLIZES 97% OF
  THE PRODUCT TO FORM PROD.CRYST
• PROCESS USE 2 x 12.1 HR CYCLES
       FINAL FILTRATION
• SOLID PROD-CRYST IS 90%
  RECOVERED USING THE SECOND
  NUTSCHE FILTER.
• PROCESS HAS 2 x 12.1 HR CYCLE
  USING A FILTRATE FLUX OF 50 L/m2-
  HR, WHICH INCLUDES A HOLD TIME
  OF 8.5 HR
            DRYING
• PRODUCT CRYSTALS ARE DRIED IN A
  TRAY DRYER.
• PROCESS USES 2 x 12.1 HR CYCLES
  AND A 3.2 HR HOLD PERIOD TO
  SYNCHRONIZE WITH THE PREVIOUS
  STEPS
• BATCH YIELD IS 246 kg

								
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