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Discover Discover at VCU at VCU

VIEWS: 13 PAGES: 37

  • pg 1
									                                                                    O
                        Naph                   O                    S O               Naph
                               N       H                             O
                                                                          H       N
                        S                                                               S
                               N       H                                  H       N
                                               O                     O
                                                        NH
                                           O       S                S O
                                               O S                   O
                                                         NH
                                   O                                          O
                                                O       Na+         O
                                                    O       O




              Discover
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                                                        N           N




  6                                            53                                                         39

C        H
          1
                E                              I                              S
                                                                                  16
                                                                                                T        Y
12.011              M                      126.90                                                    R   88.90




                                               VCU
                                               VCU
         1.00                                                                 32.06




                        at



                                                                                             10 nm
                      VCU Facts
• More than 32,000 students, > 2000 faculty
• Located in historic Richmond, the capital since 1779
• Population of Richmond metropolitan area: > 1.2 million
• Over 200 million in sponsored research funding
• VCU occupies 174 buildings; over 140 acres
• Medical, Dental, Pharmacy Schools

• Now offers two new interdisciplinary Ph.D programs in
  Nanoscience and Chemical Biology

• Now has a new Nanomaterials Characterization Center
           VCU Chemistry Facts
• 17 research active faculty
• ~ 70 graduate students
• Location: T. Edward Temple Building and Oliver Hall-
  Physical Sciences
• Focus areas in: Biological/Biophysical, Analytical,
  Inorganic, Physical, and Organic Chemistry, Chemical
  Physics, and Materials/Nanoscience
• Home of Nobel Laureate John Fenn
                       The Faculty
•17 Tenure-track faculty
•10 Collateral faculty (5 teaching, 3 research support, 1 research).
•12 were hired (8 TT) in last 8 years (nearly 50%).

   14 of 15 TT faculty are PI’s (12) or Co-PI’s (2) of grants
   with significant external funding.

     Funding from: NSF, NIH, DOE, NASA, foundations/industry


        External Funding: 2.5 million (2010)
            Undergraduate Research
•Close to 500 undergraduate chemistry majors
•Revised curriculum concentrations include a research intensive option,
Professional Chemist With Honors, leading to 12 undergraduate
chemistry theses and undergraduate departmental research seminars
(2006-10). Undergraduates are strongly encouraged to work in research
labs.
•NSF funded Research Experience for Undergraduates program
(1999-2004 & 2006-present) involved over 16 faculty from 4 departments
and over 100 students in summer research projects.
• Participated in International REU US-Brazil Program (3 students)



                         VCU Practices and Perspectives
                  Summer Undergraduate Research Experience
                Graduate Research
• Degrees offered
      • Ph.D. and M.S. in Chemistry (http://www.chemistry.vcu.edu/)
      • Ph.D. in Nanoscience (www.nano.vcu.edu)
      • Ph.D. in Chemical Biology (http://www.chembio.vcu.edu/)

• ~ 70 graduate students

• TA and RA positions available

• Research Areas: Biological/Biophysical, Analytical,
  Inorganic, Physical, and Organic Chemistry, Chemical
  Physics, Materials, and Nanoscience
         Instrumentation
• Three major instrumentation facilities
  (each staffed by a PhD):

• General
   Various IR, UV-Vis and GC-MS
    instrumentation

• NMR
   300, 400, & 600 MHz, multi-nuclear.

• Mass spectrometry
   Quadrupole ion trap and q-TOF.
   Orbitrap high-resolution mass spectrometer -
   ideal for proteomics.

   •Access to Nanomaterials Core Characterization
   Facility
           http://www.chemistry.vcu.edu/research/facilities.html
Nanomaterials Instrumentation (NCC)
   State-of-the art facility for Nanomaterials Characterization


                    Veeco ICON SPM
                     PANalytical XRD
             ThermoFisher ESCAlab 250 XPS
                   Zeiss Libra 120 TEM
                        Jeol SEM
                  Hitachi Su-70 FE-SEM
                       Ellipsometer
                    Nikon Microscope




                                                       www.nano.vcu.edu
Interested in Graduate School ?
           Consider the following:

                       Chemistry (PhD)
                       Nanoscience (PhD)
                       Chemical Biology (PhD)


Who to Contact: Dr. Maryanne Collinson (Chemistry)
                Dr. Everett Carpenter (Nanoscience)
                Dr. Nicholas Farrell (Chemical Biology)

      For general information on Graduate Studies in Chemistry

                        Email: gradchem@vcu.edu
                         Phone: (804) 828-1298
      Why Graduate School at VCU?
1.  Competitive stipends
2.  Fellowships
3.  Interdisciplinary research programs
4.  Internationally known faculty that actively publish
5.  Hands-on program; low student-to-faculty ratio
6.  Collaborations with the VCU-MCV Medical College (MD/PhD
    program)
7. Diversity
8. Centrally located; less than 2 hrs from Washington, D.C.,
    the beach, and the mountains
9. A big “small” town
10. Friendly environment
 Requirements for Graduate School
             at VCU
1. Graduation from an accredited college/university

2. Satisfactory GPA (The university minimum undergraduate GPA is
   2.7 on a 4.0 scale for at least the last 2 yrs of undergraduate
   work)

3. Satisfactory scores from the GRE (must be current, less than
   five years old)

4. Satisfactory scores on the TOEFL exam (for International
   Students only). The recommended TOEFL score is 600 (paper-
   based), 250 (computer-based), 100 (internet based). Scores
   must be current (within 2-years). In some cases, students may
   be admissible with scores lower than those listed above.

5. Strong letters of recommendation
                       Application Process
                                All documents on-line at
                 http://www.chemistry.vcu.edu/graduate/prospective.html

Domestic Students

1. Complete the Chemistry Department pre-application form

2. Complete the On-line Graduate Application Form. Fee waivers are available for domestic
   students, provided this is the first time an application has been submitted to VCU. If
   interested, please contact Dr. Collinson (mmcollinson@vcu.edu)

3. Submit a one-page personal statement describing your career goals and how a degree in
   chemistry would help you to meet those goals. Also include prior work/life experience that
   relates to your interest in chemistry and any other information that you think will help in
   the evaluation of your application.

4. Submit official (no photocopies) transcripts from all colleges and universities attended.

5. Submit the names of three people that will be sending letters on your behalf. Letters must
   be in signed/sealed envelopes or sent directly by the person writing the letter.

6. Submit official results (no photocopies) for the General GRE Exam (required); Subject
   GRE Exam (optional).

7. Submit your In-State Tuition form.
                          Application Process
                                 All documents on-line at
                  http://www.chemistry.vcu.edu/graduate/prospective.html
International Students

1. Complete the Chemistry Department pre-application form.

2. Complete the Graduate Application Form.

3. Submit a one-page personal statement describing your career goals and how a degree in
   chemistry would help you meet those goals. Also include prior work/life experience that
   relates to your interest in chemistry and any other information that you think will help in
   the evaluation of your application.

4. Submit official or officially certified copies of all grade reports for all secondary and higher
   school studies, as well as original or officially certified copies of all academic diplomas,
   certificates and national or other major examination results. Official records must be
   submitted in the native language and must be accompanied by an official English
   translation.

5. Submit the names of three people that will be sending letters on your behalf. Letters must
   be in signed/sealed envelopes or sent directly by the person writing the letter.

6.    Submit official results (no photocopies) for the General GRE Exam (required) and TOEFL
     (required); Subject GRE Exam (optional).

7.   Financial Statement and a check or money order of $50, payable to VCU .
       Application Process
               All documents on-line at
http://www.chemistry.vcu.edu/graduate/prospective.html

    Submit all application materials to:
            Virginia Commonwealth University
            Graduate School
            Moseley House
            1001 Grove Avenue
            P.O. Box 843051
            Richmond, Virginia 23284-3051

    Suggested Deadline Dates:
                 April 15 (Fall admission)
                 Oct. 15 (Spring admission)
                   Research Faculty
                 Materials/Nanoscience
                                                Biological/Biophysical
                           Collinson
                                                        Rutan
 Analytical               Carpenter
                                                        Farrell
   Collinson                Alvarez
                                                       Hartman
    Alvarez              Arachchige
                                                        Terner
    Rutan                   El-Shall
                                                        Luzar
   Gronert                  Bratko
                                                       Alvarez
                             Luzar
                                                       Sidorov
                           El-Kaderi
                                                       Gronert
                       Bertino (Physics)
                                                        Bratko
Physical                 Ye (Physics)
                                                        Cropp
  Luzar        Chemical Physics
  Bratko               Luzar               Organic
 El-Shall             Bratko                           Inorganic
                                            Sidorov
 Alvarez              El-Shall                           Farrell
                                           Gronert
 Terner             Carpenter                          Carpenter
                                           Hartman
                  Baski (Physics)          Gupton       El-Kaderi
                 Bertino (Physics)          Cropp      Arachchige
               Reshchikov (Physics)
                      Research in the Arachchige Group
                               Inorganic, Nanoscience, Materials

 Research efforts in our group are focused on the            ITO NCs Al        NCs
                                                                                      Al
                                                                                                NCs
                                                                                                      Al
                                                          Glass            Au              Au
design and synthesis of novel nanoscale materials
with unique and tunable physiochemical properties.

 The research is highly interdisciplinary, with the
aim to develop a fundamental understanding of
how structure, particle size, shape, atomic
composition are related in order to advance                        A             B               C
technologies such as information storage, sensors,
                                                              (a) Quantum Dot Materials
energy conversion, and catalysis.
                                                                 for Solar Cell Applications.



2 nm



50 nm


(b) Nanoscale Materials for Information Storage,
   Catalysis, Sensing and Imaging.                     (c) Sol-Gel Assembly of Nanomaterials
                                                       into porous network structures.
                    Chemical Biology in the Cropp Lab
                                                                         Isotopic photo-crosslinking amino acids.
  Photochemical control of FlAsH labeling




  Wilkins, B.J. et al. Bioorg. Med. Chem
  Lett. 2009, 19:4296-4298.                                                        Wilkins, B.J. et al. Mol. Biosys.
                                                                                   2008, 4(9):934-936

                           Our group in interested in developing tools for manipulating
                            and studying proteins. The work makes use of unnatural
                            amino acid mutagenesis, protein directed evolution, and
                                               synthetic chemistry.
                                                                            Scanning amino acid mutagenesis
Photochemical disguise of
“near-natural” amino acids.




Wilkins, B.J. et al. Biochemistry,                                        Daggett, K.A., et al.
2010, 49, 1557-1559.                                                      ACS Chem. Biol., 2009, 4 (2), 109–113.
                                                                                                                                                                Research in the Hartman Group
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            OH

                                                                                                                                               O
                                                                                                                                                                                                                                                                                           Molecules like cyclosporin A and vancomycin are peptide natural                  NH                                                                                                                                                                                                                                                                   2
                                                                                                                                                                                                                                                                                                                                                                              O
                                                  N
                                                                                                              N
                                                                                                                                                                N
                                                                                                                                                                                    H
                                                                                                                                                                                                                    OH                                                                     products with potent biological activity. Unfortunately, the complexity of            O
                                                                                                                                                                                                                                                                                                                                                                                       OH
                                                                                                                                                                                                                                                                                                                                                                                           OH
                                                                                                                                                                                                                                                                                                                                                                               O    O

        N                         O
                                                                                          O
                                                                                                                                                                            O
                                                                                                                                                                                                            NH                                                                             these molecules renders it difficult to make large numbers of variants.        O         O
                                                                                                                                                                                                                                                                                                                                                                                        Cl
                                                                                                                                                                                                                                                                                                                                                                                            OH


                                 O                                                                                                                                                  O                                                                                                      We prepare enormous natural-product-like cyclic-peptide libraries HO           Cl
                                                                                                                                                                                                                                                                                                                                                                                    O
                                                                                                                                                                                                                                                                                                                                                                                               OH
                                                                                                                                                                                                                                                                                                                                                                                                 O
                                                                                                                                                                                                                N                                                                                                                                                     O   H             H                                                                                                                                                                                                                                                                      H
            NH                                                                                                                                                                                                                                                                             through the use of mRNA display, libraries far larger than those   O
                                                                                                                                                                                                                                                                                                                                                                    N
                                                                                                                                                                                                                                                                                                                                                                          N
                                                                                                                                                                                                                                                                                                                                                                                 N
                                                                                                                                                                                                                                                                                                                                                                                        N
                                                                                                                                                                                                                                                                                                                                                                                               N
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               N
O                                                                                                                                                                                                                        O                                                                                                                                          H            H             H
                             NH
                                                                                  N
                                                                                                                                                                                            N                                                                                              made by any other approach. We are working on overcoming HO HN                    O
                                                                                                                                                                                                                                                                                                                                                                                  O
                                                                                                                                                                                                                                                                                                                                                                                           O

                                                                                                                                       N
                                 O
                                                                                                      O                                H                                O                                                                                                                  two obstacles in this approach: cell permeability and building      O
                                                                                                                                                                                                                                                                                                                                                                         OH
                                                                                                                                                                                                                                                                                                                                                                        OH
                                                                                                                                                                                                                                                                                                                                                                                      NH                                                                                                                                                                                                                                                             2

                                                                                                                                                                                                                                                                                                                                                                 HO
                                                                                                                                                                                                                                                                                           block diversity. Ultimately, we hope to be able to find inhibitors             Vancomycin
                                  Cyclosporin A                                                                                                                                                                                                                                            of many protein-protein interactions involved in cancer biology.
                                                                                                                                                                                                        Cell permeability                                                                                                                                                                                                                                                                                                                                                                                       Building block diversity
                                                                                                                                                                 O
                                                          O                                                                                                                     H                                                                                                                               O                                                                                                                                   O
                                                                      H                                                                                 N                                                                                                                                                                H                                                                                                                                   H
                                              N                                                                                         N                               N               OH                                                                                                             N                                                                                                                                    N
                             N                                                OH                                                                                                                                                                                                           N                        N               OH                                                                                      N                                        OH
                                                              N                                                                                                                                                                                                                                                                                                                                                                                          N
                                                                                                                                                    O                                   NH
                                      O                                       NH                                                                                            O                                                                                                                      O                             NH                                                                                                     O                            NH
                                                                                                                           N        O                                                                                                                                                                                   O
                    N     O                                       O                                                                                                                                                                                                        N            O                                                                                                                      N         O                                   O
                                                                                                                                   O                                        O
                         O                                            O                                                                                                                                                                                                                O                                O                                                                                               O                                    O
                                                                                                                                                                                        N
                                                                              N                                                                                                                                                                                                                                                  N                                                                                                                                   N
                                                                                                                           NH
                    NH                                                                                                                                                                                                                                                         NH                                                                                                                               NH
                                                                                                                   O                                                                        O
            O                                                                                                                                                                                                                                                      O                                                                 O                                                                 O
                                                                                  O                                                NH                                           N                                                                                                                                                                                                                                                                                        O
                        NH                                            N                                                                         N                                                                                                                                   NH                                      N                                                                                          NH                                        N
                                      N                                                                                                                          N                                                                                                                                 N                                                                                                                                    N
                                                      N                                                                            O                             H          O                                                                                                                                  N                                                                                                                                    N
                         O                            H           O                                                                                 O                                                                                                                                  O                       H     O                                                                                                  O                           H    O
                                          O                                                                                                                                                                                                                                                            O                                                                                                                                    O
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           O
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       H
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  N                             OH
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  N                            N
                                                                                                                                                                                                                                                                                                                                         O                                                                                                                                                                O                                 NH
                                                                                                                                                                                                                                                                                                                                                 H



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Chemoselective
                                                                                                                                                                                                                                                                                                                                    N                                                                                                                                                N        O                                    O
                                                                                                                                                                                                                                                                                                                    N                        N           OH                                                O
                                          O                                                                                                     O                                                                                                                                                                                                                                                                      H                                                                     O                                      O
                                                       H                                                                                                    H                                                                                                                                                                   O                        NH                                     N                               OH
                                                                                                                                                                                                                                                                                                                                                                                   N                            N                                                                                                                               N
                                 N                                OH                                                                   N                             OH                                                                                                                                    N     O                               O
                    N                             N                                                                    N                            N                                                                                          O
                                                                                                                                                                                                                                                           H                                                                                                                                O                                NH                                                      NH
                                                                                                                                                                                                                                      N                                                                         O                                O
                             O                                NH                                                               O                                 NH                                                      N                                         OH                                                                                                    N      O                                   O                                                        O
                                                                                                                                                                                                                                                   N                                                                                                                                                                                                                                                                                                O
        N        O                                    O                                                   N         O                                   O                                                                                                                                                                                                N                                                                                                                                   NH                                         N
                                                                                                                                                                                                                                                                                                                                                                               O                                       O



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             ligations
                                                                                                                                                                                                                                  O                                NH                                      NH                                                                                                                                                                                             N
                O                                     O                                                            O                                    O                                                                                              O
                                                                                                                                                                                                            N        O                                                                             O                                                                                                                            N                                                                                      N
                                                                  N                                                                                                 N                                                                                                                                                                                        O                                                                                                                               O                         H           O
                                                                                                                                                                                                                    O                                      O                                                   NH                                    N                    NH                                                                                                                                  O
        NH                                                                                                    NH                                                                                                                                                                                                             N                                       O



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Unnatural
                                                                                                                                                                                                                                                                   N                                                                     N                                                                                          O
    O                                                                 O                            O                                                                    O                                                                                                                                                                                                     NH                                        N
                                                                                                                                                                                                            NH                                                                                                  O                        H   O                                             N
            NH                                            N                                                       NH                                        N                                                                                                                                                                    O
                         N                                                                                                     N                                                                        O                                                              O                                                                                                                                N
                                          N                                                                                                    N                                                                                                                                                                                                                               O                        H          O
                                                                                                                                                                                                                    NH                                     N                                                                                                                                   O
                O                         H        O                                                               O                           H        O                                                                     N
                              O                                                                                                    O



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           tRNAs
                                                                                                                                                                                                                                               N                                                                                                                                                                                                                                         O
                                                                                                                                                                                                                    O                          H       O                                                                                                                                                                                                                                              H
                                                                                                                                                                                                                                  O                                                                                                                                                                                                                                              N



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            amino acids
                                                                                                                                                                                                                                                                                                                                                                                                                                                                 N                            N               OH
                                                                                   O                                                                                                                                                                                                                                                     O                                                          O                                                                     O                               NH
                                                                                               H                                                                                                                                                                                                                                                 H                                                              H
                                                                          N                                                                                                                                                                                                                                                         N                                                      N                                                        N         O                                   O
                                                      N                                                   OH                                                                                                                                                                                                        N                        N           OH                   N                                            OH
                                                                                          N                                                                                                                                                                                                                                                                                                             N
                                                                                                                                                                                            O                                                                                                                                                                                                                                                                O                                        O
                                                                  O                                    NH                                                                                               H                                                              O                                                        O                        NH                            O                                NH
                                                                                                                                                                                N                                                                                               H                                                                O                                                                                                                                                            N                                             O
                                      N            O                                          O                                                              N                                  N           OH                                             N                                               N     O                                                   N     O                                O                                                                                                                                                           H
                                                                                                                                                                                                                                           N                                               OH                                                                                                                                                           NH



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Unnatural aminoacyl-tRNAs
                                                                                                                                                                                                                                                                           N                                                                                                                                                                                                                                                                    N                               OH
                                                  O                                           O                                                                         O                                   NH                                                                                                  O                                O                        O                                                                                                                                                    N                                N
                                                                                                                                                                                                                                                                                                                                                                                                               O                                O
                                                                                                                                                                                                    O                                              O                                   NH                                                                N                                                                                                                                                        O
                                                                                                          N                                     N        O                                                                                                                                                                                                                                                              N                                NH                                           N                                     O                                   NH
                                                                                                                                                                                                                              N        O                                       O
                                          NH                                                                                                            O                                            O                                                                                                     NH                                                        NH                                                                                                  N                                        N         O                                       O
                                                                                                                                                                                                                                      O                                         O                  O                                                                                                                                                                                     N
                                 O                                                                            O                                                                                             N                                                                                                                                                O   O                                                                                           O                           H        O                        O                                        O
                                                                                                                                                                                                                                                                                                                                                     N                                                                      O                                                O
                                               NH                                                 N                                                NH                                                                                                                                      N                   NH                                                        NH                                        N
                                                                  N                                                                                                                                                                                                                                                          N                                                      N                                                                                                                                                                                           N
                                                                                                                                                                                                                              NH
                                                                                  N                                                        O                                                                    O                                                                                                                        N                                                         N                                                                                                                  NH
                                                  O                               H        O                                                                                                            N                O                                                                                      O                        H   O                            O                                 O
                                                                      O                                                                                 NH                                                                                                                                     O                                 O                                                      O          H                                                                                                      O
                                                                                                                                                                        N                                                             NH                                           N                                                                                                                                                                                                                                                                                                O
                                                                                                                                                                                                                                                   N                                                                                                                                                                                                                                                                   NH                                               N
                                                                                                                                                                                        N                                                                                                                                                                                                                                                                                                                                               N
                                                                                                                                                        O                               H           O                                                              N



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       In vitro
                                                                                                                                                                            O                                                         O                            H        O                                                                                                                                                                                                                                                                               N
                                                                                                                                                                                                                                                       O                                                                                                                                                                                                                                                                   O                                H       O
                                                                                                                                                                                                                                                                                                                                         O                                                          O                                                                                                                                       O
                                                                                                                                                                                                                                                                                                                                                 H                                                              H                                                                        O
                                                                                                                                                                                                                                                                                                                                    N                                                      N                                                                                                          H
                                                                                                                                                                                                                                                                                                                    N                        N           OH                   N                         N                  OH                                                    N                            OH
                                                                                                                                                                                                                                                                                                                                                                                                                                                                 N                            N
                                                                              O                                                                                  O                                                                                     O
                                                                                          H                                                                                     H                                                                                  H                                                            O                        NH                            O                                NH                                                O                               NH
                                                                  N                                                                                     N                               OH                                                 N                                                                                                     O                                                          O
                                               N                                  N                OH                                   N                               N                                                     N                            N               OH                              N     O                                                   N     O                                                                        N         O                                   O                                                             O



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     translation
                                                                                                                                                    O                                   NH                                                                                                                      O                                O                        O                                    O                                             O                                                                                                              H
                                                              O                                   NH                                                                                                                                   O                                   NH                                                                                                                                                                                                                         O                                                 N
                                                                                      O                                                                                     O                                                                                  O                                                                                         N                                                              N                                                                                                           N                               N                OH
                                  N        O                                                                               N        O                                                                            N        O                                                                                                                                                                                                                                                                                   N
                                          O                                                                                        O                                        O                                            O                                                                                 NH                                                        NH                                                                                 NH                                                                                      O                                   NH
                                                                                       O                                                                                                                                                                       O
                                                                                                                                                                                                                                                                                                   O                                                             O                                                                              O                                                                      N        O                                       O
                                                                                                  N                                                                                     N                                                                                  N                                                                                 O                                                              O                                                                                     O
                                                                                                                                                                                                                                                                                                               NH                                    N                   NH                                        N                                                                                  N                        O
                                  NH                                                                                       NH                                                                                       NH                                                                                                       N                                                      N                                                                    NH                                                                                                                 O
                                                                                                                                                                                                                                                                                                                                                                                                                                                                         N
                         O                                                                                         O                                                                        O               O                                                                                                                            N                                                         N                                                                                                                                                                                N
                                                                                                      O                                                                                                                                                                        O                                O                        H   O                            O                        H        O                                                                            N
                                          NH                                              N                                        NH                                           N                                        NH                                        N                                                             O                                                      O                                                                    O                           H        O                    NH
                                                                                                                                                N                                                                                                                                                                                                                                                                                                                            O
                                                          N                                                                                                                                                                           N                                                                                                                                                                                                                                                                           O
                                                                          N                                                                                      N                                                                                 N                                                                                                                                                                                                                                                                                                                                    O
                                          O                               H           O                                            O                             H          O                                            O                         H           O                                                                                                                                                                                                                                                               NH                                           N
                                                              O                                                                                     O                                                                                     O                                                                                                                                                                                                                                                                                                 N
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                N
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               O                                H       O
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    O




                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            mRNA-peptide fusion formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cyclization
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             1013 unnatural cyclic peptides
                                                                                                                                                                            O                                                                                                                                                                                                                       O
                                                                                                                                                                                        H                                                                                                                                                                                                                       H
                                                                                                                                                                N                               OH                                                                                                                                                                                         N
                                                                                                                                                N                               N                                                                                                                                                                                             N                         N                  OH
                                                                                                                                                            O                                   NH                                                                                                                                                                                     O                                NH
                                                                                                                                   N         O                                      O                                                                                                                                                                                N     O                                O
                                                                                                                                            O                                       O                                                                                                                                                                                     O                                    O
                                                                                                                                                                                                N                                                                                                                                                                                                                       N




                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              which will be used to find
                                                                                                                                   NH                                                                                                                                                                                                                                NH
                                                                                                                           O                                                                        O                                                                                                                                                            O
                                                                                                                                           NH                                           N                                                                                                                                                                                                                                   O
                                                                                                                                                        N                                                                                                                                                                                                                NH                                        N
                                                                                                                                                                                                                                                                                                                                                                                    N




                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            P
                                                                                                                                                                        N                                                                                                                                                                                                                          N
                                                                                                                                            O                           H           O
                                                                                                                                                            O                                                                                                                                                                                                             O                        H        O
                                                                                                                                                                                                                                                                                                                                                                                        O




                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             inhibitors of protein-protein
                                                                                      Large libraries of cyclic peptides                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     and receptor-ligand
                                                                                       selected for cell permeability                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        interactions
                         Research in the El-Kaderi Group
              Materials Design, Inorganic, Nanoscience, Organometallics
Our research efforts are devoted to the development of highly porous polymers for use in clean energy
applications; H2 storage and purification, and catalytic processes that utilize open-metal sights or deposited
metal nanoclusters for the production of separate molecules like methanol or long chain polymers. The
group is also interested in organometallic complexes for use in homogenous catalysis and activation of
small molecules such as N2 and CO2.

Projects:
 New    porous organic and inorganic polymers:
Design and Modeling  Synthesis and Characterization  Applications: Storage, Catalysis, etc.
 Metal-doped      polymers using Chemical Vapor Deposition (CVD) and other related techniques:
Materials (Fullerenes, MOFs, COFs)  CVD  Materials with enhanced storage and catalytic properties
   Metal-polydentate ligand complexes for ethylene polymerization and activation of small molecules:
Ligand design and synthesis  Organometallic complexes  Reactivity studies




    MOFs: Yaghi,           COFs: El-Kaderi, H. M. et al,   M@Fullerenes: JACS
 Nature 2004, 427, 523       Science 2007, 316, 268         2006, 128, 9741
                                          The Gronert Research Group
                                                                                          Mass Spectrometry Lab
                                                                                      Organic, Biological/Biophysical, and Analytical
                                       Gas-Phase Organic                                                                        Catalysis: Mechanisms                 Proteomics Studies of
                                       Reaction Mechanisms                                                                      and Stereoselectivity                 Protein Modifications

                                                                                                                                               N         N
                                                                                                                                                                                    Modified
                                                                                                                                   R           O
                                                                                                                                                     M
                                                                                                                                                          O       R                 protein
                                                    QuickTime™ and a
                                                   None decompressor




                                                                                                                                                              R
                                             are needed to see this picture.




                                                                                                                                         R
                                                                                                                                                     O
                                                                                                                                              R'         R*
                                                                                                                                                                                 Label/Digest
            QuickTime™ and a
           None decompressor
     are needed to see this picture.




                                                                                                                                             R'OR*       R"OR"
                                                                                                     QuickTime™ and a
                                                                                                    None decompressor
                                                                                              are needed to see this picture.




                                                                                                                                               N         N
                                                                                                                                                     M
                                                                                                                                   R           O          O       R             LC/MS of peptides
                                                                                                                                         R                    R
                                                                                                                                                     O
Rates                                                                                                                                         R"         R"
Stereoselectivity                                                              Isotope Effects
Substituent Effects                                                            Computational Modeling                           Using mass spectrometry to
                                                                                                                                probe the binding properties of                 Database analysis
  Gas-phase studies probe                                                                                                       catalyst intermediates that
  intrinsic mechanism and give                                                                                                  cannot be isolated in solution                       Modification
  insight into solvation effects
                                                                                                                                                                                     site map
                                                                                                                                  Projects focused on
     Projects focused on                                                                                                          alkene epoxidations
     substitution and                                                                                                             and other oxidations                Projects in diabetes
     elimination reactions                                                                                                                                            and aging research
    Physical; Biological/Biophysical; Materials and Nanoscience; Chemical Physics
  Solvation processes in bio-systems and materials are exceedingly complex, involving a range of time and length scales.
                      Multifaceted problem requires a multifaceted approach, and that’s what we do!

                                              “In silico”/ Computer experiments
Reactors                                        on computer workstations and
   in                                                   supercomputers
  UK
& France

                                                Neutron scattering experiments
                                                  on world’s most powerful
                                                       neutron source
                                                                                                               Scientific
                                                 HYDRATION PROCESSES IN                                       computing
                                                  NATURAL & SYNTHETIC
                  Molecular                             SYSTEMS
                  modeling                        Statistical mechanics- relation
                                                    between macroscopic and
                                                        microscopic world
                                                                                                              Minimalist
                                                                                                               models
                                                Condensed phase chemical dynamics



               Coarse grained
                 modeling

                                  HIGLHIGHTS: Students in our group:
                                  Work on exciting projects relevant to everyday phenomena in biochemistry and materials science
                                   (e. g. biological hydration and organization, action of detergents, intermolecular recognition)
                                  •Develop new theoretical perspectives and methods and learn how to independently write
                                   computer programs
                                  •Get international research experience early in their careers.
                                                                                            http://www.chemistry.vcu.edu/people/bio/luzar.html
                                                           The El-Shall Research Group
                                   Physical; Materials & Nanoscience; Chemical Physics
                                   Clusters                                                                                                                        Nanoparticles
                                                                                                                  The                                                    Catalysis
                            Ion-mobility mass
                               spectrometry

                                                                                                         CNN
                                                                                                                                                                    Au-Ag Nanoparticles
                Structure




                                                                         Kinetics



                                                                                                           Laboratory
                                                                                        Our research interests are in the general
                                                                                      areas of molecular clusters, gas phase and                                         10 nm
                             Binding Energy                                           cluster polymerization, nucleation
                                                                                      phenomena and nanostructured materials.                                     Assembly of ZnS rods
                            Laser vaporization                                        The major goal is to gain insights as to how
                              Time-of-flight                                          the properties of matter evolve as the size
                            mass spectrometry                                         of a material system ranges from molecular
                  120         21                           +
                                                      Si (H2O)n
                                                                                      to macroscopic dimensions.
                  100

                                    28

                    80

                                                                                                            Nucleation
Ion Intensity




                                         30


                    60


                    40                                                                                                   nucleus
                    20
                                                                                                                         ( 100-200 molecules )                             Nanowires
                      0
                             400              600    800          1000

                                         Mass(amu)



                                                                                                 W(n)

                                                                                                  RT                                  Liquid
                                                                                                                   W*                 Droplets
                                                           Nd:YAG Laser                                                                                                 Ge nanowires with
                                                                                                                                      ( 1-5 µm)
                                                                                                                                                                       controlled diameters
                                                                                                                    n*         n
                J. Am. Chem. Soc. 127, 6164 (2005)                                  J. Am. Chem. Soc. 127, 7053 (2005)      J. Chem. Phys. 123, 104704 (2005)   J. Phys. Chem. B. 109, 17350 (2005)
                 Research in the Collinson Group
                                   Analytical, Inorganic, Materials, Nanoscience
                                             “Better Materials through Chemistry”

                                                                   monoliths
   Sol-Gel Chemistry                                                                               High Surface Area Materials
                                                  R   O
                                            O            O
                                                Si O Si
                             H2O     O O Si O            O R
  Si(OR’)4 + R-Si(OR’)3            R
                                      Si   O Si
                                                   R      Si                                                                       For:
                                         O R      O Si O O
         R = CH3,…                             Si       O Si                                                                   Chemical Sensors
                                      O Si O         O       OR
                                           OH O OH Si O                                                                        Biomedicine
                                              Si
                                                                            films
                                                 O R
                                           O                                                                                   Chromatography
   Gradient Surfaces                                              powders
                                                                                       Make
                                                                                    Characterize
  Controlled rate infusion                                                            Utilize
                                             1D Gradient

                                                                                                      Hierarchical template    Hierarchical pore in gold
                                            XPS




 Gradient in Amine Groups

                                                                                           Hierarchical colloidal crystal   Hierarchical porous gold films
                                        Orthogonal 2D Gradient



                                                                                            Templating
                                                                                             Imprinting
                                                                                         Electrodeposition



Tools of the trade: SEM, AFM, XPS, FTIR, Echem, Fluorescence
Funding: National Science Foundation                                                                                 Hierarchical porous silica
                                                                 Research in the Rutan Group
                                                                                           Analytical, Biological/Biophysical
                                                                                                         http://www.people.vcu.edu/~srutan/
                                                                                                                                                                      from 1D column
                                           Development of two-dimensional liquid                                                                          from pumps             to 2D column
                                            chromatographic methods for metabolomic                                                                         2nd                      1st




                                                                                                                                         # of Components
                                                                                                                                                           loop                     loop
                                            applications




                                                                                                                                            4 3 2 1
                                           Evaluation of informing power of                                                                                             to waste

                                            chromatographic methods
                                           Analysis of multi-way data from LCxLC/DAD
                                            instrumentation                                                                                                     Com Com
                                                                                                                                                                pon     pon
                                                                                                                                                               1ent 3 4 ent 6 7
     2nd chromatographic Dimension (secs)




                                                                                                                                                                  2      5
                                                                                                                                                                1       2
                                            16 4 & N13                           9, N14 & N15
    2nd Chromatography Dimension (sec)




                                                                        5                              N6
                                                                                                         14             T                                      Com
                                            15                                               N3        N5                                                      pon
                                                                                                                        
                                                                   16
                                                                                     N4                       13
                                                         N9 N1          17                                                                                     ent
                                            14                                                          18
                                                         N2 2                                                                                                  1




                                                                                                                                         Sample L
                                                                                                  N7          10 & N8
                                                     3
                                            13
                                                                                 8          N11                                                                 Com     Com       Component 3




                                                                                                                                              Dimension


                                                                                                                                                               1
                                                                                           N12                                                                  pon     pon




                                                                                                                                                Slices
                                            12                                              N1




                                                                                                                                                  2nd
                                                                                                                                                                ent     ent




                                                                                                                                                               2
                                                                                                                                                           J
                                                               1            7               N10
                                                                                            6         1
                                                                                      15           11 2                                                         1       2
                                                                                                                            
                                            11




                                                                                                                                                               3
                                                                             6
                                                 4             6           8          10          12                                             Sample 1
                                                                                                                                                      SampleSampleSample 4 Sample L
                                                                                                                                                            2     3
                                                         1st Chromatography Dimension
                                                         1stChromatography Dimension (min) (mins)
                                        Research Overview in the Alvarez Group : the research in our group revolves around
                                        bio-analytical , bio-physical and biological projects comprising diverse approaches.
                                        Two of the ongoing projects being investigated in our group are:
Using Surface Charge as a Tool for Studying                               Catalysis of Redox Reactions :
Chemical and Biochemical Surface Processes:                               Reactions involving the transfer of protons and electrons are
Surface charge is used to monitor the adsorption and                      facilitated by mimicking enzyme strategies such as hydrogen
desorption of a positively charged protein to a                           bonding to Bronsted bases and acid-base catalysis. In this example,
microchannel surface that has been previously                             the favorable effect of hydrogen bonding is evaluated by using two
tailored with affinity bio-receptors. This approach                       bases with identical pKa but opposite hydrogen bonding behavior.
allows detection of bioprobes in a label-free fashion
and sheds insight about the kinectics of adsorption.

           PROTEIN ADSORPTION IN REAL TIME
                                Bound protein
     Bio-receptors
                                                        +   +   +
    - - - - - -                                        - - - - - -
     -   -   -                                          -   -   -
                    Microchannel                         Microchannel
     Streaming Potential / V




                               0.0

                               -0.2

                               -0.4

                               -0.6
                                                          Experiment
                               -0.8
                                                          Fit Model
                               -1.0
                                      0 100 200 300 400 500 600 700 800
                                               Time / seconds


                                 Anal. Chem., 2011, 83, 2012-2019.                     J. Phys Chem. C, 2011, 115, 10197-10805.
          Research in the Farrell Group
  New Paradigms in Platinum Chemotherapy. The goal of the laboratory is to
   produce new anti-cancer drugs based on platinum. Our laboratory designs
platinum compounds (Pt-Pt, TPA) structurally distinct from cisplatin. In this way,
      we induce different DNA conformational changes leading to different
           “downstream” cellular effects such as protein recognition.
           Research in the Bratko Group
Physical, Biological and Biophysical, Materials and Nanoscience, Chemical Physics
  We use analytical and computer modeling to:
 help uncover physics of colloids, polyelectrolytes, biopolymers
  and ionic fluids                                                                                 Reverse micelle in AOT
                                                                                                   H2O-in-oil microemulsion
 enable control or optimization of their properties for applications
 You are invited to join projects in molecular simulations and                                             osmotic pressure P
                                                                                                           vs ionization degree a
  mean-field modeling of:
• surfactant colloids, e.g. reverse micelles as m-reactors
                                                                                              osmotic
• polyelectrolytes such as DNA and ionic colloids with                                        saturation
  focus on understanding specific salt effects
                                                                                                                    a
• coarse-grained modeling of interacting proteins and                      DNA
                                                                                               Free-energy landscape of
  their association
                                                                                               a multi-protein system




                                                                             coarse-grained

                                                                             simulation

                                                   orderly or disordered
            electron micrograph of                 protein aggregates
            amyloid fibrils
                                                                                                PNAS 102, 11692 (2005)

• disordered materials               http://www.chemistry.vcu.edu/people/bio/bratko.html
                                                                                                JACS 128, 1683 (2006)
                         Research in the Sidorov Group
                 We are developing receptors for organic substrates exhibiting their activity in biological membranes

 Active Transport of Vital Substrates                                                                                                          Nanosize Devices Based on Liposomes
         into Cellular Cytosol                                     Biomembrane                                                                     Modified with the Receptors
       Na+
                     Na+
                                                                      - Active                                                                                ΔΨ            ΔΨ
                 X
             X                          K+                           Receptors
                                                                                                                                                                             flip
                                       X X
                               K+                   S
         Y
                 Y
                                                                                                                                                Receptors capable of selective uniport of
                               Na+                                                                                                              ions across biomembranes induce the
             S                                          Development of Biomembrane Assays                                                       transmembrane potential that causes
                                       Y Y
                                                                                                                      O
                                                                                                                      S O
                                                                                                                                                cationic lipids to flip from the outer bilayer
                                                                          Naph                   O                                      Naph
                     O                                                           N       H                             O
                                                                                                                            H       N           leaflet into the inner leaflet. This appro-
        O                  O
  X=             N                   Y = -NHCONHR                         S                                                               S     ach has a promise in the improvement of
                           O                                                     N       H
                     O
                                                                                             O
                                                                                                 O
                                                                                                          NH
                                                                                                                       O
                                                                                                                            H       N
                                                                                                                                                non-viral gene delivery.
                                                                                                     S                S O
                                                                                                 O S                   O
                                                                                                           NH
 Active transport utilizes the K+/Na+                                                O                                          O

 transmembrane gradient maintained                                                                O       Na+         O
                                                                                                      O       O

 in living cells. We are synthesizing
                                                                                                 N                N
 ditopic ligands that are able to bind a                                                                  N           N


 target substrate and Na+ but not K+
 cooperatively. These receptors are                     Our receptors capable of strong selective
 capable of transport of substrates                     binding of fluorescent dyes are utilized in                                            Simultaneous induction of opposite trans-
 from Na+-rich extracellular medium                     new biomembrane assays essential to                                                    membrane potentials into two popula-
 into K+-rich cytosol. This approach                    understanding the mechanisms of actions                                                tions of fusogenic liposomes results in a
 has promise in developing therapies                    of the developmental drugs.                                                            controlled cross-fusion. This highly cont-
 agains hereditary diseases and multi-                                                                                                         rolled fusiogenic system is utilized in bio-
 drug resistant tumors.                                                                                                                        compatible nanoreactors

In our team, we are working in a highly interdisciplinary environment. The individual projects cover a wide variety of
disciplines and methods of study, ranging from wet organic synthesis to state of the art electrophysiological assays. Our
students have an opportunity to learn numerous spectroscopic techniques applicable to all aspects of modern chemistry.
          Atomic Engineering Laboratory
                                     Carpenter Research Team




                                                                        Atomic engineering allows for mutually exclusive
Using novel synthesis techniques
                                                                        properties, ie resistance and magnetization, to be
such as reverse micelle
                                                                        tailored in one nanoparticle through a core-shell
synthesis it is possible to tailor
                                                                        approach. Core-shell nanoparticles allow for high
the size, shape, and composition
                                                                        magnetic moment of a metal, to be coated with a
of the resulting nanoparticle
                                                                        high resistance material like metal oxide.


  The focus of the Atomic Engineering Laboratory is the development of novel synthetic
         techniques and novel magnetic nanoparticles. Our goals are focused on a simple question with a
         very difficult answer: How can I engineer physical properties like electrical and magnetic
         properties during the synthesis? How does the structure and morphology affect properties like
         catalytic behavior, stability, and frequency response?

  Currently materials developed in the AEL are targeted for the following application areas:
      Electronic components (inductors and capacitors), communication arrays (RADAR),
      semiconductor/computer industry (Magnetic media) biomedical applications (drug delivery, MRI
      Imaging). All these areas benefit from the same type of magnetic nanoparticles.
Research in the J. Terner Group
       Physical Bio-Inorganic Chemistry
      Time-resolved resonance Raman spectroscopy
      of porphyrins and heme enzyme intermediates.
                                          Dr. Frank Gupton
                                     Dept. of Chemistry
                        Dept. of Chemical and Life Science Engineering
Continuous Flow in Microreactors                                    Heterogeneous Cross-Coupling Catalysis
                                                                           Br       B(OH)2
                                                                                +              Pd(0)

                                                                                              K2CO3
                                                                                             H2O/EtOH

                                                                                    Suzuki Reaction




Pharmaceutical Drug Synthesis                                            Gupton Research Group
                N                           Trt
                                OH                N N
    N           N           O                           N
                                                    N
        N

        Telmisartan
                                     Cl
                                                  OHC       N
                O                                                   Me
                                                                N
                                                    Cl
                       OH                               Losartan
                O     Atovaquone
                                Research in the M. Reshchikov Group
                                                                                                        (Chemical Physics)
                            Electrical and Optical Properties of Semiconductors
     The goal of our investigations is to understand the behavior of
     point defects and role of surfaces in crystalline wide-band-gap
     semiconductors, such as GaN and ZnO, nanostructures, and
     optical devices including LED and laser diodes.
  Main experimental methods are Photoluminescence and Kelvin probe.

                                                                                  10-12 s                Conduction band
                                                                                                                                                                           PL Intensity




                                                                                                                                                         0 Photon Energy
                                                                                                                                                                                                                                                                                                          8
                                                                                                                                                                                                                           Φ                                                                        10
                                                                                                 10-10              s      10-10 s                                                                     O2                                 GaN                                                                              T = 300 K
                                                                                                                                                                                                                                Φ0




                                                                                                                                                                                                                                                                         PL Intensity (rel. units)
                                                                                                                                                                                                                                                                                                          7
                                                                                         10-7-   10-4               s                                                                                                           Conduction band                                                      10                        Vacuum
                                                                                                                            10-9 s                                                                                                                                                                                             Air




                                                                                                                                                                                                                                                    Sapphire substrate
                                                                                                                                                                                                                                                                                                          6
                                                                                                                                                                                                                                                                                                     10

                                                                                                                                                                                                     Ambient
                                                                                                                                                                                                                                                                                                          5
                                                                                         10-10 s                                                                                                                                A                                                                    10




                                                                                                                                                         Eg
                                                                                      10-12 s
                                                                                                                                                                                                                                                                                                          4
VGaON complex is responsible for the Yellow band in GaN                                                                 Valence band
                                                                                                                                                                                                                                                                                                     10
                                                                                                                                                                                                                                     Valence band
                                                                                                                                                                                                                                                                                                      1.5     2     2.5        3       3.5
                                                                                  Transitions causing photoluminescence                                                                                                W                                                                                      Photon Energy (eV)
                                                                                                                                                                                                               oxide

                                                                                                                                                                                                     Band bending and depletion layer due to adsorbed species
                                                                                                                                              Excitons                     T = 15 K
                                                                                                                             Excitons - LO
                                                                                                  Excitons - 2 LO




                                                                                                                                                                                                     (a)                                                                         (b)                                Kelvin
                                                          PL Intensity (a.u.)




                                                                                                                                                                                                                                                                                                                    probe
                                                                                          DAP




                                                                                                                                                                                                                                                                                                                    head
                                                                                                                                                                                                                                                                                                     Laser



                                                                                                                                                                                                                                                                                                                    tip        sample
                                                                                      3.25 3.3 3.35 3.4 3.45 3.5                                                                                                                                                                                      PL
                                                                                                                                                                                          Excitons



                                                                                                                                                                                                                                                                                                                               sample
                                                                                                                                                                                                                                                                                                                               holder
                                                                                                                           Yellow-Green                      Shallow
                                                                                                                                                              DAP                                                                                                                   Optical
                                                                                            Red                                                                                                                                                                                     cryostat
                                                                                1.5                                 2                        2.5                           3               3.5                                                                                                                            PL
                                                                                                                         Photon Energy (eV)
              Photoluminescence set up                                                                                                                                                                                      Kelvin probe in optical cryostat
                                                                                  Photoluminescence spectrum of GaN
                      Research in the Bertino Group
                                              (Chemical Physics)
       Nanoparticle lithography                                    Conducting polymers


      UV

                        mask             hydrogel




                                                                                 100 nm

                                                                    Fibers by gamma-ray radiolysis…
                      1 mm
CdSe pattern in ambient light… …and illuminated with Ar+ laser




                                 Microturbine
                                 by X-ray lithography

                       100 mm

                                                                     … make better meth sensors…
  Dr. Ye’s Nanoscience Research Group
                               Chemical Physics
 In our group, we develop a novel technique to fabricate three
dimensional nanostructures based on physical vapor deposition
   We are interested in the applications of 3D nanostructures in
  biosensing, surface chemistry, and 3D photonic devices.
             substrate        3D Nanostructures for Photonic Devices
                          Si                 Si            Si
  motor
                



     vapor
                         Ru                 Pt
                                                                  Laser


   source

                              Nanotip-enhanced vibrational spectroscopy
The Faces of Chemistry
     VCU
     VCU Faculty
The Faces of
 Chemistry
             VCU
            VCU
            Students
       VCU
       VCU
      and You
http://www.chemistry.vcu.edu/
   Visitors Welcome
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