NIH Guide - Vol. 14, No. 1 - January 4, 1985 by NIHhealth

VIEWS: 32 PAGES: 40

									’I   NIH Guide
     for Grants and Contracts
     US. DEPARTMENT OF HEALTH 

     AND HUMAN SERVICES                                          Vol. 14, No. 1, January 4, 1985 





           IN THIS ISSUE:

           Notice - Clarification
                Academic Research Enhancement Award                            ............................                   Page 1
                National Institutes o Health
                                     f
                      Index -     NATIONAL INSTITUTES OF HEALTH

           Notice
                Stipend Increase f a r NRSA Trainees and Fellowships
                      for Fiscal Year 1985                .........................................Page 2
                National Institutes of Health
                      Index -     STIPENDS

           Notice
                    To All Persons Interested in t h e Management of
                         NKSA Training Programs                  .....................................                        Page 3
                    National Institutes of Health
                         Index -     NATIONAL RESEARCH SERVICE AWARDS

           Announcement
               Notice of Availability
               Small Business Innovation Research Program.                            ........................Page 4
               National Institutes of Health
                    Index -      NATIONAL INSTITUTES OF HEALTH

           Notice
                    New Provisions for Late  R&D Contract Proposals.                         ....................Page 5
                    National Institutes of Health
                         Index -      CONTRACTS
           Announcement
               Research Centers in Minority Institutions Award                             .....................              Page 7
               National Institutes o Health
                                    f
                    Index -      INSTITUTIONAL AWARDS
                                                                               Continued



     The NIH Guide is published at irregular intervals to announce scientific initiatives and to provide policy and administrative information to in­

     dividuals and organizations who need to be kept informed of opportunities, requirements, and changes in grants and contracts activities ad-

     ministered by the National Institutes of Health. 

     Two types of supplements are published by the respective awarding units. Those printed on yellow paper concern contracts: solicitations of 

     sources and announcement of availability of requests for proposals. Those printed on blue paper concern invitations for grant applications 

     in well-defined scientific areas to accomplish specific program purposes. 

CW
     Have You Moved? 

     If you present address differs from that shown on the address label, please send your new address to: Grants and Contract Guide Distribu­

     tion Center, National Institutes of Health, Room B3BN10, Building 31, Bethesda, Maryland 20205, and attach your address label to your let­

     ter. Prompt notice of your change of address will prevent your name from being removed from our mailing list. 

Page 2 - Index - NIH Guide for Grants and Contracts, VoL 14, No. 1, January 4,1985

Announcement                                                                                           e'

    Notice of F u t u r e Availability of Request f o r
              Application: W A - 85-EY-01- Contruction,
              Alteration and Renovation, and Instrumentation                 .................Page 9
    N a t i o n a l E y e Institute
              Index-          EYE

Announcement
    Availability of Request for Applications: RFA
              NLM-85-01 - Specialized N a t i o n a l R e f e r e n c e C e n t e r
              f o r Bioethics Literature..       ...................................         Page 12
    N a t i o n a l Library of Medicine
              Index -       LIBRARY OF MEDICINE

Announcement
    Availability of Request f o r Applications: RFA
         85-AI42 - Program Projects on the Biology
         of the Immune System                ......................................          Page 14
    National Institute of Allergy and Infectious Diseases
         Index        -
                      ALLERGY AND INFECTIOUS DISEASPc
Announcement
       Availability of Request for Applications: W A
            85-AI43 - Centers f o r Interdisciplinary
            Research on Immunologic Diseases                 ...........................     Page 16
                                                     '
       National Institute of Allergy and Infectious DlseaSeS
            Index -      ALLERGY AND INFECTIOUS D I S E A S E                                          -
Announcement
    Availability of Request f o r Applications: RFA
         85-AI44 - Asthma and Allergic Disease C e n t e r s and
         Asthma and Allergic Diseases Centers f o r Immuno­
         dermatologic Studies              .......................................           Page 18
    National Institute of Allergy and Infectious Diseases
         Index        -
                      ALLERGY AND INFECTIOUS DISEASES

Announcement
    Availability of Request f o r Applications: RFA
         85-DE41 .    Orofacial Pain Research Centers
    National Institute of Dental Research
                                                                         ...................Page 20
         Index-       DENTAL

Announcement
    Opportunities f o r Research in Medical Informatics
         Investigator-Initiated R e s e a r c h Grants and
         New Investigator R e s e a r c h Awards             ...........................     Page 22
    National Library of Medicine
         Index -       LIBRARY OF MEDICINE

                                                            Continued
       -
Page 3 Index   - M H Guide for Grants and Contracts, VoL 14, No.      1, J a n u a r y 4,1985


Announcement
    Research R e l a t e d to Integrated Academic Information
         Management Systems (IAIMS)       ................................           Page 25
    National Library of Medicine
         Index -          LIBRARY OF MEDICINE

Announcement
    Human Papilloma Viruses and Genital W a r t s    ........................        Page 28
    National Institute o Allergy and
                        f
         Infectious Diseases
         Index -      ALLERGY AND INFECTIOUS DISEASES

Announcement
    Mechanisms of Action of the Drug Cyclosporine       .....................        Page 30
    National Institute o Allergy and Infectious Diseases
                        f
         Index -      ALLERGY AND INFECTIOUS DISEASES

Notice
     Keyword Thesaurus   ..............................................              Page 32
     National Institutes of Health
          Index -      PUBLICATIONS

Notice
     Keyword Thesaurus . r o g r a m Types
                           P                 ...............................         Page 33
     National Institutes of Health
          Index -      PUBLICATIONS

Notice
     Keyword Thesaurus .   Keywords   ...................................            Page 35
     National Institutes of Health
          Index -      PUBLICATIONS
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                                     1


                                                 NOTICE

                                           CLARIFICATION


ACADEMIC RESEARCH ENHANCEMENT AWARD

 ..
PT 34,14; K.W. 1200180
NATIONAL INSTITUTES OF HEALTH


In t h e December 7, 1984 issue of t h e Guide for G r a n t s and Contracts, t h e NIH announced
a new program of Academic Research Enchancement Awards. This notice, amending t h e
prior eligibility c r i t e r i a for applicants, has evolved o u t of discussions with p o t e n t i a l
applicant institutions, organizations representing them, and o t h e r i n t e r e s t e d p a r t i e s in
t h e NIH community. W e believe t h a t t h e changes noted below will g e n e r a t e a good
                                                   e
response to t h i s unique initiative. W also believe t h a t t h e changes a r e fully consonant
with t h e i n t e n t of Congress to develop research in those institutions which provide
b a c c a l a u r e a t e training f o r a significant number of our Nation's research scientists, b u t
which have historically n o t been major participants in NIH programs.

Eligibility Criteria: 	          Eligible institutions a r e those offering b a c c a l a u r e a t e degrees
                                 in t h e sciences related to health, t h a t a r e not eligible for t h e
                                 NIH Biom dical Research Support G r a n t (BRSC) in Fiscal
                                 Year 1985.  f
Funding decisions will be based on t h e proposed research project's scientific m e r i t and
relevance to NIH programs, and t h e institution's contribution to t h e undergraduate
preparation of doctoral-level health professionals.         Among projects of essentially
equivalent scientific m e r i t and program relevance, p r e f e r e n c e will b e given to those
submitted by institutions t h a t have granted baccalaureate degrees to 25 o r more
individuals who, during t h e period 1977-1984, obtained academic or professional doctoral
degrees in t h e h e a Ith-re lated sciences.




'Education institutions eligible for BRSCs include those which received a minimum of
t h r e e allowable PHS biomedical o r health-related behavioral research g r a n t s totaling
$200,000 (including d i r e c t and indirect costs), awarded during F Y 1984 (October 1, 1983
through September 30, 1984). Application k i t s have already b e e n provided to institutions
t h a t , according to NIH records, are eligible for BKSC funding in F Y 1985. If t h e r e is any
doubt a b o u t eligibility f o r BRSCs you may c o n t a c t O f f i c e of G r a n t s Inquiries, Westwood
Building, National Institutes of Health, Bethesda, Maryland 20205.
2 





                                                     NOTICE


 STIPEND INCREASE FOR NRSA T R A I N E S AND FELLOWS FOR RSCAL YEAR 1985

P.T. 44,22; K.W. 0720005,1014002


There will b e a stipend increase for all National Research Service Awards (NRSA) f o r
institutional t r a i n e e s and individual fellows which is e f f e c t i v e immediately f o r all
appointments and a w a r d s made in Fiscal Year 1985 (October I, 1984 - September 30,
1985). This increase will b e provided on all g r a n t s and awards issued by t h e National
Institutes of Health (NIH), Alcohol, Drug Abuse, and Mental Health Administration
(ADAMHA), and Health Resources and Services Administration (HRSA)/Division of
Nursing. Awards issued for F Y 85 prior to t h e d a t e of this notice will be revised to
provide f o r t h e new stipend levels. T h e NIH and t h e Division of Nursing will implement
t h e stipend increase according to t h e following guidelines:
      1.	     The increase in stipend allowance is tied to t h e F Y 1985 Budget and t h e r e f o r e
              should be extended to e a c h t r a i n e e or fellow provided for in awards made on o r
              a f t e r October 1, 1984. No a d j u s t m e n t s will b e m a d e retroactively f o r t r a i n e e s
              o r fellows e i t h e r appointed under previous fiscal y e a r institutional NRSAs or
              included in previous fiscal y e a r individual fellowship awards regardless of                             -0

              whether o r not activated. These individuals will receive increased stipend
              levels associated with t h e i r appointments, if any, under FY 1985 awards o r
              beyond.

       2. 	   Even though selective prior fiscal y e a r awards may have funds available, t h o s e
              funds may not b e used to adjust upward t h e stipend levels of National Research
              Service Awardees covered under a w a r d s issued prior to F Y 1985.

ADAMHA will generally follow t h e s e guidelines, b u t will notify t h e i r a w a r d e e s regarding
t h e specific plans for implementation.

T h e new stipend levels a r e as follows:

       Years of Relevant Experience                   New Stipend F Y 1985
                        0 
                                            $15,996 

                        I
                                              17,004 

                        2 
                                             21,996 

                        3 
                                             23,004 

                        4 
                                             24,000 

                        5 
                                             26,004 

                        6 
                                             27,996 

                        7 or more                                       30,000 

                        Predoctoral                                      6,552
This notice revises information previously published in t h e April I, 1984 Addendum to t h e
PHS G r a n t s Policy S t a t e m e n t , and t h e NIH Guide f o r G r a n t s and C o n t r a c t s - Special
Edition Vol. 13, No. 1, January 6,1984.
NM GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                                  3





                                               NOTICE


                TO ALL PERSONS INTERESTED IN THE MANAGEMENT OF
                            NRSA TRAINING PROGRAMS

 ..
PT 44,22; K.W. 0720005,1014002

The ten-year period 1970-71 to 1980-81, saw a rise in graduate school tuition of 93                   .
p e r c e n t in private, and 8 p e r c e n t in public institutions, as derived f r o m a sample of 17
private and 3 public institutions. The cost of graduate school tuition from this s a m e
sample of schools rose a n a v e r a g e of 14.8 p e r c e n t in private and 8 7 p e r c e n t in public
                                                                                 .
institutions in 1982-83. The Consumer Price Index (CPI) f r o m 1982-1983 rose 3 5                    .
percent.

The National Institutes of Health (NIH) has had a long-standing p r a c t i c e of paying t h e
full cost of tuition on training grants. The recent increases in costs, however, a r e
placing a severe s t r a i n on t h e Institutes' ability to sustain both a s t a b l e number of
trainees and t h e full payment of tuition.

On July 31, 1984, t h e Deputy Director for Extramural Research and Training, NIH
convened a group of representative Presidents, Vice Presidents, Deans of Graduate
Schools, and Training Program Directors from large and small, public and private
universities.          The participants considered t h e rising costs of g r a d u a t e education
underlying t h e increases NIH has seen in tuition requests and made some
recommendations as to what might b e done to contain NIH expenditures in order to
p r o t e c t t h e quality of t h e g r a d u a t e training programs it supports.

As a result of t h e recommendations made at t h a t meeting, t h e NIH is considering
adopting a policy in regard to t h e payment of tuition on training grants similar to t h a t so
successfully exercised to help contain personnel costs charged to r e s e a r c h grants. The
t w o c r i t i c a l e l e m e n t s of t h e policy are:

      o	     Tuition on successful new and competing renewal research training awards
             will b e honored a t t h e awarded level for t h e f i r s t year of a multi-year award
             (generally 5 years). Annual incremental requests would b e authorized up to 6
             percent per year.

      o	     In t h e e v e n t t h e a m o u n t budgeted is insufficient to m e e t tuition increases in
             t h e outlying years, t h e institutions will be expected to m a k e up t h e
             differences. This may be done in p a r t by reprogramming available funds.
             NIH Program Managers would b e directed to allow t h e u t m o s t flexibility in
             reprogramming to p r o t e c t t h e number of trainees in t h e program without
             jeopardizing t h e quality of t h e training experience.

I t is planned t h a t this policy would go into effect for a l l research training a w a r d s made
from Fiscal Year 1986 funds.
4 




                                               ANNOUNCEMENT


 NOTICE OF AVAILABILITY

 SMALL BUSINESS INNOVATION RESEARCH PROGRAM
           ..
 P.T. 34; K W 0710035

 NATIONAL INSTITUTJ5 OF HEALTH


 The Small Business Innovation Research (SBIK) Program, authorized by P L 97-219, is                      ..
 intended to s t i m u l a t e technological innovation within t h e small business community,
 provide small businesses with a n increased role in Federal research and development, and
 a t t r a c t p r i v a t e c a p i t a l to c o m m e r c i a l i z e t h e results of Federally funded research. For
 purposes of t h e SBIK Program, a ttsmall business" is any concern t h a t is independently
 owned and operated, is organized f o r profit, has its principal p l a c e of business in t h e
 U.S., and has no more t h a n 500 employees.

 The National Institutes of Health (NIH), a participant in t h e SBIK Program, is i n t e r e s t e d
 in soliciting proposals f o r innovative research t h a t will c o n t r i b u t e towards meeting its
 program objectives. In this regard, NIH announces t h e availability of a solicitation f o r
 SBIK c o n t r a c t proposals, to b e issued on o r around January 15, 1985, with a closing d a t e
 of April 1, 1985. Requests for t h e solicitation should b e addressed to:

                                            O f f i c e of G r a n t s Inquiries
                                            Division of Research G r a n t s
                                            National Institutes of Health
                                            Westwood Building - Room 449
                                            Bethesda, Maryland 20205

 Individuals whose names and addresses a r e already on t h e NIH SBIR mailing list need n o t
 submit a request since a copy of t h e solicitation will automatically be mailed to them.
NIH GUIDE FOR GRANTS AND CONTRACTS
Vol. 14, No.1, January 4, 1985                                                                           5




NEW PROViSIONS FOR LATE K&D CONTRACT PROPOSALS

P.T. 34; K.W. 1014002
NATIONAL INSTITUTES OF HEALTH

The National Institutes of Health (NIH) research c o n t r a c t solicitations (Requests for
Proposals (RFPs) contain specific dates, t i m e s and places f o r r e c e i p t of K&D c o n t r a c t
proposals. Under t h e old Federal Procurement Regulations (FPR) NIH was p e r m i t t e d to
use a n a l t e r n a t e l a t e proposal provision allowing a c c e p t a n c e of late offers if significant
cost savings or technical advantages were foreseen.
This is no longer possible under t h e new Federal Acquisition Regulations (FAR) which
replaced t h e F P R on April I, 1984. NIH c a n no longer accept late p roposals under any
                                                                       - -
circumstances o t h e r than those caused by mishandling in t h e mail, mishandling at t h e
Government's installation or if only one poposal is received. The t e x t of this new FAR
provision follows:

                           FEDERAL ACQUISITION REGULATION (FAR)
                                     52.215-10 p.52-34

52.215-10 Late Submissions, Modifications, and Withdrawals of Proposals.
    As prescribed in 15.407(~)(6),insert t h e following provision in requests f o r proposals:

    LATE SUBMlrssIONS, MODIFICATIONS, AND WITHDRAWALS OF PROPOSALS (APR
    1984)
            (a) 	 Any proposal received at t h e o f f i c e designated in t h e solicitation a f t e r t h e
                  exact t i m e specified f o r r e c e i p t will not be considered unless it is
                  received b e f o r e award is made and it­

                  (1) 	 Was s e n t by registered or c e r t i f i e d mail not later t h a n t h e f i f t h
                        calendar day b e f o r e t h e d a t e specified for r e c e i p t of o f f e r s (e.g., a n
                        o f f e r submitted in response to a solicitation requiring r e c e i p t of
                        o f f e r s by t h e 2 0 t h of t h e month must have been mailed by t h e 15th);

                   (2) 	   Was s e n t by mail (or telegram if authorized) and it is determined by
                           t h e Government t h a t t h e l a t e r e c e i p t was due solely to mishandling
                           by t h e Government a f t e r receipt at t h e Government installation; or

                   (3)     Is t h e only proposal received.

            (b) 	 Any modification of a proposal or quotation, e x c e p t a modification
                  resulting from t h e Contracting Officer's request f o r %est and final'' offer,
                  is subject to t h e s a m e conditions as in subparagraphs (a)(l) and (2) above.
6


     (c) 	 A modification resulting from t h e Contracting Officer's request for %best
           and final" o f f e r received a f t e r t h e t i m e and d a t e specified in t h e request     -I*



           will not b e considered unless received before award and t h e l a t e r e c e i p t is
           due solely to mishandling by t h e Government a f t e r r e c e i p t at t h e
           Government installation.

     (d) 	 The only a c c e p t a b l e evidence to establish t h e d a t e of mailing of a l a t e
           proposal or modification s e n t e i t h e r by registered o r c e r t i f i e d mail is t h e
           US. o r Canadian Postal Service postmark on t h e wrapper or on t h e
           original receipt f r o m t h e U.S. o r Canadian Postal Service. If neither
           postmark shows a legible d a t e , t h e proposal, quotation, o r modification
           shall b e processed as if mailed late. "Postmark" means a printed,
           stamped, o r otherwise placed impression (exclusive of a postage m e t e r
           machine impression) t h a t is readily identifiable without f u r t h e r a c t i o n as
           having been supplied and affixed by employees of t h e U.S. or Canadian
           Postal Service on t h e d a t e of mailing. Therefore, o f f e r o r s o r q u o t e r s
           should request t h e postal c l e r k s to place a hand cancellation bull's-eye
           postmark on b o t h t h e r e c e i p t and t h e envelope o r wrapper.

     (e) 	 T h e only a c c e p t a b l e evidence to establish t h e t i m e of r e c e i p t at t h e
           Government installation is t h e t i m e / d a t e s t a m p of t h a t installation on t h e
           proposal wrapper or o t h e r documentary evidence of r e c e i p t maintained by
           t h e installation.

     (f) 	   Notwithstanding paragraph (a) above, a l a t e modification of a n otherwise
             successful proposal t h a t makes its t e r m s more favorable to t h e
             Government will be considered at any t i m e it is received and may be                         ~




             accepted.

             Proposals may be withdrawn by written notice o r t e l e g r a m (including
             mailgram) received at any t i m e b e f o r e award.         Proposals may be
             withdrawn in person by a n o f f e r o r or a n authorized representative, if t h e
             representative's identity is m a d e known and t h e r e p r e s e n t a t i v e signs a
             r e c e i p t f o r t h e proposal b e f o r e award.
                                              (End of provision)
                                          (Et 7-2002.4 1979 MAR)
                                                 (1 -3.802 -1)
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4 , 1985                                                        7

                                     ANNOUNCEMENT


RlESEARCH CENTERS IN MINORITY INSTITUTIONS AWARD
 ..
PT 34,14, 18, FF; K.W. 0780010,1014001
NATIONAL INSTITUTES OF HEALTH


                         Application Receipt Date: April 15, 1985


The National Institutes of Health (NIH)is pleased to announce a new t y p e of g r a n t , t h e
Research C e n t e r s in Minority Institutions (RCMI) Award. I t s purpose is "to establish
research c e n t e r s in those predominantly minority institutions which o f f e r doctoral
degrees in t h e health professions o r t h e sciences related to health ....I' (Report of t h e
House/Senate Conferees on t h e Fiscal Year 1985 Appropriation for t h e Office of t h e
Director, NIH).

The RCMI Program will b e managed by t h e Office of t h e Director, Division of Research
Resources. The program is designed to provide g r a n t s of up to $1,000,000 per year, for
five years, to help eligible institutions enrich their research environments via selected
improvements in their human and physical resources. For example, t h e funds awarded
could b e used for t h e salaries of key research and research-support personnel,
instrumentation, and a1terations and renovation of facilities. Such expenditures would
complement ongoing and planned research activities (e.g., projects funded by Minority
Biomedical Research Support grants, Minority Access to Research C a r e e r awards,
traditional NIH and ADAMHA research project grants, and individual and institutional
research fellowships).

To b e eligible to c o m p e t e for a n RCMI Award, an institution must have 50 percent or
m o r e minority enrollment and o f f e r doctoral degrees in t h e health professions or t h e
sciences related to health. On t h e basis of information currently available to t h e NIH,
t h e following eligible institutions have been notified and have b e e n furnished a copy of
t h e d r a f t guidelines for t h e KCMI Award:

                             A t l a n t a University Graduate School 

                             C i t y College of t h e City University of New York (CUrUY) 

                             Drew Postgraduate Medical School 

                             Florida A&M School of Pharmacy 

                             Howard University Graduate School 

                             Howard University Medical School 

                             Meharry Medical College 

                             Morehouse Medical School 

                             Ponce Medical School, P u e r t o Rico 

                             Texas Southern University

                             Tuskegee Institute 

                             University of P u e r t o Kico, Rio Piedras 

                             University of P u e r t o Rico, San J u a n 

8 


O f f i c i a l s of other doctorate-granting schools who think their institution may b e eligible
should contact:                                                                                                 ill.




                                        Ms. Mary L. Miers 

                                        Institutional Liaison O f f i c e r 

                                        O f f i c e of .&xtramural Research and Training 

                                        Shannon Building - Room 115 

                                        National Institutes of Health 

                                        Bethesda, Maryland 20205 


                                        Telephone: (301)496-5366

The NIH will host a special meeting on January 30, 1985, at which t i m e representatives
of t h e eligible institutions and o t h e r interested individuals will have a n opportunity to
o f f e r c o m m e n t s and recommendations about t h e d r a f t guidelines. For a copy of t h e d r a f t
guidelines o r o t h e r information regarding this new program, please contact:

                                        Dr. J a m e s F. O'Donnell 

                                        Deputy Director 

                                        Division of Research Resources 

                                        Building 31 - Room 5B03 

                                        National Institutes of Health 

                                        a e t h e s d a , Maryland 20205

                                        Telephone: (30 1) 496-6023
NW GUIDE FOR GRANTS AND CONTRACTS
Vol. 14, No.1, January 4, 1985                                                                     9

                                           ANNOUNCEMENT


NOTICE OF FUTURE AVAILABFLfTY OF REQUEs� FOR APPLICATION RFA

85-EY -01
CONSTRUCTION, ALTERATION AND RENOVATION, AND WSTKUMENTATION

P.T. 02, 18; K.W. 1002046, 1014001,0785145,0785150

NATIONAL EYE INSTITUTE

  I.   BACKGROUND

       The National Eye Institute (NEI) announces t h e availability of a Request for
       Applications (RFA) f o r a program that will support g r a n t s in t h r e e d i f f e r e n t areas:

              New Construction
              Alteration and Renovation of Existing Facilities

              Acquisition of Specialized Laboratory Instrumentation

       $3,300,000 was appropriated for a Vision Research Facilities Program in Fiscal
       Year 1985. The following information is being provided to allow t h e vision research
       community to begin planning for potential applications. Program guidelines will b e
       finalized following discussion at t h e January 28, 1985 meeting of t h e National
       Advisory Eye Council.

 11.   MECHANISM O F SUPPORT

        A.   New Construction is defined as t h e construction of new buildings, additions to
             existing facilities, or the completion of "shell" space in new or existing
             buildings. it is e x p e c t e d t h a t t h e facilities to be constructed will be utilized
             by investigators currently supported by t h e NEI. T h e NE1 will provide
             b e t w e e n 50-75% of t h e t o t a l allowable cost of t h e p r o j e c t up to a maximum
             of $500,000 to $1,000,000. T h e NE1 e x p e c t s to m a k e n o m o r e t h a n 3 awards
             in t h i s category.




The construction program is described in t h e Catalog of Federal Domestic Assistance
No.13.985, Eye Research Construction Grants.             Construction g r a n t s m a d e under this
program a r e subject to Executive Order 12372. Awards in support of a l t e r a t i o n and
renovations or specialized instrumentation a r e not subject to Executive Order 12372. All
awards will b e made under t h e authority of t h e Public Health Service A c t , Title 111,
Section 301 (Public Law 78-410, as amended; 42USC241) and administered under PHS
g r a n t policies and Federal Regulations 42 CFR P a r t 5 2 and 45 C F R P a r t 54.
10 



             Eligibility: Any domestic public o r non-profit institution, organization, o r
                                                                                                           *
             association is eligible to apply. Applications will b e evaluated to d e t e r m i n e
             how t h e facilities to b e constructed expand a n existing clinical vision
             research program judged to b e of high scientific merit.

             Method of Application: Applicants must use PHS Form 5162-1, (SF4241
             "Application f o r Federal Assistance f o r Construction Programs". Specific
             Program Guidelines will b e available February 1, 1985.

        B.   Alteration and Renovation and Specialized Instrumentation:

             Alteration and renovation support is intended for t h e costs of modifying
             existing s p a c e and utilities within a finished s t r u c t u r e and/or adapting
             interior building f e a t u r e s to t h e needs of a n established vision research
             program. T h e NE1 may provide up to 75% of t h e total allowable cost of t h e
             project up to a maximum of $200,000. The NE1 e x p e c t s to m a k e n o more than
             5 a w a r d s in this category.

             Support may also be provided for specialized laboratory instrumentation. The
             instrumentation may b e p r o j e c t specific, but, ideally may b e shared a m o n g
             investigators conducting vision research, and which otherwise might n o t be
             justified for individual p r o j e c t grants. T h e NE1 may provide up t o 75% of t h e
             total purchase price of major laboratory equipment costing in t h e range of
             $50,000 to $150,000. T h e NE1 e x p e c t s to make no m o r e t h a n 8-10 a w a r d s in
             this category.

             Eligibility: Any domestic public, profit, o r non-profit institution, association,             R
                                                                                                           l .

             or organization is eligible to apply.

             Method of Application: Applicants must use PHS Form 398 "Application for
             Public Health Service Grant". Specific Program Guidelines will be available
             February 1, 1985.

111.   APPLICATION PROCESS

       Specific program guidelines will be available February 1, 1985. T h e application
       deadline will likely b e in be May 1985. Awards will be made in September, 1985.

IV.    INQUIRIES

       Specific program guidelines (which will b e available February 1, 1985) for e a c h of
       t h e t h r e e a r e a s may be obtained by writing to:

                                      Ms. Tina Abel Williams
                                      National Eye Institute
                                      Building 31 - Room 6A50
                                      Bethesda, Maryland 20205
 I
N H GUIDE FOR GRANTS AND CONTRACTS
Vol. 14, No.1, January 4, 1985                                          11 

    Additional program information may be obtained from:

                              Ronald C. Celler, Ph.D. 

                              Associate Director for Extramural and 

                              Collaborative Programs 

                              National Eye Institute 

                              Building 31 - Room 6A03A 

                              Bethesda, Maryland 20205

                              Telephone: (30 1) 486-4903
12 


                                            ANNOUNCEMENT


AVAILABILITY OF R E Q U S T FOR APPLICATIONS: RFA 


85-LM-01 


SPECIALIZED NATIONAL REFERENCE CENTER FOR BIOETHICS LITERATURE 


          ..
P.T. 16; K W 1103002,0783010,1004008 


NATIONAL LIBRARY OF MEDICINE 



                              Application R e c e i p t Date: April 1, 1985


  I.   PURPOSE AND OBJECTIVES

       Advancing medical science and technology have brought g r e a t benefits to society,
       but in doing so have a l s o brought about numerous moral, legal, and e t h i c a l issues.
       Resolution of bioethical m a t t e r s frequently depends on access to relevant
       information, drawn from varied literatures. Indexing of this documentation,
       sponsored by t h e National Library of Medicine, is available through
       BIOETHICSLINE, a computerized bibliographic database. ' T h e r e is also a continuing
       need for a nationally available, comprehensive collection and repository of t h e
       biomedical literature, broadly defined, with access to it mediated by a qualified
       professional reference staff.
                                                                                                                    -

       In FY 1985, following c o m p e t i t i v e selection, t h e National Library of Medicine
       intends to support a specialized national r e f e r e n c e c e n t e r f o r bioethics where
       appropriate documentation will b e collected, organized, and made available for
       bioethics research.

 11.   MECHANISM OF SUPPORT

       The assistance mechanism will b e a specialized c e n t e r grant. Maximum program
       resources available for t h i s initiative t o t a l $400,000. F u t u r e support depends on
       availability of appropriated funds.         Applications for this invitation should b e
       submitted by April I , 1985. T h e e x p e c t e d s t a r t d a t e for a n award is S e p t e m b e r 1,
       1985.

111.   REVIEW PROCEDURES AND CRITERIA

       Applications will b e reviewed by a special panel of non-federal experts. T h e panel's
       recommendations will t h e n b e considered by t h e Board of Regents of t h e National
       Library of Medicine. Review c r i t e r i a will include t h e developmental s t r a t e g y f o r
       acquiring, collecting, and distributing materials, and for publicizing and making
       t h e m accessible. Since t h e c u r r e n t l y printed Bibliography of Bioethics and NLM's
       BIOETHICSLINE computerized d a t a b a s e a r e t h e most widely used databases, t h e
       collection and i t s organizing principles should b e compatible with t h e s e systems.
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                      13 


      Other review c r i t e r i a include instit utional involvement and com mi t men t ,
      collaborative a r r a n g e m e n t s with outstanding scholarly groups of workers in
      bioethics and moral philosophy, and a governing s t r u c t u r e which assures general
      direction by bioethicists, health c a r e practitioners, and information specialists.
      Adequacy of physical space, availability of related library services and materials,
      and access to online bibliographic database systems will a l s o b e considered.
      Professional qualifications of staff will be carefully scrutinized.

IV.   IDENTIFICATION OF CONTACT POINTS

      Requests f o r copies of this RFA may b e directed to:

                                  Peter A. Clepper 

                                  Biomedical Information Support Branch 

                                  Extramural Programs 

                                  National Library of Medicine 

                                  Bethesda, Maryland 20209 


                                  Telephone: 301-496-4221
14 


                                            ANNOUNCEMENT


AVAILABILITY OF REQUEsT FOR APPLICATIONS: RFA

85-AI42 

PROGRAM PROJECTS ON THE BIOLOGY of= THE IMMUNE SYSTEM

P.T. 34; K W 0705040,1002004,1002008,0710060,0710065,0745045
          ..
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


                              Application R e c e i p t Date: J u n e 15, 1985


  I.   BACKGROUND INFORMATION

       The Immunobiology and Immunochemistry Branch of t h e Immunology, Allergic and
       Immunologic Diseases Program of t h e National Institute of Allergy and Infectious
       Diseases (NIAID), supports fundamental studies on t h e s t r u c t u r e and function of the
       immune system to gain an understanding of immune response mechanisms at t h e i r
       basic cellular and molecular levels as t h e y function in health and disease. Program
       P r o j e c t s on t h e Biology of t h e Immune System a r e intended to expand t h e s c o p e of,
       and eventually replace, t h e c u r r e n t Program P r o j e c t s i n Lymphocyte Biology which
       utilize a n i n t e g r a t e d multidisciplinary approach for basic biologic studies of
       immunologically-functional lymphocy te populations. Seven such program projects                               '*
       a r e currently funded although support for t w o is scheduled to conclude in 1986.
       This request for applications (RFA) is intended to encourage t h e development of
       applications from collaborating investiggtors and to coordinate t h e submission and
       review of new and renewal program p r o j e c t applications providing equitable
       opportunity for b o t h to c o m p e t e f o r funds currently available f o r t h i s
       programmatic activity.

 11.   RESEARCH GOALS AND SCOPE

       The goal of these Program Projects is t h e a t t a i n m e n t of a c o m p l e t e understanding
       of t h e s t r u c t u r e and function of t h e immune system and its products, its interaction
       with o t h e r body systems, and full knowledge of t h e g e n e t i c and o t h e r f a c t o r s which
       regulate its development and function. An u l t i m a t e p r a c t i c a l application of this
       information is t h e use of s e l e c t e d cloned c e l l s of t h e s y s t e m o t h e i r products for
                                                                                          r
       the clinical c a r e o r reconstitution of immunodeficient individuals, to a l l e v i a t e
       allergic states, to provide resistance to life-threatening infections a n d to c o r r e c t
       a b e r r a n t or d e f e c t i v e immunoregulatory mechanisms.

       The scope of t h e s e program projects includes studies of e v e r y facet of t h e immune
       response, ranging f r o m t h e initial s t e p of antigen recognition to t h e final
       elaboration of immunologically distinctive products of specific immunocytes.
       Research currently supported by t h i s mechanism was designed to greatly' expand
       knowledge of t h e morphologic and functional heterogeneity of lymphocyte
       populations and to develop t h e capability for identification and selection of
       lymphocyte subpopulations with specific immune r e a c t i v i t y or antigenic                              U*Y-


       composition, for hybridization of such populations and f o r s e l e c t i v e production of
Nil( GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1385                                                             15 

       specific, biologically-active, lymphocyte products. Continuation of such studies is
       anticipated and appropriate, as a r e similar studies of macrophages, o t h e r accessory
       and e f f e c t o r cells, and activation, differentiation and regulation of t h e immune
       system. Also relevant a r e investigations on interactions and influences of o t h e r
       body systems with t h e immune system.

111.   MECHANISM O F SUPPORT

       Program project g r a n t s a r e awarded t o an institution on behalf of a program
       director for t h e support of a broadly based, multidisciplinary, long-term research
       program which has a specific major objective or basic theme. A program project
       generally involves t h e organized e f f o r t s of groups of investigators who conduct
       research projects related to t h e overall program objective. The g r a n t c a n provide
       support f o r t h e p r o j e c t s and f o r c e r t a i n core resources shared by individuals where
       t h e sharing facilitates t h e t o t a l research effort.                  Each component project,
       supported under a program p r o j e c t grant, is expected to c o n t r i b u t e and b e directly
       related to a common theme; t h e projects should d e m o n s t r a t e a n essential e l e m e n t
       of unity and interdependence.

IV.    STAFF CONTACT

       A more detailed RFA may b e obtained from:

                                         John F. Finerty, Ph.D. 

                                         Immunobiology and Immunochemistry Branch, IAIDP 

                                         National Institute of Allergy 

                                           and Infectious Diseases 

                                         Westwood Building - Room 757 

                                         National Institutes of Health 

                                         Bethesda, Maryland 20205 


                                         Telephone: (301) 496-7551 


       Prospective applicants a r e encouraged to submit a one-page l e t t e r of i n t e n t t h a t
       includes a brief synopsis of t h e proposed research and identification of any o t h e r
       participating institutions. The hIAID requests such l e t t e r s by April 1, 1985, for t h e
       purpose of providing a n indication of t h e number and s c o p e of applications to be
       received. A l e t t e r of i n t e n t is not binding. It will not e n t e r i n t o t h e review of any
       application subsequently submitted and is not a necessary requirement for
       application. L e t t e r s of i n t e n t and inquiries should b e directed to Dr. Finerty at t h e
       address shown above.
18 





                                            ANNOUNCEMENT


AVAILABILITY OF REQUEST FOR APPLICATIONS: EWA

85-A144
ASTHMA AND ALLERGIC DISEASE CENTERS AND ASTHMA AND ALLERGIC
DISEASES CENTERS FOR IMMUNODERMATOLOCK STUDIES

P.T. 04; K W OO705040,0715110,0715120,0785010,0710070,0710030,
          ..                                                                               0785035
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


                            Application Receipt Date: October 15, 1985


  I.   BACKGROUND INFORMATION

       The Allergy and Clinical Immunology Branch of t h e Immunology, Allergic and
       Immunologic Diseases Program of t h e National Institute of Allergy a n d Infectious
       Diseases (NIAID) sponsors f u n d a m e n t a l and clinical research concerned with                         P
       asthma, allergic and immunologic diseases and with relevant mechanisms of
       hypersensitivity and inflammation. For this purpose, t h i r t e e n Asthma and Allergic
       Disease C e n t e r s (AADC) a r e currently funded; sup o r t f o r f i v e is scheduled to
                                                                          7
       conclude in 1986. This request for applications (RFA is intended to encourage t h e
       t h e c r i t e r i a and requirements f o r a n AADC and to coordinate t h e submission and
       review of new and renewal applications providing equitable opportunity for both to
       c o m p e t e f o r funds currently available f o r this programmatic activity.
 11.   RESEARCH GOALS AND SCOPE

       The fundamental objective of the NIAID’s AADC program is to f o s t e r a c c e l e r a t i o n
       of t h e application of knowledge on t h e immune s y s t e m emerging f r o m relevant
       biomedical sciences to clinical hypersensitivity disorders. Especially sought as t h e
       requisite f a c t o r s within a participating institution a r e quality research in (a) basic
       science(s), (b) clinical investigation supported by a d e q u a t e clinical facilities, s t a f f
       e x p e r t i s e in diagnosis and m a n a g e m e n t of a s t h m a t i c and allergic patients, and (c)
       access t o (an) appropriate p a t i e n t population(s) within a suitable a c a d e m i c h n v e s t i ­
       g a t i v e designed to favor multidisciplinary interaction.

       The scope of the AADC program represents a n e f f o r t to f o s t e r collaborative
       approaches t h a t will i n t e g r a t e basic concepts in allergy, immunology,
       pathophysiology ,      genetics,        microbiology,   biochemistry,      biostatistics,
       bioinstrumentation, c o m p u t e r science and pharmacology i n t o clinical
       investigations, which, in addition to t h e fields of allergy and clinical immunology,
       may include such a r e a s as dermatology, rheumatology, infectious diseases,
       pulmonary medicine,hematology and otorhinolaryngology, when a high d e g r e e of                            91


       relevance to immunology exits. Program objectives are: to encourage collaboration
       between basic and clinical scientists; to provide a research environment favorable
       f o r such interaction; and to implement clinical application of adequately tested
       research findings and procedures.
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                                          19 





       In addition, a f e a t u r e of t h e AADC program is t h e opportunity for Directors to
       implement educational or community activities. Within t h e research framework of
       t h e Center, a variety of o u t r e a c h and demonstration projects may b e supported.

111.   MECHANISM O F SUPPORT

       AADC g r a n t s are awarded to an institution on behalf of a program director f o r t h e
       support of a broadly based, multidisciplinary, long-term research program which
       may have a specific objective or basic theme, or may involve t h e intergration of
       several themes. An AADC generally involves t h e e f f o r t s of groups of investigators
       who conduct research related to t h e overall program objective. T h e g r a n t c a n
       provide support f o r t h e projects and f o r c e r t a i n c o r e resources shared by individuals
       where t h e sharing f a c i l i t a t e s t h e t o t a l research effort. Each component project
       supported under an AADC g r a n t is expected to contribute to, and be directly
       related to, a common theme; t h e component projects should d e m o n s t r a t e a n
       essential e l e m e n t of unity and interdependence.

IV.    STAFF CONTACT

       A more detailed RFA may be obtained from:

                                          Dorothy D. Sogn, M.D. 

                                          Chief, Allergy and Clinical Immunology Branch 

                                          Immunology, Allergic and Immunologic
                                            Diseases Program
                                          National Institute of Allergy
                                            and Infectious Diseases
                                          Westwood Building Room 752
                                                                  4


                                          Bethesda, Maryland 20205
                                          Telephone: (301) 496-8973

       Prospective applicants a r e encouraged to submit a one-page l e t t e r of i n t e n t t h a t
       includes a brief synopsis of t h e proposed research and identification of any o t h e r
       participating institutions. The NIAID requests such l e t t e r s by July 15, 1985, for t h e
       purpose of providing an indication of t h e number and s c o p e of applications to b e
       received. A l e t t e r of i n t e n t is not binding. I t will n o t e n t e r i n t o t h e review of any
       application subsequently submitted and is not a necessary requirement for
       application. L e t t e r s of i n t e n t and inquiries should be directed to Dr. Sogn at t h e
       adress above.
    20 



                                             ANSJOUNC�MENT


AVAILABILITY OF REQUEST FOR APPIJCATKINS: RFA

85-DM1 

OROFACIAL PAIN RESEARCH CENTERS

          ..
P.T. 04; K W 0715150,0785040,0710100,0785035,0785055,0705055,0755030,0414011

NATIONAL INSTITUTE OF DENTAL RESEARCH


                               Application R e c e i p t Date: J u n e 15, 1985


The National Institute of D e n t a l Research (NIDR) invites applications f o r one o r more
mu1tidisciplinary research c e n t e r s studying orofacial pain. The NIDR is initiating support
for c e n t e r s of research excellence in this a r e a in a n e f f o r t to a c c e l e r a t e scientific
progress related to a c u t e and chronic d e n t a l orofacial pain.

The overall purpose of t h e s e Centers will be to conduct basic and clinical research
expanding knowledge concerning t h e mechanisms underlying orof acial pain a n d t h e
etiology, diagnosis, and t r e a t m e n t of various d e n t a l and orofacial pain conditions. The
u l t i m a t e a i m of such research is to establish a scientific foundation p e r m i t t i n g optimally           3x


safe and e f f e c t i v e prevention and c o n t r o l of orofacial pain.

In order to be responsive to t h e i n t e n t of t h i s RFA, t h e proposal f o r c e n t e r a c t i v i t y must
include both basic and clinical research. It is anticipated t h a t e a c h c e n t e r will d i r e c t
s o m e research e f f o r t toward studies r e l e v a n t to chronic orofacial pain.

Research objectives to b e addressed in t h e Orofacial Pain Research C e n t e r s may include,
b u t a r e not limited to t h e following:

       1. 	   Studies to identify and e l u c i d a t e t h e biological mechanisms involved in
              orofacial pain transmission a n d modulation.

       2.     Research on CNS mechanisms involved in pathological pain.

       3. 	   Neuropharmacological studies of a g e n t s f o r use in t h e control of chronic
              orofacial or a c u t e d e n t a l pain.




This program is described in t h e C a t a l o g of Federal Domestic Assistance No. 13.844,
Pain Control and Behavioral Studies. Awards will b e m a d e under t h e a u t h o r i t y of t h e
Public Health Service Act, T i t l e 111, Section 301 (Public Law 78-410, as amended; 42 USC                           'y

241) and administered under t h e PHS g r a n t policies and Federal Regulations 42 C F R P a r t
52 and 45 CFK P a r t 74. This program is not subject to t h e intergovernmental review
requirements of Executive Order 12372 o r Health S y s t e m s Agency review.
NIH GUIDE FOR GRANT'S AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                                21 





      4 	
       .     Small scale epidemiological studies assisting toward t h e identification of t h e
             incidence and distribution of chronic orofacial pain.

      5. 	   Studies of f a c t o r s influencing human pain perception, as well as studies
             developing improved behavioral and psychophysiological means of pain
             assessment.

      6. 	   Studies of t h e basic and clinical aspects of a c u t e d e n t a l pain, including post-
             surgical pain.

      7	
      .      Basic and clinical studies of chronic pain associated with t h e
             temporomandibular joint or myofascial pain, or orof a c i a l pain syndromes such
             as tic douloureux, atypical f a c i a l pain, and postherpetic neuralgia.
      8. 	   Experimental or clinical studies t h a t clarify t h e association b e t w e e n orofacial
             motor dysfunction and orofacial pain.
      9. 	   Studies to develop improved, e f f e c t i v e diagnostic and t r e a t m e n t procedures
             applicable to a c u t e d e n t a l pain and to chronic orofacial pain conditions.

The substance of e a c h research program may vary according to local expertise, interest,
resources, and r e c r u i t m e n t possibilities. Applicants should a t t e m p t to develop a unique
program which is complementary to, rather than duplicative of, ongoing research. T h e
Institution must be willing to m a k e a commitment of resources and staff to ensure t h e
development, operation, and function of t h e proposed center. Applicants may request up
to $300,000 in d i r e c t costs for t h e f i r s t year, with appropriate increases in subsequent
years. Funding is anticipated f o r a f i v e year project period with a possibility of renewal.

Copies of t h e c o m p l e t e RFA and additional information may be obtained from:

                                      Dr. P a t r i c i a Bryant

                                      Craniofacial Anomalies, Pain Con t r01, 

                                        and Behavioral Research Branch 

                                      Extramural Programs 

                                      National Institute of Dental Research 

                                      Westwood Building - Room 506 

                                      Bethesda, Maryland 20205 


                                      Telephone: (301) 496-7807 

22 





                                            ANNOUNCEMENT


OPPORTUNITIES FOR RESEARCH IN MEDICAL INFORMATICS

INVESTIGATOR-INITIATED RESEARCH GRANTS AND NEW ,INVESTIGATOR
RESEARCH AWARDS

P.T. 16,34; K.W. 1004017,1004008,1004015,0503007
NATIONAL LIBRARY OF MEDICINE


                    Application Receipt Dates: March 1, July 1, November I


  I.   BACKGROUND INFORMATION

       Through its e x t r a m u r a l programs, t h e National Library of Medicine (NLM) provides
       assistance f o r research i n t o t h e attributes, organization, and utilization of medical
       knowledge. For t h e p a s t f i v e years, in NLM's Medical Informatics program a r e a
       (formerly called C o m p u t e r s in Medicine) g r a n t e e s have m a d e notable advances in
       t h e health computer and information sciences. Their success h a s contributed to a                          v
       growing recognition of t h i s i m p o r t a n t research field. As a result, it h a s now
       become possible for NLM to support additional work in F Y 85.

       Advances of r e c e n t d e c a d e s in t h e medical sciences have f o s t e r e d large c h a n g e s in
       traditional p a t t e r n s of health c a r e , education, and research. These changes
       emphasize t h e importance of having a c c u r a t e , authoritative knowledge
       conveniently at hand. Furthermore, traditional methods of information retrieval,
       however widely available, are becoming overwhelmed by new demands and needs.
       New methods and a r r a n g e m e n t s for knowledge access must be found. They will
       depend not only on t h e evolution of higher technologies b u t also on b e t t e r
       understanding of human m e n t a l processes.

       NLM's Medical Informatics Research Program represents a n a t t e m p t to address
       needs for a wide range of investigations in this a r e a and thereby to f o s t e r a new
       research discipline - Medical Informatics.




This program is described in t h e Catalog of Federal Domestic Assistance, Medical
Library Assistance, 13.879. G r a n t s will b e awarded under t h e authority of t h e Public                       .

                                                                                                                     M

Health Service Act, Section 301 (42 USC 241) and administered under PHS g r a n t policies
and Federal Regulations, most specifically at 42 CFR P a r t 52 and 45 CFR Part 74. This
program is not subject to review by a Health Systems Agency nor to t h e requirements of
Executive Order 12372.
    NIH GUIDE FOR GRANTS AND CONTRACTS
    Vol. 14, No.1, January 4, 1985                                                                 23
t




     11.   RESEARCH GOALS AND SCOPE
           Through this program NLM supports work on fundamental knowledge issues. These
           concern t h e extraction, organization, retrieval, and utilization of knowledge,
           involving methodoIogies such as artificial intelligence, related computer sciences,
           computational linguistics, medical decision science, cognitive psychology, and
           related information-oriented fields. Subjects suitable for support include:

                 o	     B e t t e r understanding of how health professionals respond to information
                        needs.

                 o	     Integration of recorded knowledge into clinical a n d o t h e r scientific
                        activities.

                 o	     Optimal organization and retrieval for b e t t e r teaching and learning of
                        m a t e r i a l traditionally stored in libraries.

                 o	     Mental processes of medical decision making and problem solving and
                        t h e i r replication or simulation by computerized e x p e r t systems.

                 o	     Reasoning from medical knowledge, including a r t i f i c i a l intelligence as
                        applied to knowledge bases and "expert" systems.

                 o      The nature and analysis of medical bibliography.

                 o	     The classification,       organization,     and    development of        advanced
                        nomenclatures.

                 o	     Attributes, f o r m a l structures, and r e t r i e v a l processes for medical
                        languages and sub-languages.
                 o      Representation and organization of knowledge in computerized systems.

           These investigations must t a k e place in a health context. NLM must necessarily
           confine its i n t e r e s t s to those a s p e c t s of t h e computer and related sciences which
           b e a r on t h e identification, organization, and retrieval of health information.
    111.   MECHANISM OF SUPPORT

           The assistance mechanisms available a r e t h e well-established NIH g r a n t s for
           investigator-initiated research and New Investigator Research Awards. Application
           forms and instructions for t h e s e g r a n t s a r e available at most a c a d e m i c medical
           centers, or from:

                                          O f f i c e of Grants Inquiries
                                          Division of Research G r a n t s
                                          National Institutes of Health
                                          Westwood Building - Room 449
                                          5333 Westbard Avenue
                                          Bethesda, Maryland 20205

                                           Telephone: 301-496-744 1
24 





IV.    REVIEW PROCEDURES AND CRITERIA

       Applications filed on t h e r e c e i p t d a t e s noted above will be r e f e r r e d to a n
       appropriate study section o r review c o m m i t t e e . The review c r i t e r i a will be those
       announced in t h e instruction f o r m s f o r t h e d i f f e r e n t award mechanisms employed.
       Applications filed l a t e r than t h e announced d a t e s will be held for t h e n e x t review
       cycle.

 V.    METHOD OF APPLYING

       Applications should b e submitted on PHS form 398, available from t h e sources
       listed above.    Applicants should r e f e r to this program announcement in t h e
       appropriate block on t h e application form. The place of application r e c e i p t is:

                                      Division of Research G r a n t s
                                      National Institutes of Health
                                      5333 W estbard Avenue
                                      Bethesda, Maryland 20205
       L e t t e r s of i n t e n t a r e not required o r necessary for those interested in support by
       this program. However, program staff will respond to telephone inquiry o r to a
       brief l e t t e r outlining t h e research envisaged. The staff response will be limited to
       questions of program scope and relevance. If a proposal, while in t h e health
       domain, is outside t h e scope of this particular program, staff will m a k e every                 -1


       e f f o r t to r e f e r t h e applicant to a m o r e appropriate source of support.
VI.    IDENTIFICATION OF CONTACT POINTS

       Staff at t h e National Library. of Medicine will assist to t h e e x t e n t possible in
       m a t t e r s of scope, relevance, o r o t h e r questions about review, administration, and
       funding of applications received in response to this announcement.

                                      Biomedical Information Support Branch 

                                      E x t r a m u r a l Programs 

                                      National Library of Medicine 

                                      Bethesda, Maryland 20209 


                                       Telephone: 301-496-4221




                                                                                                           l Y '   '
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. IC, No.1, January 4, 1985                                                      25 





RESEARCH RELATED TO INTEGRATED ACADEMIC WFORMATION MANAGEMENT
SYSTEMS (WMS)
P.T. 16,34; K.W. 1004017,0901026,1004000,1004005,1004015,0410000
NATIONAL LIBRARY OF MEDICINE
                 Application Receipt Dates: March 1, July 1, November I

The National Library of Medicine (NLM) invites investigator-initiated research g r a n t
applications for studies related t o Integrated Academic Information Management
Systems (IAIMS). Planning and development of IAIMS at medical c e n t e r s and other
health institutions already have identified a number of unanswered fundamental research
questions t h a t go beyond t h e difficulties of establishing electronic and administrative
linking of independent computer systems. Of special importance are questions whose
investigations are enhanced by t h e IAIMS information environment and those questions
essential to b e answered in order to permit successful implementation of IAIMS
prototypes.
  I.   BACKGROUND

       NLM supports research into the role of knowledge in health professional life, new
       mechanisms and structures for managing this knowledge, and computerized
       methods for organizing and utilizing knowledge.      Such studies may concern
       principles of information organization or new arrangements for computerized
       knowledge representation.     Also involved may b e investigations of artificial
       intelligence techniques as applied to knowledge bases and expert systems. Other
       research may involve investigations of how health professionals seek and utilize
       information for problem-solving, and the managerial and organizational methods
       for improving information services.
       In 1983 NLM initiated a n IAIMS planning and development activity as a p a r t of its
       Medical Library Resource Project Grant Program. The purpose of t h e IAIMS
       initiative is to assist health institutions in linking t h e library systems and the
       multitude of additional information systems t h a t underpin t h e complex, modern
       medical center into a n integrated computer-based network. The IAIMS concept
       was derived from a n NLM-sponsored study by t h e Association of American Medical
       Colleges (AAMC) to analyze trends in biomedical information transfer and their




This program is described in t h e Catalog of Federal Domestic Assistance, Medical
Library Assistance, 13.879. Grants will b e awarded under t h e authority of t h e Public
Health Service Act, Section 394(b) (42 USC 280b-5) and administered under PHS grant
policies and Federal Regulations, most specifically at 42 CFR P a r t 52 and 45 CFR P a r t
74. 	 This program is not subject to review by a Health Systems Agency nor t o the
requirements of Executive Order 12372.
26 





implications f o r health s c i e n c e libraries over t h e n e x t decade. The AAMC report, as well
as o t h e r publications, indicate t h a t e f f e c t i v e t r a n s f e r and utilization of recorded
knowledge will require i n t e r a c t i v e network capabilities within medical centers. NLM
provides support for: 1) institution-wide IAIMS planning and policy analysis, 2) IAIMS
model development involving s o m e s e g m e n t o r cross-section of t h e institution-wide
s t r a t e g i c plan, and 3) implementation of detailed plans f o r a full-scale IAIMS prototype.
The NLM IAIMS program is described in an earlier NIH Program Announcement ( s e e m
Guide for G r a n t s and C o n t r a c t s , Vol. 13, No. 8, J u n e 29, 1984).

 11.   OBJECTIVES

       hLM encourages innovative research to support t h e development and
       implementation of IAIMS.             In order to be fully e f f e c t i v e in transforming
       information-seeking and utilization behavior, IAIMS must employ state-of-the-art
       computer and communication technologies, provide relevant information and
       decision support mechanisms, i n t e g r a t e information and data of d i f f e r e n t f o r m a t s
       and structures, respond to specific information needs and requirements, and provide
       synthesizing mechanisms to create knowledge bases. IAIMS development provides
       an expedient opportunity to exploit advances resulting from medical informatics
       research, as well as a locus for a multitude of studies to improve information
       access and use in h e a l t h science research, education, and practice.
       Research may address technological a s p e c t s of computer and communication
       systems applications to large-scale networking and inf o r m a t i o n / d a t a f i l e                        -1.


       integration, including linguistic and human f a c t o r s a s p e c t s of such applications.
       Investigations may define specific information needs and representations f o r
       various medical c e n t e r personnel, and devise organizing s t r u c t u r e s and presentation
       systems. Studies may also explore synthesizing methods a n d systems, information
       filtering techniques, knowledge base and e x p e r t systems applications to IAIMS,
       including a r t i f i c i a l intelligence methodologies. Additionally, r e s e a r c h m a y be
       directed to fundamental scientific questions underlying questions of policy,
       structures, and processes f o r managing and delivering information, a n d t h e r e l a t e d
       issues of t h e economics, ownership, privacy, and protection of information.

111.   MECHANISM OF SUPPORT

       Applicants will b e supported through t h e customary National Institutes of Health
       Research P r o j e c t G r a n t , in a c c o r d a n c e with a l l PHS policies. Responsibility f o r t h e
       planning, direction, and execution of t h e proposed research will be solely t h a t of
       t h e applicant. T h e t o t a l p r o j e c t period is not e x p e c t e d to exceed t h r e e years.

       NLM necessarily distinguishes b e t w e e n research related to IAIMS, a n d IAIMS
       planning and development projects. Proposed research p r o j e c t s m u s t closely relate
       to a n existing institutional IAIMS project.
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                              27 





IV.   ADDITIONAL INFORMATIObi AND CONTACT POINT

      Applications should b e prepared on PHS f o r m 398, available at most a c a d e m i c
      medical c e n t e r s or from:

                                     O f f i c e of G r a n t s Inquiries
                                     Division of Research G r a n t s
                                     National Institutes of Health
                                     Westwood Building - Room 449
                                     5333 Westbard Avenue
                                     Bethesda, Maryland 20205

                                     Telephone: 301-496-7441

      Applicants should r e f e r to this program announcement in t h e appropriate block on
      t h e application form.

      L e t t e r s of i n t e n t a r e not required or necessary for those interested in support by
      this program. However, program staff will respond to telephone inquiry, o r to a
      brief l e t t e r outlining t h e research envisaged. The staff response will b e limited to
      questions of program s c o p e and relevance. If a proposal, while in t h e health
      domain, is outside t h e scope of this particular program, staff will m a k e every
      e f f o r t to r e f e r t h e applicant to a m o r e appropriate source of support.

      Staff at t h e National Library of Medicine will assist, to t h e e x t e n t possible, in
      m a t t e r s of scope, relevance, or o t h e r questions about review, administration, and
      funding of applications received in response to this announcement.

                                     Biomedical Information Support Branch 

                                     E x t r a m u r a l Programs 

                                     National Library of Medicine 

                                     Bethesda, Maryland 20209 


                                     Telephone: 301-496-4221
28 





                                         ANNOUNCEMENT

HUMAN PAPILLOMA VIRUSES AND GENITAL WARTS
          ..
P.T. 34; K W 0714125,1002047,0715220,1002008
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
                   Application Receipt Dates: March 1, July 1, November 1

The National Institute of Allergy and Infectious Diseases (NIAID) invites applications for
regular research grants on t h e biology and molecular virology of human papilloma viruses
(HPV) in association with the pathogenesis, epidemiology and natural history of human
warts and laryngeal papillomas.
Genital papillomas (condyloma acuminatum) a r e now regarded as sexually transmitted
and a serious public health problem. During t h e past five years t h e number of reported
cases of genital papillomas has increased at an alarming rate relative to other sexually
transmitted diseases. Most human papillomas a r e benign and self-limiting, b u t in some
cases they are acute, chronic, persistent or progressive. Under any cirumstances genital
warts a r e a concern to t h e health of t h e individual and t h e public. T h e presence of t h e
viruses in t h e gravid f e m a l e genital t r a c t at t e r m introduces a risk of transmission to the
newborn. The HPV t h a t infect t h e genitalia also cause laryngeal papillomas. All age                    I r
groups appear to b e susceptible.
Several strains of HPV obtained from clinical specimens have been concentrated and
characterized by restriction endonuclease analysis. Newer molecular technologies led to
t h e cloning of t h e genome of some HPV strains. In turn, cloned fragments of t h e genome
have been used to make molecular probes for detecting evidence of t h e HPV in human
tissues when no viral particles could b e seen or isolated. With these technics HPV strains
6 and 11 have been identified in many cases of condyloma acuminatum and laryngeal
warts, b u t other strains a r e also be associated with these papillomas. A major obstacle
to t h e study of t h e biology of HPV and t h e epidemiology and natural history of human
warts has been t h e lack of adequate means of propagating the viruses. The papilloma
viruses appear to be highly species specific. Animal model systems have provided
valuable information on t h e structure and composition of t h e viruses and s o m e informa­
tion on pathogenesis.        However, there is a dearth of information on replication
strategies, viral proteins, immune responses, latency, host f a c t o r s regulating replication,
viral attachment, tissue tropism, modes of natural transmission and epidemiology of t h e
nonmalignant diseases. It is in these a r e a s t h a t NIAID is encouraging new investigations.




This program is described in the Catalog of Federal Domestic Assistance No. 13.856,
Microbiology and Infectious Diseases Research. Awards will b e made under t h e authority
of t h e Public Health Service Act, Title 111, Section 301 (Public Law 73-410, as amended;                  kw

42USC241) and administered under PHS g r a n t policies and Federal Regulations 42CFR
P a r t 52. This program is not subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review.
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                                29 




APPLICATION SUaMISSION AlVD REVIEW

Eligibility: Universities, medical colleges, hospitals, and laboratories of o t h e r public,
p r i v a t e o r f o r profit institutions a r e eligible.

Submission: To identify responses to this announcement, check "yes" and p u t "Human
Papilloma Viruses and Genital Warts," under Item 2 on page I of t h e g r a n t application.
Use the regular research g r a n t application form PHS 398 t h a t is available in business
offices of most research institutions o r from t h e Division of Research G r a n t s (DRG),
NIH.

The completed application should b e mailed to:

                                      Division of Research G r a n t s
                                      National Institutes of Health
                                      Westwood Building - Room 240
                                      Bethesda, Maryland 20205

The DRC will assign applications f o r technical review according to t h e NII-i process for
regular g r a n t applications. Assignments f o r funding decisions will follow p r o g r a m m a t i c
guidelines established for NIH. The earliest possible award date is approximately nine
months a f t e r t h e receipt date. The number of awards m a d e will depend on t h e
recommendations of t h e technical review c o m m i t t e e and t h e availability of funds.


INQUIRIES

Additional information may be obtained from:

                                      William P. Allen, Ph.D.
                                      Westwood Building - Room 736
                                      National Institutes of Health
                                      Bethesda, Maryland 20205

                                      Telephone: (301)496-7453
30 





                                      ANNOUNCEMENT

MECHANISMS OF ACTION OF THE DRUG CYCLOSPORINE
P.T. 34; K W 0710100,0745040,0710070,1002008
          ..
GENETICS AND TRANSPLANTATION BIOLOGY BRANCH
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

                 Application Receipt Dates: November I , March I , July 1.

The National Institute of Allergy and Infectious Diseases (NIAID) invites investigator
initiated research g r a n t applications t h a t will increase our knowledge and understanding
of t h e mechanism of action of t h e immunosuppressive drug cyclosporine and of i t s side
effects.

Cyclosporine A (CsA) has been used for several years to suppress allograft rejection in
patients receiving organ transplants. The use of cyclosporine is reported to b e of major
importance in improving the survival of kidney, liver and heart transplants. However, it
is also recognized t h a t t h e r e a r e serious postoperative problems with toxicity episodes,
especially involving the kidney, with growing evidence for the induction of chronic renal
injury by cyclosporine. The e x a c t mechanism of action of cyclosporine is unknown.
                                                                                                    -

However, t h e T helper c e l l appears to be a primary target of CsA action. Controversial
claims suggest that CsA a f f e c t s T or B lymphocytes or both. Long t e r m effects of
cyclosporine with respect to repeated infections and/or cancer have not been fully
elucidated.
The Genetics and Transplantation Biology Branch wishes to stimulate interest in basic
research in molecular biology and immunology to explore t h e nature of cell surfaces,
receptor sites, and T and B cell interactions t h a t might be involved in t h e mode of action
of t h e drug and induction of unresponsiveness to foreign allograft. Further, studies to
define possible pathogenic mechanisms and long t e r m drug effects a r e encouraged.
Applications in response to this announcement will b e assigned and reviewed in
accordance with the usual National Institutes of h e a l t h (NIH) peer review procedures.
They will first b e reviewed for scientific and technical merit by a group composed mostly
of non-Federal scientific consultants. Following this initial review, applications assigned
to NIAID will b e evaluated for program relevance by t h e National Advisory Allergy and
Infectious Diseases Council. Applications assigned to other Institutes will be reviewed by
t h e appropriate Councils. The review criteria customarily employed by t h e NIH for
regular research grant applications will prevail.


This program is described in t h e Catalog of Federal Domestic Assistance No. 13.855,
Immunology, Allergic and Immunologic Diseases Research. Awards will b e made under
t h e authority of t h e Public Health Service Act, Title 111, Section 301 (Public Law 78-410,
as amended; 42 USC 241) and administered under PHS g r a n t policies and Federal
                                                                                                    yI   .
Regulation 42 CFK P a r t 74. This program is not subject to intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency Review.
MH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                                      31 




All PHS and NIH g r a n t policies governing regular research project grants, including cost
sharing, apply to applications received in response to this program announcement.

DEADLINE:

Applications will b e a c c e p t e d in accordance with t h e usual NIH r e c e i p t dates for new
applications. Deadline d a t e s are: November 1, March 1, and July 1.

METHOD OF APPLYING

Applications should b e submitted on f o r m PHS 398, which is available in t h e g r a n t s and
c o n t r a c t s business office at most a c a d e m i c and research institutions o r f r o m t h e Division
of Research Grants (DRC, NIH). In space 1 2 on t h e f i r s t p a g e of this form, indicate t h e
                                                          1
t i t l e of this program announcement. T h e original and six copies of t h e application should
be submitted to:

                                         Application Receipt Office
                                         National Institutes of Health
                                                                -
                                         Westwood Building Room 240
                                         Bethesda, Maryland 20205

For f u r t h e r information contact:
                                         Justina Grauman, M.S. 

                                         Program Officer 

                                         G e n e t i c s and Transplantation Biology Branch 

                                         National Institute of Allergy 

                                           and Infectious Diseases 

                                         National Institutes of Health 

                                                                -
                                         Westwood Building Room 754 

                                         Bethesda, Maryland 20205 

                                         Telephone: (301)496-5598
32 





                                                 NOTICE


                                       KEYWORD THESAURUS

During t h e period February-December of 1984, announcements in t h e NIH Guide f o r
Grants and C o n t r a c t s w e r e coded using t h e Keyword Thesaurus, a p r o j e c t funded by t h e
National Science Foundation and t h e National Endowment for t h e Humanities. T h e
purpose of using t h e codes and t e r m s of t h e Keyword Thesaurus is to f a c i l i t a t e
distribution of announcements and R e q u e s t s f o r Applications (RFAs) to f a c u l t y and staff
members who have i n t e r e s t s in t h e specific a r e a s listed.

Beginning with t h e c u r r e n t issue (January 1985) t h e announcements a n d RFAs will be
coded using t h e new edition of t h e Keyword Thesaurus (Revised October 1984). For more
information about c o v e r a g e of sponsoring agencies and a i m s of t h e Keyword Thesaurus,
you may write to:
                                        Mr. John A. Rodman 

                                        Office of Sponsored Projects 

                                        University of Texas at Dallas 

                                        P O Box 830688 

                                         ..
                                        Richardson, Texas 75083-0688 


For those who may not have obtained a copy of t h e 1984 Keyword Thesaurus, t h e
relevant portion is e x c e r p t e d in t h i s issue. In t h e next issue of t h e Guide t h e same list of
t e r m s will be indexed in numerical order, by t h e 7-digit code. As displayed in individual
                                      PT"
announcements, t h e initials ".. d e n o t e "program" and "K.W." identifies one o r more
keywords corresponding to t h e subject m a t t e r of t h e program or of t h e announcement.
Occasionally, o t h e r keyword t e r m s f r o m t h e c o m p l e t e Thesaurus maybe used to classify
announcements, and codes for T a r g e t Groups may be used. For any questions about t h e
NIH use of t h e Keyword Thesaurus please c a l l Dr. John C. J a m e s at 301-496-7554.
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                      33 




                                     NOTICE


                            PROGRAM N P S

    01               ANALYTICAL SERVICES 


    02               CAPITAL CON ST K UC TION 


    04 
             CENTERS: R ESEA R C H/DE MON STR ATION/SERVICE 


    05               CHALLENGE/FUND RAISING 


    06               CONSULTING/VISITING PERSONNEL 


    08 
             CULTURAL OUTKEACH 


    12               DEMONSTRATION 


    14               DEVELOPMENT (INSTITUTIONAL/DEPARTMENTAL) 


    16               DISSEMINATION O F INFORMATION 


    18               EQUIPMENT/INSTRUMENTATION
    20               EXHIBITIONS, COLLECTIONS, PERFORMANCES 


    22               FELLOWSHIPS 


    23               FINANCIAL AID (SCHOLARSHIPS AND LOANS) 

    24               GENERAL OPERATING SUPPORT 


    25               INSTRUCTION/CURRICULUM DEVELOPMENT 

                 9

    26               INTERNATIONAL EXCHANGE PROGRAMS 


    28               MATERIALS ACQUISITION (BOOKS,TAPES, ETC.) 


    30               PKESERVATION/RESTORATION 

    32               PUBLIC A TION 


    34               K ESEA R CH 

    36               RESOURCES (SHARED/N ON-ACQUISITION) 


    38               SERVICE DELIVERY PROGRAMS 

34 





       40 	   STUDENT        SUPPORT         (INCLUDING        DISSERTATION
              SUPPORT)

       42 	   SYMPOSIUMS, CONFERENCES, WORKSHOPS, INSTITUTES,
              SEMINARS, COLLOQUIA

       44 	   T RAININ C / T tiAIN E ESHIPS/ APP KENT IC I 3 HIPS /
              IN TERNSHIPS

       46     TRANSLATIONSlEDITING

       48     TRAVEL
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                35 





                                       NOTICE


                         KEYWORD THESAURUS - KEYWORDS

0700000    HEALTH AND SAFETY/MEDICAL SCIENCES/BIOMEDICAL
0705000 ANATOMICAL SYSTEMS/SITES 	              1003019    Catalysis

0705005   Bone Marrow 
                         1003003    Chemical Dynamics

07050 IO  Brain 
                               1013020    Chemical Physics

0705015   Cardiovascular System 
               1003006    Chemical Synthesis

0705020   Connective Tissue 
                   1003008    Chemistry, Analytical

0705025   Digestive System 
                    0710040    Chemistry, Clinical 

0705030   Endocrine System 
                    1003012    Chemistry , Organic

0705035   Fetus 
                               1003014    Chemistry, Physical

0705040   Immune System 
                       0414004    Clinical Psychology

0705045 	 Lymphatic System                      1004000    Computer Science 

0705 05 0 Musculoskeletal System                1002015    c ytology

0705055   Nervous System                        0413001    Demography

0705060   Placenta                              0414006    Developmental Psychology

0705065   Respiratory System                    1002052    Development, Animal 

0705070   Sensory System                        1002053    Development, Human 

0705075   Urogenital System                     0710045    Drug Metabolism 

                                                1002016    Ecology

0706000    BIOMEDICAL ENG INEERING              0414007    Educational Psychology 

0735005      Automated Clinical Analysis        0500000    Education 

0706010      Bioelectric Phenomena              07 10050   Electrophysiology

0706020      Clinical Engineering               1002017    Embryology 

0706030      Medical/Diagnostic Imaging         07 10055   Enzymology

0706040      Physiological Controls             1002019    Genetics 

                and Systems                     1002021    Histology 

                                                07 10060   Immunochemistry 

07 10000 DISCIPLINES/FIELDS                     0710065    Immunogenetics

0710005    Adolescent Health                    0710070    Immunology

0710010    Aging/Gerontology                    0710075    Immunopathology

1002001    Anatomy                              1004017    Information 

                                                           Science/Systerns 

0201013      Animal Diseases/Pathology          0410000    Linguistics/Philology 

020 1016     Animal Genetics/Breeding           0901026    Managemen t Sciences 

020 1018     Animal Physiology/Morphology       07 10080   Medicinal Ch e mist r y

040 1001     Anthropology, Cultural/Social      0607010    Microelectronics
1004015      Artificial Intelligence            1002027    Microbiology
1002003      Bacteriology                       04 13003   Migration
0404000      Behavioral/Social Studies          1002058    Molecular Genetics
0414015      Behaviorism/Experimental           1002028    M u tagenics
               Psychology                       1002029    Mycology
1003002      Biochemistry                       07 10085   Neurophysiology
1003015      Biochemistry, Carbohydrates        1002030    Neuroscience
1003016      Biochemistry, Lipids               07 10090   Nuclear Medicine
1003017      Biochemistry, Nucleic Acid         0710095    Nu t r ition/Die tetics
1003018      Biochemistry, Proteins             1013017    Optics
0710015      Bioengineering                     1002032    Parasitology
1002000      Biological Sciences                0710100     Pharmacology
36 





1002004      Biology, Cellular                 07 10130   Pharmacy 

1002006      Biology, Developmental            0414011    Physiological Psychology

1002008      Biology, Molecular                1002040    P l a n t Sciences 

1002009      Biology, Radiation                100204 1   P l a n t Virology 

07 10020     Biomechanics                      1009013    Polymer Science 

07 10030     Biomedical Research,              04 13004   Population Biology 

                Mu Itid isc iplinary           04140 12   Psychobiology 

1002012      Biometry                          0414020    Psychodynamics 

1013004      Biophysics                        04 14000   Psychology 

07 10035     Biotechnology                     07 10105   Psychopathology

1002013      Botany                            1013026    Radiation Physics 

0710115      Reproductive Physiology           0715185    Skin Diseases 

0414014      Social Psychology                 04040 19   Smoking Behavior 

04 17000     Sociology                         0715190    Stillbirth 

0710120      Speech Pathology                  07 15195   Stress 

1010013      Stat istics                       07 15200   Stroke 

1003022      Surf ace        Chemistry         07 15205   Sudden          Infant Death 

                                                          Syndrome
1007009      Toxicology                        0404020    Suicide 

07 10 125    Transplantation Immunology        0715210    Trauma 

1002045      Viral Studies (Virology)          0715215    Tumor Immunology 

1002047      Zoology                           07 15220   Venereal Diseases 

                                               0404023    Violent Behavior 
                        -"
07 15000    DISEASE ENTITIES/MEDICAL
            PROBLEMS, BEHAVIOR AND             0720000    EDUCATION/INSTRUCTION
            FACTORS AFFECTING HEALTH           0502002      Alcohol Education
07 15005      Accidents                        0720005      Biomedical Training
0404001       Addiction                        0503007      Computer-Assisted
                                                                Instruction
0404003      Alcohol/ Alcoholism               0502009      Dental Health Education
0715010      Arthritis                         05020 11     Drug Education
0715015      Autoimmunity                      0502000      Educational/Ins tructional
107 15020    Behav ioral Medicine                               Programs
0715025      Biofeedback                       0507002      Emotionally Disturbed, Educ.
07 15030     Birth/Congenital D e f e c t s    0507004      Handicapped, Education
07 15035     C a n c e r /Carcinogenesis       05020 17     Health and S a f e t y Education
07 15040     Cardiovascular Diseases           05030 16     Instructional Materials
07 15045     Communicable Diseases                             and Practices
07 15050     Communicative Disorders,          05030 18     Learning Motivation
                Hearing                        0507005      Learning Disabled, Education
07 15055     Communicative Disorders,          0502024      Medical Education
               Sped-'                          0502027      Nursing Education
07 15060     Convulsive Disorders              0502028      Nutrition Education
0404007      Death and Dying                   0502045      P h a r m a c y Education
07 15070     D e a t h and Dying, Health and
               Physical Needs                  0725000    ENVIR~NMENT
07 15075     Diabetes                          1007001     Biology, Env ironmenta1
07 15080     Diabetic Retinopathy              1007002     Chemistry, Environmental
0715085      Digestive Diseases and            0725005     Environmental Health                I*   '
               Disorders                       1007003     Environmental E f f e c t s
0404009      Drugs/Drug Abuse                  07250 10    Health and S a f e t y Standards
MH GUIDE FOR GRANTS AND CONTRACTS
Vol. 14, No.1, January 4, 1985                                                     37 




0715090     Dyslexia                              0715015      Health, Radiation E f f e c t s 

0715095     E motional /M e ntal Health           0725020      Occupational Health dc Safety 

0715100     Eye Diseases                          0725025      Poison Control 

0715105     Hyperplasia                           1007005      Pollution, Air 

0715110     Hypersensitivity                      1007008      Pollution, Water 

07151 15    Hypertension                          0715175      Safety 

0715120     Immune System Disorders
0715125     Infectious Diseases/Agents            0730000   HEALTH CAKE
0715130     Mental Retardation                    0730005     Child/Maternal Health
0715135     Metabolic Diseases                    0730010    Family Health/Planning/Safety
0715140     Neuromuscular Disorders               0730015     Folk Medicine
0715 145    Obesity
                              0408006 
 Health C a r e Economics
0715150     Pain 
                                0730020  
 Health C a r e Administration
0715155     P e r i n a t a l Disorders 
         0730025 
 Health Facilities Studies
0413005     Population Control 
                  0730030 
 Health Insurance
0715160     Pregnancy Disorders 
                 0730035 
 Health Maintenance
0715165     Pulmonary Diseases 
                                 Organizations
0715170     Rheumatic Diseases 
                  0730040 
 l i e a l t h Manpower/Professions
0715175     Safety                                0730045 
 Health Records
0730055     Hospices
                                                  0750000 
 M ATERIALS/PRODUCTS
0730060     Nursing Homes                         0750005 
 Biomaterials
0730065     P a t i e n t C a r e and Education   0750010     Blood/Blood Products/
0730070     Public Health                                       Transfusion
                                                  0750015     Breast Milk
0735000 INSTRUMENTS/INSTRUMENTATION/              0750020     Contraceptives
          DEVICES                                 0202001     Food Additives
0735005   Automated Clinical Analysis             1009007     Materials, Composite
1004002   Computer-Assisted Design                1009008     Materials, Polymeric
1004004   Computer Graphics                       0750025     Natural P r o d u c t s
1004005   Computer Modeling
1004008   Computer Storage & R e t r i e v a l    0755000 METI-iODOLOCIES/PROCEDURES
1013038   Electron Microscopy                     0755055  Abortion (Induced) 

0735015   Instrumentation, Medical                0755005  Amniocentesis 

1002024   Instrumentation, Biological             0755010  Bioassay 

1014001   Instrumentation, Scientific             0755015  Clinical Trial 

1004020   Library Automation                      1002049  Cloning of Cells 

0706030   Medical/Diagnostic Imaging              1002050  Cloning of Organisms

1013039   Microscopy                              0755020  Disease Model 

1004022   P a t t e r n Recognition               0755025  Drug Design 

1005020   R e m o t e Sensing                     0755030  Etiology

1013034   Spectroscopy                            0202002  Food Analysis 

0607023   Telemetry                               0755035  Gene Cloning

0607024   Ultrasonic Technology                   0755040  Genetic Manipulation

                                                  0755045  Nucleic Acid Sequencing 

0740000 INTERVENTION, AGENTS FOR                  0413000  Population Studies 

0740005   Antibiotics                             0755050  Preservation of Organs/Tissue 

0740010   Anticonvulsant s                        0414013  Psychometrics

0740015   Biological Response Modifiers           0411005  K isk F a c t o r s / Analysis 

0740020
0740025
                              -
          Chemotherapeutic Agents
          Pharmaceuticals
                                                  0404021  Surveys and Survey Research 

38 





0740030     Prosthetic            Device,            Hearing   0760000    MOLECULAR/CELLULAR
                                                                          ENTITIES
0740035     P r o s t h e t i c Device, H e a r t              0760005      Collagen
0740040     P r o s t h e t i c Device, Kidney                 07600 10     Endorphins
0740045     P r o s t h e t i c Device, Limbs                  0760015      Gene P r o d u c t s
0740050     P r o s t h e t i c Device, Neural                 0760020      Growth Factors
0740055     P r o s t h e t i c Device, P a n c r e a s        0760025      Hormones
0740060     P r o s t h e t i c Device, Speech                 0760030      Hybridomas
0740065     P r o s t h e t i c Device, Vision                 0760035      Inhibitors
0740070     Prost h et i c Devices (General)                   0760040      Lipoproteins
0740075     Vaccine                                            0760045      Monoclonal Antibodies
                                                               0760050      Neurotransmitters
0745000    INTERVENTION, TYPES OF                              0760055      Opiates
0745005      Chemotherapy                                      0760060      P e p tides
0745010      Dental Health and Hygiene                         0760065      P r o staglandins
0745015      Detoxification                                    0760070      Proteins and Macromolecules
0745020      Diagnosis, M ed ical                              0760075      Receptors
0745025      Dialysis                                          0760080      Recombinant DNA
0745030      Exercise
0745035      Health Promotion                                  0765000 NATURAL PROCESSES
0745040      Im munosuppression                                1002048   Biodegradation
0745045      Immunotherapy                                     0765005   Bioenergetics
0745050      Preventive D e n t istry                          07650 10  Biosynthesis
0745055      Preventive Medicine                               07650 15  Gene Regulation                  U     L




0745060      Psychotherapy                                     0765020   M etab0 lism
0415000      Therapy/Rehabilitation                            0765025   Metabolism, Lipid
0745065      Transplantation of Organs                         0765030   Metabolism, Mineral
0765035      Pathophysiology                                   0785030   Chiropractic
1002042      Reproduction                                      0785035   Clinical Medicine, General
                                                               0785040   Dentistry
0770000  PATIENT~VOLUNTEER                                     0785045   Dermatology
         CLASS IF1C ATION                                      0785050   Endocrinology
0403001    Adolescents                                         0785055   Epidemiology
0403019    Adults                                              0785060   Gastroenterology
0770005    Children (Patients)                                 0785065   Health, Allied Fields
0770010    Handicapped/Disabled                                0785070   Hematology
07700 15   Hospitalized P a t i e n t                          0785075   Medical G e n e t i c s
0403020    Infants                                             0785080   Medicine, Family Practice
0770020    Outpatient                                          0785085   Medicine, Internal
04030 17   Volunteers                                          0785090   Midwifery
                                                               0785095   Nephrology
0775000    PHYSIOLOGICAL/DEVELOPMENT                           0785 100  Neuroanatomy
           PROCESS                                             0785105   Neuroendocrinology
0404004      Child Psychology/Development                      0785110   Neurology
0414005      Cognitive Development /                           0785115   Neuropharmacology
               Processes                                       0785 120  Neurosurgery
0775005      Hearing                                           0785125   Nurse P r a c tit ione t
04 13002     Human Reproduction/Fertility                      0785130   Nursing
0775010      Lactation                                         0785135   Obstetrics-Gynecology            ‘#I


0410001      Language Acquisition/                             0785 140  Oncology
               Developmen t                                    0785145   Ophthalmology
1002059      Morphogenesis                                      0785 150 Optometry
NIH GUIDE FOR GRANTS AND CONTRACTS 

Vol. 14, No.1, January 4, 1985                                                                39



0775015            Phy sica 1 Crowt h / R e ta rda t i on   0785155      Orthopedics 

1002034            Physiological Processes                  0785160      0torhinola ry ngology

0775020            Pregnancy                                0785165      Pathology 

0775025            Prenatal Factors                         0785170      Pediatrics 

0775030            Teratology                               0785 175     Periodon t i c s 

1002044            Vertebrate Physiology                    0785180      Physical Medicine 

1002046            Vision                                                  and Rehabilitation 

                                                            0785185      Psychiatry

0780000 RESEARCH RESOURCES                                  0785190      Rad io1ogy 

1002002   Animal Breeding and                               0785 195     Rheumatology

            Facilities                                      0785200      Serology 

0780005   Biologicals Resources                             0785205      Sports Medicine 

0780010   Biomedical Research                               07852 10     Surgery

            Resources, O t h e r                            07852 I5     Tropical Med icine 

0780015   Cell Lines                                        0785220      Urology

1103002   Research Libraries                                0201058      Veterinary Medicine 

0780020   Tissue Culture
                                                            0790000  STRUCTUKE/FUNCTION 

1014002         SCIENCE PLANNINGIPOLICY                     1003001    Atomic & Molecular S t r u c t u r e 

0201011           Animal Care                               0790005    Membrane S t r u c t u r e/Func tion 

1014003           Animal Research Policy                    0790010    Nucleic Acid S t r u c t u r e / 

0783015           Health Planning/Policy                                Function 

0783005           Human Subjects Policy                     07900 15   Ultrastructure 

0783010           Ethics, Medical
                                                            0795000  TECHNOLGY ASSESSMENT/

0785000  SPECIALTIES OF MEDICAL                                      TRANSFER/OUTREACH 

         AND ALLIED FIELDS                                  0403004    Community/Outreach Programs 

0785005    Aerospace Biomedicine                            10 16002   Technology Assessment 

07850 10   Allergy                                          1016003    Technology Planning/Policy 

07850 15   Anesthesiology                                   1016004    Technology Transfer 

0785020    Audiology                                        0795005    Therapy Evaluation 

0785025    Cardiology




  *U.S,   GOVERNMENT PRINTING OFFICE:   1985- 461-312:12

								
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