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					                     Perilla leaf

     What is Rosmarinic Acid?Super Function of
              RosA,Rosmarinic Acid?

 seminal trace...Red Perilla leaf Extracts.Perilla Seed
 Extracts,Rosemarinic Acid 10%20%UV.20283-92-
  5.Rosemary acid.M.W.C18 H16O8.Red Perilla leaf
      Stem Extracts.Sclareol,CAS 515-03-7....

    What is Rosmarinic Acid and the botanical origin
                  Purple Perilla?

               What is Rosmarinic Acid?

 Chemical Name:Cinnamic acid,3,4-dihydroxy-,2-ester
       with 3-(3,4-dihydroxyphenyl)lactic acid.
            CAS No.:20283-92-5. Molecular
    Formula:C18H16O8. Molecular Weight: 360.34
  Synonyms: Benzenepropanoic acid,alpha-((3-(3,4-
    dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-3,4-
 dihydroxy-;3,4-Dihydroxycinnamic acid 2-ester with
  3-(3,4-dihydroxyphenyl)lactic acid;R-(+)-2-(3,4-
           Dihydroxycinnamoyloxy)-3-(3,4-
      dihydroxyphenyl)propionic acid;Rosemary
         acid;Rosmarinic acid;(R)-a-[[3-(3,4-
   Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-
          dihydroxy-benzenepropanoic acid.
    Safety:Certified by FDA as public food material
(GRAS,21 CFR Chapter 21,part182). NoHarm to health.
         Stability:Good stability,stable in high
               temperature(180 deg C).
  What is Rosmarinic Acid and the botanical origin
Purple Perilla?
  Main constituents and Phytochemicals of Purple
Perilla:
  Traditional Medicinal Uses of Purple Perilla:
  Rediscovery of Perilla frutescens as medicinal plant
and vegetable with health promoting properties:
  Perilla frutescens Extract enriched for polyphenolic
phytochemical rosmarinic acid, inhibits seasonal
allergic rhinoconjunctivitis in humans:
  Effect of oral treatment of Perilla frutescens and its
constituents on type-I allergy:
  Rosmarinic acid inhibits epidermal inflammatory
responses: anticarcinogenic effect of Perilla
frutescens extract in the murine two-stage skin
model.:
  Metabolome analysis of anthocyanin-producing
Perilla frutescens and an Arabidopsis mutant:
  Common perilla (Perilla frutescens (L.) Britton.) as a
perspective immunomodulator:
  Lipoxygenase Inhibitors as Potential Cancer
Chemopreventives:
  Perilla leaves Increase the tolerance of the body
against pollen:
  Purple Perilla Rosmarinic Acid and its application
dosage:
 Medical functions of Rosemarinic Acid:
 Effects of Perilla Seed Extract:
 Application of Perilla leaf:
 Rosemarinic Acid Safety & Toxicology:
 Research update of Perilla related.:


  Basic Info of the botanical origin Purple Perilla?

 Botanical Source:Perilla frutescens(L.)
Britt.(leaf);Perilla Green or Purple Perrila.
 Dry leaf of Perilla frutescens (L.) Britt.var. crispa
(Thunb.) Hand.-Mazz.; or Perilla frutescens (L.) Britt.
var.acuta (Thunb.) Kudo.
 Scientific Name:Perilla frutescens (L.) Britt. var.
arguta (Benth.) Hand. - Mazz.
 Synoms: Dentidia nankinensis; Ocimum frutescens;
Perilla arguta; Perilla frutescens var. japonica; Perilla
nankinensis; Perilla ocimoides;Chinese
basil;Rattlesnake Weed;Perilla frutescens
Britton;Lamiaceae-heimo;Perilla crispa;Perilla-
Purple;Wild coleus.
 Common name:Folium Perillae, English Name: Perilla
Leaf;the purple-leafed variety Perilla Red;Purple
common perilla Leaf.
 Note:Rattle the dry seed stalks of a wild plant called
perilla and you may think a rattlesnake is nearby.
That's how the plant got one of its names -
rattlesnake weed - but it is also called beef steak
plant, wild basil and summer coleus. It grows widely
in the Ozarks and can be used as a food and flavoring.
 Family:lamiaceae
 Life cycle:annual
 Plant Part Used: Leaf
 Medicinal Name:Caulis Perillae
 Common name:beafsteak mint
 Name Difference:
 Perilla frutescens: Perilla Mint; Beef-steak plant;
Purple Mint; Copper leaf
 Perilla ocimoides: Chinese Basil;
 Common names extracts:Perilla Leaf Extract,Folium
Perillae Extract,Perilla frutescens (L. ) Britt.
Extract;Purple Perilla Plant Extract;
 Origin:The plant is native to South East and East
Asia,major China, to north America and Europe.Asia.
It is a traditional crop of China, India, Thailand, and
other Asian countries.
 Used plant part:There are two variants of Perilla
frutescens grown in China: The var. crispa, called
ZiSu, has attractive, crispate foliage and is grown for
the aromatic leaves, which may be green perrila or
red perrilla. The leaves are always used fresh, but can
be frozen.
 The other variant is frutescens known as white
perrila. It is valued for the oil extracted from the
seeds, which is used for food supplement.
Occasionally, the dry seeds find use as a spice.

 Annual herb with purple foliage, spikes of lavender
flowers in summer. It self-seeds abundantly in our
garden, which makes for quite a display of massed
plants. It's easy to pull up, though, and doesn't spread
itself very far from the mother plant, so it really never
becomes a nuisance.

 Sensoric quality:
 Aromatic but difficult to describe; the fragrance
reminds me of cinnamon and anise or licorice. The
taste is similar, but with a marked adstringent
component.
 As with many other plant of the same family,
olfactory characteristics are quite variable and
depend, besides genetic factors, also on soil and
climate.
  Main constituents and Phytochemicals of Purple
Perilla:

 Major Phytochemicals of Perilla oil: Pinene,
Camphene, Myrcene, Limonene, Humulene,
Caryophyllene, 3-Octanol, 1-Octen-3-ol, Linalool,
Terpineol, 10-Pinanol, Perillyl alcohol, Phenylethyl
alcohol, 10-Pinanal, Perillaldehyde, Benzaldehyde,
Carvone, Linalool oxide,1-perillaldehyde;1-perilla-
alcohol;elshottzia ketone.
 Perilla leaves contain about 0.2% of an essential oil,
which varies widely in composition. Several different
chemotypes are known: PA (see below) is the only is
the only one of culinary value; the others are PK
(main component perilla ketone, minor components
isoegomaketone and perillene), EK (main component
elsholzia ketone, minor component naginata ketone),
PL (main component perillene, minor components
citral, perilla ketone, isoegomaketone), PP
(phenylpropanoids: myristicin, dillapiol, elemicin,
safrole) and C (main component citral, minor
components perillene, perilla ketone,
isoegomaketone). There is also a type rich in
rosefurane, which might have potential as a cheaper
substitute for rose oil in perfumery.
 Perilla flowering plants:
 In the most frequently cultivated chemotype (PA),
the main component is perillaldehyd (p-menthadien-
1,8(9)-al(7), 75%) Its minor constituents are
limonene (13%), linalool, Beta-caryophyllene, l-
menthol, limonene, Alfa-pinene, perillene (2-methyl-
5-(3-oxolanyl)-2-pentene) and elemicin. Perillaldehyd
can cause skin allergies.
 The C type is a potentially interesting source of citral,
a pleasantly lemon-scented material much used in the
flavour and perfume industries; see lemon myrtle for
more on lemony flavours and citral.
 The PP type may also gain importance as a source of
simple phenylpropanoids in the pharmaceutical
industry. The high myristicin content makes this plant
considerably toxic.
 The dominating constituents of the remaining types
are monoterpenoid furanes, often ketones. Some of
these, e.g., isoegomaketone, are severe pneumotoxins
that have caused fatal poisoning in cattle repeatedly.
The PK type must be considered a toxic plant that has
no use in kitchen.
 The oxime of perilla aldehyd (perillartin) is about
2000 times sweeter than sucrose; it is used as an
artificial sweetener in China.
 Perilla seeds contain a drying oil (40%) with high
content of multiply unsaturated fatty acids (60% ¦Á-
linolenic acid, 15% both linoleic and oleic acid); their
medicinal value is sometimes matter of great
exaggeration.
 Lastly, perilla contains the pseudotannins and
antioxidants typical for the mint family; see hyssop for
details. The reddish-purple colour of some cultivars is
caused by an anthocyan pigment called perillanin
             chloride.



             Traditional Medicinal Uses of Purple
           Perilla:

             Asian herbalists prescribe perilla for
cough and lung afflictions, influenza prevention,
restless fetus, seafood poisoning, incorrect energy
balance, etc.
 Studies of perilla volatile oil have revealed that
distinct chemotypes of perilla have dramatically
different biological effects.
 Besides its pharmaceutical
applications, Perilla plays an
important role in Asian
cuisine;Beefsteak Plant, the English
name of Perilla,
is used to
prepare and
preserve meat.
Its lemon-like,                  sweetish taste makes
Perilla, and                     Perilla Red in
particular, an                   interesting ingredient.

                                    Rediscovery of
Perilla                          frutescens as
medicinal plant                  and vegetable with
health promoting properties:

 Chinese medicine has used Perilla frutescens for
centuries, either alone or in combination with other
herbs. Recent scientific studies have shown its
antiallergic, anticancerogenic, antiinflammatory and
antioxidative effects. Different plant components may
be used. Perilla essential oil, because of its
antimicrobial and antibacterial action, is not only
applied to medicine, but also to preserve food.
 The 'fatty' oil of Perilla has been shown to inhibit the
growth of some types of cancer while alpha-linolenic
acid of Perilla is nearly as effective as fish oil in
reducing blood cholesterol and triglyceride
concentrations. Especially cultivars with violet leaves
called Perilla Red show high antioxidative capacity
due to their anthocyan and flavonoid content.
 Besides its pharmaceutical applications, Perilla plays
an important role in Asian cuisine;Beefsteak Plant, the
English name of Perilla, is used to prepare and
preserve meat. Its lemon-like, sweetish taste makes
Perilla, and Perilla Red in particular, an interesting
ingredient.



   Perilla frutescens Extract enriched for polyphenolic
phytochemical rosmarinic acid, inhibits seasonal
allergic rhinoconjunctivitis in humans:

 Extract of Perilla frutescens enriched for rosmarinic
acid, a polyphenolic phytochemical, suppresses
allergic immunoglobulin responses and inflammation
caused by polymorphonuclear leukocytes (PMNL) in
mice.
 However, few placebo-controlled clinical trials have
examined the efficacy and safety of polyphenolic
phytochemicals for treatment of allergic inflammatory
diseases in humans. The present study determined
whether oral supplementation with rosmarinic acid is
an effective intervention for patients with seasonal
allergic rhinoconjunctivitis (SAR).
 In this 21-day, randomized, double-blind, age-
matched, placebo-controlled parallel group study,
patients with mild SAR were treated daily with extract
of Perilla frutescens enriched for rosmarinic acid (200
mg [n=10] or 50 mg [n=9]) or placebo (n=10).
 Patients recorded symptoms daily in a diary. Profiles
of infiltrating cells and concentrations of eotaxin, IL-
1beta, IL-8, and histamine were measured in nasal
lavage fluid. Serum IgE concentrations and routine
blood tests were also examined. As compared with
placebo supplementation, supplementation with
extract of Perilla frutescens enriched for rosmarinic
acid resulted in a significant increase in responder
rates for itchy nose, watery eyes, itchy eyes, and total
symptoms (P<0.05).
 Active treatment significantly decreased the numbers
of neutrophils and eosinophils in nasal lavage fluid
(P<0.05 vs. placebo). Patients reported no adverse
events, and no significant abnormalities were
detected in routine blood tests.
 In conclusion, extract of Perilla frutescens enriched
for rosmarinic acid can be an effective intervention for
mild SAR at least partly through inhibition of PMNL
infiltration into the nostrils. Use of this alternative
treatment for SAR might reduce treatment costs for
allergic diseases.



   Effect of oral treatment of Perilla
frutescens and its constituents on type-
I allergy:

 Perilla frutescens Britton (perilla,
Labiatae) is a medicinal herb
prescribed in formula effective for
allergic diseases such as bronchial
asthma.
 Study research was conducted to evaluate the anti-
allergic effect of orally administered perilla decoction
and to identify the active constituents using mice ear-
passive cutaneous anaphylaxis (PCA)-reaction, which
is one of the animal models for type I allergy.
 Perilla decoction significantly suppressed PCA-
reaction, and the inhibition % at the dose of 500
mg/kg was 43%.
 The perilla decoction contains 5.3% of luteolin 7-O-
[beta-glucuronosyl(2-->1)beta-glucuronide], 1.6% of
apigenin 7-O-[beta-glucuronosyl(2-->1)beta-
glucuronide], 0.49% of scutellarin, and 2.5% of
rosmarinic acid (weight of compound/dried weight of
perilla decoction %), respectively.
 When these constituents were orally administered to
mice at the dose equivalent to 500 mg/kg of perilla
decoction, rosmarinic acid and apigenin 7-O-[beta-
glucuronosyl(2-->1)beta-glucuronide] significantly
suppressed PCA-reaction, and their inhibition % was
41% (p<0.01) and 32% (p<0.05), respectively.
 Since the inhibition % or perilla decoction and
rosmarinic acid were nearly equal, the anti-allergic
effect of perilla decoction depends primarily on
                 rosmarinic acid.



                  Rosmarinic acid inhibits epidermal
               inflammatory responses:
               anticarcinogenic effect of Perilla
               frutescens extract in the murine two-
               stage skin model.:

               Perilla frutescens extract showed
               marked reduction on tumorigenesis in a
               murine, two-stage skin carcinogenesis
model.
In this model, cancer is initiated by application of
7,12-dimethylbenz[a]anthracene (DMBA) and
promoted by application of 12-tetradecanoylphorbol
13-acetate (TPA). Following tumor initiation with
DMBA, topical application of a perilla-derived fraction
(PF) at doses of 2 mg/mouse/application resulted in
significant inhibition of tumorigenesis.
 The efficacy of each fraction was correlated with
rosmarinic acid (RA) and luteolin concentration.
Topical application of perilla extract (PE) that
contained 68% RA or an equivalent amount of
commercially available RA showed nearly identical
antiinflammatory activity 5 h after TPA treatment.
 Application of luteolin had less anti-inflammatory
activity. Marked neutrophil infiltration was observed
in TPA-challenged skin by histological examination
using hematoxylin-eosin. This change was greatly
reduced by pre-treatment with PE or RA.
Myeloperoxidase activity, a marker of neutrophil
recruitment, was also increased in TPA-challenged
skin and was significantly decreased in the PE and RA
treated groups.
 Intercellular adhesion molecule 1 and vascular cell
adhesion molecule-1 mRNA expression levels were
reduced by pre-treatment with PE or RA. TPA-induced
increases in synthesis of the chemokines KC and
macrophage inflammatory protein-2 were significantly
decreased by pre-treatment with PE or RA.
Prostaglandin E2 and leukotriene B4 levels were
slightly increased 5 h after TPA treatment.
 These levels were only numerically decreased in the
PE and RA treated groups. However, induction of
cyclooxygenase-2 mRNA expression was obviously
reduced by pre-treatment with PE or RA. Reactive
oxygen radical production, detected as thiobarbituric
acid reactive substance and lipid peroxide, by double
treatment of TPA was reduced by pre-treatment with
PE or RA.
 Production of 8-hydroxy-2'deoxyguanosine, which
     was detected immunohistochemically, was also
     induced by double treatment with TPA. This
     adduct was barely visible in PE or RA treated
mice.
 Thus, we conclude that part of the anticarcinogenic
effects of P.frutescens extract is due to RA via two
independent mechanisms: inhibition of the
inflammatory response and scavenging of reactive
oxygen radicals.



  Metabolome analysis of anthocyanin-producing
Perilla frutescens and an Arabidopsis mutant:

 An anthocyanin-producing medicinal plant, Perilla
frutescens, has two chemo-varietal forms,
anthocyanin-producing red form and non-producing
green form. We have extensively studied on gene
expression in these two forms.
 Metabolome analysis was carried out with these two
forms of P. frutescens by high Performance liquid
chromatography-mass spectrometry (LC-MS),
capillary electrophoresis(CE) and LC for amino acid
analysis. We also investigated the metabolite profiling
of Arabidopsis thaliana pap1-D mutant and transgenic
lines expressing pap1 cDNA, a Myb family gene.
 There was a striking difference in anthocyanin
accumulation; however, there were no quantitative
and qualitative differences in flavonols. No
remarkable differences were observed in the level of
rosmarinic acid, the main polyphenol compound, and
primary metaabolires such as amino acids and organic
acids between two forms.
 The metabolite profiling of Arabidopsis thaliana pap1-
D mutant and transgenic lines expressing pap1 cDNA
showed that both pap1-D mutant and the transgenic
lines over-accumulated cyanidin-type anthocyanins.
The extensive metabolite profiles of these plants
indicated that the content of quercetin-type flavonols
increased; whereas that of kaempferol-type
               metabolites decreased.



                  Common perilla (Perilla frutescens
               (L.) Britton.) as a perspective
               immunomodulator:

                Common perilla (Perilla frutescens (L.)
               Britton) is a new perspective annual
               medicinal dead-nettle family
               (Lamiaceae Lindl.) plant
                Its medicinal raw material and
preparations produced of it are characterised by the
variety of pharmacological effects: desensitizing,
antimicrobial, anti tumorous, and antioxidative.
 This species was introduced from the East Asia and
cultivated in many European, Asian, and North
American countries.


  Lipoxygenase Inhibitors as Potential Cancer
Chemopreventives:

 Research and experiment proved that lipoxygenase
(LO)-catalyzed products have a profound influence on
the development and progression of human cancers.
 Compared with normal tissues, significantly elevated
levels of LO metabolites have been found in lung,
prostate, breast, colon, and skin cancer cells, as well
as in cells from patients with both acute and chronic
leukemias. LO-mediated products elicit diverse
biological activities needed for neoplastic cell growth,
influencing growth factor and transcription factor
activation, oncogene induction, stimulation of tumor
cell adhesion, and regulation of apoptotic cell death.
 Agents that block LO-catalyzed activity may be
effective in preventing cancer by interfering with
signaling events needed for tumor growth. In fact, in
a few studies, LO inhibitors have prevented
carcinogen-induced lung adenomas and rat mammary
gland cancers.
 Rosmarinic acid,linoleic acids all good Lipoxygenase
Inhibitors, and could find from perilla leaves and
perilla seeds.



   Perilla leaves Increase the tolerance
of the body against pollen:

 A natural alternative for allergies Food
supplement containing extract of
Perilla frutescens,formulas contains a
high quality herbal extract of Perilla
frutescens, which helps increase the
tolerance of the body against pollen,
dust and other materials causing allergic reactions.


  Purple Perilla Rosmarinic Acid and its application
dosage:

  1.Origin,Effective Content:

 1.Originº completely soluble in water and natural
anti-oxide essentials compound;extracted from
Labiata kind plant herb Perrila(Red Perilla Leaves);
 2.Effective Contentº:Rosmarinic Acid 10%HPLC,or
Rosmarinic Acid 20%UV, Rosemarinic Acid has good
characters to remove free waste and bases and anti-
inflammation function.
     3.Characters:Certified by FDA as public food
    material (GRAS,21 CFR Chapter 21,part182)
     High activity;a lot of kinds,apply and used as
    Nutraceutical and special food material.
     Completely soluble in water;could be used
    directly in water and other solutions;
     Antioxidation ability better than VC, at least 20
times
 Suggestive dosage 0.02%~~0.04%(200~~400ppm),
in GMP conditions;no highest dosage limited



  2. dosage in doving food£morning and evening
wheat flake;cacks;sapor sorce;first soluble:

Rosemarinic Acid in water;then got the solution into
material when mixing round,the best result could be
got when added before heating .

Usage:Suggestive Dosage of Rosmarinic Acid

 Doving Food:cookies;flimsy
cack;confectionery,etc;0.01~~0.07%
 Morning Cornmeal pound;etc.0.01~~0.05%
 Nosh:0.02~~0.08%
 Shalad;bechamel;etc:0.02~~0.1%
 Soup material:0.03~~0.1%
 Spray Dried food:0.03~~0.1%
 Mixed flavouring:0.04~~0.08%
 Confectionery biscuit materials for
food:0.03~~0.07%
 Dried pet fodder:0.04~~0.01%



  3. Dosage in meat,fish,sea-food:
 Applying Field...Dosage Method:
  Puoltry Meat:twisting meat or banger:
0.02~~0.06% of total weight of meat, First soluble in
water; added the solution during crashing or mixing.
  Poultry piece:
 0.02~~0.06% of total weight: Dissolve Rosemarinic
Acid in halogen solution or salt water,marinating;
 0.03~~0.07% of total weight: First soluble in water;
added the solution during crashing or mixing.
  Pork;banger or twisting meat: 0.03~~0.08% of total
weight: First soluble in water; added the solution
during crashing or mixing.
  Beef;banger or beef meat: 0.03~~0.08% of total
weight: First soluble in water; added the solution
during crashing or mixing.
  Beaf piece:
 0.03~~0.06% of total weight: Dissolve Rosemarinic
Acid in halogen solution or salt water,marinating or
clashing dehydrated meat
 0.04~~0.08% of total weight: First soluble in
water;added the solution during crashing or mixing.
  Fish and seafood: 0.01~~0.04% of total weight:
Dissolve Rosemarinic Acid in halogen solution or salt
                         water,marinating or clashing



                         Medical functions of
                       Rosemarinic Acid:

                          Rosemarin is Labiata kind
plant and could be used as herb medicine with full
plant, taste sour,Taste good and good for stomach;has
functions of smoothing nerve and calming down;used
for curing headache and nerve weakness.
 More functions proved to have, such as killing
bacteria;good for ladies in menopause;strenthening
pallium controlling ability;
          and with good calming;hypnosising;anti-
         convulsion;adjusting blood pressure;and
more other functions
 Also widely used as aroma;health caring food
,nutrition supplying and daily-chemical industry.



   Effects of Perilla Seed Extract:

 Perilla Seed Extract, derived from Perilla frutescens, a
traditional chinese herb, has been used in folk
medicine for years. Recent studies have shown that
Perilla Seed polyphenols regulate allergic diseases
due to 5-lipoxygenase inhibitory activity and
suppression of histamine release from mast cells.
 The functional compounds of Perilla Seed Extract are
flavonoid aglycons such as luteolin, apigenin,
chrysoeriol, and rosemarinic acid. It is known that the
antioxidative activity and lipoxygenase inhibitory
activity of flavonoid aglycons are stronger than that of
corresponding glycosides.
 Studies have shown that Perilla Seed Extract inhibits
the growth of cariogenic and periodontopathogenic
microorganisms which in turn reduces plaque
formation and acid production, helping to prevent
dental carries.
 Perilla Seed Extract also reduces inflammation of the
gingiva improving periodontal disease conditions.
 Perilla Seed Extract is an ideal, all natural addition to
tooth paste and mouthwash.


   Application of Perilla Leaf:

 1. Inducing sweat, relieving external symptoms and
facilitating the flow of lung-qi to relieve coughing:
 The purple perilla is used to treat common colds
caused by wind-cold, to relieve common cold with
headache as well as coughing caused by wind-cold
and thin sputum, and to alleviate asthma, feelings of
fullness in the chest and nasal obstruction or sneezing
due to attack of pathogenic wind-cold.

 2. Promoting circulation of qi to alleviate stagnation
in the spleen and stomach:
 It is used to treat nausea, vomiting, or vomiting
during pregnancy due to the stagnation of qi in the
spleen and stomach.

 3. Removing fish or crab Toxins:
 It is used to treat abdominal pain, vomiting, or
vomiting with diarrhea resulting from eating fish or
crabs. Cooking the leaves or stems with fish or crabs
can prevent poisoning or allergy. It is often used in
combination with ginger.

  Modern Researches:

 Perillaldehyde is the main ingredient of purple perilla
leaves.
 Synonyms:dihydrocuminyl aldehyde;4-(1-methyl
ethenyl)-1-cyclohexene-1-carboxaldehyde;4-
isopropenyl-1-cyclohexene-1-carboxaldehyde;para-
mentha-1,8-dien-7-al;perilla aldehyde

1. Its oral decoction or extraction can relieve fever.

 2. It can increase the secretion of digestive juices,
promote the peristalsis (successive waves of
involuntary contraction passing along the walls
intestines) and forcing the contents onward of the
stomach and intestines, reduce the secretion of the
bronchus and alleviate spasms of the bronchus.

3. Its active ingredients contain perillaldehyde, which
can raise the blood sugar.

4. The water decoction of this herb contains volatile
oil which can inhibit colibacillus, shigella dysenteriae
or staphylococcus.


   Rosemarinic Acid Safety & Toxicology:

 Acute toxicity(LD50):Rosemarinic Acid LD50:lethal
dose,50 percent kill. Intravenous. Rodent-mouse.
561mg/kg.
 Details of toxic effects not repeated other than lethal
dose value.
 Reference: DRFUD4 Drugs of the
Future.(J.R.Prous,S.A.,Apartado de Correos 540,08080
Barcelona,Spain) V.1-1975/76-
volume(issue)/page/year:10,756,1986.

				
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