Bayer Schering Pharmas Approach to R_amp;D Internal and external

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					                 Bayer Schering Pharma´s Approach to R&D:
                 Internal and external sourcing of innovation




Prof. Dr. Hanno Wild
Senior Vice President
Global Lead Generation & Optimization
Global Drug Discovery – Bayer Schering Pharma
       Bayer – The inventor company
       A journey through the world of research at Bayer




                                                                 Reiner Fischer:
                                                                 Research on tetramic acids (Evidor®)        Elisabeth Perzborn, Susanne Röhrig,
                  Otto Bayer:                                                                                Alexander Straub:
                  Research in isocyanate chemistry                                                           Research on factor Xa inhibitor Xarelto®
                  (Polyurethanes)

                                                   „Science is made by man“
                                                     Werner Heisenberg (1901-1976)




Felix Hoffmann:
Synthesis of Acetylsalicylic acid                                                                                                      Hermann Schnell:
(Aspirin®)
                                                                                                                                       Development of
                                                                                                                                       Macrolon®
                                    Gerhard Domagk:                                             Klaus Grohe, Hans-Joachim Zeiler:
                                    Research on sulfomamides (Prontosil®)                       Development of Ciprobay®


                                                                            Page 2
Bayer Schering Pharma*
Key Data


                                                                        Diagnostic
                                                                         Imaging
           Among the top 10 specialty
           pharma companies worldwide                       General
                                                            Medicine
           Focus on 4 major
           business units

           Sales 2008:                                      Specialty
           EUR10,704 million                                Medicine

           Investments in R&D:                                          Women’s
           mid term 15 – 17 % of total                                  Healthcare
           net sales

           * USA/Canada: Bayer HealthCare Pharmaceuticals




• Page 3
Bayer Schering Pharma
Top 10 Products
      Product                                              2007   2008
      [EUR million]

      YAZ® / Yasmin® / Yasminelle® (Women’s Healthcare)   1,042   1,222
      Betaferon® / Betaseron® (Specialty Medicine)        1,028   1,144
      Kogenate® (Specialty Medicine)                       818     848
      Adalat® (General Medicine)                           614     626
      Avalox® / Avelox® (General Medicine)                 445     462
      Nexavar® (Specialty Medicine)                        270     462
      Mirena® (Women’s Healthcare)                         361     462
      Levitra® (General Medicine)                          332     341
      Cipro® / Ciprobay® (General Medicine)                383     338
      Glucobay® (General Medicine)                         298     304
Bayer Schering Pharma
Research Focus on Specialty Indications

                                  Cardiology                  Oncology
                                  Focus on acute heart        Focus on large solid
                                  failure, pulmonary          tumors
                                  hypertension, peripheral
                                  arterial obstructive
                                  disease


                                   Women´s Health             Diagnostic Imaging
                                   Focus on gynecological     Focus on molecular
                                   therapies, incl.           imaging in CNS,
                                   endometriosis, uterine     oncology and cardiology
                                   fibroids

  Main R&D Sites                                                    Innovation Centers
  Innovation Forum • February 2009, Beijing • Page 5




                       Berlin                     Wuppertal               US West Coast   Beijing
• Page 5, Prof. Wild
           Our R&D Pipeline
           Late stage pipeline filled with innovative small molecules
              Phase I (7)                          Phase II (17)                                     Phase III (18)
           Colorectal Cancer
           Colorectal Cancer       Acute Heart Failure
                                   Acute Heart Failure        Liposomal Formulation
                                                              Liposomal Formulation    Medical ill
                                                                                       Medical ill          NSCLC
                                                                                                            NSCLC
           L19-TNFalpha
           L19-TNFalpha            Cinaciguat
                                   Cinaciguat                 Kogenate®
                                                              Kogenate®                Xarelto®
                                                                                       Xarelto®             Nexavar®
                                                                                                            Nexavar®
                                   (sGC Activator)
                                   (sGC Activator)
           Gastro IBD
           Gastro IBD                                         Breast Cancer
                                                              Breast Cancer            SPAF
                                                                                       SPAF                 Thyroid Cancer
                                                                                                            Thyroid Cancer
           Lipoxin
           Lipoxin                 DME
                                   DME                        Nexavar®
                                                              Nexavar®                 Xarelto®
                                                                                       Xarelto®             Nexavar®
                                                                                                            Nexavar®
                                   VEGF Trap-Eye
                                   VEGF Trap-Eye
           Cancer MN
           Cancer MN                                          Ovarian or Peritoneal
                                                              Ovarian or Peritoneal    VTE Treatment
                                                                                       VTE Treatment        Multiple Sclerosis
                                                                                                            Multiple Sclerosis
           Immunoconjugate
           Immunoconjugate         PH in COPD // ILD
                                   PH in COPD ILD             Cancer
                                                              Cancer                   Xarelto®
                                                                                       Xarelto®             Alemtuzumab
                                                                                                            Alemtuzumab
                                   Riociguat
                                   Riociguat                  Nexavar®
                                                              Nexavar®
           Cancer
           Cancer                  (sGC Stimulator)                                    wet AMD
                                                                                       wet AMD              Bone Met. Prev.
                                                                                                            Bone Met. Prev.
           PI3K Inhibitor          (sGC Stimulator)           CRC                      VEGF Trap-Eye        Breast Cancer
           PI3K Inhibitor                                     CRC                      VEGF Trap-Eye        Breast Cancer
                                   2nd line Breast Cancer
                                   2nd line Breast Cancer     Nexavar®
                                                              Nexavar®                                      Bonefos®
                                                                                                            Bonefos®
           Cancer
           Cancer                  Lonaprisan (ZK-PRA)                                 CRVO
                                                                                       CRVO
           MEK-Inhibitor           Lonaprisan (ZK-PRA)        Additional Indications   VEGF Trap-Eye        OC
           MEK-Inhibitor                                      Additional Indications   VEGF Trap-Eye        OC
                                   Lung // Ovar // Prostate
                                   Lung Ovar Prostate         Nexavar®
                                                              Nexavar®                                      YAZ® Flex
                                                                                                            YAZ® Flex
           Hemophilia
           Hemophilia              Sagopilone (ZK-EPO)                                 PAH
                                                                                       PAH
           rec. Factor VII         Sagopilone (ZK-EPO)        Lung Infection           Riociguat            Menopause Management
           rec. Factor VII                                    Lung Infection           Riociguat            Menopause Management
                                   Alzheimer PET Imaging
                                   Alzheimer PET Imaging      Cipro® inhale
                                                              Cipro® inhale            (sGC Stimulator)
                                                                                       (sGC Stimulator)     Angeliq low-low
                                                                                                            Angeliq low-low
           Diagnostic Imaging
           Diagnostic Imaging      Florbetaben
           PET-Tracer              Florbetaben                OC                       CTEPH                Contraception
           PET-Tracer                                         OC                       CTEPH                Contraception
                                   Cancer
                                   Cancer                     E2+DRSP
                                                              E2+DRSP                  Riociguat
                                                                                       Riociguat            LCS (ULD LNG)
                                                                                                            LCS (ULD LNG)
                                   Regorafenib
                                   Regorafenib                                         (sGC Stimulator)
                                                                                       (sGC Stimulator)
                                                              OC
                                                              OC                                            Contraception
                                                                                                            Contraception
                                   Cancer
                                   Cancer                     Valette plus
                                                              Valette plus             ACS
                                                                                       ACS                  FC Patch Low
                                                                                                            FC Patch Low
                                   L19-SIP
                                   L19-SIP                                             Xarelto®
                                                                                       Xarelto®
                                                              Gram-neg. Pneumonia
                                                              Gram-neg. Pneumonia                           MRI LCM
                                                                                                            MRI LCM
                                                              Amikacin inhale
                                                              Amikacin inhale          HRPC
                                                                                       HRPC                 Gadovist®
                                                                                                            Gadovist®
                                                                                       Alpharadin™
                                                                                       Alpharadin™



           Status as of Oct 2009       New Molecular          Life Cycle
                                       Entities (NME)         Management (LCM)




• Page 6
           Our R&D Pipeline
           Biologicals
              Phase I (7)                          Phase II (17)                                     Phase III (18)
           Colorectal Cancer
           Colorectal Cancer       Acute Heart Failure
                                   Acute Heart Failure        Liposomal Formulation
                                                              Liposomal Formulation    Medical ill
                                                                                       Medical ill                  NSCLC
                                                                                                                    NSCLC
           L19-TNFalpha
           L19-TNFalpha            Cinaciguat
                                   Cinaciguat                 Kogenate®
                                                              Kogenate®                Xarelto®
                                                                                       Xarelto®                     Nexavar®
                                                                                                                    Nexavar®
                                   (sGC Activator)
                                   (sGC Activator)
           Gastro IBD
           Gastro IBD                                         Breast Cancer
                                                              Breast Cancer            SPAF
                                                                                       SPAF                         Thyroid Cancer
                                                                                                                    Thyroid Cancer
           Lipoxin
           Lipoxin                 DME
                                   DME                        Nexavar®
                                                              Nexavar®                 Xarelto®
                                                                                       Xarelto®                     Nexavar®
                                                                                                                    Nexavar®
                                   VEGF Trap-Eye
                                   VEGF Trap-Eye
           Cancer MN
           Cancer MN                                          Ovarian or Peritoneal
                                                              Ovarian or Peritoneal    VTE Treatment
                                                                                       VTE Treatment                Multiple Sclerosis
                                                                                                                    Multiple Sclerosis
           Immunoconjugate
           Immunoconjugate         PH in COPD // ILD
                                   PH in COPD ILD             Cancer
                                                              Cancer                   Xarelto®
                                                                                       Xarelto®                     Alemtuzumab
                                                                                                                    Alemtuzumab
                                   Riociguat
                                   Riociguat                  Nexavar®
                                                              Nexavar®
           Cancer
           Cancer                  (sGC Stimulator)                                    wet AMD
                                                                                       wet AMD                      Bone Met. Prev.
                                                                                                                    Bone Met. Prev.
           PI3K Inhibitor          (sGC Stimulator)           CRC                      VEGF Trap-Eye                Breast Cancer
           PI3K Inhibitor                                     CRC                      VEGF Trap-Eye                Breast Cancer
                                   2nd line Breast Cancer
                                   2nd line Breast Cancer     Nexavar®
                                                              Nexavar®                                              Bonefos®
                                                                                                                    Bonefos®
           Cancer
           Cancer                  Lonaprisan (ZK-PRA)                                 CRVO
                                                                                       CRVO
           MEK-Inhibitor           Lonaprisan (ZK-PRA)        Additional Indications   VEGF Trap-Eye                OC
           MEK-Inhibitor                                      Additional Indications   VEGF Trap-Eye                OC
                                   Lung // Ovar // Prostate
                                   Lung Ovar Prostate         Nexavar®
                                                              Nexavar®                                              YAZ® Flex
                                                                                                                    YAZ® Flex
           Hemophilia
           Hemophilia              Sagopilone (ZK-EPO)                                 PAH
                                                                                       PAH
           rec. Factor VII         Sagopilone (ZK-EPO)        Lung Infection           Riociguat                    Menopause Management
           rec. Factor VII                                    Lung Infection           Riociguat                    Menopause Management
                                   Alzheimer PET Imaging
                                   Alzheimer PET Imaging      Cipro® inhale
                                                              Cipro® inhale            (sGC Stimulator)
                                                                                       (sGC Stimulator)             Angeliq low-low
                                                                                                                    Angeliq low-low
           Diagnostic Imaging
           Diagnostic Imaging      Florbetaben
           PET-Tracer              Florbetaben                OC                       CTEPH                        Contraception
           PET-Tracer                                         OC                       CTEPH                        Contraception
                                   Cancer
                                   Cancer                     E2+DRSP
                                                              E2+DRSP                  Riociguat
                                                                                       Riociguat                    LCS (ULD LNG)
                                                                                                                    LCS (ULD LNG)
                                   Regorafenib
                                   Regorafenib                                         (sGC Stimulator)
                                                                                       (sGC Stimulator)
                                                              OC
                                                              OC                                                    Contraception
                                                                                                                    Contraception
                                   Cancer
                                   Cancer                     Valette plus
                                                              Valette plus             ACS
                                                                                       ACS                          FC Patch Low
                                                                                                                    FC Patch Low
                                   L19-SIP
                                   L19-SIP                                             Xarelto®
                                                                                       Xarelto®
                                                              Gram-neg. Pneumonia
                                                              Gram-neg. Pneumonia                                   MRI LCM
                                                                                                                    MRI LCM
                                                              Amikacin inhale
                                                              Amikacin inhale          HRPC
                                                                                       HRPC                         Gadovist®
                                                                                                                    Gadovist®
                                                                                       Alpharadin™
                                                                                       Alpharadin™



           Status as of Oct 2009       New Molecular          Life Cycle                           NBE
                                                              Management (LCM)              New biological entity
                                       Entities (NME)




• Page 7
           Our R&D Pipeline Provides a Balanced Mix
           of NME and LCM Opportunities
              Phase I (7)                          Phase II (17)                                     Phase III (18)
           Colorectal Cancer
           Colorectal Cancer       Acute Heart Failure
                                   Acute Heart Failure        Liposomal Formulation
                                                              Liposomal Formulation    Medical ill
                                                                                       Medical ill          NSCLC
                                                                                                            NSCLC
           L19-TNFalpha
           L19-TNFalpha            Cinaciguat
                                   Cinaciguat                 Kogenate®
                                                              Kogenate®                Xarelto®
                                                                                       Xarelto®             Nexavar®
                                                                                                            Nexavar®
                                   (sGC Activator)
                                   (sGC Activator)
           Gastro IBD
           Gastro IBD                                         Breast Cancer
                                                              Breast Cancer            SPAF
                                                                                       SPAF                 Thyroid Cancer
                                                                                                            Thyroid Cancer
           Lipoxin
           Lipoxin                 DME
                                   DME                        Nexavar®
                                                              Nexavar®                 Xarelto®
                                                                                       Xarelto®             Nexavar®
                                                                                                            Nexavar®
                                   VEGF Trap-Eye
                                   VEGF Trap-Eye
           Cancer MN
           Cancer MN                                          Ovarian or Peritoneal
                                                              Ovarian or Peritoneal    VTE Treatment
                                                                                       VTE Treatment        Multiple Sclerosis
                                                                                                            Multiple Sclerosis
           Immunoconjugate
           Immunoconjugate         PH in COPD // ILD
                                   PH in COPD ILD             Cancer
                                                              Cancer                   Xarelto®
                                                                                       Xarelto®             Alemtuzumab
                                                                                                            Alemtuzumab
                                   Riociguat
                                   Riociguat                  Nexavar®
                                                              Nexavar®
           Cancer
           Cancer                  (sGC Stimulator)                                    wet AMD
                                                                                       wet AMD              Bone Met. Prev.
                                                                                                            Bone Met. Prev.
           PI3K Inhibitor          (sGC Stimulator)           CRC                      VEGF Trap-Eye        Breast Cancer
           PI3K Inhibitor                                     CRC                      VEGF Trap-Eye        Breast Cancer
                                   2nd line Breast Cancer
                                   2nd line Breast Cancer     Nexavar®
                                                              Nexavar®                                      Bonefos®
                                                                                                            Bonefos®
           Cancer
           Cancer                  Lonaprisan (ZK-PRA)                                 CRVO
                                                                                       CRVO
           MEK-Inhibitor           Lonaprisan (ZK-PRA)        Additional Indications   VEGF Trap-Eye        OC
           MEK-Inhibitor                                      Additional Indications   VEGF Trap-Eye        OC
                                   Lung // Ovar // Prostate
                                   Lung Ovar Prostate         Nexavar®
                                                              Nexavar®                                      YAZ® Flex
                                                                                                            YAZ® Flex
           Hemophilia
           Hemophilia              Sagopilone (ZK-EPO)                                 PAH
                                                                                       PAH
           rec. Factor VII         Sagopilone (ZK-EPO)        Lung Infection           Riociguat            Menopause Management
           rec. Factor VII                                    Lung Infection           Riociguat            Menopause Management
                                   Alzheimer PET Imaging
                                   Alzheimer PET Imaging      Cipro® inhale
                                                              Cipro® inhale            (sGC Stimulator)
                                                                                       (sGC Stimulator)     Angeliq low-low
                                                                                                            Angeliq low-low
           Diagnostic Imaging
           Diagnostic Imaging      Florbetaben
           PET-Tracer              Florbetaben                OC                       CTEPH                Contraception
           PET-Tracer                                         OC                       CTEPH                Contraception
                                   Cancer
                                   Cancer                     E2+DRSP
                                                              E2+DRSP                  Riociguat
                                                                                       Riociguat            LCS (ULD LNG)
                                                                                                            LCS (ULD LNG)
                                   Regorafenib
                                   Regorafenib                                         (sGC Stimulator)
                                                                                       (sGC Stimulator)
                                                              OC
                                                              OC                                            Contraception
                                                                                                            Contraception
                                   Cancer
                                   Cancer                     Valette plus
                                                              Valette plus             ACS
                                                                                       ACS                  FC Patch Low
                                                                                                            FC Patch Low
                                   L19-SIP
                                   L19-SIP                                             Xarelto®
                                                                                       Xarelto®
                                                              Gram-neg. Pneumonia
                                                              Gram-neg. Pneumonia                           MRI LCM
                                                                                                            MRI LCM
                                                              Amikacin inhale
                                                              Amikacin inhale          HRPC
                                                                                       HRPC                 Gadovist®
                                                                                                            Gadovist®
                                                                                       Alpharadin™
                                                                                       Alpharadin™



           Status as of Oct 2009       New Molecular          Life Cycle
                                       Entities (NME)         Management (LCM)



           Despite the challenges to R&D, Bayer Schering Pharma brought a
           constant flow of NMEs to the market


• Page 8
Bayer Schering Pharma’s pipeline & products
First in class & targeting high unmet medical need

  Nexavar, the first kinase inhibitor approved for renal & liver cancer

          First targeted therapy in kidney cancer (RCC)
          Only approved drug with overall survival benefit in liver cancer (HCC)
          Approved in >90 countries for RCC, >80 countries for HCC


  Xarelto, a paradigm shift in anti-thrombotic treatment

           First oral, once-daily factor Xa inhibitor
           Comprehensive development program in five thrombosis related
          indications
           Approved for VTE prevention after orthopedic surgery (EU, Canada &
          other regions)

  Riociguat - commitment to target unmet medical need

          Potential to redefine treatment for pulmonary hypertension
          Target subtypes of pulmonary hypertension without
          currently approved standard medication


       Bayer Schering Pharma’s innovations
       Bayer Schering Pharma’s innovations
Bayer Schering Pharma
Extending Innovation Sources


                                 Tap into external innovation
                                 potential, worldwide
                                  global R&D spent >1000fold higher
                                  than BSP internal R&D
                Building a
Strengthening   network of
the research    research
competencies    satellites        innovation sources: academia,
                                  biotechs, & other companies

                  Establishing
Shaping the       new
research                          leverage full potential of in-licensed
                  partnering
landscape                         innovation by utilizing our in-house
                  models
                                  technology platforms
                           Innovation Sourcing
                   … by building up alliances and collaborations


       Basic            Drug        Preclin.                                         Submission/
                                                   Clinical Development
      Research        Discovery     Develop.                                          Approval

         Early stage drug discovery                      Late stage drug discovery
         alliances & collaborations                         alliances (licensing)


     Biotech                      Academia                 Biotech          Co-development

               Access to external expertise
                 Access to external expertise                     Scarcity of late stage
                                                                   Scarcity of late stage
               Competitive advantage
                 Competitive advantage                          compounds available
                                                                 compounds available
               Enhanced discovery capability
                 Enhanced discovery capability
               High degree of flexibility
                 High degree of flexibility                       High-cost of sourcing
                                                                   High-cost of sourcing
               No need to build up in-house programs
                 No need to build up in-house programs          compounds
                                                                 compounds
               (lower risks and costs)
                (lower risks and costs)



                 Current trend:
                 Current trend:
                   Increase in early drug discovery alliances
                    Increase in early drug discovery alliances

11
Global Networks
Showcase Oncology




                                      Biomarker Research

                   Research                                            Clinical
                                              Pre-clinical Phase I / Development
       Target        Lead         Lead        Development   POC
      Discovery    Discovery   Optimization                         Phase II Phase III




     Technology Collaborations & Acquisitions in 2008
                                                                                         14

12
Emerging market
INDIA

     India is one of the biggest
     emerging markets in Asia.

     India’s excellent education
     system has resulted in a large
     number of highly skilled
     scientists.

     The pharmaceutical sector is
     growing fast

     India is a likely future
     innovation powerhouse


          Very attractive to gain an option to innovation
           Very attractive to gain an option to innovation
          from a new player
           from a new player
13
Current and future interests for collaborations


     In the past, Bayer Schering Pharma has mainly collaborated
     with Indian companies in the field of chemical synthesis for
     research and CMC purposes

     We are interested to continue and expand these activities for
     small molecules as well as in the field of biologicals

     We are continously looking into opportunities for outsourcing of
     different steps of the R&D process

     In addition, we are interested to source innovation for our core
     indications from targets to compounds in development


          We want to expand our external network for
           We want to expand our external network for
          outsourcing and innovation sourcing
           outsourcing and innovation sourcing
14
     Bayer Schering Pharma has a Successful Partnering Record


                                                    Development/
                                                     Distribution




                                                      Discovery




                                                    Technologies




15
Summary

 Bayer Schering Pharma
 is commited to innovation                       China
               China
 Internal and external networks are key for
 being world class in research & development
                                                           Singapore
 Seeking potential partners for
    - target validation research
  India
    - out-sourcing of different steps of the R&D process
    - in-licensing of drug candidates
                                                           India
 BSP will foster collaborations in Asia
 to develop new therapeutic options and
 create value for the patients
                                               Korea

16
Forward-Looking Statements
This presentation may contain forward-looking statements based
on current assumptions and forecasts made by Bayer Group or
subgroup management.

Various known and unknown risks, uncertainties and other factors
could lead to material differences between the actual future
results, financial situation, development or performance of the
company and the estimates given here. These factors include
those discussed in Bayer’s public reports which are available on
the Bayer website at www.bayer.com.

The company assumes no liability whatsoever to update these
forward-looking statements or to conform them to future events or
developments.
Bayer Business Areas
Overview

                        108,600 Employees         2008 Sales:      EUR 32.9 billion
                        ~ 350 subsidiaries        2008 R&D Budget: EUR 2.8 billion




Business Segments:
Nutrition                  High-tech Materials             Health Care
 Crop Protection            Materials                        Bayer Schering Pharma
 EnvironmentalScience       Systems                          Consumer Care
 BioScience                                                  Diabetes Care
                                                             Animals Health
                                        Page 18
Bayer Schering Pharma
Early Stage Licensing – Search Priorities


 Oncology:
Two major principles: anti- proliferative and anti-angiogenic
Targeted therapeutics for solid tumors; small molecules that have shown good data in animal
models; functional antibodies and immunoconjugate approaches; new targets for oncology.

 Cardiovascular:
Targets, small molecules and biologicals (incl. AB) for heart failure, atrial fibrillation,
cardioprotection, sepsis, acute respiratory distress syndrom as well as severe chronic
obstructive pulmonary disease.

 Women’s Health:
Targets, small molecules and biologicals (incl. AB) for endometriosis, uterine fibroids
(Leiomyoma), bleeding disorders, fertility control and menopause management (hot flushes).

 Diagnostic Imaging:
Positron Emission Tomography (PET) tracers (preferably F18) for Oncology, CNS and CV.

				
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