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Conference Program 15th CCTC 2009
Friday, July 17
8.15-9.15 Registration and Coffee
9.15-9.30 Welcome Address
Session I - Genetics in Fracture Repair and Bone Disease
9.30-10.15 Keynote – Update 2009: ENU Mutagenesis for New Mouse Models of Human Bone Disease
Dr. Jane Aubin, University of Toronto
10.15-10.30 Therapeutic Intervention to Promote Fixation of a Biocompatible Implant in Osteopenic FGFR3-/-
Mice
Letitia Z. Lim, Jean-Francois Couture, Cristoph Ladel, Chan Gao, Huifen Wang, Ailian Li, Jan
P. Suentjens, Edward J. Harvey, Janet E. Henderson
McGill University
10.30-10.45 Loss of PITX1 Transcription Factor Expression in Osteoarthritis Occurs Through Nuclear
Accumulation of Prohibitin
Martin Pellicelli, Cynthia Picard, Roxanne Doucet, Maryam Taheri, Alain Moreau
University of Montreal
10.45-11.00 Osteoarthritis Pathogenesis: A Role for Prohibitin and Sumoylation
Roxanne Doucet, Martin Pellicelli, Cynthia Picard, Maryam Taheri, Alain Moreau
University of Montreal
11.00-13.00 Poster Session and Lunch
Session II - Biomechanics and Mechanobiology of Connective Tissues
13.00 -13.45 Keynote – Mechanobiological Regulation of Mesenchymal Progenitor Cells
Dr. Craig Simmons, University of Toronto
13.45 -14.00 Streaming Potential-Based Arthroscopic Device Can Detect Changes Immediately Following
Localized Impact in an Equine Impact Model of Osteoarthritis
Adele Changoor, Eric Quenneville, Martin Garon, Mark B. Hurtig, Michael D. Buschmann
École Polytechnique
14.00 -14.15 Ligament and Menisci Injuries have Injury-Specific Effects on In Vivo Joint Surface Interactions
and Cartilage Damage
Jillian E. Beveridge, Jevon J. Y. Brown, Nigel G. Shrive, Cyril B. Frank
University of Calgary
14.15 -14.30 Intermittent Cyclic Hydrostatic Pressure: Effects on Gene Expression in Human Osteoblast-like
Cells in Contracting Collagen Gels
Kenneth A. Myers, Justin Parreno, Nigel G. Shrive, David A. Hart
University of Calgary
14.30 -14.45 Damage Detection in Healing Ligaments: Comparison of Tangent and Secant Modulus
Reduction
Laura M. Reimer, Soraya J. Bailey, Gail M. Thornton
University of Calgary
14.45 -15.00 Mitigating the Spinal Cord Distraction Injury: The In-Vitro Effect of Durotomy and Longitudinal
Cordotomy in Decreasing Cord Interstitial Pressure (CIP)
Waleed Awwad, Peter Jarzem, Mahdi Bassi
McGill University
15.00- 15.30 Coffee/Tea Break
Session III - Stem Cells, Differentiation and Regulation of Connective Tissue Formation
15.30 -16.15 Keynote – Sox and Skeletogenesis
Dr. Veronique Lefebvre, Lerner Research Institute
16.15 -16.30 Comparison of the Mesenchymal Progenitor Cells Derived from Different Porcine Tissues for
Lineage-specific Potential
Ando Wataru, Cyril B. Frank, Norimasa Nakamura, David A. Hart
University of Calgary
16.30 -16.45 Extracellular Matrix Can Drive Embryonic Stem Cells into Osteoblasts and Chondrocytes without
Exogenous Growth Factors
Roman Krawetz, Jaymi Taiani, Yuri Elizabeth Wu, Shiying Liu, Derrick Rancourt
University of Calgary
16.45 -17.00 Embryonic Stem Cell-Derived Skeletal Cells Contribute to New Bone Formation in an In Vivo
Fracture Model when Seeded on a Collagen I Matrix
Jaymi T. Taiani, Yves Pauchard, Roman J. Krawetz, Derrick E. Rancourt, Steven K. Boyd, John
R. Matyas
University of Calgary
17.00 -17.15 Embryonic Stem Cells Form Elastic, Fibrous and Hyaline Cartilage in Suspension Culture and
Reveal a Process of Perichondral Ossification
Akihiro Yamashita, Derrick E. Rancourt
University of Calgary
17.15 -17.30 Serum Free Scale Up Production of Murine Embryonic Stem Cell Derived Osteoblasts on
Microcarriers
Roz Alfred, Jaret Radford, Derrick Rancourt, Michael S. Kallos
University of Calgary
17.30 -17.45 Non-Viral Transfection of Bone Marrow Stromal Cells and Embryonic Stem Cells to be a podium.
Laura Rose, Cezary Kucharski, Xiaoyue Lin, Hasan Uludağ
University of Calgary
18.30-20.30 Welcome Reception
Saturday, July 18
Session IV - Biomaterials and Tissue Engineering
8.00-8.45 Keynote – DNA and RNA delivery using polymeric nanoparticles
Dr. Michael Buschmann, Ecole Polytechnique de Montréal
8.45-9.00 Bone Tissue Engineering with Mesenchymal Stem Cell (MSC)-seeded Dense Collagen
Scaffolds
Chan Gao, Oliver Nguyen, Vahid Serpooshan, Letitia Z. Lim, Huifen Wang, Ailian Li, M. Khayyat-Kholghi, Showan N.
Nazhat, Edward J. Harvey, Janet E. Henderson
McGill University
9.00-9.15 Development of Whole Organ Culture System for Human Intervertebral Disc Repair and
Regeneration Studies
Rahul Gawri, Jean Ouellet, Fackson Mwale, John Antoniou, Lisbet Haglund
McGill University
9.15-9.30 Lipid Nanoparticles for Bone Targeting Delivery of Osteogenic Growth Factors
Guilin Wang, Hasan Uludağ
University of Alberta
9.30-9.45 An in vitro Model of Regeneration using Bovine Coccygeal Discs
Janet Moir, Jim Bernice, Peter Roughley, Thomas Steffen, Lisbet Haglund
McGill University
9.45-10.00 Improving Early Implant Fixation in Bone: Imaging and Modeling for Local Solutions
V. A. Stadelmann
University of Calgary
10.00-10.30 Coffee/Tea Break
Session V - Matrix Formation, Remodeling and Mineralization
10.30 -11.15 Keynote – Clinical Trials
Dr. Nick Mohtadi, University of Calgary
11.15-11.30 Homocysteine Targets Inter- and Intra-molecular Disulfide-bonds in Fibrillin, Fibronectin and
Tropoelastin Leading to Functional Impairments in Homocystinuria
Dirk Hubmacher, Judith T. Cirulis, Ming Miao, Fred W. Keeley, Dieter P. Reinhardt
McGill University
11.30-11.45 Sphingomyelin Phosphodiesterase 3 Expression in Osteoblasts is Necessary for Bone
Mineralization
Zohreh Khavandgar, JingJing Li, Christophe Poirier, Monzur Murshed
McGill University
11.45-12.00 Delineating the Collagen Trafficking Pathway in Differentiating Osteoblasts
Noushin Nabavi, Rene Harrison
University of Toronto
12.00-12.15 Transglutaminases TG2 and FXIIIA are Regulated by Extracellular Collagen Matrix in MC3T3-
E14 Preosteoblasts
Sarah Piercy, Hadil Al-Jallad, Yunlin Tai, Mari Kaartinen
McGill University
12.15-13.00 Posters and Lunch
Session VI - Clinical Aspects of Connective Tissue Disease
13.00 -13.45 Keynote – Knowledge Translation of Research to Clinical Practice – Challenges and
Opportunities
Dr. Cy Frank, University of Calgary
13.45 -14.00 Systemic Disturbance of Gi Protein-Mediated Signal Transduction in Patients with Adolescent
Idiopathic Scoliosis
Marie-Yvonne Akoume, Martin Pellicelli, Isabelle Turgeon, Anita Franco, Bouziane, Azeddine,
Alain Moreau
University of Montreal
14.00 -14.15 Role of the Transcription Factor PITX1 in Osteoarthritis Pathogenesis
Cynthia Picard, Martin Pellicelli, Roxanne Doucet, DaShen Wang, Maryam Taheri, Florina
Moldovan, Alain Moreau
University of Montreal
14.15 -14.30 Assessment of Collagen Orientation in Repair Cartilage by Polarized Light and Scanning
Electron Microscopies
Adele Changoor, Monica Nelea, Nicolas Tran-Khanh, Stephane Methot, Liah Fereydoozad,
Evgheny Rossomacha, Julie Tremblay, Matthew S. Shive, Michael B. Buschmann
École Polytechnique
14.30 -14.45 Bone-marrow stimulation by Drilling Versus Microfracture Improves Cartilage Repair in a Mature
Rabbit Model
Hongmei Chen, Caroline D. Hoemann, Jun Sun, Wei Ouyang, Liviu Dragomir, Anik Chevrier,
Viorica Lascau-Coman, Nicolas Tran-Khanh, Marc D. McKee, Matthew S. Shive, Michael D.
Buschmann
École Polytechnique
15:00-15.30 Awards Committee Meeting
15.30-16.00 Award Presentations
16.00-16.30 CCTC Business Meeting
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