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Changing the health of NUTRITION future generations WINTER 2006 M AT T E R S PENNINGTON BIOMEDICAL RESEARCH CENTER AND FOUNDATION • LSU SYSTEM DID YOU DOES OBESITY BEGIN Know? • The Pennington Biomedical BEFORE WE ARE BORN? AWARD PENNINGTON CAPTURES PRESTIGIOUS COMPETITIVE NATIONAL Research Foundation recently launched a new online newsletter called, T he Pennington BiomedicalResearch Center will be the new home “This grant will allow us to bring together several scientists to work on a common theme,” “Pennington E-News.” Our of a national Clinical Ravussin said. “Moreover, we E-News emphasizes Nutrition Research Unit want to reach out to other breaking news stories, (CNRU) specializing in institutions in Louisiana with research highlights, and prenatal and early postnatal faculty who can contribute to other information on causes of obesity and other this new research effort.” activities and events. If chronic diseases. The CNRU Photo left to right: PBRC you’d like to stay connected researchers Anthony Civitarese, is funded by the National The newly funded research unit through our online Ph.D., Madlyn Frisard, Ph.D. and Institute of Diabetes and at the Center becomes one of communications, please principal investigator Eric Digestive and Kidney Diseases only ten in the country, each of Ravussin, Ph.D., discuss the visit: www.pbrf.org/ (NIDDK) of the National which has a dedicated research molecular interaction between explore.cfm/subscribe to Institutes of Health (NIH). theme. The new CNRU’s two proteins potentially involved sign up. theme is “Nutritional in the development of obesity Led by Eric Ravussin, Ph.D., a Programming: Environmental and Type 2 diabetes. • Identical twins may be different! Our genetic make- team of nearly 30 researchers and Molecular Interactions.” was awarded this competitive developing fetus and in early up tells only part of the grant of more than $5.5 Nutritional programming is a postnatal life. It investigates how story. This conclusion is million over five years. line of research that focuses on variations in nutrition or stress part of the reason for our the role of nutrition on the may impact or alter the Center’s new focus on inherited characteristics of prenatal causes of obesity. individuals. (Read news to the right). CLINICAL RESEARCHERS BECOME HURRICANE • It is difficult to lose weight EMERGENCY DISPATCHERS “Ten years ago, if I had seen but even more difficult to identical twins with an exact, this serious disease. Center hundred-percent match in keep it off. The human clinicians see many volunteers body, when forced to diet, DNA, I would have told you with diabetes, offer much in they are exactly the same. Not goes into a “starvation the way of education and mode” to protect its weight. any more,” said Ravussin, “We understanding, and are in see differences that go beyond Your body does not want to touch with manufacturers of DNA, and those differences lose weight! So how to get diabetic medications and seem to be partly due to thinner and stay that way? supplies. So, the physicians, influences of nutrients during A group of international technicians and even corporate fetal and early life scientists gathered at the Researchers and staff of the sponsors of the Center’s clinical development.” Center in December to clinic at the Pennington trials and research were well discuss just that point and Biomedical Research Center offer the latest in their positioned to render assistance Ravussin said previous research have made great strides in to those with diabetes displaced findings. The idea was to understanding the causes of suggests that early nutrient spark more research and by Hurricane Katrina. interactions may be involved in diabetes and therapies to treat learning so we can all continued on page 4 benefit. continued on page 5 Message from the Executive Director of the Pennington Biomedical Research Center T he past several months have been more eventful than we could have imagined, filled with both very unexpected and much anticipated milestones. For the first time in our technical staff who so ably transformed our former conference center into a “school” complete with wireless computer access, study space, a small bookstore, large lecture halls and small classrooms. In addition, we Center was awarded a National Institutes of Health grant to create a center for the study of prenatal causes of obesity and its complications. This is a large undertaking, history, students are on campus taking are providing office and laboratory space for and one that we hope will be productive for classes. Hurricane Katrina’s destruction of almost 200 faculty and staff from the LSU many years. This endeavor places the Center the LSU Health Sciences Center in New Health Sciences Center and other New on the very edge of learning about the Orleans and its medical, dental, nursing Orleans institutions. biology that may lead to obesity. and allied health schools forced the LSU System to find other means of teaching and Although, for our entire history we have Research suggests that the biological and housing these fine faculty members and described ourselves to our academic peers as a chemical environment within the mother’s students so education and research could “research only” institution, it is a pleasure to womb, including nutrition, may have a continue. see dedicated, energetic students working and profound affect on our health and life-long relaxing on our campus. Likewise, many of development. It appears that in addition to We were fortunate to be able to offer the students and faculty have told our staff our genetic make-up, the risks of becoming classroom, office and research space on our how much they enjoy the beauty and quiet of obese may be increased by events that occur campus, and now more than 600 students the Center. in utero and have lasting consequences. We are here studying medicine, dentistry, allied will be closely examining these as well as health professions and nursing. Many An anticipated and very significant event for events that occur immediately after birth to thanks go to our executive staff and our future was recently announced. The learn much more. I congratulate our researchers and support JOHN W. BARTON, SR. CHAIR ESTABLISHED staff who developed the proposal for this new endeavor. It was a highly competitive process, pitting the Center against other leading research institutions across the country. Please read more about that effort in this issue. 2005 has been a banner year for the Pennington Biomedical Research Center. The partnership with the USDA is growing and is beginning to impact significantly our research efforts. This is also the year in which we were able to secure two center grants from the National Institutes of Health: the Botanical Research Center grant announced earlier in 2005 and now a Clinical Nutrition Research Unit. I hope the new year will be full and rewarding for each The Louisiana Board of Regents and the LSU Foundation recently held a presentation and reception at the LSU and every one of you. I look forward to Lod Cook Alumni Center to recognize endowed chairs and professorships established through matching funds. sharing more news from the Center with you Recognized at the reception was the John W. Barton, Sr. Endowed Chair in Genetics and Nutrition at the in the future. Pennington Biomedical Research Center. The support fund provided a matching grant of $400,000 to the $625,000 in private funding from over 60 individuals and organizations to endow the chair in Barton’s name. Barton was recognized for his tireless efforts to provide guidance and leadership to the Pennington Biomedical Research Center. Attending the event were (left to right) Board of Regents Chairman Roland Toups; PBRF Barton Chair Development Committee Chairman Lee Griffin; PBRF Vice Chair Paula Pennington de la Bretonne; Claude Bouchard, Ph.D. honoree John W. Barton, Sr.; Pennington Center Executive Director Claude Bouchard; PBRF Supporter Imo Executive Director Brown; Board of Regents Vice Chairman Frances Henry; and LSU System President William L. Jenkins. two F O U N D A T I O N N E W S Cutting Edge Cancer William Hansel Laboratory of Cancer Research Underway Prevention Established With Major Gift to the William Hansel, Ph.D. is a remarkable Pennington Biomedical Research Center man. He arrived at the Center following an already lengthy career at Cornell The Pennington Biomedical Research Center University, from which he retired. has dedicated a new laboratory for cancer As a specialist in reproductive biology, prevention research to honor the scope and he brought a unique perspective to the promise of cancer research work led by Center, understanding the function and William Hansel, Ph.D. role of reproductive organs, cells and processes. While attending a scientific Through a major gift to the Pennington conference in Poland, he learned that Biomedical Research Foundation from certain hormones in the human body Edward and Loretta Downey of Maryland, behaved toward breast cancer cells in a and a matching gift from Dr. Hansel, the rather normal fashion. They attached laboratory was dedicated recently at a themselves to the surface of the breast reception held to recognize the donors and The William Hansel Laboratory of Cancer cancer cells to deliver chemical messages Prevention was dedicated recently at the – similar to how these same hormones the newly named laboratory. Pennington Biomedical Research Center with attach to ovarian cells to cause a major gift to the Pennington Biomedical ovulation. “We cannot begin to express our deep Research Foundation from Edward and gratitude to the Downey family, and the Loretta Downey (left) and a matching gift He had been working with just such support of their uncle, with this major gift from Dr. Hansel (right). The laboratory is hormones back at the lab and decided that establishes a laboratory devoted totally dedicated to the development and to create a deadly combination – for completely to the development and delivery delivery of new medications for the treatment cancer. He spliced a membrane of cancer. Drs. Hansel and Carola Leuschner destroying compound to the hormone. of drugs for the treatment of cancer,” said and their research team have developed two When the hormone attached itself to Claude Bouchard, executive director of the highly effective drugs that target and cancer cells, the “message” was a deadly Center. He praised Dr. Hansel for his work to selectively destroy cancer cells. The National blow, destroying the cancer cell develop cancer-treating drugs that have Cancer Institute has accepted one of these membrane and the cancer cell. recently been issued patents. One of these drugs into its Rapid Access to Intervention drugs is now being studied in a fast track Development Program. “It was the most remarkable result I had process by the National Cancer Institute. ever seen in my lab,” Hansel says. John Noland, chairman of the Pennington Biomedical Research Foundation, presented Within months he and his Center etched bronze medallions to the Downeys and Dr. Hansel during the reception. An etched colleague, Dr. Carola Leuschner, and wall plaque identifying the new lab was also unveiled. “Gifts such as these create viable Dr. Fred Enright of the LSU opportunities for achieving healthier lives today and for the next generation,” said Noland. Agricultural Center, were killing not only the main cancer tumors in laboratory animals, but also the cancer Also speaking at the event was Dr. William Richardson, chancellor of the LSU Agriculture cells that had split from the tumor Center, who talked about Dr. Hansel’s earlier groundbreaking research and discoveries in (metastasized) to migrate to other parts disease prevention in cattle. of the body. And he made this discovery in his eighties! Hansel, who has been a faculty member at the PBRC since 1990 and also works with the LSU Ag Center, previously served as the Gordon D. Cain Professorship of Animal The National Cancer Institute has taken Physiology. Prior to coming to Baton Rouge, Dr. Hansel served as the Liberty Hyde Bailey notice and included the cancer killing Professor of Animal Physiology at Cornell University. He has also received numerous grants compound in a “fast track” program aimed at accelerating the research from the National Institutes of Health, National Science Foundation and the USDA and process that will eventually lead to trials various scientific awards. in humans. Hansel and his research colleagues are hopeful that the first More than 60 faculty and friends attended the event held in the Atrium of the state-of-the- study for human subjects will take place art Basic Science Laboratory Building. within the next few years. Meanwhile, Hansel is in the lab daily working on the next steps and exploring new compounds. three Center Testing Means Some Diabetics May Soon Get Insulin Without Needles Literally generations of people with Type 2 The results were very good, with the diabetes have had only one means of powered insulin offering results similar to giving themselves the necessary insulin to injected insulin. That prompted the trigger their bodies’ muscles to consume manufacturers of the drug, called Exubera, glucose from their blood - daily needle to immediately apply to the Food and injections. Drug Administration (FDA) to allow the drug on the market. Dr. Cefalu was the Now, Pennington Biomedical Research only non-industry physician to go before Center physician William Cefalu, M.D., the FDA initial review board to present his has put needle-free insulin through a data. The review board recommended clinical trial to learn if patients can inhale approval of the drug by the FDA. a powdered form of insulin and get the PBRC clinician Anne Chatellier same results as the needle-injected form. demonstrates the Exubera inhaler. If A partnership between pharmaceutical approved by the FDA, patients will companies Pfizer and the sanofi-aventis Dr. Cefalu and his team recruited Type 2 use the device to crush an insulin Group developed the drug, and Nektar diabetics requiring insulin to participate in tablet into powder, then inhale it. Therapeutics created the inhaler. The the clinical trial. They were given a device FDA is currently reviewing the application that looks like a large asthma type inhaler. with a built-in handle, and then squirted and the review board’s recommendation. The clinical participants simply dropped a the dry powder in their mouths while tablet of insulin in the device, crushed it inhaling. Hurricane Emergency Dispatchers continued from page 1 Led by Drs. Steven Smith and Eric care…if they had supplies. Turning on a Texas, which the team monitored almost Ravussin, a team of physicians and dime, the team put the RV back in the daily for diabetic needs. The effort made clinicians quickly formed to go into garage, pushed aside equipment in the national and international news. nearby shelters to help those who were Center’s exercise facility to create a mini- facing the problem of managing their warehouse and, overnight, became a Since the first hectic days following the diabetes after a disaster. The team dispatch team for much-needed supplies. creation of the team, most supplies are rounded up their mobile research vehicle, They soon became the chief emergency now gone, shelters have closed and the sought assistance from the Pennington supplier of diabetic care supplies in the team believes it filled a critical need that Biomedical Research Foundation, and region, eventually serving more than 7,000 others overlooked. The effort was so reached out to insulin and diabetes supply patients. successful, a U.S. Senate staff member manufacturers. They also worked the came to learn first-hand and to take phones of the Louisiana Emergency But success brings its own problems. Smith recommendations back to Washington. Management Center and met face-to-face netted 18-wheelers of supplies that started with Red Cross staff. The team quickly rolling into the Center. That, plus a check Asked how he got so many people learned how to effectively meet the needs for $50,000 from Amylin Pharmaceuticals, involved so quickly with such success, Dr. of diabetics in the shelters; coordinating Inc. to the PBRF, to buy what they could Smith said his lab staff lives by a motto with the shelter staff. not get donated, created a huge demand that makes them think and plan big- for unloading, sorting, re-packaging and despite plenty of obstacles and naysaying: The first idea was to equip the vehicle to shipping. Even the Baton Rouge Rugby “You can’t succeed if you are not willing be a rolling clinic, driving from shelter to team got involved – recruited by a Center to fail.” shelter with insulin, oral medications, researcher/rugby player – to help unload swabs, insulin pumps and parts, nutrition, the trucks and deliver supplies. Editor’s note: As a footnote to this story, blood testing kits and the like. The team Pfizer Inc. recently made a $25,000 soon learned, though, that most shelters Smith’s group created more than 5,000 donation to the Pennington Foundation for had basic medical care and teams of 30-day “care packs” and shipped them to on-going diabetes education related to the medical personnel who could render centers across the south from Mississippi to effects of Katrina. four F O U N D A T I O N N E W S Does Obesity Begin Before We Are Born? HIBERNIA NATIONAL BANK VISITING SCIENTIST DINNER continued from page 1 causing a predisposition for common FEATURED SPEAKERS: CLAUDE BOUCHARD, PH.D., EXECUTIVE conditions, including obesity. DIRECTOR, AND JOHN NOLAND, PBRF CHAIRMAN OF THE BOARD For example, he said, other researchers have already found that low birth weight may M ore than 90 guests attended the economic development potential, and impact lifelong metabolic functions and recent 2005 Hibernia National Bank the factors for sustained and enhanced represents a significant risk factor for the Visiting Scientist Dinner Series hosted growth. Dr. Bouchard, who was development of metabolic diseases in by the Pennington Biomedical Research recently honored with the 2005 Earle adulthood. Foundation (PBRF). Cocktails were W. Crampton Award in Nutrition served in the atrium tower of the new from McGill University, demonstrated According to Ravussin, the nutritional and Basic Science Laboratory Building and in his presentation the expansion hormone mix that fetuses are subject to in dinner was served in the south atrium, potential on research discoveries, the womb seem to have a profound effect on overlooking the lake on the campus of including those in the areas of brain adulthood. The new CNRU will be dedicated the Pennington Biomedical Research development, maximizing disability to thoroughly examining these complex issues Center (PBRF). Featured speaker was free aging, stem cell and tissue and will provide an opportunity for Dr. Claude Bouchard, executive engineering applications, and in the “bridging” clinical and basic science. director of the Center. His topic was prevention of Alzheimer’s and other entitled “Unparalleled Growth-Unlimited dementia, heart disease and diabetes. Potential: Unleashing the Economic and Coypu Foundation Grant Scientific Power of PBRC.” John Noland, chairman of the Establishes New Laboratory Pennington Biomedical Research Foundation, spoke of his dedication The Pennington Biomedical Research to the institution and in calling forth Foundation proudly acknowledges an others to realize its enormous important new $200,000 grant from the potential on quality of life issues and Coypu Foundation to establish a new laboratory, designated specially to support the economic development potential to newly awarded Clinical Nutrition Research the state. He challenged individuals in Unit at the Center. the group to become advocates of the Center as well. Also attending the The new laboratory, to be called the John S. dinner was his wife, Virginia. McIlhenny Laboratory of Skeletal Muscle Welcoming guests and introducing Physiology, will focus on the vital role of Attending the scientific dinner were Noland was PBRF President and muscle mass and muscle composition, and Sr. Kathleen Cain, OSF; Jane Boyce; Chief Executive Officer Jennifer the cellular mechanisms playing a role in and Polly and John Hernandez. Winstead. response to environmental factors that trigger weight gains. The Coypu grant will also The 2005 Scientific Dinner Series was provide for much needed skeletal muscle Dr. Bouchard presented the guiding underwritten by Hibernia National studies in humans. “It is believed that principles of the Center: building a Bank, whose stockholders on the very metabolic impairments preceding the world-class research institution in same day approved the merger with development of metabolic syndrome, a preventive medicine, producing cutting- Capital One. Janet Rack, Hibernia precursor to Type 2 diabetes, reside in the edge and influential research, protecting senior vice president, spoke briefly at molecular pathways of muscle metabolism,” discoveries and promoting technology the dinner, expressing the bank’s said lead researcher Dr. Eric Ravussin. transfer, and fostering economic dedication to supporting the PBRC development which generates further and pledging continued support in “Through this new laboratory, the Coypu research opportunities. He also 2006. Foundation continues to keep its founder, discussed the breadth and depth of the John S. McIlhenny, at the forefront by Center’s work in disease prevention, its supporting grants in his lifelong areas of interest and study,” said John Hernandez, Visit www.pbrc.edu and www.pbrf.org Coypu Foundation board member. Sign up for our E-News at www.pbrf.org/explore.cfm/subcribe five Pennington Foundation Early LEGACY SOCIETY HONORS PLANNED GIFTS TO PBRC Fall Scientific Dinner Series The Pennington Biomedical Research council of financial professionals, chaired by Foundation’s (PBRF) mission is to provide PBRF board member Jerry Jolly, CPA, and Dr. Arya the Pennington Biomedical Research Center managing partner of KPMG, LLP. Serving as Sharma, a (PBRC) with vital funding for vital research co-chairman is Kevin F. Knobloch, CLU, physician and that aims to prevent premature death from CFP, client advisor at JP Morgan. Serving on faculty member chronic diseases. Since the Center first the council are other financial advisors: G. of McMaster opened, it has relied on gifts from business Rolfe Miller, branch manager, Morgan University of and industry, individuals and foundations to Keegan; Elizabeth Querbes, senior vice Canada, was a supplement its grant awards and state PBRC faculty member Dr. Steven president, Morgan Stanley; Jason T. Green, special guest funding. These private gifts are crucial to the managing director, Stanford Group speaker at the Smith; PBRC Executive Director Dr. Claude Bouchard; Scientific Dinner Center as they often provide “bridge” or Company; Kevin C. Curry, partner, Miller, Pennington interim funding not available from other Hawthorne, D’Armond, McCowan & lecturer Dr. Arya Sharma; Hibernia Biomedical sources. These private donations have Jarman, LLP; Blanchard Sanchez, partner, National Bank/Capital One Senior Research Vice President Janet Rack; and recruited top scientists, created numerous McArthur Sanchez Associates; and William Center. He Pennington Biomedical Research laboratories, endowed chairs and C. Potter, CPA, JD, managing director, spoke to Foundation Chairman John Noland professorships, and matched grants for Postlethwaite and Netterville, APAC. supporters of promising new scientific discoveries. the Pennington Biomedical Research Foundation According to Jennifer Winstead, PBRF at the Hibernia National Bank Visiting Scientist Increasing interest in long-range giving has president and CEO, “This group of estate Dinner Series held recently at the Basic Science prompted the Center to create a Legacy planning advisors is lending its collective Laboratory Building on the Center's campus. He Society for individuals and families seeking expertise and vast years of financial planning discussed the escalating rate of obesity in the planned giving opportunities. Membership knowledge to provide the PBRF with viable population, particularly in children, and the in the Legacy Society is open to anyone who instruments and methods of planned giving urgent need for research and study on all aspects includes the PBRC and PBRF in their estate that are advantageous to both the individual of its causes: the environment, genes, and food plans. According to PBRF Chairman John and the institution.” choices and portions. He demonstrated the Noland, “Charitable gifts provide an extensive societal changes during the last 50 years, individual with great personal satisfaction, The Legacy Society membership is which directly reduce one's physical exertion in and the institution with an important acknowledged in various PBRF publications, both the home and work environment. He noted opportunity to enhance the scope and recognized at scientific educational events, the escalating production of processed and fast breadth of its work. A planned gift creates a and included on the new donor wall in the foods, and the popularity of larger portions. It is long-range and enduring investment which C. B. Pennington, Jr. Building. now widely understood that obesity contributes to moves the institution forward.” the development of diabetes, heart disease, For more information on the Legacy Society, hypertension, metabolic syndrome, and some Providing leadership and direction to this contact PBRF Chief Financial Officer, Brad Jewell, cancers, he said. development activity is a newly formed at 225-763-2684 or firstname.lastname@example.org. In his visual presentation, Dr. Sharma acknowledged the importance of obesity research PBRF DEVELOPMENT DIRECTOR NAMED now underway at the Pennington Center. He emphasized the importance of the work at The Pennington Biomedical additional revenue and branding institutions and called for more research to Research Foundation opportunities. More recently, Bell led identify medical, behavioral and pharmaceutical welcomes Melissa A. Bell as multiple cross functional teams to methodologies to help individuals retain their its new Director of implement new and emerging fundraising weight loss once it has been achieved. He said Development. Bell joins the initiatives. Over the past three years, she additional study into the role of long-term Pennington team to drive development directly raised more than $15 million medications for weight management and the initiatives related to donor giving programs, dollars and acquired more than 180,000 impact of various types of surgery now used for donor cultivation and retention, planned new donors through donor cultivation and morbid obesity is vital to finding optimal giving and special event oversight to achieve retention efforts for St. Jude. solutions. the Foundation’s goals for the Center. Prior to joining the Pennington Foundation, Bell Originally from St. Tammany Parish, Dr. Sharma made his presentation to more than served as the Director of Donor Cultivation Melissa and her husband, Jeff, who is a 75 guests of the Pennington Biomedical Research Marketing for St. Jude Children’s Research landscape architect and land planner Foundation. He also spoke to the faculty and staff Hospital, working for their headquarters in employed with SJB Group, Inc. in Baton during his two day visit. The PBRF event was Memphis, Tenn. Bell began her fundraising Rouge, returned to Louisiana recently with held in the south atrium of the new Basic Science career back in 1997 where she managed the their two children to be closer to their Laboratory Building, overlooking the lake on the monthly sustainer program for St. Jude, and family and to invest their talents in the grounds of the Pennington Biomedical Research then was promoted to launch St. Jude’s first Louisiana communities that they call Center. catalog merchandising program to raise home. six Healthier Living and Weight Loss Focus of Studies Pennington researchers are currently seeking citizen volunteers for the following clinical studies Take II — Diabetic Research Study • Not taking medications or nutritional supplements to lower blood pressure The Pennington Biomedical Research Center needs volunteers to • Not taking any medications regularly (thyroid medications are accepted participate in the Take II diabetes research study. We are testing the if stable dose.) effect of FDA approved medications versus diet. You will be required to • Females cannot be pregnant, breastfeeding or planning to become have 2 fat biopsies, 2 CT scans at the Baton Rouge General, and 2 6- pregnant hour clinic visits. Participants will be compensated $350 at the completion of the study. To qualify: • Be age: 35-75 Breakfast Study — 8-Week Weight Loss Study • Have Type 2 diabetes • Control diabetes with diet or one medication The Pennington Biomedical Research Center is conducting the Breakfast • Have never taken Actos or Avandia Study to compare the effects of two different breakfasts on weight loss. • Weigh less than 300 pounds 160 people will be recruited and randomly assigned to 1 of 4 groups: • Have not had kidney, liver or lung disease 1. Egg Breakfast with no diet plan • Thyroid and some Blood Pressure medications allowed 2. Egg Breakfast with diet plan Participants will be compensated $200. 3. Bagel Breakfast with no diet plan 4. Bagel Breakfast with diet plan EKODE — 6-Day Blood Pressure Study The “Bagel Breakfast” consists of a bagel, cream cheese and yogurt. The The Pennington Biomedical Research Center is conducting a 6-day “Egg Breakfast” consists of two eggs and two pieces of toast with jelly. blood pressure study. This study will examine an oxidized fatty acid Volunteers will be responsible for buying and preparing the food at home called “EKODE,” and its influence on blood pressure. and will eat the prescribed breakfast at least 5 days/week for 8 weeks. Throughout the 6-day testing period, participants will eat a diet high in Regardless of group assignment, all volunteers will meet with a registered sodium. All foods will be provided by PBRC throughout the testing dietitian at each visit to discuss the breakfast requirements and period (no additional foods are allowed). Dinner will be eaten at PBRC compliance. while breakfast and lunch will be packed to take out. Study Design: Study Design: • 1 screening visit • 4 other clinic visits • 1 screening visit To qualify: • 6 other clinic visits (participants are admitted for one overnight stay • Age: 20 – 60 on the in-patient unit on day 4 of the testing period) • BMI: 25 – 50 To qualify: • No unstable chronic disease • Age: 35 – 65 • Cannot have a weight change of more than 5% in the past 3 months • BMI: 20 – 35 (Normal to overweight) • Cannot dislike or be allergic to eggs or bagels • No chronic disease • Volunteers with controlled diabetes are also welcome • Non-smoker Participants will be compensated $200 at the completion of the study. • Cannot have elevated blood pressure > 160/95 If you are interested in participating in a research study, call our recruiting department at 225-763-2596 or visit www.pbrc.edu NEW FACULTY FACULTY RECOGNITIONS Nathan Markward, Ph. D., Paula Geiselman, Ph.D. Weihong Pan, M.D., Ph.D., M.P.H. joins the faculty as an has been appointed to the has been asked to join the Assistant Professor-Research. Digestive Diseases and Neuroendocrinology, He is a specialist in human Nutrition Study Section of Neuroimmunology and Behavior genome epidemiology (HuGE), and his the National Institute of Diabetes and [NNB] Study Section of the National research will be part of the new program we Digestive and Kidney Diseases Institutes of Health (NIH). This panel is are developing in the area of Population (NIDDK), an institute of the National concerned with the neurobiological basis of Health and Prevention Studies. Dr. Institutes of Health (NIH). This panel is behavior across the life span, with a focus on Markward received a Master of Public concerned with obesity, digestive diseases, neuroendocrine, neuropeptide, and Health in Epidemiology from Tulane liver, nutrition, and eating behavior. Dr. neuroimmune systems. Major areas of University in 1997, and his Ph.D. in Geiselman’s appointment is effective interest include ingestive behaviors, drugs of Human Genetics from Louisiana State through June 30, 2009. In this position, abuse, stress, and interactions of the brain University in 2001. He comes to the she will review competitive research grant with immune systems. This panel will review Center from private industry in Vancouver. applications to NIH. competitive grant applications to the NIH. seven Non-Profit Org. Pennington Biomedical Research Foundation U.S. Postage 6400 Perkins Road PAID Permit NO. 664 Baton Rouge, LA 70808-4124 Baton Rouge, LA www.pbrf.org www.pbrc.edu 225-763-2511 PENNINGTON BIOMEDICAL RESEARCH CENTER LOUISIANA STATE UNIVERSITY SYSTEM PBRF BOARD OF DIRECTORS Chairman, John B. Noland Immediate Past Chair, Kevin P. Reilly, Sr. Pennington in the News in the News A ROUND-UP OF CENTER NEWS AND NEWS MAKERS • A PBRC team of physicians and clinicians offering aid to diabetic evacuees of Hurricane Katrina Vice Chair, Paula P. de la Bretonne made news locally, nationally and internationally, including the Boston Globe and Swissinfo, and all Treasurer, C. Brent McCoy local media. Secretary, Kevin R. Lyle • The Associated Press distributed a story carried by the Times Picayune and others on the Center’s Directors new, major grant to create a Clinical Nutrition Research Unit to study prenatal causes of obesity. Tim A. Barfield Annette D. Barton • Knight Ridder sought Dr. George Bray for a story on the impact of sweetened drinks on children. Madhu Beriwal Bray says the sweetener Fructose adds calories to the diet, but the brain does not sense it in the diet, J.S. "Si" Brown, III which leads to over-consumption. The story was carried in newspapers across the nation. J. Terrell Brown • Public television stations nationwide are airing a special documentary that features the work of Joseph H. Campbell, Jr. current and former Center researchers to overcome childhood obesity. Louisiana Public Broadcasting Maxine Cormier produced the program called Step by Step, Kids Trimming Down, with a significant gift from long- Dr. Roy G. Kadair time Center supporter Kevin Reilly. J. Gerald "Jerry" Jolly, CPA Charles A. Landry Betsy S. Nalty FACTS ABOUT THE PENNINGTON CENTER James M. Nolan Mission: To promote healthier lives through research and education in nutrition and preventive Nanette Noland medicine. Bert S. Turner Size: Main research facilities: 575,000 square feet; grounds: 234 acres. Ex-Officio, Claude Bouchard, Ph.D. Staff: 70 faculty members, 50 post doctorates, and more than 500 technicians and support Executive Director, PBRC personnel. Ex-Officio, William L. Jenkins, Ph.D. 6 Research Divisions: Functional Foods, Experimental Obesity, Clinical Obesity and Metabolic President, LSU System Syndrome, Nutrition and Chronic Diseases, Health and Performance Enhancement and Education, and Nutrition and the Brain. The Center also has an Education Division. CEO, Jennifer G. Winstead Laboratories: 13 laboratories and 16 core service laboratories including genomics, proteomics, CFO, J. Brad Jewell, CPA clinical chemistry, mass spectrometry, cell culture, comparative biology, transgenic, body composition, and food analysis laboratories. Clinic: Outpatient examination and interview rooms, inpatient rooms for 14 research volunteers, metabolic kitchen, metabolic procedure room, two whole-room indirect calorimeters, dual energy X-ray absorptiometry, and ultrasound imaging. Printing compliments of The Pennington Biomedical Research Foundation provides the Pennington Biomedical Research Center Blue Cross and Blue Shield of Louisiana with vital funding for nutrition-based research that aims to prevent premature death from chronic diseases.
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