William A. Hill, DVM, email@example.com
Public Health Service Policy on Humane Care and Use of Laboratory Animals
NIH, Office of Laboratory Animal Welfare. Amended August 2002. Pages 1-14.
1. The 2002 reprint of the Public Health Service Policy on Humane Care and Use of
Laboratory Animals includes the Health Research Extension Act of 1985, Public
Law 99-158. The Health Research Extension Act of 1985 describes the
composition of the institutional animal care committee. What does the act set
forth regarding composition of the committee?
2. According to the Health Research Extension Act of 1985, how often shall the
institutional animal care committee review the care and treatment of animals in all
animal study areas and facilities of the research entity?
3. According to the Health Research Extension Act of 1985, how often must the
institutional animal care committee file with the Director of NIH a certification
that the review has been conducted and report any violation of established
guidelines or assurances which were observed in such review and which have
continued after notice by the committee?
4. According to the Health Research Extension Act of 1985, who has the authority
of suspend or revoke grants or contracts if the conditions of animals care,
treatment, or use in an entity which is receiving a grant, contract, or cooperative
agreement involving research on animals under said act do not meet established
5. True or False. Guidelines and regulations promulgated under subsection a or c
may require a research entity to disclose publicly trade secrets or commercial or
financial information which is privileged or confidential.
6. The 2002 reprint of the Public Health Service Policy on Humane Care and Use of
Laboratory Animals includes the US Government Principles for the Utilization
and Care of Vertebrate Animals Used in Testing, Research, and Training.
According to these principles, if exceptions are required, where should the
decisions rest with regard to these exceptions?
7. What group or body is responsible for the development of the US Government
Principles for the Utilization and Care of Vertebrate Animals Used in Testing,
Research, and Training.
8. How does the PHS Policy on Humane Care and Use of Laboratory Animals
9. Before activity involving animals may be conducted or supported by the PHS the
institution conducting the action must provide a written Assurance acceptable to
the PHS, setting forth compliance with the PHS policy. Where must such
assurances by submitted? Who must sign the assurance?
10. Approval of an Assurance will be for a specified period of time not to exceed how
11. As related to institutional status as defined by the PHS Policy on Humane Care
and Use of Laboratory Animals, define a Category 2 institution.
12. The PHS Policy on Humane Care and Use of Laboratory Animals outlines the
composition of an Institutional Animal Care and Use Committee. According to
the policy, the committee shall consist of not less than how many members and
shall include at least?
13. What document is to be used by IACUCs when completing semi-annual
evaluations as detailed in the PHS Policy on Humane Care and Use of Laboratory
14. Define “significant deficiency” as defined in the PHS Policy on Humane Care and
Use of Laboratory Animals.
15. As outline in the PHS Policy on Humane Care and Use of Laboratory Animals,
methods of euthanasia will be consistent with the recommendations outlined
16. According to the PHS Policy on Humane Care and Use of Laboratory Animals,
how long must records relatively to applications, proposals, and proposed
significant changes in ongoing activities reviewed and approved by the IACUC be
17. What body is responsible for the general administration and coordination of the
PHS Policy on Humane Care and Use of Laboratory Animals?
18. True or False. Institutions may request a waiver of a provision or provisions of
this Policy by submitting a request to OLAW.
19. As of the 2002 revision of the Policy, what is the only accrediting body
recognized by PHS?
20. The Health Research Extension Act of 1985 requires the IACC to be appointed by
1. Each animal care committee shall be composed of not fewer than three members,
and shall include at least one individual who has no association with such entity
and at least one doctor of veterinary medicine.
2. At least semiannually to evaluate compliance with applicable guidelines
established for appropriate animal care and treatment
3. At least annually
4. Director of NIH
6. Where exceptions are required in relation to the provisions of these Principles, the
decisions should not rest with the investigators directly concerned but should be
made, with due regard to Principle II, by an appropriate review group such as an
institutional animal care and use committee. Such exceptions should not be made
solely for the purposes of teaching or demonstration.
7. Interagency Research Animal Committee
8. Any live, vertebrate animal used or intended for use in research, research training,
experimentation, or biological testing of for related purposes.
9. To the Office of Laboratory Animal Welfare (OLAW), Office of the Director,
National Institutes of Health; Institutional official
10. Five (5)
11. All of the institution’s programs and facilities for activities involving animals
have been evaluated by the IACUC and will be re-evaluated by the IACUC at
least once every six months.
12. Five (5) members; one doctor of veterinary medicine with training or experience
in laboratory animal science and medicine, who has direct or delegated program
authority and responsibility for activities involving animals at the institution; one
practicing scientist experienced in research involving animals; one member whose
primary concerns are in a nonscientific area; and one individual who is not
affiliated with the institution in any way other than as a member of the IACUC,
and is not a member of the immediate family of a person who is affiliated with the
13. Guide for the Care and Use of Laboratory Animals
14. A significant deficiency is one, which, is or may be a threat to the health or safety
of the animals.
15. American Veterinary Medical Association (AVMA) Panel on Euthanasia
16. For the duration of the activity and for an additional three years after completion
of the activity.
17. OLAW (Office of Laboratory Animal Welfare)
19. Association for Assessment and Accreditation of Laboratory Animal Care
20. Chief executive officer of the entity for which the committee is established.
OLAW considers the CEO to be the highest operating official of the organization.
If the CEO delegates authority to appoint the IACUC the delegation must be
specific and in writing. The CEO may or may not be the Institutional Official.