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Nicola L. B. Pohl

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Nicola L. B. Pohl Powered By Docstoc
					Nicola L. B. Pohl
Wilkinson Professor of Interdisciplinary Engineering, Iowa State University
Department of Chemistry, Department of Chemical and Biological Engineering, the Plant
Sciences Institute, and the Interdepartmental Graduate Program in Microbiology
Hach Hall, Room 3101B, Ames, IA 50011-3111 USA
Telephone: 515-294-2339
Fax: 515-294-0105
npohl@iastate.edu


I. EDUCATION

       Stanford University, October 1997-July 2000. National Institute of General Medical
       Sciences Postdoctoral Fellow, Department of Chemical Engineering, Stanford, CA.
       Advisor: Prof. Chaitan Khosla.

       University of Wisconsin-Madison, August 1991-September 1997. Ph.D. granted in
       December 1997. Department of Chemistry, Madison, WI. Thesis advisor: Prof. Laura L.
       Kiessling. Thesis title: Synthesis of Carbohydrate-Based Ligands for the Selectins and
       Galectins.

       Harvard-Radcliffe College, September 1987-June 1991. A.B. (cum laude) granted in June
       1991 in English and American Literature and Languages with the Comparative Study of
       Religions, Cambridge, MA. Thesis title: Disease as a Metaphor for Sin and Guilt in the
       Works of Flannery O’Connor and Walker Percy.

II. PROFESSIONAL POSITIONS

       Professor with tenure and the Wilkinson Professor of Interdisciplinary Engineering, Iowa State
       University Department of Chemistry, Department of Chemical and Biological
       Engineering, and the Plant Sciences Institute, Ames, IA, January 2011-present.

       Professor with tenure and Caldwell Chair of Chemistry, Iowa State University Department of
       Chemistry and the Plant Sciences Institute, Ames, IA, June 2009-2010.

       Faculty in the Interdepartmental Program in Microbiology, Iowa State University, Ames, IA,
       January 2009-present.

       Associate Professor with tenure and Caldwell Chair of Chemistry, Iowa State University
       Department of Chemistry and the Plant Sciences Institute, Ames, IA, June 2006-May
       2009.

       Assistant Professor, Iowa State University Department of Chemistry and the Plant
       Sciences Institute, Ames, IA, August 2000-May 2006.
                                                    NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 2


       Visiting Professor, University of Zurich Institute of Organic Chemistry, Department of
       Chemistry, Zurich (Switzerland), May-June 2005.

       Graduate Research Assistant, University of Wisconsin-Madison Department of Chemistry,
       Madison, WI, October 1991-September 1997.

       Teaching Assistant, Organic Lab Course and First Semester Organic Chemistry, University of
       Wisconsin-Madison Department of Chemistry, Madison, WI, August 1991-May 1992.
       Supervisor: Dr. Paul Schatz.

       Undergraduate Research Assistant, Harvard University Department of Chemistry,
       Cambridge, MA, December 1989-June 1991. Research Advisor: Joseph J. Grabowski.

III. AWARDS AND HONORS
       Wilkinson Professor of Interdisciplinary Engineering, 2011-present.
       Iowa Women of Innovation Award, 2010.
       Editorial Board, Organic Reactions, 2010-present.
       Horace S. Isbell Award, Division of Carbohydrate Chemistry, American Chemical
Society, 2010.
       Elected to the Executive Committee (at Large) for the Division of Biological Chemistry,
American Chemical Society, 2010-2012.
       Elected as Member-at-Large for the Division of Carbohydrate Chemistry, American
Chemical Society, 2010-2012.
       Co-Vice Chair, Carbohydrates Gordon Research Conference, 2009.
       LAS Mid-Career Achievement in Research Award, Iowa State University, 2008.
       LAS Master Teacher Award, Iowa State University, 2008.
       Editorial Board Member, Chemistry Central Journal, 2007-present.
       Editorial Advisory Board, Carbohydrate Research, 2007-present.
       Co-Chair, NSF Workshop on Complexity and Emergent Phenomena, 2007.
       Golden Goggles Invitational Lecture, Middle Tennessee State University, 2007.
       Caldwell Chair of Chemistry, Iowa State University, 2006-2010.
       Alfred P. Sloan Foundation Research Fellow, 2005-2007.
       Robert O’Malley Visiting Scholar, Boston College, 2006.
       National Science Foundation CAREER Award, 2004-2009.
       Cottrell Scholar Award of Research Corporation, 2003-2008.
       NIH Postdoctoral Fellowship, 1998-2000.
       Christine Kohler Fellowship, 1994-1997.
       Department of Education Fellowship, 1993-1994.
       Harvard College Scholarship, 1987-1991.
       J. S. Sirrine Scholarship, 1987-1991.
       Robert C. Byrd Scholarship, 1987-1988.

IV. INVITED PRESENTATIONS

2000
Natural Products Chemistry Gordon Research Conference, Plymouth, NH, 31 July.
                                                  NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 3



2001
Truman State University, Department of Chemistry, Kirksville, MO, 2 November.

2003
Carbohydrates Gordon Research Conference, Tilton, NH, 24 June.
University of Iowa, Department of Medicinal Chemistry, Iowa City, IA, 9 September.
University of Toledo, Department of Chemistry, Toledo, OH, 22 September.
St. Olaf’s College, Department of Chemistry, Northfield, MN, 9 October.

2004
Iowa State University, Analytical chemistry seminar series, Ames, IA, 30 January.
University of Nebraska at Lincoln, Department of Chemistry, Lincoln, NE, 16 February.
Clemson University, Department of Chemistry, Clemson, SC, 8 April.
NSF Workshop on Organic Synthesis and Natural Products, Squam Lake, NH, 11 June.
Bioorganic Gordon Research Conference, Andover, NH, 15 June.
University of Alberta, Department of Chemistry, Edmonton, AB (Canada), 12 August.
Emory University, Department of Chemistry, Atlanta, GA, 29 September.
West Virginia University, Department of Chemistry, Morgantown, WV, 13 October.
University of Pittsburgh, Department of Chemistry, Pittsburgh, PA, 14 October.
Boston University, Department of Chemistry, Boston, MA, 25 October.
University of Calgary, Department of Biochemistry and Molecular Biology, Calgary, AB
       (Canada), 5 November.
Princeton University, Department of Chemistry, Princeton, NJ, 22 November.
Iowa State University, Department of Biochemistry, Biophysics, and Molecular Biology, Ames,
       IA, 2 December.
University of Illinois at Urbana-Champaign, Department of Chemistry, Urbana, IL, 9 December.


2005
University of California at Irvine, Department of Molecular Biology and Biochemistry, Irvine,
       CA, 7 January.
Northwestern University, Department of Chemistry, Evanston, IL, 20 January.
University of Washington, Department of Chemistry, Seattle, WA, 28 January.
University of North Carolina, Department of Chemistry, Chapel Hill, NC, 11 February.
Biophysical Society National Meeting, Long Beach, CA, 13 February.
Duke University, Department of Chemistry, Durham, NC, 15 February.
University of Arkansas, Department of Chemistry, Fayetteville, AR, 28 February.
Iowa State University College of Veterinary Medicine, Department of Biomedical Sciences,
        Ames, IA, 9 March.
American Chemical Society National Meeting, Hudson Award Symposium, San Diego, CA, 14
       March.
Michigan Technological University, Department of Chemistry, Houghton, MI, 8 April.
National Institutes of Health (NIH), Laboratory of Experimental and Computational Biology,
        National Cancer Institute, Frederick, MD, 22 April.
                                                   NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 4


Iowa State University, Biorenewable Resources and Technology seminar series, Ames, IA, 26
          April.
Carbohydrate Symposium, Alberta Ingenuity Centre for Carbohydrate Science, Lake Louis, AB
          (Canada), 29 April.
University of California at Los Angeles, Department of Chemistry and Biochemistry, Los
         Angeles, CA, 5 May.
Institut de Chimie des Substances Naturelles (ICSN), CNRS, Gif-sur-Yvette (France), 12 May.
University of Berne, Department of Chemistry and Biochemistry, Berne (Switzerland), 31 May.
F. Hoffmann-La Roche Ltd., Basel (Switzerland), 6 June.
University of Konstanz, Department of Chemistry, Konstanz (Germany), 6 June.
University of Milan, Department of Organic and Industrial Chemistry, Milan (Italy), 9 June.
Carbohydrates Gordon Research Conference, Tilton, NH, 22 June.
Iowa State University, REU in Computational Chemistry seminar series, Ames, IA, 28 June.
Cottrell Scholars Conference, Research Corporation, Tuscon, AZ, 8 July.
Natural Products Gordon Research Conference, Tilton, NH, 26 July.
American Chemical Society National Meeting, Fluorous Chemistry Symposium, Washington,
         DC, 29 August.
California Institute of Technology, Department of Chemistry, Pasadena, CA, 14 September.
Georgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta, GA, 27
         September.
University of California at Davis, Department of Chemistry, Davis, CA, 29 September.
University of Wisconsin, Department of Chemistry, Madison, WI, 6 October.
Edgewood College, Department of Natural Science, Madison, WI, 7 October.
University of California at Los Angeles, California NanoSystems Institute (CNSI), Los Angeles,
         CA, 11 October.
Iowa State University, Organic/inorganic chemistry seminar series, 21 October.
University of Rochester, Department of Chemistry, Rochester, NY, 28 October.
University of Texas at Austin, College of Pharmacy, Medicinal Chemistry Program, Austin, TX,
          3 November.
Texas A&M University, Department of Chemistry, College Station, TX, 4 November.
University of Oklahoma ACS PROGRESS Lecture, Department of Chemistry and Biochemistry,
          Norman, OK, 14 November.
Massachusetts Institute of Technology (MIT), Department of Chemistry, Cambridge, MA, 22
          November.
ArQule, Inc., Woburn, MA, 23 November.
University of Georgia, Department of Chemistry, Athens, GA, 1 December.
8th Japanese-American Frontiers of Science Symposium, Shonan Village Center, Kanagawa
          (Japan), 9-12 December.

2006
ACS-CSIR Indo-US Workshop on Organic Chemistry and Chemical Biology, Pune and
        Hyderabad (India), 6-12 January.
Creighton University, Department of Chemistry, Omaha, NE, 19 January.
University of Michigan, Department of Biological Chemistry, Ann Arbor, MI, 31 January.
University of California-Berkeley, Department of Chemistry, Berkeley, CA, 7 February.
Louisiana State University, Department of Chemistry, Baton Rouge, LA, 17 February.
                                                   NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 5


Tulane University, Department of Chemistry, New Orleans, LA, 20 February.
Iowa State University College of Veterinary Medicine, Departments of Veterinary Microbiology
         and Pathology, Ames, IA, 28 February.
Indianapolis University School of Medicine, Department of Biochemistry and Molecular Biology,
         Indianapolis, IN, 6 March.
 th
4 International Microwaves in Chemistry Conference, Orlando, FL, 8-11 March.
Syracuse University, Life Sciences Retreat, Syracuse, NY, 14 March.
American Chemical Society National Meeting, Carbohydrate Recognition Symposium, Atlanta,
         GA, 27-28 March.
Oberlin College, Department of Chemistry and Biochemistry, Oberlin, OH, 5 April.
Vanderbilt University, Institute of Chemical Biology, Nashville, TN, 12 April.
Brown University, Department of Chemistry, Providence, RI, 12 May.
University of California at Santa Barbara, Department of Chemistry and Biochemistry, Santa
         Barbara, CA, 16 May.
University of California at San Francisco, Biophysics/Chemistry and Chemical Biology seminar
         series, San Francisco, CA, 1 June.
XXIIIrd International Carbohydrate Symposium, Keynote Lecture, Whistler, BC (Canada), 23-28
         July.
Society for Industrial Microbiology Annual Meeting, Emerging Areas and Systems in Biocatalysis
         session, Baltimore, MD, 2 August.
Iowa State University Molecular Parasitology Minisymposium, Ames, IA, 26 August.
University of Northern Iowa, Department of Chemistry, Cedar Falls, IA, 31 August.
American Chemical Society National Meeting, Carbohydrate Division Symposium, San
         Francisco, CA, 11 September.
Boston College, Robert O'Malley Visiting Scholar, Department of Chemistry, Chestnut Hill,
         MA, 26 and 28 September.
2nd Annual Midwest Carbohydrate Symposium, Plenary Lecture, Wayne State University,
         Detroit, MI, 30 September.
University of California at Santa Barbara, Materials Research Laboratory, Santa Barbara, CA, 27
         October.
University of Nebraska at Lincoln, Department of Chemistry, Departmental Colloquium,
         Lincoln, NE, 10 November.
University of Colorado, Department of Chemistry and Biochemistry, Boulder, CO, 14
         November.
Society for Glycobiology National Meeting, Los Angeles, CA, 16 November.

2007
University of California at Los Angeles, Department of Chemistry and Biochemistry, Los
        Angeles, CA, 12 January.
Bachem Holding AG, Bubendorf (Switzerland), 24 January.
ABC Technologies Conference, Plenary Lecture, Basel (Switzerland), 26 January.
The College of St. Catherine, Department of Chemistry, St. Paul, MN, 23 February.
Danforth Plant Sciences Center, St. Louis, MO, 14 March.
American Chemical Society National Meeting, Francis P. Garvan-John M. Olin Award
        Symposium, Chicago, IL, 28 March.
Middle Tennessee State University, Golden Goggles Lecture, Department of Chemistry,
                                                  NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 6


         Murfreesboro, TN, 6 April.
 th
5 International Microwaves in Chemistry Conference, Imperial College, London (UK), 19
         April.
 th
7 Carbohydrate Bioengineering Meeting, Keynote Lecture, Braunschweig (Germany), 23 April.
Combinatorial Chemistry Gordon Research Conference, New London, NH, 3-8 June.
Momenta Pharmaceuticals, Inc., Cambridge, MA, 22 June.
2nd International Symposium on Fluorous Technologies, Plenary Lecture, Yokohama (Japan), 31
         July.
The University of Tokyo, Graduate School of Pharmaceutical Sciences, Tokyo (Japan), 2 August.
New York University, Department of Chemistry, New York, NY, 7 September.
Auburn University, Department of Chemistry and Biochemistry, Auburn, AL, 20 September.
University of Missouri-St. Louis, Department of Chemistry and Biochemistry, St. Louis, MO, 1
         October.
Kansas State University, Department of Biochemistry, Manhattan, KS, 10 October.
University of California at Irvine, Department of Chemistry, Departmental Colloquium, Irvine,
         CA, 2 November.
Yale University, Department of Chemistry, New Haven, CT, 14 November.
Boehringer Ingelheim, Ridgefield, CT, 15 November.
National Institutes of Health, Inter-Institute NIH Chemistry Seminar Series, Bethesda, MD, 14
         December.

2008
Biochemistry Undergraduate Club, Iowa State University, Ames, IA, 23 January.
University of Pennsylvania, Department of Chemistry, Philadelphia, PA, 28 January.
Temple University, Department of Chemistry, Philadelphia, PA, 29 January.
University of Minnesota, Department of Chemistry, Minneapolis, MN, 5 February.
European Conference on Carbohydrates, Killarney (Ireland), 9-13 March.
Winthrop University, Department of Chemistry, Physics, and Geology, Rock Hill, SC, 26 March.
American Chemical Society National Meeting, ACS Award for Creative Work in Fluorine
         Chemistry Award Symposium, New Orleans, LA, 7 April.
State University of New York-ESF, Department of Chemistry, Syracuse, NY, 25 April.
6th International Microwaves in Chemistry Conference, Cambridge, MA, 14 May.
Alnylam Pharmaceuticals, Inc., Cambridge, MA, 16 May.
ZuChem, Inc., Chicago, IL, 9 June.
Cottrell Scholars Conference, Research Corporation, Tuscon, AZ, 11 July.
Iowa State University/University of Iowa Vaccine Meeting, Newton, IA, 20 August.
University of Tennessee at Knoxville, Department of Chemistry, Knoxville, TN, 11 September.
University of Missouri at Kansas City, Department of Chemistry, Kansas City, MO, 2 October.
Iowa State University, Organic/inorganic chemistry seminar series, 10 October.
Calvin College, Department of Chemistry and Biochemistry, Grand Rapids, MI, 23 October.
Hope College, Department of Chemistry, Holland, MI, 24 October.

2009
19th Winter Fluorine Conference, St. Petersburg Beach, FL, 12 January.
University of British Columbia, Lectures in Modern Chemistry series speaker, Vancouver, BC
        (Canada), 20 January.
                                                  NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 7


Consortium for Functional Glycomics Workshop, La Jolla, CA, 15 March.
15 th European Carbohydrate Symposium, Plenary Lecture, Vienna (Austria), 24-29 July.
19th International Symposium on Fluorine Chemistry/ISoFT'09, Jackson Hole, WY, 24 August.
Abo Akademi University, Department of Chemistry, Turku (Finland), 31 August.
Finnish Glycoscience Graduate School, Island of Seili (Finland), 1 and 2 September.
Iowa State University, Genetics, Developmental and Cell Biology seminar, 25 September.
Midwest Regional American Chemical Society Meeting, Cope Scholar Synthesis Symposium,
         Iowa City, IA, 23 October.
University of Pennsylvania, Department of Chemistry, Philadelphia, PA, 13 November.
Purdue University, Department of Chemistry, West Lafayette, IN, 17 November.

2010
Indiana University, Department of Chemistry, Bloomington, IN, 18 January.
University of Iowa, Department of Chemistry, Iowa City, IA, 22 January.
University of North Carolina at Charlotte, Department of Chemistry, Charlotte, NC, 8
         February.
President's Council, Iowa State University, Ames, IA, 5 March.
17th New Orleans Carbohydrate Symposium, New Orleans, LA, 26 March.
Indiana University, Department of Biochemistry, Bloomington, IN, 14 May.
American Chemical Society National Meeting, Wolfram/Isbell/New Investigator's Awards
         Symposium, Boston, MA, 22 August.
Iowa State University, Department of Chemical and Biological Engineering, 7 September.
4th Baltic Meeting on Microbial Carbohydrates, Hyytiälä Forestry Field Station (Finland), 20
         September.
Iowa State University Foundation Governors' Board Meeting, Ames, IA, 1 October.
Truman State University, Department of Chemistry, Kirksville, MO, 8 October.
The Pennsylvania State University, Department of Chemistry, University Park, PA, 8 November.
Joint Southwest and Southeastern Regional ACS Meeting, New Orleans, LA, 3 December.


V. PUBLICATIONS FROM G RADUATE AND POSTDOCTORAL WORK (* =
      CORRESPONDING AUTHOR)

1)   Manning, D. D.; Bertozzi, C. R.; Pohl, N. L.; Rosen, S. D.; Kiessling, L. L.*
       Selectin—Saccharide Interactions: Revealing Structure—Function Relationships with
       Chemical Synthesis. J. Org. Chem. 1995, 60, 6254-6255.

2)   Kiessling, L. L.*; Pohl, N. L. Strength in numbers:non-natural polyvalent carbohydrate
       derivatives. Chem. Biol. 1996, 3, 71-77. (invited review)

3)   Pohl, N. L.; Kiessling, L. L.* Para-Chlorobenzyl Protecting Groups as Stabilizers of the
       Glycosidic Linkage: Synthesis of the 3'-O-Sulfated Lewis X Trisaccharide. Tetrahedron
       Lett. 1997, 38, 6985-6988.
                                                   NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 8


4)   Pohl, N. L.; Gokhale, R. S.; Cane, D. E.; Khosla, C.* Synthesis and Incorporation of an N-
       Acetylcysteamine Analogue of Methylmalonyl-CoA by a Modular Polyketide Synthase. J.
       Am. Chem. Soc. 1998, 120, 11206-11207.

5)   Richardson, M. T.; Pohl, N. L.; Kealey, J. T.; Khosla, C.* Tolerance and Specificity of
        Recombinant 6-Methylsalicylic Acid Synthase. Metabolic Engineering 1999, 1, 180-187.

6)   Pohl, N. L.; Kiessling, L. L.* Scope of Multivalent Ligand Function: Lactose-Bearing
       Neoglycopolymers By Ring-Opening Metathesis Polymerization. Synthesis, 1999, 1515-
       1519.

7)   Marti, T.; Hu, Z.; Pohl, N.; Shah, A.; Khosla, C.* Cloning, Nucleotide Sequence, and
       Heterologous Expression of the Biosynthetic Gene Cluster for R1128, a Non-Steroidal
       Estrogen Receptor Antagonist. Insights into an Unusual Priming Mechanism. J. Biol.
       Chem. 2000, 275, 33443-33448.

8)   Pohl, N. L.; Hans, M.; Lee, H. Y.; Kim, Y. S.; Cane, D. E.; Khosla, C.* Remarkably Broad
       Substrate Tolerance of Malonyl-CoA Synthetase, an Enzyme Capable of Intracellular
       Synthesis of Polyketide Precursors. J. Am. Chem. Soc. 2001, 123, 5822-5823.

VI. PUBLICATIONS FROM I NDEPENDENT CAREER (* = CORRESPONDING AUTHOR)

1)   Pohl, N. L.* Developing New Antibiotics With Combinatorial Biosynthesis. J. Chem. Educ.
       2000, 77, 1421-1423. (invited review)

2)   Pohl, N.*; Clague. A.; Schwarz, K. Chiral Compounds and Green Chemistry in
       Undergraduate Organic Laboratories: Reduction of a Ketone By Sodium Borohydride
       And Baker’s Yeast. J. Chem. Educ. 2002, 79, 727-728.

3)   Pohl, N. L.* Nonnatural Substrates for Polyketide Synthases and their Associated
       Modifying Enzymes. Curr. Opin. Chem. Biol. 2002, 6, 773-778. (invited review)

4)   Ko, K.-S.; Kruse, J.; Pohl, N. L.* Synthesis of Isobutyl-C-galactoside (IBCG) as an
       Isopropylthiogalactoside (IPTG) Substitute for Increased Induction of Protein
       Expression. Org. Lett. 2003, 5, 1781-1783.

5)   Jaipuri, F. A.; Bower, B. D.; Pohl, N. L.* Protic Acid-Catalyzed Polymerization of β -
        Lactones for the Synthesis of Chiral Polyesters. Tetrahedron: Asymmetry 2003, 14,
        3249-3252.

6)   Zea, C. J.; MacDonell, S. W.; Pohl, N. L.* Discovery of the Archaeal Chemical Link
       Between Glycogen (Starch) Synthase Families Using a New Mass Spectrometry Assay. J.
       Am. Chem. Soc. 2003, 125, 13666-13667.
                                                      NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 9


7)    Zea, C. J.; Pohl, N. L.* Kinetic and Substrate Binding Analysis of Phosphorylase b Via
        Electrospray Ionization Mass Spectrometry: A Model for Chemical Proteomics of Sugar
        Phosphorylases. Anal. Biochem. 2004, 327, 107-113.

8)    Jaipuri, F. A.; Jofre, M. F.; Schwarz, K.; Pohl, N. L.* Microwave-assisted cleavage of
         Weinreb amide for carboxylate protection in the synthesis of a (R)-3-hydroxyalkanoic
         acid. Tetrahedron Lett. 2004, 45, 4149-4152.

9)    Zea, C. J.; Pohl, N. L.* General Assay for Sugar Nucleotidyltransferases Using Electrospray
        Ionization Mass Spectrometry. Anal. Biochem. 2004, 328, 196-202.

10)   Yu, Y.; Ko, K.-S.; Zea, C. J.; Pohl, N. L.* Discovery of the Chemical Function of
        Glycosidases: Design, Synthesis, and Evaluation of Mass-differentiated Carbohydrate
        Libraries. Org. Lett. 2004, 6, 2031-2033.

11)   Pohl, N.* Cellular Addresses: Step One in Creating a Glycocode. Chem. Biol. 2004, 11,
        891-892. (invited commentary)

12)   Ko, K.-S.; Zea, C. J.; Pohl, N. L.* Surprising Bacterial Nucleotidyltransferase Selectivity in
        the Conversion of Carbaglucose-1-phosphate. J. Am. Chem. Soc. 2004, 126, 13188-
        13189.

13)   Mizanur, R. M.; Zea, C. J.; Pohl, N. L.* Unusually Broad Substrate Tolerance of a Heat-
        Stable Archaeal Sugar Nucleotidyltransferase for the Synthesis of Sugar Nucleotides. J.
        Am. Chem. Soc. 2004, 126, 15993-15998.

14)   Mizanur, R. M.; Jaipuri, F. A.; Pohl, N. L.* One-Step Synthesis of Labeled Sugar Nucleotides
        for Protein O-GlcNAc Modification Studies by Chemical Function Analysis of an
        Archaeal Protein. J. Am. Chem. Soc. 2005, 127, 836-837.

15)   Pohl, N. L.* Functional Proteomics for the Discovery of Carbohydrate-Related Enzyme
        Activities. Curr. Opin. Chem. Biol. 2005, 9, 76-81. (invited review)

16)   Ko, K.-S.; Zea, C. J.; Pohl, N. L.* Strategies for the Chemoenzymatic Synthesis of
        Deoxysugar Nucleotides: Substrate Binding Versus Catalysis. J. Org. Chem. 2005, 70,
        1919-1921.

17) Dutca, L.-M.; Ko, K.-S.; Pohl, N. L.; Kostic, N. M.* Platinum(II) Complex as an Artificial
      Peptidase: Selective Cleavage of Peptides and a Protein by cis-[Pt(en)(H2 O)2 ]2+ Ion
      under Different Irradiations. Inorg. Chem. 2005, 44, 5141-5146.

18) Zea, C. J.; Pohl, N. L.* Unusual Sugar Nucleotide Recognition Elements of Mesophilic
      Versus Thermophilic Glycogen Synthases. Biopolymers, 2005, 79, 106-113.

19)   Ko, K.-S.; Jaipuri, F. A.; Pohl, N. L.* Fluorous-Based Carbohydrate Microarrays. J. Am.
        Chem. Soc. 2005, 127, 13162-13163.
                                                     NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 10



20)   Pohl, N.* Acyclic Peptide Inhibitors of Amylases. Chem. Biol. 2005, 12, 1257-1258. (invited
        commentary)

21)   Choi, D. W.; Zea, C. J; Do, Y. S.; Semrau, J. D.; Antholine, W. E.; Hargrove, M. S.; Pohl, N.
        L.; Boyd, E. S.; Geesey, G. G.; Hartsel, S. C.; Shafe, P. H.; McEllistrem, M. T.; Kisting, C.
        J.; Campbell, D.; Rao, V.; de la Mora, A. M.; DiSpirito, A. A.* Spectral, Kinetic, and
        Thermodynamic Properties of Cu(I)- and Cu(II)-binding by Methanobactin from
        Methylosinus trichosporium OB3b, Biochemistry, 2006, 45, 1442-1453.

22)   Pohl, N. L.* Array methodology singles out pathogenic bacteria. Nature Chem. Biol. 2006,
        2, 125-126. (invited commentary)

23)   Pohl, N. L.* Building a Bridge to New Antibiotics. ACS Chem. Biol. 2006, 1, 14-16. (invited
        commentary)

24)   Wacker, M.; Feldman, M. F.; Callewaert, N.; Kowarik, M.; Clarke, B. R.; Pohl, N. L.;
       Hernandez, M.; Vines, E. D.; Valvano, M. A.; Whitfield, C.; Aebi, M.* Substrate
       Specificity of Bacterial Oligosaccharyltransferase Suggests a Common Transfer
       Mechanism for the Bacterial and Eukaryotic Systems, Proc. Natl Acad. Sci., USA, 2006,
       103, 7088-7093.

25)   Mamidyala, S. K.; Ko, K.-S.; Jaipuri, F. A.; Park, G.; Pohl, N. L.* Noncovalent Fluorous
        Interactions for the Synthesis of Carbohydrate Microarrays. J. Fluorine Chem. 2006,
        127, 571-579. (special issue)

26)   Choi, D. W.; Do, Y. S.; Zea, C. J.; McEllistrem, M. T.; Lee, S.-W.; Semrau, J. D.; Pohl, N. L.;
        Kisting, C. J.; Scardino, L. L.; Hartsel, S. C.; Boyd, E. S.; Gessey, G. G.; Riedel, T. P.;
        Shafe, P. H.; Kranski, K. A.; Tritsch, J. R.; Antholine, W. W.; DiSpirito, A. A.* Spectral
        and Thermodynamic Properties of Ag(I), Au(III), Cd(II), Co(II), Fe(III), Hg(II), Mn(II),
        Ni(II), Pb(II), U(IV), and Zn(II) Binding by Methanobactin from Methylosinus trichosporium
        OB3b. J. Inorg. Biochem. 2006, 100, 2150-2161. (special issue)

27)   Pohl, N. L.* Carbohydrate Microarrays and Fluorous-Phase Synthesis: Interfacing
         Fluorous-Phase Tags with the Direct Formation of Glycoarrays. In Current
         Fluoroorganic Chemistry: New Synthetic Directions, Technologies, Materials, and Biological
         Applications; Soloshonok, V. A.; Mikami, K.; Yamazaki, T.; Welch, J. T.; Honek, J. F., Eds.
         ACS Symposium Series 949; American Chemical Society: Washington, DC, 2007, pp.
         261-270. (invited book chapter)

28)   Mizanur, R. M.; Pohl, N. L.* Cloning and characterization of a heat-stable CMP-N-
         acylneuraminic acid synthetase from Clostridium thermocellum. Appl. Microbiol. Biotechnol.
         2007, 76, 827-834.
                                                      NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 11


29)   Mizanur, R. M.; Griffin, A. K. K.; Pohl, N. L.* Recombinant production and biochemical
         characterization of a hyperthermostable α-glucan/maltodextrin phosphorylase from
         Pyrococcus furiosus. Archaea, 2007, 2, 169-176.

30)   Pohl, N. L.* Automated Solution-Phase Oligosaccharide Synthesis and Carbohydrate
         Microarrays: Development of Fluorous-Based Tools for Glycomics. In Chemical
         Glycobiology; Chen, X.; Halcomb, R.; Wang, G. P., Eds. ACS Symposium Series 990;
         American Chemical Society: Washington, DC, 2008, pp. 272-287. (invited book
         chapter)

31)   Yu, Y.; Mizanur, R. M.; Pohl, N. L.* Glycosidase activity profiling for bacterial identification
          by a chemical proteomics approach. Biocatal. Biotransform. 2008, 26, 25-31. (special
          issue)

32)   Mizanur, R. M.; Pohl, N. L.* A thermostable promiscuous glucose-1-phosphate
         uridyltransferase from Helicobacter pylori for the synthesis of nucleotide sugars. J. Mol.
         Catal. B: Enzymatic. 2008, 50, 13-19.

33)   Jaipuri, F. A.; Collet, B. Y. M.; Pohl, N. L.* Synthesis and Quantitative Evaluation of Glycero-
          D-manno-heptose Binding to Concanavalin A by Fluorous-tag Assistance. Angew. Chem.
          Int. Ed. 2008, 47, 1707-1710.

34)   Pohl, N.*; Schwarz, K. Polymer-Supported Reagents and 1 H- 19F NMR Couplings: The
         Synthesis of 2-Fluoroacetophenone. J. Chem. Educ. 2008, 85, 834-835.

35)   Chen, G.-S.; Pohl, N. L.* Synthesis of Fluorous Tags for Incorporation of Reducing Sugars
         into a Quantitative Microarray Platform. Org. Lett. 2008, 10, 785-788.

36)   Pohl, N. L.* Fluorous Tags Catching on Microarrays. Angew. Chem. Int. Ed. 2008, 47,
         3868-3870. (invited review)

37)   Jaipuri, F. A.; Pohl, N. L.* Toward Solution-Phase Automated Iterative Synthesis: Fluorous-
          tag Assisted Solution-Phase Synthesis of Linear and Branched Mannose Oligomers,
          Org. Biomol. Chem. 2008, 6, 2686-2691.

38)   Hui, Z.; Brokman, S.; Fang, N.; Pohl, N.; Yeung, E.* Linkage Position and Residue
         Identification of Disaccharides by Tandem MS and Linear Discriminant Analysis, Rapid
         Commun. Mass Spectrom. 2008, 22, 1579-1586.

39)   Park, G.; Ko, K.-S.; Zakharova, A.; Pohl, N. L.* Mono- Vs. Di-fluorous Tagged
         Glucosamines for Iterative Oligosaccharide Synthesis. J. Fluorine Chem. 2008, 129,
         978-982. (special issue)

40)   Zea, C. J.; Camci-Unal, G.; Pohl, N. L.* Thermodynamics of Binding of Divalent Magnesium
         and Manganese to Uridine Phosphates: Implications for Diabetes-Related
         Hypomagnesaemia and Carbohydrate Biocatalysis. Chem. Cent. J., 2008, 2, 15.
                                                   NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 12



41)   Mizanur, R. M.*; Pohl, N. L.* Bacterial CMP-Sialic Acid Synthetases: Production, Properties
         and Applications. Appl. Microbiol. Biotechnol. 2008, 80, 757-765. (invited review)

42)   Ko, K.-S.; Park, G.; Yu, Y.; Pohl, N. L.* Protecting Group-based Colorimetric Monitoring
         of Fluorous-phase and Solid-phase Synthesis of Oligoglucosamines. Org. Lett. 2008, 10,
         5381-5384.

43) Mizanur, R. M.; Pohl, N. L. B.* Phosphomannose isomerase/GDP-mannose
        pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the
        synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides.
        Org. Biomol. Chem. 2009, 7, 2135-2139.

44)   Pohl, N. L. B. The expanding world of glycobiology. Nature Chem. Biol. 2009, 5, 373
         (invited book review)

45)   Song, E.-H.; Pohl, N. L. B.* Fluorous-based small-molecule microarrays for protein,
         antibody, and enzyme screening. Future Med. Chem. 2009, 1, 889-896. (invited special
         report)

46)   Collet, B. Y. M.; Nagashima, T.; Yu, M. S.; Pohl, N. L. B.* Fluorous-based Peptide
         Microarrays for Protease Screening. J. Fluorine Chem. 2009, 130, 1042-1048.

47)   Song, E.-H.; Pohl, N. L. B.* Carbohydrate arrays: Recent developments in fabrication and
         detection methods with applications. Curr. Opin. Chem. Biol. 2009, 1 3, 626-632.
         (invited review)

48)   Camci-Unal, G.; Pohl, N. L. B.* Quantitative Determination of Heavy Metal Contaminant
        Complexation by the Carbohydrate Polymer Chitin. J. Chem. Eng. Data, 2010, 55,
        1117-1121.

49)   Utku, Y.; Rohatgi, A.; Yoo, B.; Zuckermann, R. N.; Pohl, N. L.; Kirshenbaum, K.* Rapid
         multistep synthesis of a bioactive peptidomimetic oligomer for the undergraduate lab.
         J. Chem. Educ. 2010, 87, 637-639.

50)   Roychoudhury, R.; Pohl, N. L. B.* New Structures, Chemical Functions, and Inhibitors for
         Glycosyltransferases. Curr. Opin. Chem. Biol. 2010, 14, 168-173. (invited review)

51)   Camci-Unal, G.; Pohl, N. L. B.* Thermodynamics of binding interactions between divalent
        copper and chitin fragments by isothermal titration calorimetry (ITC). Carbohydr.
        Polym. 2010, 81, 8-13.

52)   Pohl, N.* The Sugar Code: Fundamentals of Glycosciences. ChemBioChem, 2010, 1 1,
         1147. (invited book review)
                                                      NICOLA POHL ◊ JANUARY 24, 2011 ◊ PAGE 13


53)   Carrillo-Conde, B.; Chavez-Santoscoy, A.; Song, E.-H.; Pohl, N.; Wannemuehler, M. J.;
         Narasimhan, B.* Targetting dendritic cells with functionalized polyanhydride
         nanoparticles. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.), 2010, 51, 765-766.

54)   Song, E.-H.; Osanya, A. O.; Petersen, C. A.; Pohl, N. L. B.* Synthesis of multivalent
         tuberculosis and Leishmania-associated capping carbohydrates reveals structure-
         dependent responses allowing immune evasion. J. Am. Chem. Soc. 2010, 132, 11428-
         11430.

55)   Choi, D. W.; Bandow, N. L.; McEllistrem, M. T.; Semrau, J. D.; Antholine, W. W.; Hartsel,
         S. C.; Gallagher, W.; Zea, C. J.; Pohl, N. L.; Zahn, J. A.; DiSpirito, A. A.* Spectral and
         thermodynamic properties of methanobactin from gamme-proteobacterial methane
         oxidizing bacteria: A case for copper competition on a molecular level. J. Inorg.
         Biochem. 2010, 104, 1240-1247.

56)   Pohl, N. L. B.*; Kirshenbaum, K.; Yoo, B.; Schulz, N.; Zea, C. J.; Streff, J. M.; Schwarz, K. L.
         Student-driven design of peptide mimetics: microwave-assisted synthesis of peptoid
         oligomers. J. Chem. Educ. 2011, in press.

VII. PUBLISHED PATENTS

1)    Khosla, Chaitan; Lau, Janice; Pohl, Nicola L. Methods for making polyketides by
        replacement of ketosynthase and aminotransferase domains in polyketide synthases.
        (Leland Stanford University, USA). PCT Int. Appl. (2000), 32 pp. Application: WO 99-
        US15047 19990702. Licensed to Kosan.

 2)   Pohl, Nicola L.; Ko, Kwang-Seuk. A More Stable Analog of Iso-Propylthiogalactoside for
         Induction of Protein Expression. (Iowa State University Research Foundation, Inc,
         USA). PCT Int. Appl. (2004), 22 pp. Application: WO 2004-US12095 20041104.

 3)   Pohl, Nicola L.; Ko, Kwang-Seuk. Colorimetric monitoring of reactions in solution and
         solid phase automated and manual systems. (Iowa State University Research
         Foundation, Inc, USA). U.S. (2010), 12 pp. Application: US 2006-403381 20060413.
         Patent No. US 7842511.

 4)   Pohl, Nicola L.; Park, Gisun. Automated solution-phase iterative synthesis of
         biomoleculars and apparatus. (Iowa State University Research Foundation, Inc, USA).
         U.S. (2010), 17 pp. Application: Application: US 2007-767098 20070622. Patent No.
         US 20100159604.

				
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