Conference Program 15 CCTC 2009 Friday, July 17 Session

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Conference Program 15 CCTC 2009 Friday, July 17 Session Powered By Docstoc
					                               Conference Program 15th CCTC 2009


Friday, July 17
8.15-9.15      Registration and Coffee
9.15-9.30      Welcome Address


Session I - Genetics in Fracture Repair and Bone Disease
9.30-10.15     Keynote – Update 2009: ENU Mutagenesis for New Mouse Models of Human Bone Disease
               Dr. Jane Aubin, University of Toronto



10.15-10.30    Therapeutic Intervention to Promote Fixation of a Biocompatible Implant in Osteopenic FGFR3-/-
               Mice
               Letitia Z. Lim, Jean-Francois Couture, Cristoph Ladel, Chan Gao, Huifen Wang, Ailian Li, Jan
               P. Suentjens, Edward J. Harvey, Janet E. Henderson
               McGill University

10.30-10.45    Loss of PITX1 Transcription Factor Expression in Osteoarthritis Occurs Through Nuclear
               Accumulation of Prohibitin
               Martin Pellicelli, Cynthia Picard, Roxanne Doucet, Maryam Taheri, Alain Moreau
               University of Montreal

10.45-11.00    Osteoarthritis Pathogenesis: A Role for Prohibitin and Sumoylation
               Roxanne Doucet, Martin Pellicelli, Cynthia Picard, Maryam Taheri, Alain Moreau
               University of Montreal


11.00-13.00    Poster Session and Lunch


Session II - Biomechanics and Mechanobiology of Connective Tissues
13.00 -13.45   Keynote – Mechanobiological Regulation of Mesenchymal Progenitor Cells
               Dr. Craig Simmons, University of Toronto


13.45 -14.00   Streaming Potential-Based Arthroscopic Device Can Detect Changes Immediately Following
               Localized Impact in an Equine Impact Model of Osteoarthritis
               Adele Changoor, Eric Quenneville, Martin Garon, Mark B. Hurtig, Michael D. Buschmann
               École Polytechnique

14.00 -14.15   Ligament and Menisci Injuries have Injury-Specific Effects on In Vivo Joint Surface Interactions
               and Cartilage Damage
               Jillian E. Beveridge, Jevon J. Y. Brown, Nigel G. Shrive, Cyril B. Frank
               University of Calgary

14.15 -14.30   Intermittent Cyclic Hydrostatic Pressure: Effects on Gene Expression in Human Osteoblast-like
               Cells in Contracting Collagen Gels
               Kenneth A. Myers, Justin Parreno, Nigel G. Shrive, David A. Hart
               University of Calgary
14.30 -14.45   Damage Detection in Healing Ligaments: Comparison of Tangent and Secant Modulus
               Reduction
               Laura M. Reimer, Soraya J. Bailey, Gail M. Thornton
               University of Calgary

14.45 -15.00   Mitigating the Spinal Cord Distraction Injury: The In-Vitro Effect of Durotomy and Longitudinal
               Cordotomy in Decreasing Cord Interstitial Pressure (CIP)
               Waleed Awwad, Peter Jarzem, Mahdi Bassi
               McGill University


15.00- 15.30   Coffee/Tea Break



Session III - Stem Cells, Differentiation and Regulation of Connective Tissue Formation
15.30 -16.15   Keynote – Sox and Skeletogenesis
               Dr. Veronique Lefebvre, Lerner Research Institute


16.15 -16.30   Comparison of the Mesenchymal Progenitor Cells Derived from Different Porcine Tissues for
               Lineage-specific Potential
               Ando Wataru, Cyril B. Frank, Norimasa Nakamura, David A. Hart
               University of Calgary

16.30 -16.45   Extracellular Matrix Can Drive Embryonic Stem Cells into Osteoblasts and Chondrocytes without
               Exogenous Growth Factors
               Roman Krawetz, Jaymi Taiani, Yuri Elizabeth Wu, Shiying Liu, Derrick Rancourt
               University of Calgary

16.45 -17.00   Embryonic Stem Cell-Derived Skeletal Cells Contribute to New Bone Formation in an In Vivo
               Fracture Model when Seeded on a Collagen I Matrix
               Jaymi T. Taiani, Yves Pauchard, Roman J. Krawetz, Derrick E. Rancourt, Steven K. Boyd, John
               R. Matyas
               University of Calgary

17.00 -17.15   Embryonic Stem Cells Form Elastic, Fibrous and Hyaline Cartilage in Suspension Culture and
               Reveal a Process of Perichondral Ossification
               Akihiro Yamashita, Derrick E. Rancourt
               University of Calgary

17.15 -17.30   Serum Free Scale Up Production of Murine Embryonic Stem Cell Derived Osteoblasts on
               Microcarriers
               Roz Alfred, Jaret Radford, Derrick Rancourt, Michael S. Kallos
               University of Calgary

17.30 -17.45   Non-Viral Transfection of Bone Marrow Stromal Cells and Embryonic Stem Cells to be a podium.
               Laura Rose, Cezary Kucharski, Xiaoyue Lin, Hasan Uludağ
               University of Calgary


18.30-20.30    Welcome Reception
Saturday, July 18
Session IV - Biomaterials and Tissue Engineering
8.00-8.45      Keynote – DNA and RNA delivery using polymeric nanoparticles
               Dr. Michael Buschmann, Ecole Polytechnique de Montréal


8.45-9.00      Bone Tissue Engineering with Mesenchymal Stem Cell (MSC)-seeded Dense Collagen
               Scaffolds
               Chan Gao, Oliver Nguyen, Vahid Serpooshan, Letitia Z. Lim, Huifen Wang, Ailian Li, M. Khayyat-Kholghi, Showan N.
               Nazhat, Edward J. Harvey, Janet E. Henderson
               McGill University

9.00-9.15      Development of Whole Organ Culture System for Human Intervertebral Disc Repair and
               Regeneration Studies
               Rahul Gawri, Jean Ouellet, Fackson Mwale, John Antoniou, Lisbet Haglund
               McGill University

9.15-9.30      Lipid Nanoparticles for Bone Targeting Delivery of Osteogenic Growth Factors
               Guilin Wang, Hasan Uludağ
               University of Alberta

9.30-9.45      An in vitro Model of Regeneration using Bovine Coccygeal Discs
               Janet Moir, Jim Bernice, Peter Roughley, Thomas Steffen, Lisbet Haglund
               McGill University

9.45-10.00     Improving Early Implant Fixation in Bone: Imaging and Modeling for Local Solutions
               V. A. Stadelmann
               University of Calgary



10.00-10.30    Coffee/Tea Break


Session V - Matrix Formation, Remodeling and Mineralization
10.30 -11.15   Keynote – Clinical Trials
               Dr. Nick Mohtadi, University of Calgary


11.15-11.30    Homocysteine Targets Inter- and Intra-molecular Disulfide-bonds in Fibrillin, Fibronectin and
               Tropoelastin Leading to Functional Impairments in Homocystinuria
               Dirk Hubmacher, Judith T. Cirulis, Ming Miao, Fred W. Keeley, Dieter P. Reinhardt
               McGill University

11.30-11.45    Sphingomyelin Phosphodiesterase 3 Expression in Osteoblasts is Necessary for Bone
               Mineralization
               Zohreh Khavandgar, JingJing Li, Christophe Poirier, Monzur Murshed
               McGill University

11.45-12.00    Delineating the Collagen Trafficking Pathway in Differentiating Osteoblasts
               Noushin Nabavi, Rene Harrison
               University of Toronto

12.00-12.15    Transglutaminases TG2 and FXIIIA are Regulated by Extracellular Collagen Matrix in MC3T3-
               E14 Preosteoblasts
               Sarah Piercy, Hadil Al-Jallad, Yunlin Tai, Mari Kaartinen
               McGill University


12.15-13.00    Posters and Lunch
Session VI - Clinical Aspects of Connective Tissue Disease
13.00 -13.45   Keynote – Knowledge Translation of Research to Clinical Practice – Challenges and
               Opportunities
               Dr. Cy Frank, University of Calgary

13.45 -14.00   Systemic Disturbance of Gi Protein-Mediated Signal Transduction in Patients with Adolescent
               Idiopathic Scoliosis
               Marie-Yvonne Akoume, Martin Pellicelli, Isabelle Turgeon, Anita Franco, Bouziane, Azeddine,
               Alain Moreau
               University of Montreal

14.00 -14.15   Role of the Transcription Factor PITX1 in Osteoarthritis Pathogenesis
               Cynthia Picard, Martin Pellicelli, Roxanne Doucet, DaShen Wang, Maryam Taheri, Florina
               Moldovan, Alain Moreau
               University of Montreal

14.15 -14.30   Assessment of Collagen Orientation in Repair Cartilage by Polarized Light and Scanning
               Electron Microscopies
               Adele Changoor, Monica Nelea, Nicolas Tran-Khanh, Stephane Methot, Liah Fereydoozad,
               Evgheny Rossomacha, Julie Tremblay, Matthew S. Shive, Michael B. Buschmann
               École Polytechnique

14.30 -14.45   Bone-marrow stimulation by Drilling Versus Microfracture Improves Cartilage Repair in a Mature
               Rabbit Model
               Hongmei Chen, Caroline D. Hoemann, Jun Sun, Wei Ouyang, Liviu Dragomir, Anik Chevrier,
               Viorica Lascau-Coman, Nicolas Tran-Khanh, Marc D. McKee, Matthew S. Shive, Michael D.
               Buschmann
               École Polytechnique


15:00-15.30    Awards Committee Meeting
15.30-16.00    Award Presentations
16.00-16.30    CCTC Business Meeting