Griffith-CV by yaoyufang

VIEWS: 9 PAGES: 10

									                               CURRICULUM VITAE

                                 Leslie Claire Griffith

DATE OF BIRTH:                 October 12, 1959, Lansing, MI


WORK ADDRESS:                  Department of Biology MS008
                               Brandeis University
                               415 South St.
                               Waltham, MA 02454-9110
                               TEL (781)736-3125
                               FAX (781)736-3107
                               E-mail: griffith@brandeis.edu


EMPLOYMENT:

          1992-1998 Assistant Professor, Department of Biology and Volen Center for
          Complex Systems, Brandeis University

          1998-2004, Associate Professor, Department of Biology and Volen Center for
          Complex Systems, Brandeis University

          2004-present, Professor, Department of Biology and Volen Center for Complex
          Systems, Brandeis University

          July 2009- present, Chair, Department of Biology, Brandeis University


EDUCATION AND TRAINING:

                        S.B., 1981, Life Sciences
                        Massachusetts Institute of Technology

                        Ph.D., 1987, Pharmacology
                        Advisor: Howard Schulman
                        Stanford University
                        Thesis Title: "Regulation of Neuronal Function by Calcium-
                        dependent Phosphorylation"

                        M.D., 1989
                        Stanford University Medical School

                        Postdoctoral Research, 1988-1992, Neuroscience
                        Advisor: Ralph J. Greenspan
                        Roche Institute of Molecular Biology
                        Role of calcium/calmodulin-dependent protein kinases in neuronal
                        function and behavior in Drosophila melanogaster
HONORS AND AWARDS:
            National Merit Scholar
            Phi Beta Kappa, M.I.T.
            NSF Predoctoral Fellowship, 1981-1984
            Pharmaceutical Manufacturers Association Foundation Advanced Predoctoral
            Fellowship, 1985-1987
            NRSA Postdoctoral Fellowship, 1989-1992
            Rothschild Fellowship, Hoffman-LaRoche, 1989-1992
            Alfred P. Sloan Research Fellowship, 1994-1996
            Klingenstein Research Fellowship, 1994-1997
            Whitehall Foundation Grant, 1995-1997
            NIH Career Development Award, 1996-2001
            McKnight Technological Innovation Award 1999-2000
            Scholar in residence, Neural Systems and Behavior, Marine Biological Labs, Woods
            Hole 2007
            Meyerhof Lecturer, Max-Planck Institute, Heidelberg, 2008
            Society for Neuroscience Presidential Lecture, 2008


SERVICE ACTIVITIES:

     Ad Hoc Reviewer for NIH Study Section BIOL2, 1998
     Member of the steering committee of the Boston Area Neuroscience Group (BANG) 1999-2007
     Member of NIH Study Section MDCN-1/SYN, 1998-2005, Chair 2004-2005
     Course instructor, Marine Biological Labs Neurobiology course 1999 and 2000
     Member of the Medical Foundation Fellowship Selection Board 2000-2005
     Member of Society for Neuroscience Chapters Committee 2001-2004
     Ad hoc reviewer for NIH Study Section IFCN-7, 2002
     Tufts University School of Medicine Neuroscience Program Review Committee, 2005
     Organizer for 2005 Cold Spring Harbor Drosophila Neurobiology Meeting
     Ad hoc reviewer for NIH Study Section LAM, 2006, 2007
     Instructor, Cold Spring Harbor “Drosophila Neurobiology” course, July 18-19, 2007
     NIH Blueprint Meeting on Plasticity, August 29-30, 2007
     Reviewer for NIH EUREKA program, 2008
    Organizer for 2008 Janelia Farm Drosophila Learning and Memory Meeting
    Member of the Drosophila Board (elected position, New England Region) 2008-2011
    Ad Hoc reviewer for NIH Study Section MNG, 2008
    Ad Hoc reviewer for NIH Study SEP, 2009
    Visiting Scholar, University of Pennsylvania Neuroscience Program May 2009
    Organizer for 2011 Genetics Society of America Drosophila Meeting



SOCIETY MEMBERSHIPS:
    Society for Neuroscience
    International Society for Neuroethology
    Genetics Society of America
                                      PUBLICATIONS

1.    Spindel, E., Griffith, L. and Wurtman, R.J. (1983). "Neuroendocrine effects of caffeine. II.
      Effects on thyrotropin and corticosterone secretion," J. Pharmacol. Exp. Ther. 225:346-350.

2.    Spindel, E.R., Wurtman, R.J., McCall, A., Carr, D.B., Conlay, L., Griffith, L. and Arnold,
      M.A. (1984). "Neuroendocrine effects of caffeine in normal subjects," Clin. Pharmacol.
      Ther. 36:402-407.

3.    Nosé, P.S., Griffith, L.C. and Schulman, H. (1985). "Ca2+-dependent phosphorylation of
      tyrosine hydroxylase in PC12 cells," J. Cell. Biol. 101:1182-1190.

4.    Griffith, L.C. and Schulman, H. (1988). "The multifunctional Ca2+/calmodulin-dependent
      protein kinase mediates Ca2+-dependent phosphorylation of tyrosine hydroxylase," J. Biol.
      Chem. 263:9542-9549.

5.    Griffith, L.C. and Schulman, H. (1988). "The multifunctional calcium/calmodulin-
      dependent protein kinase mediates calcium action in vivo," in Molecular Basis of the Action
      of Drugs and Toxic Substances (T.P. Singer, N. Catagnoli and C.C. Wang, eds.), Walter de
      Gryter, Berlin and New York.

6.    Griffith, L.C., Tagawa, M. and Schulman, H. (1989). "In vitro and in vivo phosphorylation
      of murine lymphocyte differentiation antigen CD5," Biochem. Biophys. Res. Comm.
      159:536-541.

7.    Tagawa, M. and Griffith, L.C. (1990). "Murine T-cell differentiation antigen CD8 is a direct
      substrate of protein kinase C," Biochem. Biophys. Res. Com. 170:10-16.

8.    Tagawa, M, Koike, T. and Griffith, L.C. (1991) "Phosphorylation of mouse thymocyte CD4
      and CD8: Regulation of surface expression," Biochem. Internatl. 24:739-747

9.    Muller, W., Petrozzino, J.J., Griffith, L.C., Danho, W. and Connor, J.A. (1992) "Specific
      involvement of Ca2+-calmodulin kinase II in cholenergic modulation of neuronal
      responsiveness” J. Neurophysiol. 68:2264-2269

10.   Griffith, L.C., Verselis, L.M., Aitken, K.M., Kyriacou, C.P., Danho, W. and Greenspan, R.J.
      (1993) “Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts
      behavioral plasticity”, Neuron 10:501-509

11.   Griffith, L.C. and Greenspan, R.J. (1993) “The diversity of calcium/calmodulin-dependent
      protein kinase II isoforms in Drosophila is generated by alternative splicing of a single
      gene”, J. Neurochem. 61:1534-1537

12.   Griffith, L.C., Wang, J., Zhong, Y., Wu, C.-F. and Greenspan, R.J. (1994)
      “Calcium/calmodulin-dependent protein kinase II and potassium channel subunit Eag
      similarly affect plasticity in Drosophila “ Proc. Natl. Acad. Sci. 91:10044-10048
13.   Wang, J., Renger, J., Griffith, L.C., Greenspan, R.J. and Wu, C.-F. (1994) “Concomitant
      Alterations of Physiological and Developmental Plasticity at CaM kinase II-inhibited
      Synapses in Drosophila” Neuron 13:1373-1384

14.   GuptaRoy, B. and Griffith, L.C. (1996) “Functional characterization of alternatively spliced
      isoforms of Drosophila Ca2+/calmodulin-dependent protein kinase II” J. Neurochem.
      66:1282-1288

15.   GuptaRoy, B., Beckingham, K. and Griffith, L.C. (1996) “Functional diversity of
      alternatively spliced isoforms of Drosophila Ca2+/calmodulin-dependent protein kinase II:
      A role for the variable domain in activation” J. Biol. Chem. 271:19846-19851

16.   Otmakhov, N., Griffith, L.C. and Lisman, J.E. (1997) “Postsynaptic inhibitors of CaM-
      kinase block induction but not maintenance of pairing-induced LTP” J. Neurosci., 17:5357-
      5365

17.   Barria, A., Muller, D., Derkach, V., Griffith, L.C. and Soderling, T.R. (1997) "Regulatory
      phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term
      potentiation" Science 276:2042-2045

18.   Joiner, M.A. and Griffith L.C. (1997) “CaM kinase II and visual input modulate memory
      formation in the neuronal circuit controlling courtship conditioning” J. Neurosci. 17: 9384-
      9391

19.   Griffith, L.C. (1997) “Drosophila melanogaster as a model system for the study of the
      function of calcium/calmodulin-dependent protein kinase II in synaptic plasticity”, Invert.
      Neurosci. 3:93-102

20.   Wang, Z., Palmer, G. and Griffith, L.C. (1998) “Regulation of Drosophila
      Ca2+/calmodulin-dependent protein kinase II by autophosphorylation analyzed by site-
      directed mutagenesis”, J. Neurochem. 71:378-387

21.   Wilson, G.F., Wang, Z., Chouinard, S.W., Griffith, L.C. and Ganetzky, B. (1998)
      “Interaction of the K channel  subunit, Hyperkinetic, with EAG family members” J. Biol.
      Chem. 273: 6389-6394

22.   Schopperle, W.M., Holmqvist, M., Zhou, Y., Wang, J., Wang, Z., Griffith, L.C., Kusinitz,
      R., Dagan, D. and Levitan, I. B. (1998) “Slob, a novel protein that binds to and modulates
      the Slopoke calcium-dependent potassium channel” Neuron 20: 565-573

23.   Withers, M.D., Kennedy, M.B., Marder, E. and Griffith, L.C. (1998) "Characterization of
      calcium/calmodulin-dependent protein kinase II activity in the nervous system of the lobster,
      Panulirus interruptus" Inv. Neurosci. 3:335-345

24.   Jin, P., Griffith, L.C. and Murphey, R.K. (1998) "Presynaptic Ca2+/calmodulin-dependent
      protein kinase II regulates habituation of a simple reflex in adult Drosophila" J. Neurosci.
      18:8955-8964
25.   Zhou, Y., Schopperle, W.M., Murrey, H., Jarmillo, A., Dagan, D., Griffith, L.C., Levitan, I.
      (1999) "A 14-3-3, Slob and Slowpoke potassium channel complex in Drosophila
      presynaptic nerve terminals" Neuron 22:809-818

26.   Joiner, M.A. and Griffith, L.C. (1999) "Mapping of the anatomical circuit of CaM kinase-
      dependent courtship conditioning in Drosophila" Learn. & Mem 6:177-192


27.   Koh, Y.H., Popova, E., Thomas, U., Griffith, L.C. and Budnik, V. (1999) "Regulation of
      DLG localization at synapses by CaMKII-dependent phosphorylation" Cell 98:353-363


28.   Joiner, M.A. and Griffith, L.C. (2000) "Visual input regulates circuit configuration in
      courtship conditioning of Drosophila melanogaster" Learn. & Mem. 7:32-42


29.   GuptaRoy, B., Marwaha, N., Pla, M., Wang, Z., Nelson, H.B., Beckingham, K. and Griffith,
      L.C. (2000) “Alternative splicing of Drosophila calcium/calmodulin-dependent protein
      kinase II regulates substrate specificity and activation” Mol. Brain Res. 30:26-34


30.   Long, X. and Griffith, L.C. (2000) “ Identification and characterization of a SUMO-1
      conjugation system that modifies neuronal CaMKII in Drosophila melanogaster” J. Biol.
      Chem. 275:40765-40776


31.   Griffith, L.C. (2001) “Potassium channels: The importance of transport signals” Curr. Biol.
      11:R226-228


32.   Park, D., Coleman, M.J., Hodge, J.J.L., Budnik, V. and Griffith, L.C. (2002) "Regulation of
      neuronal excitability in Drosophila by constitutively active CaMKII " J. Neurobiol. 52:24-
      42


33.   Wang, Z., Wilson, G.F. and Griffith, L.C. (2002) “Calcium/calmodulin-dependent protein
      kinase II phosphorylates and regulates the Drosophila Eag potassium channel” J. Biol.
      Chem. 227:24022-24029


34.   Pratt, K., Watt, A., Griffith, L.C., Nelson, S.B. and Turrigiano, G.G. (2003) “Activity-
      dependent remodeling of presynaptic inputs by postsynaptic expression of activated
      CaMKII” Neuron 39:269-281


35.   Griffith, L.C., Lu, C.S. and Sun, X.X. (2003) “CaMKII, an Enzyme on the Move:
      Regulation of Temporospatial Localization” Mol. Interv. 3:386-403
36.   Lu, C., Hodge, J.J.L., Sun, X.-X., Mehren, J.E. and Griffith, L.C. (2003) “Regulation of the
      Ca2+/CaM responsive pool of CaMKII by scaffold-dependent autophosphorylation” Neuron
      40:1185-1197


37.   Sun, X.X., Hodge, J.J.L., Zhou, Y., Nguyen, M.-D. and Griffith, L.C. (2004) “The eag
      potassium channel binds and locally activates CaMKII” J. Biol. Chem. 279:10206-10214


38.   Choi, J., Park, D. and Griffith, L.C. (2004) “Electrophysiological and morphological
      characterization of identified motor neurons in the Drosophila third instar larva central
      nervous system” J. Neurophysiol. 91: 2353-2365


39.   Griffith, L.C. (2004) “Receptor clustering: Nothing succeeds like success” Curr. Biol.
      14:R413-R415


40.   Griffith, L.C. (2004) “Calcium/calmodulin-dependent protein kinase II: An unforgettable
      kinase” J. Neurosci. 24:8391-8393


41.   Griffith, L.C. (2004) “Regulation of calcium/calmodulin-dependent protein kinase II
      activation by intramolecular and intermolecular interactions” J. Neurosci. 24:8394-8398


42.   Mehren, J.E., Ejima, A. and Griffith, L.C. (2004) “Unconventional sex: Fresh approaches to
      courtship learning” Curr. Opin. Neurobiol. 14:745-750


43.   Mehren, J.E. and Griffith, L.C. (2004) “Calcium-independent CaMKII in the adult
      Drosophila CNS enhances the training of pheromonal cues” J. Neurosci. 24:10584-10593
      (Featured in “This Week in the Journal” J Neurosci 24:i)


44.   Hodge, J.J.L., Choi, J. C., O’Kane, C.J. and Griffith, L.C. (2005) “Shaw potassium channel
      genes in Drosophila J. Neurobiol. 63:235-254


45.   Ejima, A., Smith, B.P.C., Lucas, C., Levine, J.D. and Griffith, L.C. (2005) “Sequential
      learning of pheromonal cues modulates memory consolidation in trainer-specific associative
      courtship conditioning” Curr. Biol. 15:194-206 (“Recommended” by Faculty of 1000 and
      featured in a Curr Biol “Dispatch” 15:R88-R90)


46.   Griffith, L.C. (2006) “Watching the fly brain learn” Neuron 49:171-174
47.   Slonimsky, J.D., Mattaliano, M.D., Moon, J.-i., Griffith, L.C. and Birren, S.B. (2006) “Role
      for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of
      sympathetic cholinergic transmission” Proc. Natl. Acad. Sci. 103:2915-2919 PMC1413855


48.   Park, D. and Griffith, L.C. (2006) “Electrophysiological and anatomical characterization of
      PDF-positive clock neurons in the intact adult Drosophila brain” J. Neurophysiol. 95:3955-
      3960


49.   Hodge, J.J.L., Mullasseril, P. and Griffith, L.C. (2006) “Activity-dependent gating of
      CaMKII autonomous activity by Drosophila CASK” Neuron 51:327-337


50.   Mehren, J.E. and Griffith, L.C. (2006) “Cholinergic neurons mediate CaMKII-dependent
      enhancement of courtship suppression” Learn. & Mem. 13:686-689


51.   Griffith, L.C. and Budnik, V. (2006) “Plasticity and second messengers during synaptic
      development” In: The Fly Neuromuscular Junction: Structure and Function, International
      Review of Neurobiology, V 75 (Budnik, Ruiz-Canada, eds), San Diego, Elsevier Academic
      Press.


52.   Ejima, A., Smith, B.P.C., Lucas, C., Van der Goes van Naters, W., Miller, C., Carlson, J.R.,
      Levine, J.D. and Griffith, L.C. (2007) “Generalization of courtship learning in Drosophila is
      mediated by cis-vaccenyl acetate” Curr. Biol. 17:599-605 (Featured in a Curr Biol
      “Dispatch” 17:R240-R242 and a Nature “News and Views” 446:502-504) PMC1913718


53.   Mattaliano, M.D., Montana, E.S., Parisky, K.M., Littleton, J.T. and Griffith, L.C. (2007)
      “The Drosophila ARC homolog regulates behavioral responses to starvation” Mol. Cell.
      Neurosci. 36:211-221 PMC2094000


54.   Mullasseril, P., Dosemeci, A., Lisman, J.E. and Griffith, L.C. (2007) “A structural
      mechanism for maintaining the “on-state” of the CaMKII memory switch in the postsynaptic
      density” J. Neurochem. 103:357-364 PMC2665908


55.   Pulver, S.R. and Griffith, L.C. (2007) “Dr. Strangeslug, or how I learned to stop worrying
      and love the brain” Nat. Neurosci. 10:933


56.   Ejima, A and Griffith, L.C. (2007) “Measurement of courtship behavior in Drosophila” CSH
      Protocols; doi:10.1101/pdb.prot4847


57.   Griffith, L.C. (2008) “Love hangover” Nature 451:24-25 PMC2742166
58.   Agosto, J., Choi, J.C., Parisky, K.M., Stilwell, G., Rosbash, M. and Griffith, L.C. (2008)
      “Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in
      Drosophila” Nat. Neurosci. 11:354-359 PMC2655319


59.   Griffith, L.C. and Rosbash, M. (2008) “Sleep: Hitting the reset button” Nat. Neurosci.
      11:123-124 PMC2655316


60.   Griffith, L.C. (2008) “CaMKII: New tricks for an old dog” Cell 133:5-7 PMC2655315


61.   Ejima, A. and Griffith, L.C. (2008) “Courtship initiation is stimulated by acoustic signals in
      Drosophila melanogaster” PLoS ONE 3(9):e3246 PMC2531232


62.   Parisky, K.M., Agosto, J., Pulver, S.R., Shang, Y., Kuklin, E., Hodge, J.J.L., Kang, K., Liu,
      X., Garrity, P., Rosbash, M. and Griffith, L.C. (2008) “PDF cells are a GABA-responsive
      wake-promoting component of the Drosophila sleep circuit” Neuron 60:672-682
      PMC2734413


63.   Shang, Y., Griffith, L.C. and Rosbash, M. (2008) “Light-arousal and circadian
      photoreception circuits intersect at the large PDF cells of the Drosophila brain” Proc. Natl.
      Acad. Sci. 150:19587-19594 PMC2596742


64.   Griffith L.C. and Ejima, A. (2009) “Multimodal sensory integration of courtship stimulating
      cues in Drosophila melanogaster: Contextual effects on chemosensory cues” Ann. N.Y.
      Acad. Sci. 1170:394-398 PMCID in process


65.   Sun, X.X., Bostrom, S.L. and Griffith, L.C. (2009) “Alternative splicing of the eag
      potassium channel gene in Drosophila generates a novel signal transduction scaffolding
      protein” Mol. Cell. Neurosci. 40:338-343 PMC2646804


66.   Hornstein, N.J., Pulver, S.R. and Griffith, L.C. (2009) “Channelrhodopsin2-mediated
      stimulation of synaptic potentials at Drosophila neuromuscular junctions” J. Vis. Exp. 6
      (25). pii:1133. doi: 10.3791/1133 PMCID in process


67.   Slawson, J.B., Kim, E.Z. and Griffith, L.C. (2009) “High-resolution video tracking of
      locomotion in adult Drosophila melanogaster” J. Vis. Exp. pii: 1096. doi: 10.3791/1096
      PMCID in process


68.   Pulver, S.R., Pashkovski, S.L., Hornstein, N.J., Garrity, P.A., Griffith, L.C. (2009).
      “Temporal dynamics of neuronal activation by channelrhodopsin-2 and TRPA1 determine
      behavioral output in Drosophila larvae” J. Neurophys. 101:3075-3088 PMC2694103
69.   Griffith, L.C. and Ejima, A. (2009) “Courtship learning in Drosophila melanogaster:
      Diverse plasticity of a reproductive behavior” Learn. & Mem. 16:743-750


70.   Bostrom, S.L., Dore, J. and Griffith L.C. (2009) “CaMKII uses GTP as a phosphate donor
      for both substrate and autophosphorylation” Biochem. Biophys. Res. Comm. 390:1154-1159
      PMC2787665


71.   Griffith, L.C. (2009) “Attention K-Mart shoppers: Blowout on aisle 7!” Neuron 64:443-445
      PMC2742166


72.   Pulver, S.R. and Griffith, L.C. (2010) “Spike integration and cellular memory in a rhythmic
      network from the dynamics of a Na+/K+ pump current” Nat. Neurosci. 13:53-59


73.   Kang, K., Pulver, S.R., Panzano, V.C., Chang, E.C., Griffith, L.C., Theobold, D.L. and
      Garrity, P.A. (2010) “Analysis of Drosophila TRPA1 reveals an ancient origin for human
      chemical nociception” Nature In Press


74.   Li, Y., Liu, X., Wu, Y., Xu, Z., Li, H., Griffith, L.C. and Zhou, Y. (2010) “Intracellular
      regions of the eag potassium channel play a critical role in voltage-dependent activation”
      Submitted

								
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