PBRF_PBRC NL_DEC 05.qxd by liuhongmei


									                                                                                                             Changing the health of

                                                                                                                future generations

WINTER 2006                           M AT T E R S

      DID YOU                                   DOES OBESITY BEGIN
• The Pennington Biomedical
                                               BEFORE WE ARE BORN? AWARD
  Research Foundation
  recently launched a new
  online newsletter called,
                                   T      he Pennington
                                   Center will be the new home
                                                                      “This grant will allow us to
                                                                      bring together several scientists
                                                                      to work on a common theme,”
  “Pennington E-News.” Our         of a national Clinical             Ravussin said. “Moreover, we
  E-News emphasizes                Nutrition Research Unit            want to reach out to other
  breaking news stories,           (CNRU) specializing in             institutions in Louisiana with
  research highlights, and         prenatal and early postnatal       faculty who can contribute to
  other information on             causes of obesity and other        this new research effort.”
  activities and events. If
                                   chronic diseases. The CNRU                                             Photo left to right: PBRC
  you’d like to stay connected                                                                            researchers Anthony Civitarese,
                                   is funded by the National          The newly funded research unit
  through our online                                                                                      Ph.D., Madlyn Frisard, Ph.D. and
                                   Institute of Diabetes and          at the Center becomes one of
  communications, please                                                                                  principal investigator Eric
                                   Digestive and Kidney Diseases      only ten in the country, each of    Ravussin, Ph.D., discuss the
  visit: www.pbrf.org/
                                   (NIDDK) of the National            which has a dedicated research      molecular interaction between
  explore.cfm/subscribe to
                                   Institutes of Health (NIH).        theme. The new CNRU’s               two proteins potentially involved
  sign up.
                                                                      theme is “Nutritional               in the development of obesity
                                   Led by Eric Ravussin, Ph.D., a     Programming: Environmental          and Type 2 diabetes.
• Identical twins may be
  different! Our genetic make-     team of nearly 30 researchers      and Molecular Interactions.”
                                   was awarded this competitive                                           developing fetus and in early
  up tells only part of the
                                   grant of more than $5.5            Nutritional programming is a        postnatal life. It investigates how
  story. This conclusion is
                                   million over five years.           line of research that focuses on    variations in nutrition or stress
  part of the reason for our
                                                                      the role of nutrition on the        may impact or alter the
  Center’s new focus on
                                                                                                          inherited characteristics of
  prenatal causes of obesity.
  (Read news to the right).          CLINICAL RESEARCHERS BECOME HURRICANE
• It is difficult to lose weight             EMERGENCY DISPATCHERS                                        “Ten years ago, if I had seen
  but even more difficult to                                                                              identical twins with an exact,
                                                                     this serious disease. Center         hundred-percent match in
  keep it off. The human                                             clinicians see many volunteers
  body, when forced to diet,                                                                              DNA, I would have told you
                                                                     with diabetes, offer much in         they are exactly the same. Not
  goes into a “starvation                                            the way of education and
  mode” to protect its weight.                                                                            any more,” said Ravussin, “We
                                                                     understanding, and are in            see differences that go beyond
  Your body does not want to
                                                                     touch with manufacturers of          DNA, and those differences
  lose weight! So how to get
                                                                     diabetic medications and             seem to be partly due to
  thinner and stay that way?
                                                                     supplies. So, the physicians,        influences of nutrients during
  A group of international
                                                                     technicians and even corporate       fetal and early life
  scientists gathered at the       Researchers and staff of the      sponsors of the Center’s clinical    development.”
  Center in December to            clinic at the Pennington          trials and research were well
  discuss just that point and      Biomedical Research Center
  offer the latest in their                                          positioned to render assistance      Ravussin said previous research
                                   have made great strides in        to those with diabetes displaced
  findings. The idea was to        understanding the causes of                                            suggests that early nutrient
  spark more research and                                            by Hurricane Katrina.                interactions may be involved in
                                   diabetes and therapies to treat
  learning so we can all                                                       continued on page 4
  benefit.                                                                                                            continued on page 5
   Message from the Executive Director of the
      Pennington Biomedical Research Center

T            he past several months have been
             more eventful than we could
             have imagined, filled with both
 very unexpected and much anticipated
 milestones. For the first time in our
                                                          technical staff who so ably transformed our
                                                          former conference center into a “school”
                                                          complete with wireless computer access,
                                                          study space, a small bookstore, large lecture
                                                          halls and small classrooms. In addition, we
                                                                                                                 Center was
                                                                                                                 awarded a National
                                                                                                                 Institutes of Health grant to create a center
                                                                                                                 for the study of prenatal causes of obesity and
                                                                                                                 its complications. This is a large undertaking,
 history, students are on campus taking                   are providing office and laboratory space for          and one that we hope will be productive for
 classes. Hurricane Katrina’s destruction of              almost 200 faculty and staff from the LSU              many years. This endeavor places the Center
 the LSU Health Sciences Center in New                    Health Sciences Center and other New                   on the very edge of learning about the
 Orleans and its medical, dental, nursing                 Orleans institutions.                                  biology that may lead to obesity.
 and allied health schools forced the LSU
 System to find other means of teaching and               Although, for our entire history we have               Research suggests that the biological and
 housing these fine faculty members and                   described ourselves to our academic peers as a         chemical environment within the mother’s
 students so education and research could                 “research only” institution, it is a pleasure to       womb, including nutrition, may have a
 continue.                                                see dedicated, energetic students working and          profound affect on our health and life-long
                                                          relaxing on our campus. Likewise, many of              development. It appears that in addition to
 We were fortunate to be able to offer                    the students and faculty have told our staff           our genetic make-up, the risks of becoming
 classroom, office and research space on our              how much they enjoy the beauty and quiet of            obese may be increased by events that occur
 campus, and now more than 600 students                   the Center.                                            in utero and have lasting consequences. We
 are here studying medicine, dentistry, allied                                                                   will be closely examining these as well as
 health professions and nursing. Many                     An anticipated and very significant event for          events that occur immediately after birth to
 thanks go to our executive staff and                     our future was recently announced. The                 learn much more.

                                                                                                                 I congratulate our researchers and support
    JOHN W. BARTON, SR. CHAIR ESTABLISHED                                                                        staff who developed the proposal for this new
                                                                                                                 endeavor. It was a highly competitive process,
                                                                                                                 pitting the Center against other leading
                                                                                                                 research institutions across the country. Please
                                                                                                                 read more about that effort in this issue.

                                                                                                                 2005 has been a banner year for the
                                                                                                                 Pennington Biomedical Research Center.
                                                                                                                 The partnership with the USDA is growing
                                                                                                                 and is beginning to impact significantly our
                                                                                                                 research efforts. This is also the year in
                                                                                                                 which we were able to secure two center
                                                                                                                 grants from the National Institutes of Health:
                                                                                                                 the Botanical Research Center grant
                                                                                                                 announced earlier in 2005 and now a
                                                                                                                 Clinical Nutrition Research Unit. I hope the
                                                                                                                 new year will be full and rewarding for each
The Louisiana Board of Regents and the LSU Foundation recently held a presentation and reception at the LSU      and every one of you. I look forward to
Lod Cook Alumni Center to recognize endowed chairs and professorships established through matching funds.        sharing more news from the Center with you
Recognized at the reception was the John W. Barton, Sr. Endowed Chair in Genetics and Nutrition at the           in the future.
Pennington Biomedical Research Center. The support fund provided a matching grant of $400,000 to the
$625,000 in private funding from over 60 individuals and organizations to endow the chair in Barton’s name.
Barton was recognized for his tireless efforts to provide guidance and leadership to the Pennington Biomedical
Research Center. Attending the event were (left to right) Board of Regents Chairman Roland Toups; PBRF
Barton Chair Development Committee Chairman Lee Griffin; PBRF Vice Chair Paula Pennington de la Bretonne;        Claude Bouchard, Ph.D.
honoree John W. Barton, Sr.; Pennington Center Executive Director Claude Bouchard; PBRF Supporter Imo            Executive Director
Brown; Board of Regents Vice Chairman Frances Henry; and LSU System President William L. Jenkins.

                      F O U N D A T I O N                  N E W S

                                                                                                     Cutting Edge Cancer
William Hansel Laboratory of Cancer                                                                  Research Underway
Prevention Established With Major Gift to the                                                      William Hansel, Ph.D. is a remarkable
Pennington Biomedical Research Center                                                              man. He arrived at the Center following
                                                                                                   an already lengthy career at Cornell
The Pennington Biomedical Research Center                                                          University, from which he retired.
has dedicated a new laboratory for cancer
                                                                                                   As a specialist in reproductive biology,
prevention research to honor the scope and
                                                                                                   he brought a unique perspective to the
promise of cancer research work led by
                                                                                                   Center, understanding the function and
William Hansel, Ph.D.                                                                              role of reproductive organs, cells and
                                                                                                   processes. While attending a scientific
Through a major gift to the Pennington                                                             conference in Poland, he learned that
Biomedical Research Foundation from                                                                certain hormones in the human body
Edward and Loretta Downey of Maryland,                                                             behaved toward breast cancer cells in a
and a matching gift from Dr. Hansel, the                                                           rather normal fashion. They attached
laboratory was dedicated recently at a                                                             themselves to the surface of the breast
reception held to recognize the donors and        The William Hansel Laboratory of Cancer          cancer cells to deliver chemical messages
                                                  Prevention was dedicated recently at the         – similar to how these same hormones
the newly named laboratory.
                                                  Pennington Biomedical Research Center with       attach to ovarian cells to cause
                                                  a major gift to the Pennington Biomedical        ovulation.
“We cannot begin to express our deep              Research Foundation from Edward and
gratitude to the Downey family, and the           Loretta Downey (left) and a matching gift        He had been working with just such
support of their uncle, with this major gift      from Dr. Hansel (right). The laboratory is       hormones back at the lab and decided
that establishes a laboratory devoted             totally dedicated to the development and         to create a deadly combination – for
completely to the development and delivery        delivery of new medications for the treatment    cancer. He spliced a membrane
                                                  of cancer. Drs. Hansel and Carola Leuschner      destroying compound to the hormone.
of drugs for the treatment of cancer,” said
                                                  and their research team have developed two       When the hormone attached itself to
Claude Bouchard, executive director of the        highly effective drugs that target and           cancer cells, the “message” was a deadly
Center. He praised Dr. Hansel for his work to     selectively destroy cancer cells. The National   blow, destroying the cancer cell
develop cancer-treating drugs that have           Cancer Institute has accepted one of these
                                                                                                   membrane and the cancer cell.
recently been issued patents. One of these        drugs into its Rapid Access to Intervention
drugs is now being studied in a fast track        Development Program.
                                                                                                   “It was the most remarkable result I had
process by the National Cancer Institute.                                                          ever seen in my lab,” Hansel says.

John Noland, chairman of the Pennington Biomedical Research Foundation, presented                  Within months he and his Center
etched bronze medallions to the Downeys and Dr. Hansel during the reception. An etched             colleague, Dr. Carola Leuschner, and
wall plaque identifying the new lab was also unveiled. “Gifts such as these create viable          Dr. Fred Enright of the LSU
opportunities for achieving healthier lives today and for the next generation,” said Noland.       Agricultural Center, were killing not
                                                                                                   only the main cancer tumors in
                                                                                                   laboratory animals, but also the cancer
Also speaking at the event was Dr. William Richardson, chancellor of the LSU Agriculture           cells that had split from the tumor
Center, who talked about Dr. Hansel’s earlier groundbreaking research and discoveries in           (metastasized) to migrate to other parts
disease prevention in cattle.                                                                      of the body. And he made this
                                                                                                   discovery in his eighties!
Hansel, who has been a faculty member at the PBRC since 1990 and also works with the
LSU Ag Center, previously served as the Gordon D. Cain Professorship of Animal                     The National Cancer Institute has taken
Physiology. Prior to coming to Baton Rouge, Dr. Hansel served as the Liberty Hyde Bailey           notice and included the cancer killing
Professor of Animal Physiology at Cornell University. He has also received numerous grants         compound in a “fast track” program
                                                                                                   aimed at accelerating the research
from the National Institutes of Health, National Science Foundation and the USDA and
                                                                                                   process that will eventually lead to trials
various scientific awards.                                                                         in humans. Hansel and his research
                                                                                                   colleagues are hopeful that the first
More than 60 faculty and friends attended the event held in the Atrium of the state-of-the-        study for human subjects will take place
art Basic Science Laboratory Building.                                                             within the next few years. Meanwhile,
                                                                                                   Hansel is in the lab daily working on
                                                                                                   the next steps and exploring new

              Center Testing Means Some Diabetics
              May Soon Get Insulin Without Needles
Literally generations of people with Type 2                                                     The results were very good, with the
diabetes have had only one means of                                                             powered insulin offering results similar to
giving themselves the necessary insulin to                                                      injected insulin. That prompted the
trigger their bodies’ muscles to consume                                                        manufacturers of the drug, called Exubera,
glucose from their blood - daily needle                                                         to immediately apply to the Food and
injections.                                                                                     Drug Administration (FDA) to allow the
                                                                                                drug on the market. Dr. Cefalu was the
Now, Pennington Biomedical Research                                                             only non-industry physician to go before
Center physician William Cefalu, M.D.,                                                          the FDA initial review board to present his
has put needle-free insulin through a                                                           data. The review board recommended
clinical trial to learn if patients can inhale                                                  approval of the drug by the FDA.
a powdered form of insulin and get the
                                                     PBRC clinician Anne Chatellier
same results as the needle-injected form.         demonstrates the Exubera inhaler. If          A partnership between pharmaceutical
                                                   approved by the FDA, patients will           companies Pfizer and the sanofi-aventis
Dr. Cefalu and his team recruited Type 2           use the device to crush an insulin           Group developed the drug, and Nektar
diabetics requiring insulin to participate in      tablet into powder, then inhale it.          Therapeutics created the inhaler. The
the clinical trial. They were given a device                                                    FDA is currently reviewing the application
that looks like a large asthma type inhaler.     with a built-in handle, and then squirted      and the review board’s recommendation.
The clinical participants simply dropped a       the dry powder in their mouths while
tablet of insulin in the device, crushed it      inhaling.

Hurricane Emergency Dispatchers
continued from page 1

Led by Drs. Steven Smith and Eric                care…if they had supplies. Turning on a        Texas, which the team monitored almost
Ravussin, a team of physicians and               dime, the team put the RV back in the          daily for diabetic needs. The effort made
clinicians quickly formed to go into             garage, pushed aside equipment in the          national and international news.
nearby shelters to help those who were           Center’s exercise facility to create a mini-
facing the problem of managing their             warehouse and, overnight, became a             Since the first hectic days following the
diabetes after a disaster. The team              dispatch team for much-needed supplies.        creation of the team, most supplies are
rounded up their mobile research vehicle,        They soon became the chief emergency           now gone, shelters have closed and the
sought assistance from the Pennington            supplier of diabetic care supplies in the      team believes it filled a critical need that
Biomedical Research Foundation, and              region, eventually serving more than 7,000     others overlooked. The effort was so
reached out to insulin and diabetes supply       patients.                                      successful, a U.S. Senate staff member
manufacturers. They also worked the                                                             came to learn first-hand and to take
phones of the Louisiana Emergency                But success brings its own problems. Smith     recommendations back to Washington.
Management Center and met face-to-face           netted 18-wheelers of supplies that started
with Red Cross staff. The team quickly           rolling into the Center. That, plus a check    Asked how he got so many people
learned how to effectively meet the needs        for $50,000 from Amylin Pharmaceuticals,       involved so quickly with such success, Dr.
of diabetics in the shelters; coordinating       Inc. to the PBRF, to buy what they could       Smith said his lab staff lives by a motto
with the shelter staff.                          not get donated, created a huge demand         that makes them think and plan big-
                                                 for unloading, sorting, re-packaging and       despite plenty of obstacles and naysaying:
The first idea was to equip the vehicle to       shipping. Even the Baton Rouge Rugby           “You can’t succeed if you are not willing
be a rolling clinic, driving from shelter to     team got involved – recruited by a Center      to fail.”
shelter with insulin, oral medications,          researcher/rugby player – to help unload
swabs, insulin pumps and parts, nutrition,       the trucks and deliver supplies.               Editor’s note: As a footnote to this story,
blood testing kits and the like. The team                                                       Pfizer Inc. recently made a $25,000
soon learned, though, that most shelters         Smith’s group created more than 5,000          donation to the Pennington Foundation for
had basic medical care and teams of              30-day “care packs” and shipped them to        on-going diabetes education related to the
medical personnel who could render               centers across the south from Mississippi to   effects of Katrina.

                   F O U N D A T I O N              N E W S

                                                                                      Does Obesity Begin Before We Are Born?
HIBERNIA NATIONAL BANK VISITING SCIENTIST DINNER                                      continued from page 1

                                                                                      causing a predisposition for common
    FEATURED SPEAKERS: CLAUDE BOUCHARD, PH.D., EXECUTIVE                              conditions, including obesity.
                                                                                      For example, he said, other researchers have
                                                                                      already found that low birth weight may
M      ore than 90 guests attended the      economic development potential, and       impact lifelong metabolic functions and
recent 2005 Hibernia National Bank          the factors for sustained and enhanced    represents a significant risk factor for the
Visiting Scientist Dinner Series hosted     growth. Dr. Bouchard, who was             development of metabolic diseases in
by the Pennington Biomedical Research       recently honored with the 2005 Earle      adulthood.
Foundation (PBRF). Cocktails were           W. Crampton Award in Nutrition
served in the atrium tower of the new       from McGill University, demonstrated      According to Ravussin, the nutritional and
Basic Science Laboratory Building and       in his presentation the expansion         hormone mix that fetuses are subject to in
dinner was served in the south atrium,      potential on research discoveries,        the womb seem to have a profound effect on
overlooking the lake on the campus of       including those in the areas of brain     adulthood. The new CNRU will be dedicated
the Pennington Biomedical Research          development, maximizing disability        to thoroughly examining these complex issues
Center (PBRF). Featured speaker was         free aging, stem cell and tissue          and will provide an opportunity for
Dr. Claude Bouchard, executive              engineering applications, and in the      “bridging” clinical and basic science.
director of the Center. His topic was       prevention of Alzheimer’s and other
entitled “Unparalleled Growth-Unlimited     dementia, heart disease and diabetes.
Potential: Unleashing the Economic and                                                Coypu Foundation Grant
Scientific Power of PBRC.”                  John Noland, chairman of the              Establishes New Laboratory
                                            Pennington Biomedical Research
                                            Foundation, spoke of his dedication       The Pennington Biomedical Research
                                            to the institution and in calling forth   Foundation proudly acknowledges an
                                            others to realize its enormous            important new $200,000 grant from the
                                            potential on quality of life issues and   Coypu Foundation to establish a new
                                                                                      laboratory, designated specially to support the
                                            economic development potential to
                                                                                      newly awarded Clinical Nutrition Research
                                            the state. He challenged individuals in
                                                                                      Unit at the Center.
                                            the group to become advocates of the
                                            Center as well. Also attending the
                                                                                      The new laboratory, to be called the John S.
                                            dinner was his wife, Virginia.
                                                                                      McIlhenny Laboratory of Skeletal Muscle
                                            Welcoming guests and introducing          Physiology, will focus on the vital role of
 Attending the scientific dinner were       Noland was PBRF President and             muscle mass and muscle composition, and
 Sr. Kathleen Cain, OSF; Jane Boyce;        Chief Executive Officer Jennifer          the cellular mechanisms playing a role in
   and Polly and John Hernandez.            Winstead.                                 response to environmental factors that trigger
                                                                                      weight gains. The Coypu grant will also
                                            The 2005 Scientific Dinner Series was     provide for much needed skeletal muscle
Dr. Bouchard presented the guiding
                                            underwritten by Hibernia National         studies in humans. “It is believed that
principles of the Center: building a
                                            Bank, whose stockholders on the very      metabolic impairments preceding the
world-class research institution in
                                            same day approved the merger with         development of metabolic syndrome, a
preventive medicine, producing cutting-
                                            Capital One. Janet Rack, Hibernia         precursor to Type 2 diabetes, reside in the
edge and influential research, protecting
                                            senior vice president, spoke briefly at   molecular pathways of muscle metabolism,”
discoveries and promoting technology
                                            the dinner, expressing the bank’s         said lead researcher Dr. Eric Ravussin.
transfer, and fostering economic
                                            dedication to supporting the PBRC
development which generates further
                                            and pledging continued support in         “Through this new laboratory, the Coypu
research opportunities. He also
                                            2006.                                     Foundation continues to keep its founder,
discussed the breadth and depth of the
                                                                                      John S. McIlhenny, at the forefront by
Center’s work in disease prevention, its
                                                                                      supporting grants in his lifelong areas of
                                                                                      interest and study,” said John Hernandez,
    Visit www.pbrc.edu and www.pbrf.org                                               Coypu Foundation board member.

           Sign up for our E-News at
Pennington Foundation Early                                    LEGACY SOCIETY HONORS PLANNED GIFTS TO PBRC
 Fall Scientific Dinner Series                            The Pennington Biomedical Research                council of financial professionals, chaired by
                                                          Foundation’s (PBRF) mission is to provide         PBRF board member Jerry Jolly, CPA, and
Dr. Arya
                                                          the Pennington Biomedical Research Center         managing partner of KPMG, LLP. Serving as
Sharma, a
                                                          (PBRC) with vital funding for vital research      co-chairman is Kevin F. Knobloch, CLU,
physician and
                                                          that aims to prevent premature death from         CFP, client advisor at JP Morgan. Serving on
faculty member
                                                          chronic diseases. Since the Center first          the council are other financial advisors: G.
of McMaster                                               opened, it has relied on gifts from business      Rolfe Miller, branch manager, Morgan
University of                                             and industry, individuals and foundations to      Keegan; Elizabeth Querbes, senior vice
Canada, was a                                             supplement its grant awards and state
                       PBRC faculty member Dr. Steven
                                                                                                            president, Morgan Stanley; Jason T. Green,
special guest                                             funding. These private gifts are crucial to the   managing director, Stanford Group
speaker at the       Smith; PBRC Executive Director Dr.
                     Claude Bouchard; Scientific Dinner   Center as they often provide “bridge” or          Company; Kevin C. Curry, partner, Miller,
Pennington                                                interim funding not available from other          Hawthorne, D’Armond, McCowan &
                     lecturer Dr. Arya Sharma; Hibernia
Biomedical                                                sources. These private donations have             Jarman, LLP; Blanchard Sanchez, partner,
                     National Bank/Capital One Senior
Research                Vice President Janet Rack; and    recruited top scientists, created numerous        McArthur Sanchez Associates; and William
Center. He             Pennington Biomedical Research     laboratories, endowed chairs and                  C. Potter, CPA, JD, managing director,
spoke to            Foundation Chairman John Noland       professorships, and matched grants for            Postlethwaite and Netterville, APAC.
supporters of                                             promising new scientific discoveries.
the Pennington Biomedical Research Foundation                                                               According to Jennifer Winstead, PBRF
at the Hibernia National Bank Visiting Scientist          Increasing interest in long-range giving has      president and CEO, “This group of estate
Dinner Series held recently at the Basic Science          prompted the Center to create a Legacy            planning advisors is lending its collective
Laboratory Building on the Center's campus. He            Society for individuals and families seeking      expertise and vast years of financial planning
discussed the escalating rate of obesity in the           planned giving opportunities. Membership          knowledge to provide the PBRF with viable
population, particularly in children, and the             in the Legacy Society is open to anyone who       instruments and methods of planned giving
urgent need for research and study on all aspects         includes the PBRC and PBRF in their estate        that are advantageous to both the individual
of its causes: the environment, genes, and food           plans. According to PBRF Chairman John            and the institution.”
choices and portions. He demonstrated the                 Noland, “Charitable gifts provide an
extensive societal changes during the last 50 years,      individual with great personal satisfaction,      The Legacy Society membership is
which directly reduce one's physical exertion in          and the institution with an important             acknowledged in various PBRF publications,
both the home and work environment. He noted              opportunity to enhance the scope and              recognized at scientific educational events,
the escalating production of processed and fast           breadth of its work. A planned gift creates a     and included on the new donor wall in the
foods, and the popularity of larger portions. It is       long-range and enduring investment which          C. B. Pennington, Jr. Building.
now widely understood that obesity contributes to         moves the institution forward.”
the development of diabetes, heart disease,                                                                 For more information on the Legacy Society,
hypertension, metabolic syndrome, and some                Providing leadership and direction to this        contact PBRF Chief Financial Officer, Brad Jewell,
cancers, he said.                                         development activity is a newly formed            at 225-763-2684 or brad.jewell@pbrc.edu.

In his visual presentation, Dr. Sharma
acknowledged the importance of obesity research                     PBRF DEVELOPMENT DIRECTOR NAMED
now underway at the Pennington Center. He
emphasized the importance of the work at                                    The Pennington Biomedical       additional revenue and branding
institutions and called for more research to                                Research Foundation             opportunities. More recently, Bell led
identify medical, behavioral and pharmaceutical                             welcomes Melissa A. Bell as     multiple cross functional teams to
methodologies to help individuals retain their                              its new Director of             implement new and emerging fundraising
weight loss once it has been achieved. He said                              Development. Bell joins the     initiatives. Over the past three years, she
additional study into the role of long-term               Pennington team to drive development              directly raised more than $15 million
medications for weight management and the                 initiatives related to donor giving programs,     dollars and acquired more than 180,000
impact of various types of surgery now used for           donor cultivation and retention, planned          new donors through donor cultivation and
morbid obesity is vital to finding optimal                giving and special event oversight to achieve     retention efforts for St. Jude.
solutions.                                                the Foundation’s goals for the Center. Prior
                                                          to joining the Pennington Foundation, Bell        Originally from St. Tammany Parish,
Dr. Sharma made his presentation to more than             served as the Director of Donor Cultivation       Melissa and her husband, Jeff, who is a
75 guests of the Pennington Biomedical Research           Marketing for St. Jude Children’s Research        landscape architect and land planner
Foundation. He also spoke to the faculty and staff        Hospital, working for their headquarters in       employed with SJB Group, Inc. in Baton
during his two day visit. The PBRF event was              Memphis, Tenn. Bell began her fundraising         Rouge, returned to Louisiana recently with
held in the south atrium of the new Basic Science         career back in 1997 where she managed the         their two children to be closer to their
Laboratory Building, overlooking the lake on the          monthly sustainer program for St. Jude, and       family and to invest their talents in the
grounds of the Pennington Biomedical Research             then was promoted to launch St. Jude’s first      Louisiana communities that they call
Center.                                                   catalog merchandising program to raise            home.

            Healthier Living and Weight Loss Focus of Studies
 Pennington researchers are currently seeking citizen volunteers for the following clinical studies
Take II — Diabetic Research Study                                             • Not taking medications or nutritional supplements to lower blood
The Pennington Biomedical Research Center needs volunteers to
                                                                              • Not taking any medications regularly (thyroid medications are accepted
participate in the Take II diabetes research study. We are testing the
                                                                                if stable dose.)
effect of FDA approved medications versus diet. You will be required to       • Females cannot be pregnant, breastfeeding or planning to become
have 2 fat biopsies, 2 CT scans at the Baton Rouge General, and 2 6-            pregnant
hour clinic visits.
                                                                              Participants will be compensated $350 at the completion of the study.
To qualify:
• Be age: 35-75                                                               Breakfast Study — 8-Week Weight Loss Study
• Have Type 2 diabetes
• Control diabetes with diet or one medication                                The Pennington Biomedical Research Center is conducting the Breakfast
• Have never taken Actos or Avandia                                           Study to compare the effects of two different breakfasts on weight loss.
• Weigh less than 300 pounds                                                  160 people will be recruited and randomly assigned to 1 of 4 groups:
• Have not had kidney, liver or lung disease
                                                                              1. Egg Breakfast with no diet plan
• Thyroid and some Blood Pressure medications allowed
                                                                              2. Egg Breakfast with diet plan
Participants will be compensated $200.                                        3. Bagel Breakfast with no diet plan
                                                                              4. Bagel Breakfast with diet plan
EKODE — 6-Day Blood Pressure Study
                                                                              The “Bagel Breakfast” consists of a bagel, cream cheese and yogurt. The
The Pennington Biomedical Research Center is conducting a 6-day               “Egg Breakfast” consists of two eggs and two pieces of toast with jelly.
blood pressure study. This study will examine an oxidized fatty acid          Volunteers will be responsible for buying and preparing the food at home
called “EKODE,” and its influence on blood pressure.                          and will eat the prescribed breakfast at least 5 days/week for 8 weeks.
Throughout the 6-day testing period, participants will eat a diet high in     Regardless of group assignment, all volunteers will meet with a registered
sodium. All foods will be provided by PBRC throughout the testing             dietitian at each visit to discuss the breakfast requirements and
period (no additional foods are allowed). Dinner will be eaten at PBRC        compliance.
while breakfast and lunch will be packed to take out.                         Study Design:
Study Design:                                                                 • 1 screening visit            • 4 other clinic visits
• 1 screening visit                                                           To qualify:
• 6 other clinic visits (participants are admitted for one overnight stay     • Age: 20 – 60
  on the in-patient unit on day 4 of the testing period)                      • BMI: 25 – 50
To qualify:                                                                   • No unstable chronic disease
• Age: 35 – 65                                                                • Cannot have a weight change of more than 5% in the past 3 months
• BMI: 20 – 35 (Normal to overweight)                                         • Cannot dislike or be allergic to eggs or bagels
• No chronic disease                                                          • Volunteers with controlled diabetes are also welcome
• Non-smoker                                                                  Participants will be compensated $200 at the completion of the study.
• Cannot have elevated blood pressure > 160/95
   If you are interested in participating in a research study, call our recruiting department at 225-763-2596 or visit www.pbrc.edu

 NEW FACULTY                                                                FACULTY RECOGNITIONS
             Nathan Markward, Ph. D.,                                 Paula Geiselman, Ph.D.                        Weihong Pan, M.D., Ph.D.,
             M.P.H. joins the faculty as an                           has been appointed to the                     has been asked to join the
             Assistant Professor-Research.                            Digestive Diseases and                        Neuroendocrinology,
             He is a specialist in human                              Nutrition Study Section of                    Neuroimmunology and Behavior
genome epidemiology (HuGE), and his                     the National Institute of Diabetes and         [NNB] Study Section of the National
research will be part of the new program we             Digestive and Kidney Diseases                  Institutes of Health (NIH). This panel is
are developing in the area of Population                (NIDDK), an institute of the National          concerned with the neurobiological basis of
Health and Prevention Studies. Dr.                      Institutes of Health (NIH). This panel is      behavior across the life span, with a focus on
Markward received a Master of Public                    concerned with obesity, digestive diseases,    neuroendocrine, neuropeptide, and
Health in Epidemiology from Tulane                      liver, nutrition, and eating behavior. Dr.     neuroimmune systems. Major areas of
University in 1997, and his Ph.D. in                    Geiselman’s appointment is effective           interest include ingestive behaviors, drugs of
Human Genetics from Louisiana State                     through June 30, 2009. In this position,       abuse, stress, and interactions of the brain
University in 2001. He comes to the                     she will review competitive research grant     with immune systems. This panel will review
Center from private industry in Vancouver.              applications to NIH.                           competitive grant applications to the NIH.

                                                                                                                                           Non-Profit Org.
            Pennington Biomedical Research Foundation                                                                                        U.S. Postage
            6400 Perkins Road                                                                                                                   PAID
                                                                                                                                           Permit NO. 664
            Baton Rouge, LA 70808-4124                                                                                                     Baton Rouge, LA


        PBRF BOARD
Chairman, John B. Noland
Immediate Past Chair, Kevin P. Reilly, Sr.
                                                                 in the News
                                                                        in the News
                                             A ROUND-UP OF CENTER NEWS AND NEWS MAKERS
                                             • A PBRC team of physicians and clinicians offering aid to diabetic evacuees of Hurricane Katrina
Vice Chair, Paula P. de la Bretonne          made news locally, nationally and internationally, including the Boston Globe and Swissinfo, and all
Treasurer, C. Brent McCoy                    local media.
Secretary, Kevin R. Lyle                     • The Associated Press distributed a story carried by the Times Picayune and others on the Center’s
Directors                                    new, major grant to create a Clinical Nutrition Research Unit to study prenatal causes of obesity.
Tim A. Barfield
Annette D. Barton                            • Knight Ridder sought Dr. George Bray for a story on the impact of sweetened drinks on children.
Madhu Beriwal                                Bray says the sweetener Fructose adds calories to the diet, but the brain does not sense it in the diet,
J.S. "Si" Brown, III                         which leads to over-consumption. The story was carried in newspapers across the nation.
J. Terrell Brown
                                             • Public television stations nationwide are airing a special documentary that features the work of
Joseph H. Campbell, Jr.                      current and former Center researchers to overcome childhood obesity. Louisiana Public Broadcasting
Maxine Cormier                               produced the program called Step by Step, Kids Trimming Down, with a significant gift from long-
Dr. Roy G. Kadair                            time Center supporter Kevin Reilly.
J. Gerald "Jerry" Jolly, CPA
Charles A. Landry
Betsy S. Nalty                               FACTS ABOUT THE PENNINGTON CENTER
James M. Nolan                               Mission: To promote healthier lives through research and education in nutrition and preventive
Nanette Noland                               medicine.
Bert S. Turner                               Size: Main research facilities: 575,000 square feet; grounds: 234 acres.
Ex-Officio, Claude Bouchard, Ph.D.           Staff: 70 faculty members, 50 post doctorates, and more than 500 technicians and support
Executive Director, PBRC                     personnel.
Ex-Officio, William L. Jenkins, Ph.D.        6 Research Divisions: Functional Foods, Experimental Obesity, Clinical Obesity and Metabolic
President, LSU System                        Syndrome, Nutrition and Chronic Diseases, Health and Performance Enhancement and
                                             Education, and Nutrition and the Brain. The Center also has an Education Division.
CEO, Jennifer G. Winstead                    Laboratories: 13 laboratories and 16 core service laboratories including genomics, proteomics,
CFO, J. Brad Jewell, CPA                     clinical chemistry, mass spectrometry, cell culture, comparative biology, transgenic, body
                                             composition, and food analysis laboratories.
                                             Clinic: Outpatient examination and interview rooms, inpatient rooms for 14 research volunteers,
                                             metabolic kitchen, metabolic procedure room, two whole-room indirect calorimeters, dual energy
                                             X-ray absorptiometry, and ultrasound imaging.
Printing compliments of                      The Pennington Biomedical Research Foundation provides the Pennington Biomedical Research Center
Blue Cross and Blue Shield of Louisiana      with vital funding for nutrition-based research that aims to prevent premature death from chronic

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