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					Department of Oncology

                                    Job Description



Job Title:            Postdoctoral Research Scientist

Reference:            AN-11-021-JF

Salary Grade:         University Grade 7
                      £29,099 - £35,788 per annum

Location:             Old Road Campus Research Building, Oxford

Responsible to:       Dr John Fenwick

Tenure:               The post is available until 30th September 2013 in the first instance

Role Summary:         To quantify the variability of radiotracer uptake levels visualized in
positron-emission-tomography (PET) tumour images collected using different imaging
systems and reconstruction algorithms, and to design radiobiological metrics (for
transforming tumour maps of hypoxia and proliferation into maps of selective dose
escalation) which are robust to imaging system variability.


Background

The Department of Oncology was created in October 2010, under the headship of Professor
Gillies McKenna, to enhance the coordination of clinical and basic cancer research in Oxford.
The Department incorporates the Cancer Research UK-MRC Gray Institute for Radiation
Oncology & Biology, the Department of Medical Oncology, the Department of Clinical
Pharmacology and the Surgical Oncology Group of the Nuffield Department of Surgical
Sciences.

The Department is the second largest in the University’s Medical Sciences Division. Its
activities currently cover four sites: the Old Road Campus Research Building, science
facilities in the Weatherall Institute of Molecular Medicine at the John Radcliffe Hospital, the
Radiobiology Research Institute on the Churchill Hospital site, and clinical service and
facilities at the Cancer Hospital.

The creation of the new Department marks an exciting step towards truly multidisciplinary
and collaborative oncology research in Oxford and positions us to take this discipline to new
heights. Working closely with colleagues in the new state-of-the-art NHS Oxford Cancer
Centre, research can be rapidly and efficiently translated into cutting-edge clinical treatment
for cancer patients.



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Over the last 15 years radiation oncology has been transformed by the successive advances
of conformal therapy, intensity modulated radiotherapy (IMRT), rotational IMRT, and image-
guided radiotherapy (IGRT). A core aim of the Department of Oncology’s physics group is to
develop new treatments that use functional imaging, genomics, and biomarker data to further
enhance classic anatomy-based IMRT and IGRT. In particular functional imaging will
facilitate specific targeting (‘dose-painting’) of hypoxic and rapidly proliferating tumour
regions, enabling dose-escalation to be achieved with minimal increase in normal tissue
toxicity. Additionally sequential data (imaging, genomics or biomarker) may open up new
avenues for individualization of dose and radiation scheduling. Our group is using detailed
computational modeling to incrementally fine-tune these functional approaches and to
delineate their ultimate potential and limitations.

                                     Responsibilities

Research


      The post-holder will use experimental and computational techniques to quantify the
       variability of radiotracer uptake levels visualized in positron-emission-tomography
       (PET) tumour images collected using different imaging systems and reconstruction
       algorithms. Additionally he/she will contribute to the development of radiobiological
       metrics used to transform tumour image-maps of hypoxia and proliferation tracers into
       idealized dose-maps, in which hypoxic or rapidly proliferating tumour regions receive
       escalated dose-levels.

       Specifically, the aim of the work is to design metrics that are as robust as possible to
       changes in the performance of imaging systems, and to differences between imaging
       systems and algorithms, so that dose-painted treatment plans are an accurate and
       reproducible reflection of patients’ tumour function rather than details of the imaging
       system. Currently our group is working hard, using computational biology techniques
       to analyse sequential tumour proliferation (PET-FLT) and perfusion image,
       developing image-to-dose conversion metrics on the premise that the imaging data is
       accurate. This project will make that work more robust and bring it closer to clinical
       deployment.

      The project lies at the interface between radiotherapy, imaging physics and
       computational biology. Applications are welcome from candidates with a research
       background in medical physics or bioengineering, or in mathematical/systems
       biology.

Supervision


      The post-holder may be required to assist with the supervision of students on a day-
       to-day basis.

Communication


      Generate high quality data and reports suitable for publication and for submission in
       the context of grant proposals.
      Participate and contribute to group discussions and meetings including the
       presentation of own or published data.
      Present results in oral and written form, and discuss scientific findings at national and
       international meetings.


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      Inform the Group Head and senior team members about progress or difficulties in
       research projects or services.
      Maintain confidentiality regarding research data when interacting with non-
       collaborating researchers.
      Take the lead in, or contribute to, as appropriate, the preparation of manuscripts for
       peer-review and publication in scientific journals.

Education and Training

      Keep up to date with developments in functional imaging, radiotherapy of lung and
       head-and-neck cancers, and computational biology.
      Assist in the education and training of other staff in laboratory procedures.

General responsibilities

      Be accountable for their professional conduct within the Group.
      To undertake duties as may be required from time to time that are commensurate
       with the grade and responsibilities of the post.
      To conduct him or herself with due regard to the University Equal Opportunities and
       Data Protection policies.


                                   Person Specification

Essential Criteria

The successful applicant will be expected to meet the following criteria:

      PhD in imaging or radiotherapy physics, or computational biology.
      A high level of technical competence in computational modelling.
      Good publication record.
      Ability to work independently and under their own initiative.
      Ability, skills and confidence to communicate in English, both orally and in writing.
      Highly-motivated, enthusiastic individual.


Desirable criteria
      Experience of medical imaging.
      Experience of statistical analysis.
      Some background knowledge of both medical physics and computational biology.
      Experience of successfully preparing and submitting scientific data for publication.
      Good oral and written presentation skills.




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                                      Application Procedure

To apply please send a letter of application describing why you are applying for the position
and how you meet the advertised criteria together with your CV and the Personal Details
form (that is available from the website www.rob.ox.ac.uk/opportunities) to:

Personnel Manager
Department of Oncology
University of Oxford
Old Road Campus Research Building
Off Roosevelt Drive
Headington
Oxford OX3 7DQ

or email it to: recruitment@rob.ox.ac.uk

The closing date for applications is Wednesday 31st August 2011. Applications received
after this date will not be considered.

The University reserves the right to screen individuals for employment. Any such screening
would be discussed with you in advance of it taking place.

Please ensure that you quote the reference AN-11-021-JF in all correspondence.



                                          Pay and benefits

The salary offered for a full-time appointment to this job will be University grade 7 in the range £29,099
- £35,788 per annum (with a discretionary range to £39,107 per annum), depending on qualifications
and experience. If you are appointed at a salary below the top of the substantive range, your salary
will automatically be increased each year until you have reached the top point. Increases beyond this
point may be available in certain cases. If appointed within the discretionary range, no automatic
incremental progression should be expected during this appointment. There is also an annual ‘cost-of-
living’ salary review, which normally takes place in summer each year. For a full-time appointment, the
annual holiday entitlement will be 38 days (including 8 public holidays). Full Time hours of work are
37.5 hours per week. Pay and benefits (including holiday entitlement) for part-time appointments are
worked out on a ‘pro rata’ basis.

The appointment is subject to satisfactory completion of a one year probationary period, during which
the notice period will be one month on either side. Once the appointment has been confirmed, the
notice period will be three months on either side.

The post is pensionable and the post holder eligible for membership of the Universities
Superannuation Scheme (USS), a contributory scheme to which members pay 6.35 per cent of annual
salary. Subject to the Statement of Pensions Policy, which will be issued to the successful candidate,
the appointee will be deemed to be in membership of the above pension scheme until such time as
he/she gives notice in writing to exercise the right not to be a member of the scheme. At present the
University’s normal retirement date for academic and related staff is 30 September preceding the 66th
birthday, except if the successful candidate can establish vested rights, as defined in the University’s
statutes (details available on request), to retirement at 67 or later, the date of retirement will not
normally be later than the 30 September immediately preceding the 68th birthday.

The University is currently considering the introduction of an Employer Justified Retirement Age of 67.
If adopted, this would mean that, with effect from 1 October 2011, the normal retirement date for all
academic and academic-related staff would be 30 September immediately preceding the 68th
birthday. There would be a procedure for considering requests from individuals to continue in
employment beyond that age. Employees contributing to USS will also be automatically enrolled in the
University’s Salary Exchange scheme for pension contributions from three months after joining the


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pension scheme, unless they give notice in writing to the Payroll Manager that they elect not to take
advantage of this facility at least one month before automatic enrolment. Details are available from the
following website: http://www.admin.ox.ac.uk/finance/salaries_expenses/salexchange/index.shtml.
The University also offers a Stakeholder pension scheme which most employees may join either
instead of, or in addition to, the main scheme.

The University has a generous maternity leave scheme and also offers paternity leave to expectant
fathers and partners, and adoption leave. It offers subsidised nursery places, a childminding network,
a holiday playscheme, and tax and National Insurance savings schemes. For further information see
http://www.admin.ox.ac.uk/eop/child.

                        Equal opportunities at the University of Oxford

As an Equal Opportunity employer, we positively encourage applications from people of different
backgrounds. All our jobs are filled in line with our equal opportunities code of practice, which helps us
make sure that men and women, people of different religions or beliefs, ages, racial groups, and those
with disabilities are all treated fairly.

POLICY STATEMENT
The policy and practice of the University of Oxford require that all staff are afforded equal opportunities
within employment. Entry into employment with the University and progression within employment will
be determined only by personal merit and the application of criteria which are related to the duties of
each particular post and the relevant salary structure. In all cases, ability to perform the job will be the
primary consideration. Subject to statutory provisions, no applicant or member of staff will be treated
less favourably than another because of his or her gender, marital or civil partnership status, sexual
orientation, religion or belief, racial group, age or disability.

If you have any questions about equal opportunities at the University of Oxford, please visit our web-
site at www.admin.ox.ac.uk/eop.


                               Working for the University of Oxford

At the University of Oxford, we’re naturally very proud of our outstanding reputation for scholarship
and research. But we’re also proud to say that we’re one of the region’s biggest and best-established
employers, with a real diversity of staff helping to sustain our success - from lab. assistants, cleaners,
technicians and secretaries, to IT, finance and administrative professionals. Join us, and you can
expect to find yourself working in a friendly, open-minded atmosphere where your ideas will be
welcomed, with an interesting and satisfying job to do, and with plenty of opportunities to learn new
skills, or maybe even get some extra qualifications.

As well as pay and other benefits such as generous holidays and an excellent pension scheme, we
may be able to help you with:

       Training – We train our staff, both in the skills needed for starting the job, and to help them
        develop afterwards. If you don’t have all the skills we are looking for (e.g. computer
        packages), but you know that you are a quick learner, it’s worth asking if training might be
        available.
       Working hours – We may be able to be flexible about working patterns to help you combine
        work with responsibilities at home. Even for full-time jobs, we can often adjust starting and
        finishing times, or even sometimes consider term-time-only working: if this is important to you,
        let us know.
       Disability – If you have a disability, we have specialist staff who can help you to start and stay
        in work.
       Childcare – We have several subsidised nurseries for under-fives, a holiday play scheme,
        and tax and national insurance savings schemes. For further information see
        http://www.admin.ox.ac.uk/eop/child.
       Parenting – As well as providing childcare facilities, we have generous maternity, paternity
        and adoption leave schemes to help new parents on our staff.


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       Cultural and religious needs – We respect the cultural and religious lives of our staff. If you
        need time away from work, or special facilities, and can give plenty of notice for arrangements
        to be made, this will always be considered.
       Travel arrangements – We offer an interest-free season ticket loan scheme for bus or train
        season tickets. Annual passes for Oxford Bus Company routes are available at discounted
        rates.
       Use of University facilities – All University staff can use the study facilities provided by
        University libraries and museums; join the University Club, a sports and social club which has
        its own bar, café, and reading room; and make use of the University Sports Complex and the
        Pulse fitness centre.
       Discounts – A number of discounts are available to University staff e.g. for insurance, holiday
        travel, and computer equipment.

The range of benefits is continuously reviewed and extended. For further information see
http://www.admin.ox.ac.uk/ps/staff/benefits/




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