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									- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Sigma Chemical
MANUFACTURER: SIGMA CHEMICAL COMPANY POST OFFICE BOX 14508 SAINT LOUIS, MISSOURI 63178, USA FAX: USA/CANADA: 1-800-325-5052 OUTSIDE USA/CANADA: 314-771-5757 TELEX: 910-761-0593 or 434475 ANSWERBACK "SIG OK COLLECT" TELEPHONE: USA/CANADA: 1-800-325-3010 OUTSIDE USA/CANADA call COLLECT 314-771-5750 EMERGENCY PHONE: 1-314-771-5765 DATE: 02/27/93 CUST#: 6-033-95841 PO#: 2782 ----------------------------------------------------------IDENTIFICATION ----------------------------------------------------------PRODUCT #: T 4625 NAME: Thiamine Hydrochloride CAS #: 67-03-8 MF: C12H17ClN4OS SYNONYMS: Aneurine hydrochloride, Apate drops, Beatine, Bedome, Begiolan, Benerva, Bequin, Berin, Betabion Hydrochloride, Betalin S, Betaxin, Bethiazine, Beuion, Bevitex, Bevitine, Bewon, Biuno, Bivatin, Bivita, Clotiamina, Eskaphen, Eskaphen, Lixa-Beta, Metabolin, Slowten, THD, Thiadoxine, Thiaminal, Thiamin Chloride, Thiamin Dichloride, Thiamine Chloride, Thiamine Dichloride, Thiamine Hydrochloride, Thamin Hydrochloride, Thiaminium Chloride, Hydrochloride, Thiamol, Thiavit, Tiamidon, Tiaminal, Trophite, USAF CB-20, Vetalin S, Vinothiam, Vitamin B Hydrochloride, Vitamin B1 Hydrochloride, Vitamin B (Sub 1) Hydrochloride, Vetaneuron. ----------------------------------------------------------TOXICITY HAZARDS ----------------------------------------------------------RTECS NO: XI7350000 Thiamine, Chloride, Hydrochloride TOXICITY DATA: ORL-RAT LD50: 3710 mg/kg AGACBH: 4,125,74 IPR-RAT LD50: 500 mg/kg USXXAM: #3016380 IVN-RAT LD50: 118 mg/kg AEPPAE: 236,149,59 ORL-MUS LD50: 8224 mg/kg IZVIAK: 37,82,67 IPR-MUS LD50: 200 mg/kg NTIS**: AD277-689 IVN-MUS LD50: 89 mg/kg IZVIAK: 37,82,67 IVN-RBT LD50: 117 mg/kg PSEBAA: 68,153,48 REVIEWS, STANDARDS, AND REGULATIONS: NOHS 1974: HZD 72200; NIS 6; TNF 1288; NOS 14; TNE 18364 NOES 1983: HZD 72200; NIS 10; TNF 1872; NOS 28; TNE 48078; TFE 31774 EPA TSCA CHEMICAL INVENTORY, June 1990 TARGET ORGAN DATA: Behavioral (muscle contraction or spasticity) Lungs, thorax or respiration (cyanosis) Lungs, thorax or respiration (other changes) Only selected registry of toxic effects of chemical substances (RTECS) data is presented here. See actual entry in RTECS for complete information. ----------------------------------------------------------HEALTH HAZARD DATA ----------------------------------------------------------ACUTE EFFECTS: May be harmful by inhalation, ingestion, or skin absorption. May cause eye irritation. May cause skin irritation. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

THIAMINE HYDROCHLORIDE
FIRST AID: IN CASE OF CONTACT: immediately flush eyes with copious amounts of water for at least 15 minutes. IN CASE OF CONTACT: immediately wash skin with soap and copious amounts of water. IF INHALED: remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. IF SWALLOWED: wash out mouth with water provided person is conscious. Call a physician. Wash contaminated clothing before reuse. ADDITIONAL INFORMATION: Exposure to high concentrations can cause nausea, tightness of the throat, itching, and weakness. ----------------------------------------------------------PHYSICAL DATA ----------------------------------------------------------MELTING POINT: 260 deg C (DEC) APPEARANCE AND ODOR: White powder ----------------------------------------------------------FIRE AND EXPLOSION HAZARD DATA ----------------------------------------------------------EXTINGUISHING MEDIA: Water spray. Carbon dioxide, dry chemical powder or appropriate foam. SPECIAL FIREFIGHTING PROCEDURES: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. UNUSUAL FIRE AND EXPLOSIONS HAZARDS: Emits toxic fumes under fire conditions. ----------------------------------------------------------REACTIVITY DATA ----------------------------------------------------------INCOMPATIBILITIES: Strong oxidizing agents. Protect from moisture. HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS: TOXIC FUMES OF: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, hydrogen chloride gas. ----------------------------------------------------------SPILL OR LEAK PROCEDURES ----------------------------------------------------------STEPS TO BE TAKEN IF MATERIAL IS RELEASED OR SPILLED: Wear respirator, chemical safety goggles, rubber boots and heavy rubber gloves. Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. WASTE DISPOSAL METHOD: Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all Federal, State and local environmental regulations. ----------------------------------------------------------PRECAUTIONS TO BE TAKEN IN HANDLING AND STORAGE ----------------------------------------------------------Chemical safety goggles. Compatible chemical-resistant gloves. NIOSH/MSHA-approved respirator. Safety shower and eye bath. Mechanical exhaust required. Avoid inhalation. Avoid contact with eyes, skin and clothing. Avoid prolonged or repeated exposure. Wash thoroughly after handling. Keep tightly closed. Hygroscopic. Store under nitrogen. Store in a cool dry place. LABEL PRECAUTIONARY STATEMENTS: CAUTION: Avoid contact and inhalation.

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- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Sigma Chemical
----------------------------------------------------------THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE. ----------------------------------------------------------COPYRIGHT 1993 SIGMA CHEMICAL CO. LICENSE GRANTED TO MAKE UNLIMITED COPIES FOR INTERNAL USE ONLY. ----------------------------------------------------------DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES: although preparer and owner have taken reasonable care in the preparation of this document, we extend no warranties and make no representation as to the accuracy or completeness of the information contained herein, and assume no responsibility regarding the suitability of this information for the user's intended purposes or for the consequences of its use. Each user should make a determination as to the suitability of the information for their particular purpose(s). A request has been made to the manufacturer to approve the contents of this material safety data sheet. Upon receipt of any changes a new MSDS will be made available. ----------------------------------------------------------COMPAS Code: 11960250

THIAMINE HYDROCHLORIDE

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