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Vol. 1 7 , No. 39 November 25, 1988
Vol. 17, No. 39, November 25,
1988
J
DATED ANNOUNCEMENTS (RFPs AND RFAS)
NIH SMALL INSTRUMENTS GRANTS PROGRAM ............................. National Institutes of Health
Index: NATIONAL INSTITUTES OF HEALTH
TOXICOLOGY OF LHRH ANTAGONIST (RFP) .............................. National Institute of Child Health and Human Development
Index: CHILD HEALTH AND HUMAN DEVELOPMENT
TOXICOLOGY OF TWO STEROIDAL ESTERS (RFP) ......................... National Institute of Child Health and Human Development
Index: CHILD HEALTH AND HUMAN DEVELOPMENT
AIDS VACCINE EVALUATION UNITS (RFP) ..............................
National Institute of Allergy and Infectious Diseases
Index: ALLERGY AND INFECTIOUS DISEASES
PROSTHETIC SENSORY TRANSDUCERS (RFP) .............................
National Institute of Neurological Disorders and Stroke
Index: NEUROLOGICAL DISORDERS AND STROKE
THE ROLE OF INFLAMMATORY MEDIATORS IN THE INITIATION AND
MAINTENANCE OF CHRONIC INTERSTJITIAL CYSTITIS OF THE
URINARY BLADDER (RFA) ............................................
National Institute of Diabetes, Digestive and Kidney Diseases
Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES
ONGOING PROGRAM ANNOUNCEMENTS
GERIATRIC RESEARCH AND TRAINING CENTERS (P30) National Institute on Aging
Index: AGIhj:
1
1
2
2
3
3
....................
5
MOLECULAR BIOLOGY DATA; REPRESENTATIONAL ANALYSIS BY
COMPUTER (RFA) ................................................... National Library of Medicine
Index: NATIONAL LIBRARY OF 3EDICINE
GERIATRIC RESEARCH INSTITUTIONAL TRAINING (GRIT) AWARD (T32) National Institute on Aging
Index: AGING
GERIATRIC ACADEMIC PROGRAM (GAP) AWARD (K12) National Institute of Aging
Index: AGING
6
.....
7
.....................
9
HIV-RELATED ILLNESSES: TOPICS FOR HEALTH SERVICES RESEARCH National Center for Health Services Research
Index: HEALTH SERVICES RESEARCH
.....12
DATED ANNOUNCEMENTS (RFPs AND RFAs)
N I H SMALL INSTRUMENTS GRANTS PROGRAM P.T. 34;
'J
K.W. 0 7 3 5 0 0 0
F e b r u a r y 13, 1989
National I n s t i t u t e s of Health Application Receipt Date: BACKGROUND I n i t s a p p r o p r i a t i o n f o r t h e N I H f o r F i s c a l Year 1987, t h e Congress i n c l u d e d a t o t a l o f $16 m i l l i o n t o b e s p e n t by t h e r e s p e c t i v e Bureaus/Institutes/Divisions ( B I D S ) f o r t h e f u n d i n g o f g r a n t s t o p u r c h a s e s m a l l i n s t r u m e n t s c o s t i n g between $ 5 , 0 0 0 and $ 6 0 , 0 0 0 . T h i s a c t i o n was i n r e s p o n s e t o s e v e r a l r e c e n t s t u d i e s o f t h e problem o f o b s o l e t e b i o m e d i c a l r e s e a r c h i n s t r u m e n t a t i o n , i n d i c a t i n g t h a t t h e s t a t e o f biomedical r e s e a r c h i n s t r u m e n t a t i o n had s e r i o u s l y eroded o v e r t h e l a s t t e n y e a r s and t h a t t h i s s i t u a t i o n i s r e t a r d i n g t h e p r o g r e s s o f b i o m e d i c a l r e s e a r c h . The most s i g n i f i c a n t need i d e n t i f i e d i n t h e s e s t u d i e s i s f o r t h e r e l a t i v e l y low-cost p i e c e s of equipment i n t h e p r i c e r a n g e o f a p p r o x i m a t e l y $5,000 t o $60,000. Approximately $16 m i l l i o n w i l l b e a v a i l a b l e a g a i n f o r s m a l l i n s t r u m e n t a t i o n grants t h i s year.
E L I G I B I L I T Y AND TERMS OF AWARD
Each i n s t i t u t i o n t h a t r e c e i v e d s u p p o r t under t h e Biomedical R e s e a r c h S u p p o r t Grant (BRSG) Program i n F i s c a l Year 1988 and c u r r e n t l y h a s a c t i v e N I H r e s e a r c h g r a n t s i s e l i g i b l e t o a p p l y . Only one a p p l i c a t i o n may be s u b m i t t e d from e a c h e l i g i b l e i n s t i t u t i o n o r o r g a n i z a t i o n a l component. Each i n s t i t u t i o n may e s t a b l i s h i t s own p r o c e d u r e s f o r i d e n t i f y i n g equipment r e q u e s t s t o b e included. The s m a l l i n s t r u m e n t a t i o n award w i l l b e r e s t r i c t e d t o t h e p u r c h a s e o f equipment c o s t i n g between $ 5 , 0 0 0 and $ 6 0 , 0 0 0 . Awards w i l l be made on o r b e f o r e September 30, 1989. The amount o f t h e award w i l l b e b a s e d upon a p e r c e n t a g e o f t h e i n s t i t u t i o n ' s Biomedical Research S u p p o r t Grant award f o r F i s c a l Year 1988 o r $ 5 , 0 0 0 , whichever i s g r e a t e r . S p e c i f i c f u n d i n g d e c i s i o n s w i l l depend on a v a i l a b l e B I D a p p r o p r i a t i o n s a s w e l l a s t h e a p p r o p r i a t e n e s s df t h e r e q u e s t . I n s t i t u t i o n s w i l l be n o t i f i e d o f t h e maximum amount f o r which t h e y may a p p l y . M T O OF APPLYING EH D L e t t e r s o f i n s t r u c t i o n t o e l i g i b l e i n s t i t u t i o n s w i l l b e m a i l e d on o r a b o u t November 2C. 1988. Completed a p p l i c a t i o n s must b e r e c e i v e d by F e b r u a r y 13, 1989. Investigators interested i n participating i n t h e i r institution's application must c o n t a c t t h e i n s t i t u t i o n ' s Biomedical R e s e a r c h S u p p o r t Grant Program D i r e c t o r . I n s t i t u t i o n a l o f f i c i a l s who e x p e c t t o b e i n v o l v e d i n p r e p a r i n g an a p p l i c a t i o n are r e q u e s t e d t o review t h e l e t t e r o f i n s t r u c t i o n s p r i o r t o contacting NIH
.
TOXICOLOGY OF A LHRH ANTAGONIST
RFP AVAILABLE: NICHD-CD-89-9
P . T . 34;
K . W . 1007009, 0750020, 0765035
N a t i o n a l I n s t i t u t e o f C h i l d H e a l t h and Human Development The C o n t r a c e p t i v e Development Branch, C e n t e r f o r P o p u l a t i o n R e s e a r c h , N a t i o n a l I n s t i t u t e o f C h i l d H e a l t h and Human Development, h a s a Small B u s i n e s s Set-Aside r e q u i r e m e n t f o r t o x i c o l o g y s t u d i e s on a LHRH A n t a g o n i s t . The o b j e c t i v e o f t h i s p r o j e c t i s t o o b t a i n s u f f i c i e n t animal s a f e t y data on t h e a n t a g o n i s t i n o r d e r t o p e r m i t f i l i n g o f a N o t i c e o f Claimed I n v e s t i g a t i o n a l Exemption f o r a N e w Drug ( I N D ) w i t h t h e Food and Drug A d m i n i s t r a t i o n (FDA) i n s u p p o r t o f Phase I and I1 c l i n i c a l i n v e s t i g a t i o n s .
'd
O f f e r o r s must have in-house c a p a b i l i t i e s t o s u p p o r t r a b b i t and r o d e n t s t u d i e s and b e p r e p a r e d t o conduct a l l s t u d i e s i n f u l l compliance w i t h Good L a b o r a t o r i e s P r a c t i c e s (GLP) r e g u l a t i o n s . I n a d d i t i o n , t h e y must have t h e Vol. 1 7 , No. 39, November 25, 1988
-
Page 1
a b i l i t y t o u n d e r t a k e a l l c h e m i c a l and p a t h o l o g i c a l a s p e c t s o f t h e p r o j e c t and
t o a c q u i r e a n i m a l s and i n i t i a t e s t u d i e s w i t h i n 60 d a y s o f c o n t r a c t award. The
I n s t i t u t e e x p e c t s t o award one ( 1 ) c o n t r a c t .
T h i s i s n o t a Request f o r P r o p o s a l s . The RFP w i l l b e i s s u e d on o r a b o u t
December 1 , 1988, w i t h a due d a t e a p p r o x i m a t e l y 90 d a y s t h e r e a f t e r . Copies o f
t h e RFP may b e o b t a i n e d by s e n d i n g w r i t t e n r e q u e s t s t o t h e f o l l o w i n g a d d r e s s .
Please enclose a self-addressed l a b e l .
P a u l J . Duska, C o n t r a c t i n g Officer
C o n t r a c t s Management S e c t i o n , OGC
N a t i o n a l I n s t i t u t e of C h i l d H e a l t h and Human Development
E x e c u t i v e P l a z a North, Room 610
B e t h e s d a , Maryland 20892
TOXICOLOGY OF TWO STEROIDAL ESTERS
RFP AVAILABLE: P.T. 34; NICHD-CD-89-8
K.W. 1007009, 0750020
N a t i o n a l I n s t i t u t e o f C h i l d H e a l t h and Human Development
The C o n t r a c e p t i v e Development Branch, C e n t e r f o r P o p u l a t i o n R e s e a r c h , N a t i o n a l
I n s t i t u t e o f C h i l d H e a l t h and Human Development, h a s a r e q u i r e m e n t f o r
t o x i c o l o g y s t u d i e s on two s t e r o i d a l e s t e r s . The o b j e c t i v e o f t h i s p r o j e c t i s
t o o b t a i n s u f f i c i e n t animal s a f e t y d a t a on a l e v o n o r g e s t e r e l e s t e r and a
t e s t o s t e r o n e e s t e r i n o r d e r t o p e r m i t f i l i n g o f a N o t i c e o f Claimed
I n v e s t i g a t i o n a l Exemption f o r a N e w Drug ( I N D ) w i t h t h e Food and Drug
A d m i n i s t r a t i o n (FDA) i n s u p p o r t o f Phase I and I1 c l i n i c a l i n v e s t i g a t i o n s .
O f f e r o r s must have in-house c a p a b i l i t i e s t o s u p p o r t p r i m a t e and r o d e n t s t u d i e s
and b e p r e p a r e d to conduct all s t u d i e s i n f u l l compliance w i t h Good L a b o r a t o r y
I n a d d i t i o n , t h e y must have t h e a b i l i t y t o
P r a c t i c e s (GLP) r e g u l a t i o n s . u n d e r t a k e a l l c h e m i c a l and p a t h o l o g i c a l a s p e c t s o f t h e p r o j e c t and t o a c q u i r e
a n i m a l s and i n i t i a t e s t u d i e s w i t h i n 6 0 d a y s o f c o n t r a c t award. Q u a l i f i e d
o r g a n i z a t i o n s w i l l have t h e c h o i c e o f s u b m i t t i n g a p r o p o s a l f o r c o n d u c t i n g t h e
t o x i c o l o g y on a s i n g l e compound o r on b o t h . The I n s t i t u t e w i l l award a
maximum o f two (2) c o n t r a c t s f o r t h i s a c t i v i t y .
T h i s i s n o t a Request f o r P r o p o s a l s . The RFP w i l l b e i s s u e d on o r a b o u t
Copies o f
December 1 , 1988 w i t h a due d a t e a p p r o x i m a t e l y 90 d a y s t h e r e a f t e r . t h e RFP may b e o b t a i n e d by s e n d i n g w r i t t e n r e q u e s t s t o t h e f o l l o w i n g a d d r e s s .
Please enclose a self-addressed label.
P a u l J . Duska, C o n t r a c t i n g Officer
C o n t r a c t s Management S e c t i o n , OGC
N a t i o n a l I n s t i t u t e o f C h i l d H e a l t h and Human Development
E x e c u t i v e P l a z a North, Room 610
B e t h e s d a , Maryland 20892
AIDS VACCI NE EVALUATION UNITS RFP AVAILABLE: RFP-NIH-NIAID-AIDSP-90-01
P.T. 34;
K.W. o715008, 0740075
N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases The AIDS Pmgram, N I A I D , N I H , h a s a r e q u i r e m e n t t o e s t a b l i s h AIDS v a c c i n e evaluation u n i t s t o e v a l u a t e candidate AIDS vaccines. T h i s NIAID-sponsored p r o j e c t w i l l t a k e a p p r o x i m a t e l y t h r e e ( 3 ) y e a r s t o c o m p l e t e . A c o s t reimbursement c o n t r a c t is a n t i c i p a t e d . I t is a n t i c i p a t e d t h a t t e n ( 1 0 ) awards w i l l b e made. T h i s i s an announcement f o r a n a n t i c i p a t e d Request f o r P r o p o s a l (RFP). RFP-NIH-NIAID-AIDSP-90-01 s h a l l be i s s u e d on o r a b o u t December 19, 1988, w i t h a c l o s i n g d a t e t e n t a t i v e l y s e t f o r A p r i l 3, 1989.
Vol. 17, No. 39, November 25, 1988
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Page 2
R e q u e s t s f o r t h e RFP s h a l l b e d i r e c t e d i n w r i t i n g t o : Lawrence M . B u t l e r
C o n t r a c t Management Branch
5333 Westbard Avenue
Westwood B u i l d i n g , Room 707
N a t i o n a l I n s t i t u t e o f A l l e r g y & I n f e c t i o u s Diseases National I n s t i t u t e of Health B e t h e s d a , Maryland 20892 Telephone: ( 3 0 1 ) 496-0192 To r e c e i v e a copy o f t h e RFP, p l e a s e s u p p l y t h i s o f f i c e w i t h two (2) s e l f - a d d r e s s e d l a b e l s . A l l r e s p o n s i b l e s o u r c e s may submit a p r o p o s a l which w i l l be considered. T h i s a d v e r t i s e m e n t d o e s n o t commit t h e Government t o award a c o n t r a c t .
. J
RFP AVAILABLE: P.T. 34;
NIH-NINDS-89-05 0740045
K.W.
N a t i o n a l I n s t i t u t e o f N e u r o l o g i c a l D i s o r d e r s and S t r o k e The N a t i o n a l I n s t i t u t e o f N e u r o l o g i c a l D i s o r d e r s and S t r o k e h a s a r e q u i r e m e n t t o d e v e l o p and e v a l u a t e t r a n s d u c e r s o f thumb g r a s p f o r c e and thumb, i n d e x f i n g e r and w r i s t p o s i t i o n . O f f e r o r s s h o u l d have e x p e r i e n c e i n t h e d e s i g n and f a b r i c a t i o n o f t r a n s d u c e r s o f f o r c e and p o s i t i o n . I n a d d i t i o n , e x p e r i e n c e i n t h e problems i n d e s i g n o f w e a r a b l e t r a n s d u c e r s i s d e s i r e d . T h i s i s a n announcement o f an a n t i c i p a t e d Request f o r P r o p o s a l s . RFP-NIH-NINDS-89-05 w i l l b e i s s u e d on o r a b o u t December 9 , 1988, w i t h a c l o s i n g d a t e f o r r e c e i p t o f p r o p o s a l s f o r F e b r u a r y 10, 1989. T h i s r e q u i r e m e n t r e p r e s e n t s t h e r e c o m p e t i t i o n o f a c u r r e n t c o n t r a c t w i t h Case Western R e s e r v e U n i v e r s i t y and t h e incumbent i s e x p e c t e d t o r e a p p l y . The I n s t i t u t e e x p e c t s t o award one ( 1 ) c o n t r a c t as a r e s u l t o f t h i s r e c o m p e t i t i o n .
d
To r e c e i v e a copy o f t h e RFP, you must s u p p l y t h i s o f f i c e w i t h two
The RFP w i l l b e a v a i l a b l e upon w r i t t e n r e q u e s t t o : C o n t r a c t i n g Officer
C o n t r a c t s Management Branch
N a t i o n a l I n s t i t u t e o f N e u r o l o g i c a l
D i s o r d e r s and S t r o k e , N I H F e d e r a l B u i l d i n g , Room 901
7550 Wisconsin Avenue
B e t h e s d a , Maryland 20892
A t t n : RFP-NIH-NINDS-89-05
FJ T RFA AVAILABLE: P.T. 34; 89-DK-03
s e l f - a d d r e s s e d m a i l i n g l a b e l s . A l l r e s p o n s i b l e s o u r c e s may submit a p r o p o s a l which s h a l l b e c o n s i d e r e d by t h e agency.
K.W. 0715026, 0705075, 0710070
N a t i o n a l I n s t i t u t e o f D i a b e t e s and D i g e s t i v e and Kidney Diseases A p p l i c a t i o n R e c e i p t Date: A p r i l 21, 1989
, J
The D i v i s i o n o f Kidney, U r o l o g i c and Hematologic D i s e a s e s (DKUHD), N a t i o n a l I n s t i t u t e of D i a b e t e s and D i g e s t i v e and Kidney Diseases ( N I D D K ) i n v i t e s g r a n t a p p l i c a t i o n s f o r s u p p o r t o f b a s i c and c l i n i c a l r e s e a r c h on t h e r o l e o f inflammatory m e d i a t o r s i n t h e i n i t i a t i o n and maintenance o f Chronic I n t e r s t i t i a l C y s t i t i s ( I C ) of t h e u r i n a r y b l a d d e r . The emphasis o f t h i s program i s on r e s e a r c h w i t h specimens from p e r s o n s w i t h I n t e r s t i t i a l C y s t i t i s . When non-human models such a s a n i m a l s and c e l l c u l t u r e s a r e u t i l i z e d f o r i n v e s t i g a t i o n , t h e f i n d i n g s s h o u l d b e c o r r e l a t e d w i t h c l i n i c a l d a t a . The u l t i m a t e g o a l s o f t h i s p r o j e c t a r e t o d e v e l o p knowledge which w i l l l e a d t o t h e e f f e c t i v e p r e v e n t i o n and/or t r e a t m e n t o f I n t e r s t i t i a l C y s t i t i s , and t o a c q u i r e a d a t a b a s e of p e r s o n s w i t h I C f o r f u t u r e s t u d i e s . Vol. 1 7 , No. 39, November 25, 1988
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BACKGROUND INFORMATION
I n t e r s t i t i a l C y s t i t i s i s a c h r o n i c inflammatory d i s o r d e r o f t h e u r i n a r y
b l a d d e r o f unknown e t i o l o g y . The most a c c u r a t e method o f d i a g n o s i s i s b a s e d
p r i m a r i l y on t h e symptoms o f t h e d i s e a s e . The most p r e v a l e n t symptom i s p a i n ;
o t h e r common symptoms a r e u r i n a r y f r e q u e n c y and u r g e n c y . P a t h o l o g i c a l
f i n d i n g s from b i o p s y a r e v a r i a b l e and most commonly i n c l u d e mononuclear c e l l
and mast c e l l i n f i l t r a t e s . Other f i n d i n g s i n c l u d e c o l l a g e n d e p o s i t i o n ,
f i b r o s i s , g r a n u l a t i o n t i s s u e and, r a r e l y , mucosal u l c e r a t i o n s . Numerous
e t i o l o g i c a l t h e o r i e s f o r t h i s d i s e a s e have been p r o p o s e d b u t none have been
s u b s t a n t i a t e d with c l i n i c a l f i n d i n g s . A r e p o r t o f t h e r e c e n t NIDDK sponsored
Workshop on I n t e r s t i t i a l C y s t i t i s was p u b l i s h e d i n t h e J o u r n a l o f Urology 140
(1): 203-206, J u l y , 1988. T h i s r e p o r t c o n t a i n s a t a b l e o f c r i t e r i a f o r t h e
d i a g n o s i s o f I C which s h o u l d b e u s e d o n l y f o r t h e s t a n d a r d i z a t i o n o f i n c l u s i o n
o f p a t i e n t s i n r e s e a r c h s t u d i e s . These c r i t e r i a a r e n o t meant t o be used a s
c r i t e r i a f o r c l i n i c a l d i a g n o s i s o f t h e d i s e a s e . The c r i t e r i a , a s p u b l i s h e d ,
a r e p r e l i m i n a r y and i n v e s t i g a t o r s s h o u l d c o n t a c t t h e Urology Program D i r e c t o r
f o r any m o d i f i c a t i o n s p r i o r t o i n c l u d i n g them i n a g r a n t a p p l i c a t i o n .
The p r e v a l e n c e o f p a i n a s t h e major symptom m a n i f e s t a t i o n o f t h e d i s o r d e r and
t h e p r e s e n c e o f mast c e l l s i n b i o p s y specimens o f b l a d d e r s i n p a t i e n t s w i t h I C
s u g g e s t t h a t t h e d i s o r d e r i s m e d i a t e d by i n f l a m m a t o r y mechanisms.
I n f l a m m a t o r y m e d i a t o r s i n e i t h e r t h e u r i n e o r b l a d d e r specimens have n o t ,
however, b e e n f r e q u e n t l y i n v e s t i g a t e d o r c o n s i s t e n t l y documented. N e i t h e r h a s
t h e r e been a thorough i n v e s t i g a t i o n i n t o t h e effect o f anti-inflammatory
a g e n t s on t h e p a t h o l o g y and symptomatology o f t h e d i s e a s e .
OBJECTIVES AND SCOPE OF RESEARCH
R e s e a r c h areas f o r i n v e s t i g a t i o n i n c l u d e :
1 . t h e r o l e o f mast c e l l s and mast c e l l d e g r a n u l a t i o n i n t h i s c h r o n i c inflammatory d i s o r d e r ,
2 . t h e p r e s e n c e o f p r o s t a g l a n d i n s and l e u k o t r i e n e s i n b l a d d e r s o f p a t i e n t s w i t h I C and t h e r o l e o f t h e s e s u b s t a n c e s i n p r o m o t i n g and m a i n t a i n i n g t h e c h r o n i c inflammation,
3. t h e p r e s e n c e and r o l e o f c y t o k i n e s and complement d e r i v e d p e p t i d e inflammatory mediators i n I C ,
i n f l a m m a t o r y m e d i a t o r s and t h e i n t e r a c t i o n s o f t h e s e v a r i o u s m e d i a t o r s i n t h e c h r o n i c inflammatory p r o c e s s o f I C . The g o a l o f t h i s r e s e a r c h i s t o d e v e l o p f u r t h e r i n s i g h t i n t o t h e e t i o l o g y and p a t h o g e n e s i s o f I n t e r s t i t i a l C y s t i t i s as a c h r o n i c i n f l a m m a t o r y d i s o r d e r o f It i s a n t i c i p a t e d t h a t t h e s e f i n d i n g s w i l l l e a d t o t h e t h e urinary bladder. development o f more e f f e c t i v e t r e a t m e n t m o d a l i t i e s and, u l t i m a t e l y , t o t h e p r e v e n t i o n and c u r e o f t h i s d i s o r d e r . By u t i l i z i n g c l i n i c a l p a t i e n t s w i t h I C , t h e d a t a b a s e o f I C p a t i e n t s w i l l b e expanded f o r f u t u r e s t u d i e s . By u s i n g e i t h e r e x p e r i m e n t a l a n i m a l s o r c e l l c u l t u r e s , r e l i a b l e e x p e r i m e n t a l models w i l l b e d e v e l o p e d which c a n b e c o r r e l a t e d w i t h c l i n i c a l f i n d i n g s . It i s a n t i c i p a t e d t h a t r e s e a r c h a p p l i c a t i o n s w i l l i n c l u d e c o l l a b o r a t i o n between b a s i c s c i e n c e and c l i n i c a l i n v e s t i g a t o r s . C o l l a b o r a t i o n w i t h o t h e r i n s t i t u t i o n s i s a l s o e n c o u r a g e d , when n e c e s s a r y , t o expand t h e c l i n i c a l d a t a base. APPLICATION AND SUPPORT PROCEDURES E i g h t hundred t h o u s a n d d o l l a r s h a s been d e s i g n a t e d t o s u p p o r t t h i s program f o r t h e c u r r e n t f i s c a l y e a r . The s p e c i f i c number o f g r a n t s and t h e t o t a l number o f f u n d s t o b e awarded w i l l , however, depend on t h e merit and s c o p e o f t h e a p p l i c a t i o n s r e c e i v e d and on t h e a v a i l a b i l i t y o f f u n d s . Funding o f t h e g r a n t s w i l l b e t h r o u g h t h e i n d i v i d u a l R e s e a r c h P r o j e c t Grant ( R o l l mechanism. A p p l i c a t i o n s must b e s u b m i t t e d on t h e r e v i s e d (9186) form PHS-398, a v a i l a b l e i n t h e b u s i n e s s o r r e s e a r c h g r a n t s o f f i c e a t most academic o r r e s e a r c h i n s t i t u t i o n s , o r from t h e D i v i s i o n o f R e s e a r c h G r a n t s , N a t i o n a l I n s t i t u t e s o f H e a l t h . A p p l i c a t i o n s from women and m i n o r i t y i n v e s t i g a t o r s a r e e n c o u r a g e d . A p p l i c a t i o n s w i l l b e r e v i e w e d f o r s c i e n t i f i c and t e c h n i c a l m e r i t i n a c c o r d a n c e w i t h t h e u s u a l N I H p e e r r e v i e w p r o c e d u r e s by a s p e c i f i c a l l y convened i n s t i t u t e r e v i e w c o m m i t t e e . F o l l o w i n g t h a t f i r s t r e v i e w , t h e a p p l i c a t i o n s w i l l b e g i v e n a s e c o n d a r y r e v i e w by t h e N I D D K A d v i s o r y C o u n c i l . A p p l i c a t i o n s must b e r e c e i v e d by A p r i l 21, 1989 t o b e c o n s i d e r e d f o r f u n d i n g t h r o u g h t h i s RFA.
4. f a c t o r s i n t h e u r i n e which e i t h e r a c t i v a t e o r d e a c t i v a t e t h e s e
V o l . 17, No. 39, November 25, 1988
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Page 4
-.I (* '
THE RFA LABhi CONTAINED I N THE APPLICATION K I T M S BE AFFIXED T THE BOTTOM UT O OF THE FACE PAGE OF THE O R I G I N A L COPY OF THE APPLICATION. FAILURE TO USE THIS LABEL COULD RESULT I N DELAYED PROCESSING OF YOUR A P P L I C A T I O N . FOR PURPOSES OF IDENTIFICATION AND PROCESSING, THE RFA NUMBER AND T I T L E "THE ROLE OF INFLAMMATORY MEDIATORS I N THE I N I T I A T I O N AND MAINTENANCE OF C H R O N I C INTERSTITIAL CYSTITIS OF THE URINARY BLADDER" SHOULD BE TYPED I N ITEM 2 ON THE FACE PAGE OF THE APPLICATION.
The o r i g i n a l and f o u r c o p i e s o f t h e a p p l i c a t i o n s h o u l d b e s e n t o r d e l i v e r e d
to:
D i v i s i o n o f Research Grants
Westwood B u i l d i n g , Room 240
National I n s t i t u t e s of Health
Bethesda, Maryland 20892xn
Two a d d i t i o n a l c o p i e s o f t h e a p p l i c a t i o n s h o u l d b e s e n t t o :
C h i e f , Review Branch
D i v i s i o n o f Extramural A c t i v i t i e s , NIDDK
National I n s t i t u t e s of Health
Westwood B u i l d i n g , Room 406
B e t h e s d a , Maryland 20892
L e t t e r o f I n t e n t : It i s r e q u e s t e d t h a t t h e p r o s p e c t i v e a p p l i c a n t submit a one
page l e t t e r o f i n t e n t which w i l l g i v e a d e s c r i p t i v e t i t l e o f t h e r e s e a r c h , t h e
name, a d d r e s s and t e l e p h o n e number o f t h e p r i n c i p a l i n v e s t i g a t o r and t h e names
o f o t h e r key p e r s o n n e l . Such l e t t e r s a r e r e q u e s t e d f o r t h e p u r p o s e o f
p r o v i d i n g a n i n d i c a t i o n o f t h e number and scope o f a p p l i c a t i o n s t o be
e x p e c t e d . A l e t t e r o f i n t e n t i s n o t b i n d i n g and it w i l l n o t e n t e r i n t o t h e
It is not a necessary
review o f any a p p l i c a t i o n s u b s e q u e n t l y s u b m i t t e d . r e q u i r e m e n t f o r a p p l c a t i o n . The l e t t e r o f i n t e n t s h o u l d be r e c e i v e d by
J a n u a r y 13, 1989.
L e t t e r s o f i n t e n t and any i n q u i r e s a b o u t t h i s RFA s h o u l d b e s e n t t o :
Leroy M . Nyberg, J r . , Ph.D., M . D .
Urology Program D i r e c t o r , NIDDK/DKUHD
National I n s t i t u t e s of Health
F e d e r a l B u i l d i n g , Room 102
B e t h e s d a , Maryland 20892 Telephone: ( 3 0 1 ) 496-8248 GERIATRIC RESEARCH AND TRAINING CENTERS (P30)
I b , f
RFA AVAILABLE:
P.T. 04;
89-AG-01 0710010, 0720005, 0710030
K.W.
N a t i o n a l I n s t i t u t e on Aging A p p l i c a t i o n R e c e i p t Date: INTRODUCTION The N a t i o n a l I n s t i t u t e on Aging ( N I A ) i n v i t e s a p p l i c a t i o n s f o r s u p p o r t o f c e n t e r s o f e x c e l l e n c e i n r e s e a r c h i n g e r i a t r i c s and g e r o n t o l o g y and t r a i n i n g o f g e r i a t r i c i a n s f o r l e a d e r s h i p i n academic m e d i c i n e . A G e r i a t r i c R e s e a r c h and T r a i n i n g C e n t e r ( G R T C ) i n c l u d e s c o r e a c t i v i t i e s f o r s u p p o r t u f r e s e a r c h , t r a i n i n g , and career development. F i r s t y e a r b u d g e t s may n o t e x c e e d $800,000 direct costs. Scope To enhance t h e q u a l i t y o f r e s e a r c h i n g e r i a t r i c s and g e r o n t o l o g y , and p r o v i d e a s u i t a b l e environment f o r f e l l o w s and j u n i o r f a c u l t y t o a c q u i r e r e s e a r c h s k i l l s and e x p e r i e n c e , t h r e e g e n e r a l t y p e s o f a c t i v i t i e s w i l l b e s u p p o r t e d i n GRTCs: r e s e a r c h c o r e s , l e a d e r s h i p / a d m i n i s t r a t i v e c o r e s and r e s e a r c h development c o r e s . R e s e a r c h c o r e s p r o v i d e f u n d s f o r p e r s o n n e l , equipment, and o t h e r r e s o u r c e s which w i l l enhance t h e q u a l i t y o f c u r r e n t l y s u p p o r t e d r e s e a r c h .
iIy'
March 17, 1989
The leadership/administrative c o r e p r o v i d e s f u n d s f o r t h e GRTC D i r e c t o r , GRTC A d m i n i s t r a t o r , and s u p p o r t s t a f f . C o s t s a s s o c i a t e d w i t h i n f o r m a t i o n t r a n s f e r and o u t r e a c h programs may a l s o b e r e q u e s t e d h e r e . V o l . 17, No. 39, November 25, 1988
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Page 5
The r e s e a r c h development c o r e p r o v i d e s f u n d s f o r p i l o t p r o j e c t s t o b e c o n d u c t e d by j u n i o r f a c u l t y members. S u p p o r t f o r s a l a r y , equipment and o t h e r r e s e a r c h e x p e n s e s may be r e q u e s t e d . Mechanism and S c a l e o f S u p p o r t G e r i a t r i c R e s e a r c h and T r a i n i n g C e n t e r s w i l l b e s u p p o r t e d t h r o u g h t h e customary g r a n t - i n - a i d mechanism. P l a n s a r e t o make up t o two awards i n f i s c a l y e a r 1989 and f u r t h e r awards i n f i s c a l y e a r 1990 depending upon a v a i l a b i l i t y of funds. The A p p l i c a t i o n The a p p l i c a n t s h o u l d submit t h e a p p l i c a t i o n u s i n g PHS 398 ( r e v i s e d 9 / 8 6 ) . A p p l i c a t i o n k i t s c o n t a i n i n g t h i s form and t h e n e c e s s a r y g e n e r a l i n s t r u c t i o n s a r e a v a i l a b l e i n most i n s t i t u t i o n a l b u s i n e s s o f f i c e s o r may b e o b t a i n e d from P l e a s e n o t e t h a t s p e c i a l GRTC t h e D i v i s i o n o f Research Grants, N I H . G u i d e l i n e s s h o u l d b e u s e d t o c o m p l e t e t h e a p p l i c a t i o n . ( S e e below) T i m e t a b l e f o r R e c e i p t and Review o f A p p l i c a t i o n s The o r i g i n a l and f o u r c o p i e s o f t h e a p p l i c a t i o n a r e due i n t h e D i v i s i o n o f R e s e a r c h G r a n t s on o r b e f o r e March 1 7 , 1989. A p p l i c a t i o n s must b e s e n t t o : A p p l i c a t i o n R e c e i p t O ffic e
D i v i s i o n o f Research Grants
National I n s t i t u t e s of Health
Westwood B u i l d i n g ? Room 240
B e t h e s d a , Maryland 20892nn
A t t h e same t i m e t h e a p p l i c a t i o n i s s u b m i t t e d t o t h e D i v i s i o n
o f R e s e a r c h G r a n t s , a copy o f t h e c o v e r i n g l e t t e r and two
c o p i e s o f t h e a p p l i c a t i o n should be s e n t t o :
C h i e f , S c i e n t i f i c Review Office
N a t i o n a l I n s t i t u t e on Aging
Room 5C12, B u i l d i n g 31
9000 R o c k v i l l e P i k e
B e t h e s d a , Maryland 20892
A copy o f t h e c o m p l e t e RFA and t h e GRTC G u i d e l i n e s may b e o b t a i n e d from:
Stanley L. S l a t e r , M.D.
D i r e c t o r , G e r i a t r i c Research and T r a i n i n g Program
G e r i a t r i c s Branch
N a t i o n a l I n s t i t u t e on Aging
B u i l d i n g 31, Room 5C27
9000 R o c k v i l l e P i k e
B e t h e s d a , Maryland 20892
Telephone ( 3 0 1 ) 496-6761
..-
MOLECULAR BIOLOGY; DATA REPRESENTATION/ANALYSIS BY COMPUTER
RFA AVAILABLE:
89-LM-01 1002008, 0755018, 1004008, 0755045, 0790010, 1215018, 1004000
P.T. 34;
K.W.
N a t i o n a l L i b r a r y o f Medicine A p p l i c a t i o n R e c e i p t Date: F e b r u a r y 1 0 , 1989
The N a t i o n a l L i b r a r y o f Medicine i n v i t e s t h e s u b m i s s i o n o f R e s e a r c h g r a n t a p p l i c a t i o n s from i n v e s t i g a t o r s who a r e i n t e r e s t e d i n t h e computer and i n f o r m a t i o n s c i e n c e a s p e c t s o f m o l e c u l a r b i o l o g y d a t a management and a n a l y s i s . The o b j e c t i v e i s t o promote h i g h q u a l i t y r e s e a r c h t h a t h a s v a l u e f o r f u r t h e r i n g our understanding of s t r u c t u r e / f u n c t i o n r e l a t i o n s h i p s i n n u c l e i c a c i d s , p r o t e i n s , and o t h e r b i o l o g i c a l l y i m p o r t a n t m o l e c u l e s , i n o r d e r t o d i a g n o s e , and t r e a t human d i s o r d e r s . R e s e a r c h t o p i c s i n c l u d e d a t a - b a s e d e s i g n and q u e r y methods, a l g o r i t h m s t o improve e f f i c i e n c y o f i n f o r m a t i o n r e t r i e v a l , e x p e r t s y s t e m s , m a t h e m a t i c a l t e c h n i q u e s and computer hardware d e s i g n f o r p a t t e r n r e c o g n i t i o n and a l g o r i t h m s f o r p r e d i c t i n g s t r u c t u r e a n d / o r f u n c t i o n b a s e d on p r i m a r y s e q u e n c e s . I n F i s c a l Year 1989 up t o one m i l l i v n d o l l a r s w i l l b e a l l o c a t e d t o t h e r e s e a r c h i n i t i a t i v e s d e s c r i b e d i n t h i s RFA.
Vol. 17, No. 39, November 25, 1988
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Page 6
INQUIRIES
P o t e n t i a l a p p l i c a n t s are s t r o n g l y a d v i s e d t o c o n t a c t NLM s t a f f b e f o r e
submitting applications f o r support.
'Y'
A p p l i c a t i o n s s h o u l d b e s u b m i t t e d on t h e new Form PHS 398 ( r e v . more i n f o r m a t i o n , a p p l i c a n t s may c o n t a c t :
9/86).
For
D r . Roger W. Dahlen
C h i e f , Biomedical I n f o r m a t i o n S u p p o r t Branch
E x t r a m u r a l Programs
N a t i o n a l L i b r a r y o f Medicine
8600 R o c k v i l l e P i k e
B u i l d i n g 3 8 A , Room 5s-522
Bethesda, Maryland 20894
Telephone: ( 3 0 1 ) 496-4221
O N G O I N G PROGRAM ANNOUNCEMENTS
GERIATRIC RESEARCH INSTITUTIONAL TRAINING ( G R I T ) AWARD (T32)
P.T. 44;
K.W.
0720005, 0710010
N a t i o n a l I n w t i t u t e on Aging I n i t i a l A p p l i c a t i o n R e c e i p t Date: May 10, 1989
Subsequent A p p l i c a t i o n R e c e i p t Dates: September 10, 1989; and J a n u a r y 10, May 10, and September 10 o f e a c h y e a r t h e r e a f t e r . The N a t i o n a l I n s t i t u t e on Aging ( N I A ) s o l i c i t s a p p l i c a t i o n s f o r t h e s u p p o r t o f G e r i a t r i c R e s e a r c h I n s t i t u t i o n a l T r a i n i n g ( G R I T ) programs.
BACKGROUND AND GOALS
ef
There i s i n c r e a s e d r e c o g n i t i o n o f t h e growing need f o r t r a i n e d p e r s o n n e l i n g e r i a t r i c s . A N a t i o n a l Academy o f S c i e n c e s committee (J. Am. G e r i a t r i c s SOC. 35:773-91 ( 1 9 8 7 ) ) emphasized t h a t f i l l i n g t h i s need w i l l r e q u i r e enough academic l e a d e r s i n g e r i a t r i c s t o t r a i n t h e needed number o f g e r i a t r i c i a n s . The committee emphasized t h a t h i g h - q u a l i t y t r a i n i n g i n r e s e a r c h , t e a c h i n g , and c l i n i c a l p r a c t i c e were a l l n e c e s s a r y f o r t h e development o f s u c h l e a d e r s , and t h a t t h i s c o u l d b e s t b e done i n an environment where t h e r e were enough g e r i a t r i c r e s e a r c h e r s , t e a c h e r s , and p r a c t i t i o n e r s t o p r o v i d e t h o r o u g h e x p e r i e n c e f o r f u t u r e academic l e a d e r s . Developing academic l e a d e r s h i p r e q u i r e s a continuum o f s u p p o r t from t h e f e l l o w s h i p t o t h e f a c u l t y l e v e l . The development o f g e r i a t r i c i a n s w i t h t h e r e s e a r c h a b i l i t i e s needed f o r academic l e a d e r s h i p w i l l g e n e r a l l y r e q u i r e a t l e a s t one y e a r o f i n t e n s i v e r e s e a r c h e x p e r i e n c e a t t h e f e l l o w s h i p l e v e l , f o l l o w e d by a s u b s t a n t i a l amount o f r e s e a r c h a t t h e j u n i o r f a c u l t y l e v e l . N I A ' s GRIT award s u p p o r t s r e s e a r c h t r a i n i n g f o r p h y s i c i a n s who have completed one o r more y e a r s o f c l i n i c a l g e r i a t r i c f e l l o w s h i p t r a i n i n g . T h i s award i s s u i t a b l e f o r i n s t i t u t i o n s with s u f f i c i e n t a c t i v i t i e s i n g e r i a t r i c s t o support ( N I A c o n t i n u e s t o encourage a n i n s t i t u t i o n a l r e s e a r c h t r a i n i n g program. a p p l i c a t i o n s f o r i n d i v i d u a l r e s e a r c h f e l l o w s h i p s f o r p e r s o n s and i n s t i t u t i o n s where t h i s i s more a p p r o p r i a t e . ) The GRIT award w i l l s u p p o r t one t o two y e a r s o f i n t e n s i v e , s u s t a i n e d r e s e a r c h e x p e r i e n c e t o f a c i l i t a t e t h e development o f f e l l o w s as i n d e p e n d e n t r e s e a r c h e r s . S i n c e s t r e n g t h e n i n g t h e s c i e n c e b a s e o f g e r i a t r i c s and g e r o n t o l o g y i s a g o a l o f t h i s award, c o l l a b o r a t i o n among p e r t i n e n t b a s i c r e s e a r c h e r s , c l i n i c a l i n v e s t i g a t o r s , and e p i d e m i o l o g i s t s i n t h e t r a i n i n g o f f e l l o w s s u p p o r t e d by t h i s award i s p a r t i c u l a r l y e n c o u r a g e d . Because a continuum o f s u p p o r t f o r c a r e e r development i s needed from t h e f e l l o w s h i p t o t h e f a c u l t y l e v e l , N I A s u p p o r t s o t h e r awards f o r career development i n g e r i a t r i c s a t s u b s e q u e n t s t a g e s . I n t e r e s t e d p a r t i e s a r e encouraged t o c o n t a c t N I A s t a f f l i s t e d under "Method o f Application1' (below) f o r f u r t h e r information. I n p a r t i c u l a r , N I A ' s G e r i a t r i c Academic Program Award s u p p o r t s career development i n t h e p o s t - f e l l o w s h i p p e r i o d . P r o s p e c t i v e a p p l i c a n t i n s t i t u t i o n s a r e encouraged t o c o n s i d e r comprehensive c a r e e r development programs which may b e s u p p o r t e d by a c o m b i n a t i o n o f N I A and o t h e r i n s t i t u t i o n a l awards, i n c l u d i n g t h e H e a l t h Resources and S e r v i c e s A d m i n i s t r a t i o n ' s F a c u l t y T r a i n i n g P r o j e c t s i n G e r i a t r i c Medicine and D e n t i s t r y , V e t e r a n s A d m i n i s t r a t i o n programs, and o t h e r s o u r c e s .
*-
Vol. 1 7 , No. 39, November 25, 1988
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STRUCTURE OF AWARD The mechanism of s u p p o r t w i l l b e t h e i n s t i t u t i o n a l N a t i o n a l R e s e a r c h S e r v i c e Award. The award p r o v i d e s f i v e y e a r s o f renewable s u p p o r t t o t h e g r a n t e e i n s t i t u t i o n . Support w i l l b e provided f o r i n s t i t u t i o n a l r e s e a r c h t r a i n i n g programs e x t e n d i n g from one t o two y e a r s a f t e r c l i n i c a l f e l l o w s h i p t r a i n i n g i n g e r i a t r i c s . A p p l i c a n t s may r e q u e s t s u p p o r t f o r two t o s i x f e l l o w s h i p p o s i t i o n s p e r y e a r . No GRIT Award w i l l s u p p o r t more t h a n s i x f e l l o w s h i p p o s i t i o n s i n any g i v e n award y e a r . S u p p o r t may b e r e q u e s t e d f o r f e l l o w s a t t h e c u r r e n t l e v e l o f s u p p o r t f o r NRSA s t i p e n d s , and f o r i n s t i t u t i o n a l c o s t s o f up t o $2,500 p e r f e l l o w f o r t r a i n i n g r e l a t e d e x p e n s e s s u c h as s t a f f s a l a r i e s , c o n s u l t a n t c o s t s , r e s e a r c h s u p p l i e s , equipment, and t r a v e l . An i n d i r e c t c o s t a l l o w a n c e o f 8 p e r c e n t of t o t a l a l l o w a b l e d i r e c t c o s t s f o r f e l l o w s h i p t r a i n i n g is provided. ELIGIBILITY REQUIREMENTS A p p l i c a n t i n s t i t u t i o n s must h a v e :
o An e s t a b l i s h e d c l i n i c a l f e l l o w s h i p t r a i n i n g program i n g e r i a t r i c s . F e l l o w s t o b e s u p p o r t e d by t h i s award must have completed a t l e a s t It is not one y e a r o f c l i n i c a l f e l l o w s h i p t r a i n i n g i n g e r i a t r i c s . r e q u i r e d t h a t t h i s t r a i n i n g have been a t t h e a p p l i c a n t i n s t i t u t i o n . o F a c u l t y w i t h s u f f i c i e n t p e r t i n e n t r e s e a r c h e x p e r i e n c e t o s e r v e as mentors f o r f e l l o w s . o Ongoing r e s e a r c h a c t i v i t i e s t o p r o v i d e a n a d e q u a t e environment f o r t h e r e s e a r c h development o f f e l l o w s .
I n a d d i t i o n t o programs a t i n d i v i d u a l i n s t i t u t i o n s , j o i n t programs c o n d u c t e d
by two o r more i n s t i t u t i o n s a r e e l i g i b l e f o r s u p p o r t .
M T O OF APPLICATION
EH D A p p l i c a t i o n s s h o u l d b e p r e p a r e d on form PHS 398, f o l l o w i n g t h e i n s t r u c t i o n s
f o r i n s t i t u t i o n a l t r a i n i n g g r a n t a p p l i c a t i o n s . The PHS 398 a p p l i c a t i o n form
i s a v a i l a b l e a t most i n s t i t u t i o n a l b u s i n e s s o f f i c e s o r from t h e D i v i s i o n of
R e s e a r c h G r a n t s , N I H , (301) 496-7441. On i t e m 2 o f t h e f a c e page o f t h e
a p p l i c a t i o n , a p p l i c a n t s s h o u l d e n t e r : I n s t i t u t i o n a l NRSA: N I A G e r i a t r i c
R e s e a r c h I n s t i t u t i o n a l T r a i n i n g Awards. A p p l i c a n t s s h o u l d a l s o r e f e r t o t h e
N I H Guide t o G r a n t s and C o n t r a c t s , V o l . 16, No. 20, J u n e 12, 1987, f o r
background on i n s t i t u t i o n a l t r a i n i n g g r a n t s .
A l e t t e r o f i n t e n t i s n o t a p r e r e q u i s i t e f o r a p p l y i n g ; however, p r o s p e c t i v e
a p p l i c a n t s a r e encouraged t o send a l e t t e r w i t h a d e s c r i p t i v e t i t l e t o t h e N I A
c o n t a c t a t l e a s t one month b e f o r e s u b m i s s i o n o f t h e p r o p o s a l .
The completed o r i g i n a l a p p l i c a t i o n and f o u r c o p i e s s h o u l d b e s e n t t o :
Application Receipt
D i v i s i o n o f Research Grants
N a t i o n a l I n s t i t u t e s of H e a l t h
Westwood B u i l d i n g , Room 240
B e t h e s d a , Maryland 2 0 8 9 2 H
The N I A c o n t a c t o f f i c e l i s t e d below s h o u l d b e s e n t two c o p i e s o f t h e
a p p l i c a t i o n a t t h e t i m e o f s u b m i s s i o n . I n q u i r i e s and c o r r e s p o n d e n c e s h o u l d b e
directed to:
G e r i a t r i c s Branch
N a t i o n a l I n s t i t u t e on Aging
B u i l d i n g 31, Room 5C-27
B e t h e s d a , Maryland 20892
( 3 0 1 ) 496-6761
Telephone: The a p p l i c a t i o n s h o u l d i d e n t i f y :
o A program d i r e c t o r who w i l l assume o v e r a l l r e s p o n s i b i l i t y f o r management o f t h e program. The a p p l i c a t i o n s h o u l d d e s c r i b e p l a n s f o r q u a l i t y c o n t r o l o f t h e program and f o r maximizing commitment o f f e l l o w s t o a g i n g r e s e a r c h a f t e r t h e completion o f f e l l o w s h i p support.
o The f a c u l t y s p o n s o r s who w i l l p r o v i d e t r a i n i n g f o r f e l l o w s .
The s p o n s o r s ' p a s t and p r e s e n t r e s e a r c h s h o u l d b e d e s c r i b e d , a s w e l l a s t h e i r p r e v i o u s e x p e r i e n c e i n t r a i n i n g r e s e a r c h f e l l o w s , and t h e
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c u r r e n t s t a t u s o f a l l f e l l o w s p r e v i o u s l y t r a i n e d by t h e f a c u l t y sponsors. The f a c u l t y and i n s t i t u t i o n ' s p l a n s f o r p r o v i d i n g r e s e a r c h e x p e r i e n c e t o f e l l o w s , i n c l u d i n g examples o f t h e t y p e s o f r e s e a r c h p r o j e c t s t o be undertaken, p r o v i s i o n of ex p eri en ce i n o t h e r laboratories t o l e a r n pertinent techniques, etc. Plans f o r providing other t r a i n i n g t o fellows i n addition t o laboratory experience, e . g . didactic t r a i n i n g i n basic sciences, r e s e a r c h methodology, o r s t a t i s t i c s . P r o v i s i o n o f a s y s t e m - t i c e x p o s u r e t o c u r r e n t knowledge i n g e r o n t o l o g y i s e n c o u r a g e d . P l a n s f o r e x t e r n a l review o f t h e s e l e c t i o n and p r o g r e s s o f f e l l o w s and t h e o v e r a l l conduct o f t h e program. T h i s review s h o u l d b e conducted once y e a r l y , and p r o v i d e w r i t t e n r e p o r t s t o b e s u b m i t t e d t o NIA w i t h t h e awardeels annual p r o g r e s s r e p o r t s . Plans f o r e f f o r t s t o r e c r u i t minority trainees, consistent with N I H l s p o l i c y o f e n c o u r a g i n g such r e c r u i t m e n t . Such p l a n s a r e a r e q u i r e d component o f a p p l i c a t i o n s f o r N I H r e s e a r c h t r a i n i n g programs. A d d i t i o n a l i n f o r m a t i o n on N I H ' s m i n o r i t y r e c r u i t m e n t p o l i c y may b e found i n t h e N I H Guide f o r G r a n t s and C o n t r a c t s V o l . 15, No. 4, March 28, 1986.
EVALUATION CRITERIA
A p p l i c a t i o n s w i l l b e judged on:
The r e s e a r c h c a p a b i l i t i e s o f f a c u l t y s p o n s o r s i n areas r e l a t e d t o g e r i a t r i c s .
The a b i l i t i e s and r e c o r d o f f a c u l t y s p o n s o r s i n t r a i n i n g f e l l o w s i n a g i n g
research.
The i n s t i t u t i o n ' s p l a n s and commitment t o t h e development o f f e l l o w s '
a b i l i t i e s i n g e r i a t r i c r e s e a r c h , i n c l u d i n g t h e a c q u i s i t i o n o f background i n
b a s i c s c i e n c e s ( i n c l u d i n g g e r o n t o l o g y ) and r e s e a r c h methodology.
Q u a l i t y o f p r o p o s e d t r a i n i n g o b j e c t i v e s and d e s i g n o f t r a i n i n g program.
Availability of research support.
L i k e l i h o o d and/or p r e v i o u s r e c o r d o f a t t r a c t i n g h i g h - q u a l i t y t r a i n e e s .
Renewal a p p l i c a t i o n s w i l l a l s o b e judged on t h e s u c c e s s o f p r e v i o u s l y t r a i n e d
fellows i n g e r i a t r i c research.
REVIEW PROCEDURES AND CRITERIA
A p p l i c a t i o n s w i l l b e r e c e i v e d by t h e N I H D i v i s i o n o f R e s e a r c h G r a n t s and w i l l
be a s s i g n e d t o t h e N I A . Responsive a p p l i c a t i o n s w i l l b e a s s i g n e d t o a n
a p p r o p r i a t e group f o r r e v i e w . A p p l i c a t i o n s w i l l b e reviewed i n a c c o r d w i t h
t h e u s u a l NiH p e e r r e v i e w p r o c e d u r e s . F o l l o w i n g s t u d y s e c t i o n r e v i e w , t h e
a p p l i c a t i o n s w i l l b e e v a l u a t e d by t h e N a t i o n a l Advisory C o u n c i l on Aging.
For f u r t h e r i n f o r m a t i o n and a copy o f t h e PA c o n t a c t :
S t a n l e y L. S l a t e r , M.D.
D i r e c t o r , G e r i a t r i c R e s e a r c h and T r a i n i n g Program
N a t i o n a l I n s t i t u t i o n on Aging
B u i l d i n g 31, Room 5C27
9000 R o c k v i l l e P i k e
B e t h e s d a , MD 20892
Telephone: ( 3 0 1 ) 496-6761
GERIATRIC ACADEMIC PROGRAM (GAP) AWARD WL2-I
P.T. 34;
K.W.
0710010
N a t i o n a l I n s t i t u t e on Aging
I n i t i a l A p p l i c a t i o n R e c e i p t Date:
J u n e 1 , 1989 Subsequent A p p l i c a t i o n R e c e i p t Dates: October 1 , 1989; and F e b r u a r y 1 , J u n e 1 , and October 1 o f e a c h y e a r t h e r e a f t e r .
Vol. 17, No. 39, November 25, 1988
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The N a t i o n a l I n s t i t u t e on Aging ( N I A ) s o l i c i t s a p p l i c a t i o n s f o r t h e s u p p o r t o f academic career development programs f o r j u n i o r f a c u l t y i n g e r i a t r i c s .
BACKGROUND AND GOALS
T h e r e i s i n c r e a s e d r e c o g n i t i o n o f t h e growing need f o r t r a i n e d p e r s o n n e l i n g e r i a t r i c s . A committee s p o n s o r e d by t h e N a t i o n a l Academy o f S c i e n c e s ( J . Am. G e r i a t r i c s SOC. 35:773-91, (1987) emphasized t h a t f i l l i n g t h i s need w i l l r e q u i r e enough academic l e a d e r s i n g e r i a t r i c s t o t r a i n t h e needed number o f g e r i a t r i c i a n s . The committee emphasized t h a t h i g h - q u a l i t y t r a i n i n g i n r e s e a r c h , t e a c h i n g , and c l i n i c a l p r a c t i c e were a l l n e c e s s a r y f o r t h e development o f s u c h l e a d e r s , and t h a t t h i s c o u l d b e s t b e done i n a n environment where t h e r e were enough g e r i a t r i c r e s e a r c h e r s , t e a c h e r s , and p r a c t i t i o n e r s t o p r o v i d e t h o r o u g h e x p e r i e n c e f o r f u t u r e academic l e a d e r s . Developing academic l e a d e r s h i p r e q u i r e s a continuum o f s u p p o r t from t h e f e l l o w s h i p t o t h e s e n i o r f a c u l t y l e v e l . Support f o r g e r i a t r i c f e l l o w s h i p s i s a v a i l a b l e t h r o u g h s e v e r a l programs, i n c l u d i n g N I A ' s G e r i a t r i c R e s e a r c h I n s t i t u t i o n a l T r a i n i n g (GRIT) award, t h e H e a l t h R e s o u r c e s and S e r v i c e s A d m i n i s t r a t i o n ' s F a c u l t y T r a i n i n g P r o j e c t s i n G e r i a t r i c Medicine and D e n t i s t r y , V e t e r a n s A d m i n i s t r a t i o n f e l l o w s h i p s , and o t h e r s o u r c e s . However, s t a b l e career development s u p p o r t a t t h e j u n i o r f a c u l t y l e v e l i s a l s o e x t r e m e l y i m p o r t a n t i n e s t a b l i s h i n g academic c a r e e r s .
Career development s u p p o r t f o r i n d i v i d u a l j u n i o r f a c u l t y i n g e r i a t r i c s i s p r o v i d e d by N I A ' s Academic Award ( N I H Guide t o G r a n t s and C o n t r a c t s , V o l . 10, No. 5, March 27, 19811, and by i t s C l i n i c a l I n v e s t i g a t o r Award ( N I H Guide t o G r a n t s and C o n t r a c t s , Vol. 13, No. 8, J u n e 29, 1 9 8 4 ) . N I A c o n t i n u e s t o e n c o u r a g e a p p l i c a t i o n s f o r t h e s e awards f o r s u i t a b l e c a n d i d a t e s and i n s t i t u t i o n s . T h i s announcement d e s c r i b e s a n i n s t i t u t i o n a l form o f t h e Academic Award, t h e G e r i a t r i c Academic Program (GAP) Award. T h i s award i s appropriate f o r i n s t i t u t i o n s having s u f f i c i e n t f a c u l t y with a s t a b l e base of ongoing r e s e a r c h i n g e r i a t r i c s and r e l a t e d d i s c i p l i n e s t o s e r v e a s mentors f o r s e v e r a l j u n i o r f a c u l t y over a n extended p e r i o d .
S i n c e s t r e n g t h e n i n g t h e s c i e n c e b a s e o f g e r i a t r i c s and g e r o n t o l o g y i s a g o a l o f t h i s award, c o l l a b o r a t i o n among c l i n i c a l , b a s i c , e p i d e m i o l o g i c , b e h a v i o r a l , and s o c i a l r e s e a r c h e r s i n s u p p o r t o f c a r e e r development a c t i v i t i e s i s p a r t i c u l a r l y encouraged. C o l l a b o r a t i o n w i t h b a s i c s c i e n c e r e s e a r c h e r s i n gerontology is p a r t i c u l a r l y d e s i r a b l e . Because a continuum o f s u p p o r t f o r c a r e e r development i s needed from t h e f e l l o w s h i p t o t h e f a c u l t y l e v e l , t h e N I A s u p p o r t s o t h e r awards f o r career development i n g e r i a t r i c s a t o t h e r s t a g e s . I n t e r e s t e d p a r t i e s a r e encouraged t o c o n t a c t N I A s t a f f l i s t e d under "Method o f Applying" f o r f u r t h e r i n f o r m a t i o n . P r o s p e c t i v e a p p l i c a n t i n s t i t u t i o n s a r e encouraged t o c o n s i d e r d e v e l o p i n g comprehensive c a r e e r development programs which may be s u p p o r t e d by a c o m b i n a t i o n o f N I A and o t h e r i n s t i t u t i o n a l a w a r d s .
ELIGIBILITY
A p p l i c a n t s must have i n p l a c e a g e r i a t r i c f e l l o w s h i p program a t t h e t i m e o f a p p l i c a t i o n . J u n i o r f a c u l t y t o be s u p p o r t e d by t h e program must have a h e a l t h p r o f e s s i o n a l d e g r e e i n t h e c l i n i c a l s c i e n c e s ( M . D . , D . O . , o r D.D.S, o r e q u i v a l e n t ) and must have e i t h e r completed a t l e a s t one y e a r o f f e l l o w s h i p t r a i n i n g i n g e r i a t r i c s o r g e r o p s y c h i a t r y o r o b t a i n e d c e r t i f i c a t i o n o f Added Q u a l i f i c a t i o n s i n G e r i a t r i c Medicine from t h e American Board o f I n t e r n a l MedicinelAmerican Board o f Family P r a c t i c e . I t i s n o t r e q u i r e d t h a t f e l l o w s h i p t r a i n i n g have been a t t h e a p p l i c a n t i n s t i t u t i o n . A p p l i c a n t i n s t i t u t i o n s must have a s t r o n g and s t a b l e b a s e o f r e s e a r c h and c l i n i c a l a c t i v i t i e s r e l a t e d t o g e r i a t r i c s t o p r o v i d e an a d e q u a t e environment f o r t h e development o f academic g e r i a t r i c i a n s . I n a d d i t i o n t o programs a t i n d i v i d u a l i n s t i t u t i o n s , programs c o n d u c t e d by two o r more i n s t i t u t i o n s a r e e l i g i b l e f o r support. STRUCTURE OF SUPPORT The mechanism o f s u p p o r t w i l l b e t h e i n s t i t u t i o n a l r e s e a r c h career award (K12). The award w i l l s u p p o r t a program p r o v i d i n g up t o f i v e y e a r s o f s a l a r y s u p p o r t and a l i m i t e d amount f o r r e s e a r c h e x p e n s e s f o r j u n i o r f a c u l t y , under t h e l e a d e r s h i p o f a program d i r e c t o r who w i l l o v e r s e e t h e program, and f a c u l t y s p o n s o r s who w i l l s e r v e as mentors f o r i n d i v i d u a l j u n i o r f a c u l t y , t o o v e r s e e t h e i r academic development, and t o a r r a n g e a p p r o p r i a t e a c t i v i t i e s needed f o r f u r t h e r development. For e a c h j u n i o r f a c u l t y member so s p o n s o r e d , t h e award w i l l a l s o p r o v i d e up t o t e n p e r c e n t o f e a c h s p o n s o r ' s s a l a r y and f r i n g e b e n e f i t s f o r t h e f i r s t t h r e e y e a r s o f s p o n s o r s h i p . The award w i l l a l s o s u p p o r t a l i m i t e d amount o f c o r e r e s o u r c e s needed f o r s p o n s o r e d i n d i v i d u a l s ' Vol. 17, No. 39, November 25, 1988
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Page 10
career development ( e . g . key c l i n i c a l r e s e a r c h c e n t e r p e r s o n n e l , o r a n i m a l
f a c i l i t i e s ) i f c e n t r a l a d m i n i s t r a t i o n improves t h e i r e f f e c t i v e n e s s .
Up t o f i v e y e a r s o f r e n e w a b l e s u p p o r t may b e r e q u e s t e d by t h e g r a n t e e
i n s t i t u t i o n . I n d i v i d u a l j u n i o r f a c u l t y s p o n s o r e d by t h e program may b e
s u p p o r t e d from t h r e e t o f i v e y e a r s . No more t h a n t h r e e p e r s o n s a t a n awardee
i n s t i t u t i o n may b e g i n t h e i r s p o n s o r e d a c t i v i t i e s i n any y e a r l y b u d g e t p e r i o d
o f t h i s award, and none may b e g i n s p o n s o r e d a c t i v i t i e s i n t h e f o u r t h and f i f t h
y e a r s . The t o t a l number o f s p o n s o r e d i n d i v i d u a l s may i n c r e a s e t o no more t h a n
e i g h t i n t h e t h i r d y e a r o f t h e award, and remain c o n s t a n t o r d i m i n i s h
thereafter.
M T O OF APPLYING
EH D A p p l i c a t i o n s s h o u l d b e p r e p a r e d on form PHS 398. A p p l i c a n t s s h o u l d f o l l o w t h e
s u p p l e m e n t a l i n s t r u c t i o n s f o r a p p l i c a t i o n s f o r t h i s award, a v a i l a b l e from t h e
G e r i a t r i c s Branch, N I A ( a d d r e s s on page 5). The PHS 398 a p p l i c a t i o n form i s
a v a i l a b l e a t most i n s t i t u t i o n a l b u s i n e s s o f f i c e s o r from t h e D i v i s i o n o f
R e s e a r c h G r a n t s , N I H , (301) 496-7441. On i t e m 2 o f t h e f a c e page o f t h e
a p p l i c a t i o n , a p p l i c a n t s s h o u l d e n t e r : N I A G e r i a t r i c Academic Program Award.
A l e t t e r o f i n t e n t i s n o t a p r e r e q u i s i t e f o r a p p l y i n g ; however, p r o s p e c t i v e
a p p l i c a n t s are encouraged t o send a l e t t e r t h a t i n c l u d e s a d e s c r i p t i v e t i t l e
and r e s o u r c e s o f t h e p r o p o s e d p r o j e c t . T h i s l e t t e r s h o u l d b e s e n t t o t h e N I A
c o n t a c t by t h r e e months b e f o r e t h e s u b m i s s i o n d e a d l i n e .
A c o m p l e t e d o r i g i n a l a p p l i c a t i o n and f o u r c o p i e s s h o u l d b e s e n t t o :
Application Receipt
D i v i s i o n o f Research Grants
National I n s t i t u t e s o f Health
Westwood B u i l d i n g , Room 240
B e t h e s d a , Maryland 20892xx
The N I A c o n t a c t o f f i c e l i s t e d below s h o u l d be s e n t two c o p i e s o f t h e
a p p l i c a t i o n a t t h e t i m e o f s u b m i s s i o n . I n q u i r i e s and c o r r e s p o n d e n c e s h o u l d b e
directed t o :
G e r i a t r i c s Branch
N a t i o n a l I n s t i t u t e on Aging
b B u i l d i n g 31, Room 5C-27 ’ B e t h e s d a , Maryland 20892 Telephone: (301) 496-6761
The a p p l i c a t i o n s h o u l d i d e n t i f y :
A program d i r e c t o r who w i l l assume o v e r a l l r e s p o n s i b i l i t y f o r management o f t h e program. The a p p l i c a t i o n s h o u l d d e s c r i b e p l a n s f o r r e c r u i t m e n t and s e l e c t i o n o f j u n i o r f a c u l t y t o be s p o n s o r e d , q u a l i t y c o n t r o l o f t h e program and f o r maximizing commitment o f s p o n s o r e d i n d i v i d u a l s t o a g i n g r e s e a r c h a f t e r t h e completion o f support.
F a c u l t y s p o n s o r s . The s p o n s o r s ’ p a s t and p r e s e n t r e s e a r c h , c l i n i c a l and t e a c h i n g a c t i v i t i e s should be described, as w e l l as t h e i r previous experience i n t r a i n i n g f e l l o w s and j u n i o r f a c u l t y , and t h e c u r r e n t s t a t u s o f a l l f e l l o w s and o t h e r i n d i v i d u a l s whom t h e y have p r e v i o u s l y t r a i n e d . The f a c u l t y and i n s t i t u t i o n ’ s p l a n s f o r p r o v i d i n g r e s e a r c h , c l i n i c a l and t e a c h i n g e x p e r i e n c e f o r s p o n s o r e d i n d i v i d u a l s , i n c l u d i n g examples o f t h e t y p e s o f r e s e a r c h p r o j e c t s t o be u n d e r t a k e n , p r o v i s i o n o f e x p e r i e n c e i n o t h e r l a b o r a t o r i e s t o l e a r n p e r t i n e n t t e c h n i q u e s , needed d i d a c t i c t r a i n i n g i n g e r o n t o l o g y , o t h e r b a s i c s c i e n c e s , r e s e a r c h methodology, s t a t i s t i c s , and c l i n i c a l and t e a c h i n g r e s p o n s i b i l i t i e s . P l a n s f o r e f f o r t s t o r e c r u i t m i n o r i t y t r a i n e e s where a p p l i c a b l e , c o n s i s t e n t Such p l a n s a r e a r e q u i r e d with N I H ’ s policy o f encouraging such recruitment. component o f a p p l i c a t i o n s f o r N I H r e s e a r c h t r a i n i n g programs. A d d i t i o n a l i n f o r m a t i o n on N I H ‘ s m i n o r i t y r e c r u i t m e n t p o l i c y may b e f o u n d i n t h e N I H Guide f o r G r a n t s and C o n t r a c t s V o l . 15, No. 4, March 28, 1986.
REVIEW PROCEDURES
-,W
A p p l i c a t i o n s w i l l b e r e c e i v e d by t h e N I H D i v i s i o n o f R e s e a r c h G r a n t s and w i l l be a s s i g n e d t o t h e N I A . Responsive a p p l i c a t i o n s w i l l b e a s s i g n e d t o a n a p p r o p r i a t e g r o u p f o r r e v i e w . A p p l i c a t i o n s judged by t h e N I A t o be non-responsive w i l l be t r e a t e d as r e g u l a r g r a n t a p p l i c a t i o n s .
Vol. 17, No. 39, November 25, 1988
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Page 1 1
A p p l i c a t i o n s w i l l b e reviewed i n a c c o r d w i t h t h e u s u a l N I H p e e r review
procedures. Following s t u d y s e c t i o n review, t h e a p p l i c a t i o n s w i l l be
e v a l u a t e d by t h e N a t i o n a l Advisory C o u n c i l on Aging.
A For f u r t h e r i n f o r m a t i o n and a copy o f t h e P c o n t a c t :
S t a n l e y L . S l a t e r , M.D. D i r e c t o r , G e r i a t r i c R e s e a r c h and T r a i n i n g Program
N a t i o n a l I n s t i t u t e on Aging
B u i l d i n g 31, Room 5C27
9000 R o c k v i l l e P i k e
B e t h e s d a , Maryland 20892
Telephone: ( 3 0 1 ) 496-6761
HIV-RELATED ILLNESSES: P.T. 3 4 ; TOPICS FOR HEALTH SERVICES RESEARCH
" I
K.W.
0715008, 0730050, 0408006, 0730030, 0413000
N a t i o n a l C e n t e r f o r H e a l t h S e r v i c e s R e s e a r c h and H e a l t h Care Technology
Assessment (NCHSR)
BACKGROUND INFORMATION
The r e c e n t P u b l i c H e a l t h S e r v i c e m e e t i n g i n C h a r l o t t e s v i l l e , VA, on t h e
p r e v e n t i o n and c o n t r o l o f AIDS and t h e human immunodeficiency v i r u s ( H I V )
c a l l e d f o r s t u d i e s t h a t f o c u s on t h e c o s t e f f e c t i v e n e s s and f i n a n c i n g o f care
for i l l n e s s e s related t o HIV. I t a l s o recommended b r o a d e n i n g t h e s c o p e o f
h e a l t h s e r v i c e s r e s e a r c h beyond economic i s s u e s . A s p a r t o f t h e P u b l i c H e a l t h
S e r v i c e , NCHSR h a s been a s k e d t o i n v e s t i g a t e ways t o add t o e x i s t i n g knowledge
on h e a l t h s e r v i c e s r e s e a r c h on H I V - r e l a t e d i l l n e s s e s .
I n r e s p o n s e , NCHSR i s i n t e r e s t e d i n t h e s t u d y o f t h e a v a i l a b i l i t y , c o s t , and
u t i l i z a t i o n o f h e a l t h s e r v i c e s f o r H I V - r e l a t e d i l l n e s s e s . I n f o r m a t i o n needed
by p o l i c y - and d e c i s i o n m a k e r s i n v o l v e s d i f f e r e n t r i s k g r o u p s , p o p u l a t i o n s ,
g e o g r a p h i c a r e a s , s t a g e s o f i l l n e s s , and t r e a t m e n t m o d a l i t i e s . R e s e a r c h
t o p i c s i n c l u d e t h e f i n a n c i n g , o r g a n i z a t i o n , and management o f h e a l t h c a r e
s e r v i c e s f o r HIV-related i l l n e s s e s .
C u r r e n t e p i d e m i o l o g i c and economic i n f o r m a t i o n a b o u t AIDS and o t h e r
HIV-related i l l n e s s e s h i g h l i g h t s t h e c o m p l e x i t y o f i s s u e s and g a p s i n
knowledge t h a t s h o u l d b e a d d r e s s e d i n h e a l t h s e r v i c e s r e s e a r c h . R e s e a r c h
t o p i c s and q u e s t i o n s a r e d i s c u s s e d b r i e f l y i n s u b s e q u e n t s e c t i o n s w i t h r e s p e c t
t o h e a l t h s t a t u s measures and i n f o r m a t i o n s y s t e m s , access and b a r r i e r s t o
care, q u a l i t y o f c a r e , h e a l t h s y s t e m s a n a l y s i s , c o s t e f f e c t i v e n e s s o f
a l t e r n a t i v e s e r v i c e and o r g a n i z a t i o n a l s t r a t e g i e s , and p r o v i d e r i s s u e s . For
g r e a t e r d e t a i l , see "HIV-Related I l l n e s s e s : T o p i c s f o r H e a l t h S e r v i c e s
R e s e a r c h , " a program n o t e p u b l i s h e d i n October 1988 t h a t i s a v a i l a b l e from
NCHSR.
PRIORITY RESEARCH ISSUES
Cost and F i n a n c i n g o f Care
H e a l t h s e r v i c e s r e s e a r c h on H I V - r e l a t e d i l l n e s s e s h a s f o c u s e d on t h e c o s t s and
e x p e n d i t u r e s f o r t r e a t m e n t , b u t a number o f r e s t r i c t i o n s have made it
d i f f i c u l t t o estimate c u r r e n t and f u t u r e c o s t s . I n a d d i t i o n , t h e c o s t and
f i n a n c i n g o f t r e a t m e n t w i l l b e a f f e c t e d by t h e expanded d e f i n i t i o n o f AIDS,
t h e p o s s i b i l i t y o f new d i a g n o s t i c t e c h n i q u e s t h a t a r e more s e n s i t i v e and can
d e t e c t t h e p r e s e n c e o f t h e i l l n e s s e s much e a r l i e r t h a n c o n v e n t i o n a l s c r e e n i n g
t e c h n i q u e s , and t h e expanded u s e o f AZT and o t h e r new t r e a t m e n t s . Examples o f
researchable questions follow:
o What i s t h e v a r i a t i o n i n c o s t s o f t r e a t i n g a n e p i s o d e o f i l l n e s s ? o How do c o s t s f o r t r e a t m e n t o f H I V - r e l a t e d i l l n e s s e s v a r y by r e g i o n , r i s k f a c t o r s , demographics, and socioeconomic v a r i a b l e s ? o What a r e t h e i n d i r e c t c o s t s o f HIV-related i l l n e s s e s , and how do t h e y v a r y f o r d i f f e r e n t t r e a t m e n t s , t y p e s o f s e r v i c e s , and p o p u l a t i o n groups? o What a r e t h e p r o j e c t e d d i r e c t and i n d i r e c t c o s t s , c h a r g e s , and e x p e n d i t u r e s f o r HIV-related i l l n e s s e s , and how do t h e y v a r y w i t h d i f f e r e n t assumptions? o How h a s t h e a v a i l a b i l i t y and c o v e r a g e o f i n s u r a n c e f o r HIV-related i l l n e s s e s been a f f e c t e d by l e g i s l a t i o n , employer s e l f - i n s u r a n c e , use o f s c r e e n i n g f o r H I V i n f e c t i o n by employers and i n s u r e r s , and other factors? o What i s t h e e x t e n t o f unreimbursed c a r e f o r HIV-related i l l n e s s e s and s e r o p o s i t i v e i n d i v i d u a l s , and how a r e t h e s e c o s t s a b s o r b e d ?
Vol. 17, No. 39, November 25, 1988
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Page 1 2
o How a r e f i n a n c i n g s o u r c e s o f H I V care p r o j e c t e d t o change i n
r e s p o n s e t o changes i n t h e p o p u l a t i o n w i t h HIV-related i l l n e s s e s ? o What impact do v o l u n t e e r s e r v i c e s have on a c c e s s t o h e a l t h c a r e s e r v i c e s , q u a l i t y o f care, and f i n a n c i a l burden f o r t h e i n d i v i d u a l and community?
L c I J
H e a l t h S t a t u s Measures and I n f o r m a t i o n Systems I n f o r m a t i o n s y s t e m s a r e needed t o produce a c c u r a t e , t i m e l y , and comprehensive d a t a u s e f u l f o r h e a l t h s e r v i c e s r e s e a r c h and p o l i c y a n a l y s e s , f o r e p i d e m i o l o g i c i n q u i r i e s , and f o r c l i n i c a l i n v e s t i g a t i o n s . NCHSR i s e s p e c i a l l y i n t e r e s t e d i n i s s u e s and q u e s t i o n s t h a t i n c l u d e t h e f o l l o w i n g :
o Design o f m e d i c a l r e c o r d s s y s t e m s t o p e r m i t t h e c o n f i d e n t i a l c o l l e c t i o n and a g g r e g a t i o n o f l o n g i t u d i n a l , p a t i e n t - s p e c i f i c d a t a i n order t o develop s e v e r i t y indices, p a t t e r n s of i l l n e s s , h e a l t h s t a t u s m e a s u r e s , and a n a l y s e s o f p r a c t i c e v a r i a t i o n s . o Development o f r e c o r d k e e p i n g s y s t e m s t h a t can a c q u i r e and i n t e g r a t e i n f o r m a t i o n from i n f o r m a l c a r e g i v e r s and o r g a n i z a t i o n s . o C o n s t r u c t i o n o f d a t a banks o r r e g i s t r i e s t o p e r m i t more a c c u r a t e i d e n t i f i c a t i o n and comparisons o f d i f f e r e n t p r a c t i c e p a t t e r n s , more f o c u s e d and e f f i c i e n t c l i n i c a l and e p i d e m i o l o g i c i n v e s t i g a t i o n s , and more r i g o r o u s a s s e s s m e n t o f medical t e c h n o l o g i e s . o What a r e t h e e f f e c t s o f t h e H I V epidemic on p o l i c i e s and p r o c e d u r e s i n health care settings? o How c a n b e t t e r h e a l t h outcome i n d i c a t o r s , f u n c t i o n a l s t a t u s m e a s u r e s , and measures o f i l l n e s s s e v e r i t y b e c o n s t r u c t e d ? Can e x i s t i n g i n s t r u m e n t s f o r o t h e r d i s e a s e s b e a d o p t e d o r improved?
Access and Barriers t o Care Access t o care may b e l i m i t e d because p a t i e n t s w i t h HIV-related i l l n e s s e s may be more l i k e l y t o p o s s e s s no i n s u r a n c e o r t o r e q u i r e p u b l i c a s s i s t a n c e . Both f a c t o r s may l i m i t t h e number o f h e a l t h care p r o v i d e r s f o r t h e s e p a t i e n t s . F u r t h e r m o r e , t h e i n f e c t i o u s n a t u r e o f t h e d i s e a s e may l i m i t t h e w i l l i n g n e s s of p r o v i d e r s t o g i v e a p p r o p r i a t e and s u s t a i n e d t r e a t m e n t . Examples o f q u e s t i o n s include :
i l l n e s s e s , and how do t h e y v a r y by g e o g r a p h i c a r e a s , r i s k g r o u p s , s e v e r i t y of i l l n e s s e s , and t h e n a t u r e o f t h e d i s e a s e ? o How do t h e t y p e s o f a v a i l a b l e s e r v i c e s and c o n t i n u i t y o f s e r v i c e s u s e d v a r y by h e a l t h care s e t t i n g and t h e f i n a n c i n g o f care? o How do a v a i l a b i l i t y o f s e r v i c e s , r e s o u r c e u t i l i z a t i o n , and c o n t i n u i t y of s e r v i c e s c o r r e l a t e w i t h i n s u r a n c e c o v e r a g e o r m i n o r i t y and socioeconomic s t a t u s ? o What community and i n d i v i d u a l f a c t o r s promote o r h i n d e r e s t a b l i s h m e n t o f HIV-related s e r v i c e s ? Q u a l i t y o f Care The many f a c t o r s a f f e c t i n g q u a l i t y o f c a r e i n c l u d e t h e s u p p l y o f p r a c t i t i o n e r s and s e t t i n g s equipped t o d e a l w i t h HIV-related i l l n e s s e s , t h e demand f o r t r e a t m e n t , and p a t i e n t c h a r a c t e r i s t i c s . Among t h e q u e s t i o n s t h a t need t o b e addressed:
o What s e r v i c e s a r e a v a i l a b l e and u s e d f o r t r e a t m e n t o f HIV-related
o What i s t h e q u a l i t y o f c a r e p r o v i d e d t o p a t i e n t s w i t h HIV-related i l l n e s s e s ? Q u a l i t y o f t r e a t m e n t may b e d e f i n e d by such measures as patient s a t i s f a c t i o n , increased longevity, quality-adjusted s u r v i v a l , reduced p a i n , and t h e e d u c a t i o n o f p a t i e n t s a b o u t t h e i r d i s e a s e and o p t i o n s f o r t r e a t m e n t . o What i s t h e n a t u r e o f p a t i e n t and p r a c t i t i o n e r i n t e r a c t i o n s ? How do t h e s e i n t e r a c t i o n s a f f e c t p a t i e n t compliance, s a t i s f a c t i - n , and funct i o n i n g? o How d o e s p a t i e n t p r e f e r e n c e a f f e c t t r e a t m e n t ? How i s p a t i e n t p r e f e r e n c e weighed a g a i n s t o t h e r f a c t o r s ? o How d o e s q u a l i t y of care v a r y by r e g i o n a l p r e v a l e n c e o f t h e d i s e a s e , t h e s u p p l y and t y p e s o f t r e a t m e n t s e t t i n g s , t h e p r a c t i t i o n e r s who t r e a t t h e d i s e a s e , and p a t i e n t c h a r a c t e r i s t i c s ?
Health Systems Analysis
1,-f
The AIDS e p i d e m i c i s l i k e l y t o have f a r - r e a c h i n g e f f e c t s on t h e d i s t r i b u t i o n of h e a l t h care r e s o u r c e s ; t h e o r g a n i z a t i o n and management o f f o r m a l and i n f o r m a l h e a l t h c a r e d e l i v e r y networks; and t h e d e t e c t i o n , t r e a t m e n t , and f i n a n c i n g o f o t h e r d i s e a s e s . Q u e s t i o n s on t h e impact o f H I V - r e l a t e d i l l n e s s e s include : Vol. 17, No. 39, November 25, 1988
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o How have HIV-related i l l n e s s e s a f f e c t e d t h e s t r u c t u r e , f u n c t i o n s , i n t e r r e l a t i o n s h i p s , and f i s c a l v i a b i l i t y o f i n s t i t u t i o n a l and community-based h e a l t h care o r g a n i z a t i o n s ? o What a r e t h e s i m i l a r i t i e s and d i f f e r e n c e s i n i n t e r n a t i o n a l e x p e r i e n c e s i n t h e p r e v e n t i o n , c o s t , f i n a n c i n g , q u a l i t y o f care, and access t o h e a l t h care f o r t h o s e a f f l i c t e d by HIV-related i l l n e s s e s ? A r e t h e s e e x p e r i e n c e s a p p l i c a b l e t o t h e United S t a t e s ? o What a r e t h e s p i l l o v e r e f f e c t s o f , and r e s o u r c e t r a d e o f f s between, HIV-related i l l n e s s e s and o t h e r i l l n e s s e s ? What e t h i c a l i s s u e s a r e involved i n resource t r a d e o f f s ?
Cost E f f e c t i v e n e s s o f A l t e r n a t i v e S e r v i c e and O r g a n i z a t i o n a l S t r a t e g i e s The i d e n t i f i c a t i o n o f c o s t - e f f e c t i v e ways f o r o r g a n i z i n g , managing, and d e l i v e r i n g h e a l t h s e r v i c e s t o H I V p a t i e n t s i s c r i t i c a l . That a n a l y s i s , however, n e e d s t o d i s t i n g u i s h c o s t s from c h a r g e s , c o n s i d e r s e v e r i t y o f i l l n e s s and q u a l i t y sf l i f e , and u s e c o n s i s t e n t measures o f t h e r e l a t i v e e f f e c t i v e n e s s o f d i f f e r e n t s t r a t e g i e s f o r p r o v i d i n g h e a l t h c a r e s e r v i c e s . NCHSR i s i n t e r e s t e d i n s t u d i e s t h a t examine:
o How do t r e a t m e n t and c o s t v a r y by o r g a n i z a t i o n a l c h a r a c t e r i s t i c s s u c h as o w n e r s h i p , t e a c h i n g s t a t u s , s i z e , c o n c e n t r a t i o n o f H I V c a s e l o a d , and i n t e g r a t i m i n a m u l t i - i n s t i t u t i o n a l h e a l t h care system? o What i s t h e c o m p a r a t i v e c o s t e f f e c t i v e n e s s o f c e n t r a l i z a t i o n v e r s u s d e c e n t r a l i z a t i o n o f s e r v i c e d e l i v e r y a t t h e f a c i l i t y l e v e l ? Is t h e u s e o f d e d i c a t e d u n i t s i n h o s p i t a l s v e r s u s s c a t t e r e d b e d s a more cost-effective strategy? o How h a s t h e e p i d e m i c a f f e c t e d h e a l t h c a r e f a c i l i t i e s w i t h a l a r g e number o f cases i n terms o f s t a f f i n g r a t i o s , p e r s o n n e l mix, and p a t i e n t demand? o How a r e v o l u n t e e r s e r v i c e s c o o r d i n a t e d w i t h e a c h o t h e r and w i t h t h e f o r m a l h e a l t h c a r e d e l i v e r y system? What i s t h e p o t e n t i a l f o r t h e expanded u s e and e f f e c t i v e n e s s o f community-based v o l u n t e e r o r g a n i z a t i o n s i n d e a l i n g w i t h HIV-related i l l n e s s e s ?
Provider Issues P o t e n t i a l p r o v i d e r e x p o s u r e t o body f l u i d s o f p a t i e n t s n e c e s s i t a t e s g r e a t l y i n c r e a s e d s a f e g u a r d s t h a t may b e i n c o n v e n i e n t and may i n c r e a s e r e l u c t a n c e t o treat HIV patients. Some p r o v i d e r s may h e s i t a t e t o c a r e f o r H I V p a t i e n t s who engage i n s u b s t a n c e a b u s e and homosexual a c t i v i t y . Moreover, t h e p r o g n o s i s o f t h e s e p a t i e n t s i s a l m o s t always t e r m i n a l . A l l o f t h e s e i s s u e s have l e d t o c o n c e r n by h e a l t h c a r e p r a c t i t i o n e r s who a r e o r may b e t r e a t i n g H I V - r e l a t e d cases and may c o n t r i b u t e t o p r o f e s s i o n a l “burnout.l’ Q u e s t i o n s f o r r e s e a r c h include :
o How a r e h e a l t h c a r e p r a c t i t i o n e r s and v o l u n t e e r s r e a c t i n g t o t h e e p i d e m i c i n terms o f a v a i l a b i l i t y , t u r n o v e r , w i l l i n g n e s s t o t r e a t HIV-related i l l n e s s e s , and b u r n o u t from t r e a t i n g H I V v i c t i m s ? What f i n a n c i a l and o r g a n i z a t i o n a l f a c t o r s a f f e c t p r o v i d e r b u r n o u t ? o Does t h e a b i l i t y t o e x e r c i s e d i s c r e t i o n a r y judgment i n t h e d e c i s i o n t o t r e a t H I V p a t i e n t s v a r y a c r o s s employment s e t t i n g s and t y p e s o f health care professionals? o What i s t h e e f f e c t o f v a r i a t i o n s i n t h e mix o f h e a l t h p r o f e s s i o n a l s k i l l s on t r e a t m e n t o f H I V - r e l a t e d i l l n e s s e s ? What i s t h e most c o s t - e f f e c t i v e mix f o r v a r i o u s t r e a t m e n t s e t t i n g s and p o p u l a t i o n groups? o How i s t h e e p i d e m i c a f f e c t i n g p r o v i d e r c h o i c e o f s p e c i a l t y , c h o i c e o f l o c a t i o n , and o t h e r p r a c t i c e d e c i s i o n s ?
’ 1
APPLICATION AND REVIEW PROCEDURES A p p l i c a t i o n s may b e s u b m i t t e d by any p u b l i c o r p r i v a t e n o n p r o f i t i n s t i t u t i o n o r u n i t o f S t a t e o r l o c a l government. A p p l i c a t i o n s must b e s u b m i t t e d on P u b l i c H e a l t h S e r v i c e Form 398, Grant A p p l i c a t i o n , e x c e p t f o r a p p l i c a t i o n s from S t a t e and l o c a l governments. The l a t t e r a r e r e q u i r e d t o submit Form DHHS 5161, A p p l i c a t i o n f o r F e d e r a l A s s i s t a n c e ( n o n c o n s t r u c t i o n p r o g r a m s ) . A p p l i c a t i o n materials a r e a v a i l a b l e from John D . G a l l i c c h i o
C h i e f , Review and Advisory S e r v i c e s Program
N a t i o n a l Center f o r H e a l t h S e r v i c e s Research
and H e a l t h Care Technology Assessment 5600 F i s h e r s Lane, Room 18A-20 R o c k v i l l e , Maryland 20857 Telephone: ( 3 0 1 ) 443-3091 Vol. 17, No. 39, November 25,
1988
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A p p l i c a t i o n m a t e r i a l s may b e a v a i l a b l e from b u s i n e s s , g r a n t s , and c o n t r a c t s o f f i c e s o f academic o r r e s e a r c h i n s t i t u t i o n s , and a l s o c a n b e o b t a i n e d from t h e N a t i o n a l I n s t i t u t e s o f H e a l t h , D i v i s i o n o f R e s e a r c h G r a n t s ( D R G ) , whose a d d r e s s a p p e a r s below.
L d 1, 2
The a p p l i c a n t s h o u l d c h e c k t h e box on t h e a p p l i c a t i o n f o r m ' s face s h e e t ( l i n e i n d i c a t i n g t h a t t h e p r o p o s a l i s i n r e s p o n s e t o t h i s program announcement o r t h e more d e t a i l e d NCHSR program n o t e and p r i n t ( n e x t t o t h e checked box) "NCHSR Program Note on H e a l t h S e r v i c e s Research and HIV-Related I l l n e s s e s . " The a p p l i c a n t a l s o s h o u l d e n c l o s e a c o v e r l e t t e r c i t i n g t h i s announcement o r t h e program n o t e . The s c h e d u l e f o r s u b m i s s i o n and review o f a p p l i c a t i o n s i s a s f o l l o w s :
NIHIDRG Submission
June 1 October 1 February 1
Study S e c ti o n Review October February June
Earliest Start Date December 1 April 1 August 1
The o r i g i n a l and s i x c o p i e s o f t h e a p p l i c a t i o n s h o u l d b e s e n t o r delivered t o : National I n s t i t u t e s o f Health D i v i s i o n o f Research Grants Westwood B u i l d i n g , Room 240 5333 Westbard Avenue B e t h e s d a , M,ryland 20892XX
&/
A l l NCHSR r e s e a r c h g r a n t a p p l i c a t i o n s are reviewed f o r s c i e n t i f i c and t e c h n i c a l merit by a r e v i e w p a n e l o r s t u d y s e c t i o n comprised o f non-Federal s c i e n t i s t s . Each a p p l i c a t i o n w i l l b e reviewed by t h e a p p r o p r i a t e NCHSR s t u d y s e c t i o n a c c o r d i n g t o t h e f o l l o w i n g c r i t e r i a : s i g n i f i c a n c e and o r i g i n a l i t y o f t h e p r o j e c t from a s c i e n t i f i c and t e c h n i c a l v i e w p o i n t , adequacy o f t h e methodology p r o p o s e d t o c a r r y o u t t h e p r o j e c t , a v a i l a b i l i t y o f d a t a and adequacy o f t h e d a t a c o l l e c t i o n p l a n , a p p r o p r i a t e n e s s o f t h e work p l a n and s c h e d u l e f o r o r g a n i z i n g and c o m p l e t i n g t h e p r o j e c t , q u a l i f i c a t i o n s o f t h e p r i n c i p a l i n v e s t i g a t o r ( s 1 and s t a f f , adequacy o f t h e f a c i l i t i e s a v a i l a b l e t o c a r r y o u t t h e p r o j e c t , r e a s o n a b l e n e s s o f t h e b u d g e t , and adequacy o f t h e p r o p o s e d p r o t e c t i o n o f human and animal s u b j e c t s .
If t h e p r o p o s e d p r o j e c t s on HIV-related i l l n e s s e s a r e no more t h a n 2 y e a r s i n l e n g t h and r e q u i r e no more t h a n $50,000 i n t o t a l d i r e c t c o s t s f o r t h e e n t i r e p r o j e c t p e r i o d , t h e y are e l i g i b l e f o r a c c e l e r a t e d review. P r o j e c t s intended f o r a c c e l e r a t e d r e v i e w must b e s e n t d i r e c t l y t o NCHSR (Room 18A-20). Because o f a m o d i f i e d r e v i e w p r o c e s s t h a t i n v o l v e s b o t h F e d e r a l and non-Federal e x p e r t s , NCHSR i s a b l e t o n o t i f y a p p l i c a n t s o f f u n d i n g d e c i s i o n s w i t h i n a p p r o x i m a t e l y 120 d a y s . D e a d l i n e s f o r r e c e i p t o f t h e s e a p p l i c a t i o n s a t NCHSR are t h e f i r s t working day of t h e f o l l o w i n g months: J a n u a r y , March, May, July, September , and November. F u r t h e r i n f o r m a t i o n on h e a l t h s e r v i c e s r e s e a r c h and HIV-related b e o b t a i n e d from:
i l l n e s s e s may
D i v i s i o n of Extramural Research N a t i o n a l C e n t e r f o r H e a l t h S e r v i c e s Research and H e a l t h Care Technology Assessment Room 18A-19, Parklawn B u i l d i n g 5600 F i s h e r s Lane R o c k v i l l e , Maryland 20857 Telephone: ( 3 0 1 ) 443-7352
AIDS R e s e a r c h C o o r d i n a t i o n S t a f f
I r a E . Raskin, Ph.D.
A copy o f t h e program n o t e on HIV-related
i l l n e s s e s c a n b e o b t a i n e d from:
P u b l i c a t i o n s and I n f o r m a t i o n Branch
N a t i o n a l Center f o r H e a l t h S e r v i c e s Research
and H e a l t h Care Technology Assessment Parklawn B u i l d i n g , Room 18-12 R o c k v i l l e , Maryland 20857 Telephone: ( 3 0 1 ) 443-4100
Vol. 17, No. 39, November 25, 1988
*U. S.GOVfRNmfNT
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P R I N T I N G O f f ICE:1986-241-215r60019