Center for Clinical Trials Network Dr Harold Perl

NIDA NIDA NATIONAL INSTITUTE ON DRUG ABUSE National Drug Abuse Treatment Clinical Trials Network Research Training Directors Meeting November 3, 2006 Harold I Perl, PhD Center for the Clinical Trials Network NIDA/NIH/DHHS Institute of Medicine, 1998 Research Bridging the Gap Practice Mission of CTN To Improve Drug Abuse Treatment Throughout the Nation… Using SCIENCE as the Vehicle The CTN Enterprise A unique partnership among: NIDA … treatment researchers … community-based service providers CTN Objectives Study behavioral, pharmacological, and integrated treatment interventions to determine effectiveness across a broad range of community-based settings and diversified patient populations Ensure the transfer of research results to physicians, clinicians, providers, and patients CTN On-the-Ground Regional Research and Training Center (RRTC) State with Community Treatment Program (CTP) The CTN Trials (1999 – 2006) Under Development Active Intervention Active FollowFollow-Up Data Analysis, Publication, & Dissemination CTN 0031 CTN 00xx CTN 0014 CTN 0027 CTN 0028 CTN 0029 CTN 0030 CTN 0010 CTN 0015 Medical Interventions: 9 Behavior Interventions: 11 HIV/HCV Interventions: 4 Others: 3 CTN 0001 CTN 0002 CTN 0003 CTN 0004 CTN 0005 CTN 0006 CTN 0007 CTN 0008 CTN 0009 CTN 0011 CTN 0012 CTN 0013 CTN 0016 CTN 0017 CTN 0018 CTN 0019 CTN 0020 CTN 0021 Selected CTN Trials Opiate Dependence 0003: Buprenorphine/Naloxone Stabilization and Taper Schedules 0010: Buprenorphine/Naloxone for Adolescents Nicotine Dependence 0009: Smoking Cessation Ethnic Minorities 0021: MET for Spanish Speakers Women 0013: MET for Pregnant Women 0015: Seeking Safety Intervention for Trauma and Substance Use Families 0014: BSFT for Adolescents HIV/HCV 0017: HIV/HCV Intervention 0018: HIV Risk Reduction for Men 0019: HIV Risk Reduction for Women CTN Trials in Progress • Buprenorphine/Naloxone for prescription opioid analgesic dependence • Osmotic-Release Methylphenidate for smoking cessation in ADHD adults • Osmotic-Release Methylphenidate for treating ADHD and SA disorders in adolescents • Effects of Buprenorphine/Naloxone vs. Methadone on liver function Research Utilization Adoption of Buprenorphine Adoption of Motivation Incentives Source: Roman et al ; Presented 2006 Making Use of CTN Infrastructure Treatment and Services Research • • • • • Independent RPGs using CTN as a platform Ancillary studies connected to a CTN trial Career Development awards Minority Researcher supplements Research Training Pre-doctoral and Post-doctoral Fellowships • “Junior” Investigators affiliated with CTN • T32 training programs Training Opportunities in CTN • Pre-Doctoral Training PreT32, T32, F31, F30, R03 • Post-Doctoral Training PostT32, T32, F32 • Career Development Awards K01, K02, K05, K08, K12, K22, K23, K24, K25 • Research Supplements to Promote Diversity in HealthHealth-Related Research CTN Data for Secondary Analyses DOWNLOAD DATA FILES www.ctndatashare.org www.nida.nih.gov/CTN/Index.htm