The Kyushu University Research Superstar Program (SSP) by jlesterback

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									The Kyushu University Research Superstar Program (SSP)




                         141
Division of Cell Regulation Systems
Lee W, Swarup S, Chen J, Ishitani T, Verheyen EM

Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization
of beta-catenin/Arm and stimulation of target gene expression.

Development, 136, 241-251
Tohru Ishitani, Shizuka Ishitani, Kunihiro Matsumoto
Nemo-like kinase is a critical mediator of NGF-regulated axonal development




Tohru Ishitani      Young Investigators Forum

Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active

transcriptional complex
"The Joint Symposium of the 4th International Symposium of Institutes Network and Osaka
University Global COE (Frontier Biomedical Science Underlying Organelle Network Biology)
Symposium"
Division of Protein Chemistry




                                                                       (i)                  (ii)
productive folding         (iii)




                       DsbA-DsbB
                                                             EDEM-ERdj5-BiP


  RseP




                         DsbB


DsbA-DsbB-                                                                           DsbB


  DsbA                                                        2006      DsbA-DsbB-
                                             (Inaba et al, Cell, 2006) DsbB             DsbB
                            de novo
          DsbB                                                       DsbA
                                   DsbB
DsbB
       DsbB
                 Fab                  DsbB
                                    3.4



                                               147
   DsbB                         DsbA-DsbB-
            DsbA                              DsbB
                                                                                    DsbB    DsbA


          DsbB                   DsbB




                                            DsbB
       DsbA      DsbB
                                     DsbA                               DsbB




                           “ERdj5”                   Ushioda et al. Science, 2008   ERdj5
                               BiP                       J
                                                                                       ERdj5


   EDEM                                                      ERdj5
                                     ERdj5
                   ERdj5
                                      ERdj5




                                              RseP
RseP




                                              148
                                                                                  DegS
                                                     anti-   E          (RseA)
                                                                 RseP    RseA

                                       E

                                 RseP                                    RseA       1
                       PDZ                                                PDZ


                             N              PDZ           (PDZ-N)                   1.4             C            PDZ
           (PDZ-C)                     0.98
                                                                                                        RseP
                                           PDZ-N
                                           RseP                                           PDZ-N


RseP




1. Kenji Inaba*, Satoshi Murakami, Atsushi Nakagawa, Hiroka Iida, Mai Kinjo, Koreaki Ito and Mamoru Suzuki, 2009

   (*corresponding author)

   Dynamic nature of disulphide bond formation catalysts revealed by crystal structures of DsbB.

   EMBO J. 28, 779-791

2. Kenji Inaba*, Mamoru Suzuki*, Ken-ichi Maegawa*, Shuji Akiyama, Koreaki Ito and Yoshinori Akiyama, 2008

   (*equally contributed)

   A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of E. coli.

   J. Biol. Chem. 283, 35042-35052

3. Kenji Inaba*, 2008 (*corresponding author)

   Protein disulfide bond generation in Escherichia coli DsbB-DsbA

   J. Synchr. Rad. 15, 199-201




1. Koreaki Ito and Kenji Inaba, 2008




                                                         149
     The disulfide bond formation (Dsb) system

     Curr. Opin. Struct. Biol. 18, 450-458

2.                , 2009

                        DsbB-DsbA

                           51, 100-103




1.                , 2008

                            ,                                 , Dsb

                                                    Vol. 53, p 940, 969, 1043




1. Kenji Inaba (2008, May 25-30)

     Structural basis for protein disulfide generation in the cell. (invited lecture)

     Gordon conference on thiol-based redox regulation & signaling, Lucca, Italy

2. Kenji Inaba (2008, Aug. 23-30)

     Structure and mechanism of the DsbB-DsbA protein disulfide generation system in E. coli. (invited lecture)

     XXI Congress and General Assembly of the International union of Crystallography, Osaka, Japan

3. Maegawa, K., Ushioda, R., Hoseki, J., Hagiwara, M., Nagata, K., Suzuki, M., and Inaba, K. (2008, Nov. 9)

     Structural and functional analyses of an ER-resident protein disulfide reductase, ERdj5 (poster)

     The 2nd Global COE International Symposium joint with the 18th Hot Spring Harbor Symposium of Medical Institute

     of Bioregulation, Fukuoka, Japan

4. Kenji Inaba (2009, Feb. 16)

     Molecular basis for protein disulfide formation in the cell. (talk)

     The 3rd G-COE international symposium on Stem Cells and Regenerative Medicine, Singapore



1.                 (2008, 8/2)




2.                 (2008, 12/9-12)

     Molecular basis for protein disulfide bond formation in E. coli.




                                                                150
     BMB2008

3.                                        (2008, 12/3-5)

                                  ERdj5

      46

4.             (2009, 3/29-30)



      17              Frontiers




                                    151
Division of Organogenesis and Regeneration




                                     152
153
154
155
156
1. Suzuki, A.*, Sekiya, S., Buscher, D., Izpisua Belmonte, J.C., Taniguchi, H. 2008a. (*

     corresponding author)

     Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF

     expression.

     Development 135, 1589-1595.

2. Suzuki, A.*, Sekiya, S., Onishi, M., Oshima, N., Kiyonari, H., Nakauchi, H., Taniguchi, H.* 2008b.

     (* corresponding author)

     Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor

     cells in adult mouse liver.

     Hepatology 48, 1964-1978.




1.             . 2008



                   Vol. 7, No. 3.




1.              (2008, 6/28)

        15

2.              (2008, 11/13)

        23

3.              (2009, 3/5)

        1




1.              (2008, 5/16)

     Tbx3

        6

2.              (2008, 6/28)




                                                157
     Tbx3

        15

3. Suzuki, A. (2008, 11/2)

     Novel functions of T-box proteins, TBX And Liver Stem Cells (Invited speaker)

     The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)

     “Stem cells in Liver Diseases and Hepatobiliary Cancers”, San Francisco, CA, USA

4. Suzuki, A. (2008, 11/13)

     T-box genes and liver stem cells (poster)

     The       23rd   Naito     Conference   “Molecular   Basis   for   Maintenance   and    Differentiation

     of Stem Cells [III]”, Kanagawa, Japan

5. Suzuki, A. (2009, 2/16)

     Novel functions of T-box proteins in controlling hepatic stem cell fate (Invited speaker)

     The 3rd Global COE International Symposium “Stem Cells and Regenerative Medicine”, Singapore

6.                (2009, 2/21)



       5

7.                (2009, 3/5)



           8



8.                (2009, 3/5)

                                  /                                     [YIA

       ]

       8

9.                (2009, 3/18)




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