Summary of Research Interests by ygc11592


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									                                            Faculty Profile

Name:                      Toshio Akiyama, M. D.

Unit/Division:             Cardiology/Medicine

Phone:                     (585) 275-1667


URMC Box #:                679

Summary of Research

My primary interests are currently in the areas of cardiac arrhythmia, heart block, pacemaker,
defibrillator, and medical education/training. The projects, which were conducted in the recent past
by medical students/residents under my guidance; occurrence of myocardial stunning in the survivors
of cardiac arrest due to VT/VF (a pilot study was conducted in the summer of 1999 strongly
suggesting that the myocardial stunning did take place in those survivors in whom successful
resuscitation was begun within 4-6 minutes of the cardiac arrest, while the myocardial stunning not
taking place when the resuscitation was begun either immediately after or after prolonged periods of
asystole---this occurrence of myocardial stunning after cardiac arrest has never previously
documented.); P.H. Takeyama and T. Akiyama. Acta Medica et Biologica 2004;52:97-101.);
Evaluation with cardiac catheterization and echocardiography in patients undergoing ICD implantation
(A pilot study with former medical residents J.D. Filippone and R. Bhah, Showing relatively higher
frequency of coronary artery disease (at least 44%) and valvular heart disease (at least 52%) of 120
consecutive ICD implanted patients. This study, thus, suggests a need for coronary angiography and
echocardiogram prior to ICD implant. Manuscript submitted for publication; Lightning-induced
ventricular fibrillation by D.R. Levy (former medical resident). Dr. Akiyama’s recent publication
includes also, “Resumption of driving after life-threatening ventricular tachyarrhythmia”, T. Akiyama,
et al. New England J Medicine 2001; 345:391-7 (a lead article.)
                                            Faculty Profile

Name:                Bradford C. Berk, MD, PhD

Unit/Division:       Cardiology

Phone:               (585) 275-0810


URMC Box #:          MED

Research Interests:
  Dr. Berk's lab studies the mechanisms by which cells in the vascular wall respond to hemodynamic
and hormonal stimuli. The four major research projects include: 1) Mechanisms by which endothelial
cells respond to fluid shear stress and regulate gene expression and cell function. The role of redox
sensitive proteins such as thioredoxin in regulation of pro-inflammatory (e.g. ASK1) and anti-
inflammatory (e.g. ERK5) kinases is under investigation. 2) The control of smooth muscle cell growth
by angiotensin II focusing on the role of scaffold proteins in the activation of intracellular kinases by
the angiotensin II receptor. 3) The mechanisms by which oxidative stress alters the vascular
response to injury. The role of cyclophilin A, a chaperone and antioxidant protein, in atherosclerosis
and the response to injury is being studied. 4) The genetic basis for vascular remodeling in response
to altered blood flow is being investigated. A carotid flow reduction model has been characterized and
is being used to identify genes by QTL and microarray analysis in a cross between SJL and C3H
mouse strains.
  A clinical project that investigates the mechanisms responsible for increased thrombotic events in
patients receiving chemotherapy is underway. The role of circulating endothelial progenitor cells and
the mechanisms for endothelial cell apoptosis in response to chemotherapy are being studied.

Residents worked with: Ryan Hoefen (2006), Tom Cooney (2006)

                                            Faculty Profile

Name:                John D. Bisognano, MD PhD
                     Associate Professor of Medicine

Unit/Division:       Internal Medicine/Cardiology

Phone:               (585) 273-3760

Email:               John_Bisognano@URMC.Rochester.Edu

URMC Box #:          679T

Research interests:
  1. Acute Heart Failure
  2. Severe and Refractory Heart Failure
  3. Refractory Hypertension
  4. Hypertensive Emergencies and Urgencies
  5. Role of Structured Exercise Program in Secondary Prevention of Cardiovascular Disease
   Residents worked with: Ryan Nelson (2006)


                                            Faculty Profile

Name:                      Leway Chen, M.D., M.P.H.

Unit/Division:             Medicine/Cardiology

Phone:                     (585) 273-3760


URMC Box #:                679-T

Summary of Research
Interested in heart failure, transplant, and mechanical assist device research; also cardiovascular
health services research, database research, and clinical trials.

Current projects:
   Outcomes assessment database in the Cardiology Unit
   Heart failure databases and registries (inpatient and outpatient)
   Quality of life in heart failure
   Cardiopulmonary exercise testing and B-type naturetic therapy
   Echocardiographic and hemodynamic markers of cardiac rejection
   Cardiac rehabilitation in heart failure
   New mechanical assist device therapies
   Comparing transplant rejection medical therapies
   Diastolic dysfunction and diastolic heart failure
   Sleep disorders in heart failure patients
   Depression and heart failure


                                            Faculty Profile

Name:               Peter Kringstein, MD

Unit/Division:      Cardiology

Phone:              (585) 442-5320


Address:            2365 S. Clinton Avenue
                    Rochester, NY 14618

Research interests:
●    Ambulatory Blood Pressure Monitoring
●    Paradoxical Stroke
●    Adult Congenital Heart Disease

                                              Faculty Profile

Name:                       Frederick Ling, M.D.

Unit/Division:              Cardiology Unit

Phone:                      (585) 275-1669


URMC Box #:                 679C

Summary of Research:

I am the director of the Cardiac Catheterization Laboratory at Strong. Multiple research studies are
ongoing. Current areas of research suitable for resident projects include outcomes assessments of
patients with acute coronary syndromes or acute myocardial infarction treated by coronary

                                              Faculty Profile

Name:                Arthur J. Moss, M.D. and Wojciech Zareba, M.D., PhD

Unit/Division:       Heart Research Follow-up Program of the Cardiology Unit

Phone:              (585) 275-5391


URMCBox#:            653

Research interests:
Drs. Arthur J. Moss and Wojciech Zareba will offer a two week Core Research
Rotation in the Heart Research Follow-up Program of the Cardiology Unit to two residents (PGY-1)
for the academic year beginning July, 2005. The two week experience will involve regular meetings
with Drs. Moss and Zareba and associates
to develop and design a relevant clinical research study related to risk stratification, the clinical
course, or therapeutic efficacy of drugs in patients with coronary heart disease who are a part of our
existing MADIT or THROMBO databases. The rotation will include analyses of relevant medical
articles and a presentation at one of our weekly research meetings. For those so motivated we will
provide hands on experience in data analysis. The overall experience will be an in-depth exposure to
clinical cardiovascular research that can serve as a starting point for a specific research project that
can be carried out during the four and eight week rotations in PGY-2 and PGY-3 periods.

Residents worked with: Jae Hong (2005)

                                            Faculty Profile

Name:                      Thomas A. Rocco, Jr., MD

Unit/Division:             Cardiology/URMC /Highland Hospital

Phone:                     (585) 341-6780


URMC Box #:                15

Research interests:

CHF/Diastolic Dysfunction
Primary/Secondary Prevention
Electocardiographic Markers of Myocardial Dysfunction in Heart Failure
Aerobic Exercise in CHF
Aldosterone Receptor Blockade

Residents worked with: Ryan Connell (2005)


                                            Faculty Profile

Name:               Gladys Velarde, MD

Unit/Division:      Cardiology Unit/Internal Medicine

Phone:              (585) 341-7709


URMC Box #:         679 SCA

Research interests:

My research interests lie in the area of gender and ethnic differences in cardiovascular disease. I am
currently funded to start studying women with several markers of increased cardiovascular risk but no
overt CV disease. The PINK study will evaluate Prothrombotic, INflammatory, and platelet reactivity
marKers in women with the metabolic syndrome and test their response to specific therapy with
HMGCoA reductase vs. placebo. This will be a first of its kind women only study.
I am also interested in diastolic dysfunction in diabetics, hypertensives (especially African American)
and the elderly (especially women who suffer disproportionally of this condition) and the role of
echocardiography in trying predict which patients are at highest risk for DHF.

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