Blot Lane Antibody#Protein Expected Obs Rpt 1 Rpt 2 Ave Dilution B 7 F46820 14-3-3 epsilon-27KD 29 27 1007 1067 1037 1:1000 14-3-3 epsilon-33KD 29 33 527 652 589 B 34 556596 14-3-3-27KD 30 27 4148 3484 3816 C 31 F97320 4F2 hc/CD98HC-75KD 80 75 550 547 548 1:250 B 29 B92320 53BP2 137 163 649 1488 1068 1:250 B 31 F58420 5-Lipoxygenase 79 79 587 679 633 1:250 D 16 P42820 80K-H 90 98 3663 2579 3121 1:2500 B 23 A63920 ABP-280 280 280 1084 1129 1107 1:250 A 24 A80820 ABR 100 108 627 349 488 1:1000 D 5 A27320 Acetylcholinesterase 68 70 4318 4962 4640 1:2500 B 29 A43920 Adaptin alpha 112 105 2309 1850 2080 1:1000 C 5 A35620 Adaptin beta 106 101 2032 1225 1629 1:5000 C 13 A36120 Adaptin gamma 104 96 1909 1997 1953 1:5000 A 2 A60520 AF6 182 175 4796 5371 5084 1:500 C 12 A79920 AIB-1 160 169 999 557 778 1:250 C 28 A78720 AIM-1 41 40 261 257 259 1:250 B 30 A12520 AIP1 105 100 694 858 776 1:250 B 16 A99520 AKAP121/S-AKAP84-106KD 121/84 106 423 455 439 1:250 AKAP121/S-AKAP84-127KD 121/84 127 473 460 467 B 5 A59820 AKAP149 149 140 1188 530 859 1:500 B 10 A84320 ALDH 55 50 979 975 977 1:250 C 7 A50620 ALG-2 22 21 14087 10242 12165 1:2500 C 21 S13120 alpha-/beta-SNAP-33KD 35/36 33 5213 5277 5245 1:5000 alpha-/beta-SNAP-37KD 35/36 37 323 466 395 D 25 C21620 alpha-Catenin 102 113 605 655 630 1:250 A 5 S63320 alpha-Synuclein 19 20 394 573 483 1:500 C 30 A64120 AMPK beta 38 37 439 427 433 1:250 B 26 A13920 Annexin I 38 37 6191 4554 5373 1:5000 A 14 A14020 Annexin II 36 38 20824 27972 24398 1:5000 B 28 A29920 Annexin IV 36 34 1653 760 1206 1:2500 C 10 A30120 Annexin VI 70 67 2330 2114 2222 1:5000 B 9 A56920 Annexin VII 51 46 464 882 673 1:1000 C 21 A61220 Annexin XI-53KD 56 53 276 253 265 1:15,000 C 33 A96220 AOX1 150 139 294 562 428 1:250 A 37 A92120 AP50 50 52 768 727 748 1:250 B 31 A92820 Apaf-1 130 138 821 789 805 1:250 D 35 A82620 APM 120 130 1079 943 1011 1:250 C 3 A40720 ApoE 36 33 859 1583 1221 1:1000 A 39 A11120 APP-BP1 59 62 1018 510 764 1:1000 D 30 A78520 Aralar-63KD 70 63 2440 2566 2503 1:2500 Aralar-70KD 70 70 2973 2192 2583 A 11 A63220 ARF-3 20 21 10330 12906 11618 1:500 C 18 A37720 Arp3 50 47 613 721 667 1:1000 A 39 A34020 ASAP1 130 135 2419 1304 1862 1:500 D 2 A10020 ASS 46 51 673 1079 876 1:2500 A 20 B40820 B2 Bradykinin Receptor-39KD 42 39 117235 118616 117926 1:1000 B2 Bradykinin Receptor-43KD 42 43 67300 55730 61515 C 23 B54120 B56 alpha 56 49 824 905 864 1:5000 B 30 B36420 Bad 23 22 20134 24026 22080 1:500 A 4 B33720 BAF47 47 47 4730 3827 4278 1:250 C 20 B11020 BAF60a 60 57 4600 2373 3486 1:500 B 15 F67720 basic FGF-19KD 18-24 20 3839 2815 3327 1:1000 basic FGF-21KD 18-24 21 921 465 693 basic FGF-22KD 18-24 22 2933 1901 2417 basic FGF-24KD 18-24 24 951 666 808 D 2 B73520 Bax 21 22 1297 1054 1176 1:250
Background The family of 14-3-3 proteins has b
4F2 antigen (CD98) was identified Apoptosis occurs under a variety o 5-Lipoxygenase (5-LO) is the initia The fibroblast growth factors (FGF ABP-280, also known as non-mus The biological activity of Ras and o Acetylcholinesterase (AChE) is a t Sorting of integral membrane prote Sorting of integral membrane prote Sorting of integral membrane prote AF6 (ALL-1 Fusion partner in chro Signal transduction via nuclear ho The mitotic phase of the cell cycle Apoptosis is a selective process o Intracellular compartmentalization
The targeting of protein kinases an Aldehyde dehydrogenase (ALDH) Apoptosis is a selective process o Eukaryotic protein trafficking involv
The catenins (a-, b-, and g-) are cy Synuclein cDNA was isolated from AMP activated protein kinase (AM Annexin I (a.k.a. lipocortin-1 or ca Annexin II (p36), originally discove Annexins are a widely expressed f Annexins are a widely expressed f Annexin VII, also known as synexi Annexins are a widely expressed f Aldehyde oxidase (AOX), xanthine Sorting of integral membrane prote The process of apoptosis requires Enkephalins are neuropeptides tha Apolipoprotein E (ApoE) is an imp Amyloid precursor protein (APP) g Mitochondria are the primary sites
The ADP-ribosylation factors (ARF Cellular morphology, adhesion, an The ADP-ribosylation factors (ARF Argininosuccinate synthetase (AS Bradykinin is a nine-amino-acid va
Reversible phosphorylation by pro Isolated by screening for Bcl-2 inte SWI/SNF complexes facilitate gen SWI/SNF complexes facilitate gen Basic Fibroblast Growth Factor (bF
Proper development and maintena
B D E C D B E D A A C C C D E C B B A A A C A A A C E C
C A A D B E D B B D C A C C D E D
34 B61220 Bcl-x-22KD 21 B22620 Bcl-x-32KD 36 B35220 Beclin-56KD Beclin-63KD 39 B32320 Bet1 22 A47520 beta-Arrestin1-55KD beta-Arrestin1-57KD 5 C19220 beta-Catenin-95KD 23 D34020 beta-Dystroglycan 30 B97920 Bid 1 G73320 BiP/GRP78-78KD BiP/GRP78-87KD 5 B58720 BM28-120KD BM28-131KD 3 B63620 BMX 30 B12520 Bog 20 B10520 Btf 25 B80520 Btk 31 B11520 Bub3 27 C77720 Cab45 2 C45520 Calnexin 38 C41720 Calreticulin 1 C69520 Calretinin 36 C89220 CaM Kinase II 2 C46920 CaM Kinase Kinase-69KD CaM Kinase Kinase-75KD 4 C42920 CAS 1 C40520 Casein Kinase I epsilon 29 C11320 Casein Kinase II alpha-40KD Casein Kinase II alpha-44KD 3 C63120 CASK 29 662305 Caspase 8 6 C97020 Caspase-14 7 I75620 Caspase-2/ICH-1L-43KD Caspase-2/ICH-1L-46KD Caspase-2/ICH-1L-51KD Caspase-2/ICH-1L-55KD 6 C31720 Caspase-3/CPP32 26 C76920 Caspase-3/CPP32-33KD 23 M64620 Caspase-7/MCH-3 9 C64020 Cathepsin D-35KD Cathepsin D-43KD 28 C43420 Caveolin 1-18KD 19 C13620 Caveolin 1-23KD 26 C92720 CD40 7 C45820 CDC25B-57KD CDC25B-60KD 3 C40920 CDC27 16 C50820 CDC37 9 C70820 CDC42 2 C20020 CDC42GAP-56KD CDC42GAP-60KD 24 C12720 Cdk1/Cdc2 9 C18520 Cdk2 18 554090 Cdk5-37KD 39 C29920 Cdk7 3 15811A c-erb-B2
26 26 61 61 18 55 55 92 43 23 78 78 125 125 80 19 150 77 40 45 90 60 29 52 68 68 100 47 45 45 120 55 36 48 48 48 48 32 32 35 43/28 43/28 22 22 44 63 63 97 50 22 53 53 34 33 31 42/44 185
22 32 56 63 17 55 58 95 45 21 79 87 119 131 71 21 144 71 44 43 93 57 34 51 70 75 96 48 40 44 121 58 34 43 46 51 55 31 33 37 35 43 18 23 43 57 60 97 53 21 56 61 30 29 38 42 228
1048 4865 10850 8586 3637 4933 8715 5670 854 4397 2872 55317 14089 30119 941 2248 6206 300 20732 2900 2484 3869 470 2921 1901 2185 22986 1848 1488 1918 1510 152 1455 884 2552 1508 1082 75331 310 8151 614 920 429 3099 1148 400 255 6036 3232 5734 2066 2732 11115 1993 2100 7366 5590
1125 3423 14022 4766 2814 3859 7636 5087 507 3623 14533 94527 15073 34122 2962 2151 6185 392 15208 2208 3553 4319 413 2711 1376 1606 14663 3190 837 1197 1600 251 1093 850 1359 2171 702 62029 195 6491 211 337 415 2323 2251 507 305 3497 2956 4549 1551 1744 11007 1865 2299 4030 4132
1086 4144 12436 6676 3226 4396 8175 5379 681 4010 8703 74922 14581 32120 1951 2199 6196 346 17970 2554 3019 4094 441 2816 1639 1896 18825 2519 1163 1558 1555 201 1274 867 1956 1840 892 68680 252 7321 412 629 422 2711 1699 454 280 4767 3094 5141 1808 2238 11061 1929 2200 5698 4861
1:500 1:500 1:500
Bcl-x is related to the Bcl-2 protein Bcl-x is related to the Bcl-2 protein Autophagy is the bulk degradation
1:10,000 Most vesicular fusion events requi 1:250 b-Arrestins were discovered due to 1:500 1:500 1:1000 1:250 1:500 1:1000 1:1000 1:250 1:250 1:500 1:250 1:1000 1:2500 1:250 1:2500 1:1000 1:1000 1:250 1:500 1:500 1:250 1:1000
b-Catenin is a 92 kDa protein that Formation of the neuromuscular ju Members of the Bcl-2 protein fami Synthesis of nascent proteins occu
BM28 is a phosphoprotein that mig
BMX (bone marrow X kinase) is a The retinoblastoma (Rb) tumor su Apoptosis, a selective process of g Bruton's tyrosine kinase (Btk) is a Accurate chromosome segregatio Calcium is a key participant in a m Calnexin is a 90kDa integral mem Proteins undergo numerous modif A low level of intracellular free Ca2 Ca2+/calmodulin-dependent prote Ca2+/Calmodulin (CaM)–depende
CAS (Cellular Apoptosis Susceptib Casein Kinase Ie (CKIe) is a produ Casein kinase II (CKII, CK2) is a p
CASK is a recently identified cytos
Apoptosis, a selective process of g Caspase-2/ICH-1 is related to the
1:1000 1:1000 1:1000 1:1000 1:5000 1:500 1:2500 1:1000 1:500 1:1000 1:250 1:250 1:2500 1:2500 1:250
Apoptosis, a selective process of g Apoptosis, a selective process of g Apoptosis is induced by cysteine p Cathepsin D, an enzyme that degr
Identified as a tyrosine phosphory Identified as a tyrosine phosphory CD40, a member of the TNF recep In the eukaryotic cell cycle, the M
CDC16 and CDC27 were discover Progression through the cell cycle Rho family members are small GT CDC42GAP is a GTPase-activatin
p34cdc2 is a ubiquitously express Cyclin-dependent kinase 2 (Cdk2)
Progression of the mammalian cel
B B D E A A D A A C C D B A D E E C A C D D B D D C D C A A D C B D C B D C A B D C A B D A
19 19 26 5 8 18 33 38 16 1 25 34 1 2 23 37 27 7 39 9 20 4 6 7 13 34 10 4 26 7 28 4 11 14 32 7 31 10 19 26 23 11 5 29 20 15
C25020 C25020 C99420 C43820 C81820 C38720 C28020 C16120 C13720 C39520 C22420 R19120 C12620 C73220 C14520 C32820 C33020 C39220 C32620 C62920 C88020 C28620 D29720 D56620 D90420 D77620 D76320 D58520 D67820 D80320 D99320 D73020 D86520 556597 P61520 D39920 D10520 D80020 D74620 D25520 D27120 D63020 D62320 E51120 E46420 E39120
B B E B B
32 E83020 13 4 23 32 E88120 C20820 E50020 E83920
CHD3-246KD CHD3-261KD Chk2 Clathrin Heavy Chain-169KD CLIP-115 Cofilin Coilin COMT-23KD COMT-24KD Connexin-43 CoRest Cox-2 C-Raf-68KD C-Raf-74KD Crk CRP1 Csk CtBP1-47KD CtBP2-52KD CTCF-134KD CUL-1 CUL-2 Cyclin A Cyclin D3 DAP Kinase DAP3 DBP2 Dematin DFF45 DHFR Dlg-124KD DLP1-90KD DMPK DNA Polymerase delta DNA Polymerase epsilon cat. DNA Topo I Dok1/p62dok DRBP76-83KD DRBP76-89KD drp1 DSIF Dynactin Dynamin Dynamin II Dystrobrevin Dystrobrevin E2F1 EB1 EB3-38KD EB3-40KD EB3-43KD EBP50-49KD EBP50-54KD ECA39 E-Cadherin-120KD EFP Eg5
221 221 60 180 115 19 80 24/28 24/28 43 66 70 74 74 40 23 50 48 48 140 90 76 60 33 160 46 119 48-52 45 21 140 84/79 88 125 261 100 62 90 90 27 160 50 100 100 87 87 46 30 38 38 38 50-53 50-53 43 120 71 120
246 261 56 169 111 20 81 23 25 42 61 65 68 74 37 24 52 47 52 135 87 68 56 36 146 45 141 56 48 22 124 90 85 126 246 113 63 83 89 33 148 53 102 116 77 97 45 35 38 40 43 49 54 43 120 73 128
3943 3717 2589 42873 3673 2310 1802 4120 655 3226 2721 644 2864 6190 8726 4719 1544 3847 38477 1945 718 1054 3950 4602 1046 844 792 5126 1627 13302 989 1429 1714 15171 1857 849 384 7147 20950 59628 2440 1115 6562 1448 2826 1901 2308 9407 1101 820 541 8703 10261 11465 2835 1648 2186
3629 4022 3219 38953 2833 2481 882 1721 366 4492 2827 998 2488 3720 8297 3174 1636 4433 28040 2929 282 1154 3033 3978 847 886 801 4224 1321 9513 457 571 1926 12570 5120 577 729 8991 21681 34108 2554 1155 4960 2341 3562 2006 1282 7783 482 306 275 12769 9620 21622 3106 1420 2466
3786 3869 2904 40913 3253 2395 1342 2920 510 3859 2774 821 2676 4955 8512 3947 1590 4140 33258 2437 500 1104 3492 4290 946 865 796 4675 1474 11408 723 1000 1820 13870 3489 713 556 8069 21316 46868 2497 1135 5761 1894 3194 1954 1795 8595 791 563 408 10736 9940 16543 2970 1534 2326
1:250 1:250 1:1000 1:250 1:2500 1:500 1:10,000 1:250 1:250 1:250 1:1000 1:5000 1:1000 1:500 1:2500 1:1000 1:500 1:250 1:250 1:250 1:1000 1:250 1:1000 1:1000 1:1000 1:500 1:250 1:1000 1:1000 1:1000 1:1000 1:250 1:250 1:250 1:500 1:1000 1:250 1:1000 1:250 1:250 1:1000 1:250 1:500 1:250
The SNF2-related family of protein
The cell cycle is regulated by mult Clathrin is the major protein comp Microtubules, integral components Cell motility is a basic cellular beh Ramon Cajal described small silve Catechol-O-methyltransferase (CO
Gap junctions are intercellular pro Histone deacetylases (HDACs) are Cyclooxygenase (Cox) is also kno Raf (c-Raf-1) is a cytoplasmic seri
Crk was first isolated as the v-crk Cysteine-rich proteins (CRP1, CRP The csk gene encodes a protein k Transcriptional repression is critica Transcriptional repression is critica The family of nucleic acid-binding The cullins are a family of proteins The cullins are a family of proteins Progression of the mammalian cel Several classes of cyclins (A-E) ha Chronic exposure to extracellular s Chronic exposure to interferons in Splicing, the removal of introns fro Identified as a human erythroid cy Apoptosis, a selective process of g Dihydrofolate reductase (DHFR) re The human homologue of the Dro Dynamins, phosphoproteins with i Myotonic dystrophy (DM), characte Errors in DNA sequence result fro Damaged or erroneous DNA may
p62dok (downstream of tyrosine k The double stranded RNA (dsRNA
In culture, cell density can have pr In living systems, the relative amo Dyneins are ubiquitous, multimeric Dynamin is a nerve terminal phosp Dynamin is a membrane-associate Acetylcholine receptor clustering is Acetylcholine receptor clustering is E2Fs are DNA-binding proteins th Familial adenomatous polyposis is Mutations in the adenomatous pol
1:250 1:250 1:2500 1:5000 1:1000
Integral plasma membrane protein
The c-myc oncogene is important E-Cadherin is a 120kDa transmem Steroid hormones, unlike polypept The mitotic spindle apparatus equ
B C C C A
2 33 21 16 20
E27620 E77020 E15920 E80720 E85120
B A B A B A C
34 29 36 12 12
E90320 E86620 E87220 S41820 E35520
4 E18220 11 E78920
B D E B C B D C D B
30 556452 20 M37520 40 M12320 4 E16220 7 21 21 15 7 19 E72920 E11620 E53020 F39620 F36620 F15020
B A B D C B A D D C C C E B B B C A B C D A A
24 F37720 15 F72520 11 37 24 19 16 17 17 28 13 4 41 6 5 36 4 9 8 13 32 22 5 F88920 F89320 F69620 F11020 F64420 F51420 F56020 F82720 F65020 E35820 F83520 F26820 F23220 F91120 F19720 G51820 G29620 G81020 G10920 C26220 G60420
eIF-4E eIF-5 eIF-5a eIF-6 ENC-1-65KD ENC-1-71KD ENC-1-80KD Endoglin Endopeptidase 3.4.24.16 Endothelin 1 Receptor EphA4/Sek EPLIN-105KD EPLIN-89KD eps8 ERAB-22KD ERAB-23KD ERAB-27KD Ercc-1-36KD Ercc-1-39KD ERK1 ERK1-44KD ERK2-40KD ERK2-42KD ERp72-70KD Exportin-1/CRM1 Ezrin-86KD FACTp140 FADD FAK-108KD FAK-116KD FAK-126KD Fas Ligand Fatty Acid Synthase-214KD Fatty Acid Synthase-226KD FBP FEN-1 FIN13 FIP-2 FIP-2-68KD FKBP12 FKBP51 FKBP65 FLAP-69KD Flotillin-1-42KD Flotillin-1-45KD Flotillin-2/ESA Fnk FPTase alpha FPTase beta FXR2 fyn G alpha t G beta G3BP GAD67 gamma-Catenin Gap1m
25 49 18 27 66 66 66 95 80 50 130 90/110 90/110 97 27 27 27 36 36 44/42 44/42 42 42 69 112 80 140 24 125 125 125 37 265 265 74 50 75 74 74 14 51 72/68 85 48 48 42 70 48 46 95 59 40 37 68 67 82 100
24 54 18 24 65 71 80 103 80 45 123 105 89 107 22 23 28 36 40 44 44 40 42 70 106 87 132 31 109 116 126 36 214 227 74 47 72 76 68 18 59 79 69 42 45 45 66 46 44 96 56 37 35 64 67 88 107
8891 4616 1315 9808 2709 3349 7612 820 2525 2991 14768 2082 4899 1320 3340 3593 497 1356 370 6024 4036 11359 572 2142 2964 13492 10954 933 1662 3719 2350 15316 1851 11852 3355 3459 4753 8178 4076 5038 2861 21555 31427 1135 2798 8580 2436 940 1768 3600 16661 1731 7292 3333 1023 3321 2326
7110 4180 1307 14991 3329 3168 5616 643 1441 2384 16120 601 4218 1046 3531 4991 849 2750 686 5754 1854 9273 143 3916 2083 9425 10743 1039 2383 2264 1267 16367 1555 11075 2539 2152 4932 18253 5383 5304 2829 21546 58435 1255 3118 8950 1550 727 1498 3742 14885 3141 7644 3088 3487 2368 4156
8000 4398 1311 12400 3019 3258 6614 731 1983 2687 15444 1342 4559 1183 3436 4292 673 2053 528 5889 2945 10316 358 3029 2524 11458 10849 986 2023 2992 1809 15842 1703 11463 2947 2806 4843 13215 4729 5171 2845 21551 44931 1195 2958 8765 1993 834 1633 3671 15773 2436 7468 3211 2255 2845 3241
1:500 1:250 1:10,000 1:1000 1:250
The eukaryotic translation initiation Initiation of eukaryotic translation i Initiation of eukaryotic translation i Initiation of eukaryotic translation i Neurogenesis involves complex pr
1:250 1:250 1:1000 1:1000 1:250 1:5000 1:1000
Endoglin (CD105), a major glycop Endopeptidase 3.4.24.16 (neuroly Endothelin-1 (ET-1) is a potent vas EphA4/Sek is a glycosylated prote The LIM is a protein-protein intera
The p97eps8 protein, a substrate The etiology of the neuronal dysfu
1:5000 1:5000 1:5000 1:250 1:1000 1:250 1:500 1:250 1:1000
The family of serine/threonine kina The family of serine/threonine kina The family of serine/threonine kina
Within the ER lumen, numerous m The nuclear pore complex (NPC) i First described as an 80kDa prote The structure of chromatin is critic During apoptosis, cells exhibit mor Focal Adhesion Kinase (FAK) is a
1:1000 1:250 1:1000 1:250 1:500 1:250 1:1000 1:250 1:1000 1:250 1:250 1:5000 1:250 1:2500 1:250 1:250 1:1000 1:1000 1:1000 1:250 1:2000 1:1000
The Fas ligand (FasL), a type II m Fatty acid biosynthesis occurs in a
The c-myc proto-oncogene is an e The fidelity of DNA replication, rec The cell cycle is regulated by mult Control of TNFa-induced cell deat
Transforming growth factor-b bind FK506, one of several potent com FK506, one of multiple potent com Gelsolin, an actin binding protein, Caveolae are specialized membra Flotillin-2/ESA (epidermal surface
Farnesyl-protein transferase (FPT Farnesyl-protein transferase (FPT The fragile X syndrome results fro Stimulation of the T cell antigen re The GTP binding regulatory protei The GTP binding regulatory protei The Ras proteins are low molecula Glutamic acid decarboxylase (GAD g-Catenin (plakoglobin) was identi The biological activity of Ras is me
A C
A D D D A B A B C D D C A C D C C B C B E C C D D B C D B C B D D E B B C B D B B C B D C
9 G54220 GCAP-1-22KD GCAP-1-23KD 15 G20620 GCIP-43KD GCIP-46KD GCIP-49KD 21 G55620 GDNFR-alpha-56KD GDNFR-alpha-62KD 2 G37820 Gelsolin-102KD Gelsolin-92KD 30 G49220 GFAP 37 G25920 GGA3 37 G94420 GIT1 11 G85920 Glucocorticoid R 11 G45020 Glutamine Synthetase 30 G65120 GM130 15 G10020 GMAP-210 30 G93720 Golgin-84-91KD 8 G51720 GRB14-56KD 8 G16720 GRB2 35 G90520 GRIP 6 G72420 GS15 10 G76220 GS27 28 G83820 GS28 24 G22320 GSK-3 beta 4 G59720 GST-pi 10 H65220 HAX-1 30 H80920 HDAC3 32 H31020 HDJ-2 20 H11320 Headpin 14 H76520 HEC 12 H77220 Heme Oxygenase 2 3 H75420 hHR23B 6 H72320 HIF-1 alpha 12 A78420 HIF-1 beta/ARNT1 7 H62120 hILP/XIAP-60KD hILP/XIAP-66KD 16 H90720 hPrp16 15 H86320 hPrp17-67KD 33 R90820 hRAD9 8 H42020 HRF 27 H65520 HSF4 34 H83120 HsORC4 7 H44620 Hsp110 19 H22420 Hsp40-36KD 20 H22020 Hsp40-39KD 19 H22420 Hsp40-43KD Hsp40-45KD 18 H99020 Hsp60-59KD Hsp60-64KD 4 H53220 Hsp70-64KD Hsp70-72KD 1 H38220 Hsp90 29 H98620 HspBP1 27 I58220 I kappa B alpha 18 I95020 I kappa B epsilon-46KD 9 I71320 IAK1-39KD IAK1-41KD
23 23 46 46 46 45_60 45_60 93 93 50 90 95 94 45 130 210 84 61 24 130 15 27 28 46 23 35 50 45 44 76 36 58 120 95 57 57 140 66 60 23 55 45 110 40 40 40 40 60 60 70 70 90 40 38 45 46 46
22 22 43 46 49 56 63 102 92 48 90 87 88 46 138 220 92 56 23 132 15 29 26 45 23 33 51 45 42 71 40 65 108 94 60 66 146 68 62 25 54 48 106 36 39 43 45 59 64 64 72 92 42 39 46 39 41
430 1245 1412 1792 200 974 789 1006 1923 1214 757 871 2269 833 505 1140 2042 2657 12307 1173 4394 5349 5489 2160 1366 864 813 3069 3010 953 3033 4518 2400 1193 7651 970 1862 3489 1709 15889 288 8094 5561 2979 2430 1271 1141 12811 37208 9799 11779 4319 566 987 15471 425 785
556 1022 1933 973 505 661 5587 966 1318 1687 1287 506 3029 101 872 1206 3615 3034 10945 580 5078 9965 3608 1977 767 571 1496 2358 5102 1091 6602 4036 2018 1053 8562 1134 980 3638 1456 21130 667 4353 4568 2110 4795 1082 1352 16548 20333 11356 11878 6073 218 672 18849 488 576
493 1133 1673 1382 353 817 3188 986 1620 1450 1022 688 2649 467 689 1173 2829 2845 11626 876 4736 7657 4548 2069 1067 717 1154 2714 4056 1022 4818 4277 2209 1123 8107 1052 1421 3564 1583 18509 477 6224 5065 2545 3612 1177 1246 14680 28771 10577 11829 5196 392 829 17160 457 681
1:1000 1:500
Free intracellular calcium (Ca2+),
Adaptor proteins are critical for the
1:5000 1:2500 1:250 1:2500 1:250 1:2500 1:5000 1:250 1:250 1:250 1:500 1:5000 1:1000 1:250 1:1000 1:1000 1:2500 1:1000 1:250 1:500 1:250 1:2500 1:250 1:250 1:250 1:250 1:1000 1:250 1:250 1:1000 1:250 1:250 1:250 1:1000 1:2500 1:2500 1:2500
The development and function of t Gelsolin was identified as a result
The cytoskeleton is an array of hig The ADP-ribosylation factors (ARF Activation of adrenergic receptors Steroid hormone receptors are ho Glutamine synthetase catalyzes th Maturation and post translational m Trip230 was identified as a protein The Golgi apparatus is a complex Grb (growth factor receptor-bound Growth-factor Receptor-Bound Pro Rapid neuronal excitation within th Eukaryotic protein trafficking involv Eukaryotic protein trafficking involv Most vesicular fusion events requi Glycogen Synthase Kinase-3b (GS Glutathione-S-transferases (GSTs Cell-cell interactions in the immun Regulation of gene expression occ Heat shock proteins (Hsp) are high Serine proteinase inhibitors (serpin Cell division is a highly regulated p Heme Oxygenase (HO) mediates Nucleotide excision repair (NER) i Molecular oxygen (O2) is essentia The Ah-receptor (AHR) is a ligand Apoptosis is a genetically program
Splicing, the removal of introns fro Splicing, the removal of introns fro Cell cycle checkpoints are regulato One of the most powerful effector Heat shock proteins (HSP) are a f Initiation of eukaryotic DNA replica With the exception of Hsp110, the Heat shock proteins (Hsp) are a se Heat shock proteins (Hsp) are a se
1:5000 1:1000 1:1000 1:1000 1:500 1:250 1:250
Heat shock proteins (Hsp) are a se
Hsp70 is a member of the heat sh
The 90 kDa heat shock protein (H Hsp70 is a member of the heat sh NF-kB is a transcription factor that NF-kB is a ubiquitously expressed Cell division is a tightly regulated p
E A B D D B B A B B D C E B B E B D E D D A
11 1 10 3
I13220 I17720 I87320 I89920
28 I10220 6 I58620 8 25 5 30 5 18 3 33 12 1 V75320 E99620 I31220 I53820 I61620 J12420 J24320 J36020 S98420 554286
23 J31920 35 K82520 20 9 9 9 K32120 K55520 K55520 R43020
E B A C B C B D D A B B C C E A C
25 24 17 30 17 7 21 24 13 21 16 39 33 3
K34220 K35620 K96920 K98220 H10520 K57620 K91620 K92620 65941A L16720 L69320 L37820 L59920 L76620
29 L74520 25 L80120 23 C56520
E D A B B B
35 15 23 1 25 23
L89820 L11520 G25020 L44820 L64920 L85220
IAK1-45KD ICBP90-97KD IKAP IKK beta IKK gamma-48KD IKK gamma-56KD ILK Inhibitor 2-36KD Inhibitor 2-38KD Integrin alpha 2/VLA-2 Intersectin/ESE-1-136KD IP3R-3 IQGAP1 IRAK JAB1 JAK1 JAM-1 JBP1/Skb1Hs JNK1-44KD JNK1-52KD Jun Kanadaptin-54KD Kanadaptin-57KD KAP KAP3A-111KD KAP3A-98KD Karyopherin alpha 2-45KD Karyopherin alpha 2-48KD Karyopherin alpha 2-59KD Karyopherin alpha 2-69KD KIF1A KIF2 KIF3A KIF3B KNP-1/HES1-24KD KRIP-1-103KD Ku70 Ku80 Ku80-85KD Ku80-95KD L22 La Protein Lamin A/C-58KD Laminin B2-211KD Lamp-1-108KD Lamp-1-95KD LAP2-56KD LAT L-Caldesmon-65KD L-Caldesmon-69KD L-Caldesmon-75KD LCB1-54KD LITAF LR11/SorLA/gp250 LRP LSF LXR
46 97 150 87 48 48 50 32 32 150 140/200 300 195 100 38 130 38 72 54/46 54/46 39 53 53 34 100 100 58 58 58 58 200 110 80/85 95 28 105 70 80 80 80 15 47 65/74 220 110 110 53 42 80 80 80 53 24 250 110 63 56
45 97 165 92 48 56 54 36 38 155 136 262 186 128 36 126 39 72 44 53 42 54 57 34 111 98 45 48 59 69 205 113 86 84 24 103 73 91 85 95 19 50 58 241 108 96 56 43 65 70 75 54 25 250 104 68 55
904 9549 2431 1434 3064 6418 1507 1236 295 2324 1929 1010 877 5802 1491 2658 3463 1726 3469 3191 1678 890 860 32348 435 568 2812 6855 86367 4343 1529 2233 180 891 19574 4872 4063 5067 1244 3936 2628 6372 874 504 18377 1032 8249 4562 6205 12944 8371 7952 785 2936 1216 3889 866
732 12536 4004 1420 2133 6813 1820 1207 199 937 3703 1007 879 4703 1409 3042 3205 959 5202 3831 1178 475 897 36759 3475 1399 2655 5327 75029 3303 1306 810 664 1185 16944 4587 3171 6627 496 3338 5027 6768 950 562 22925 971 4780 2297 4298 12774 7473 4542 928 2314 856 4238 469
818 11042 3217 1427 2599 6616 1663 1221 247 1631 2816 1008 878 5253 1450 2850 3334 1342 4335 3511 1428 682 878 34554 1955 984 2734 6091 80698 3823 1417 1522 422 1038 18259 4730 3617 5847 870 3637 3827 6570 912 533 20651 1002 6514 3430 5252 12859 7922 6247 856 2625 1036 4064 667
1:250 1:5000 1:250 1:250 1:1000 1:250 1:250 1:1000 1:5000 1:500 1:250 1:250 1:500
DNA topoisomerases are ubiquito In most cells, NF-kB is sequestere In most cells, NF-kB is sequestere In most cells, NF-kB is sequestere
Integrins are transmembrane rece Protein phosphatase 1 (PP1) is inv
Integrins are a family of dimeric pr
Inositol 1,4,5-triphosphate (IP3) fu GTPases (Ras, Rho, cdc42Hs, an Interleukin 1 (IL-1) is a proinflamm JAB1 (Jun activation domain-bindi The JAK family of receptor-associ Tight junctions (zonulae occludens
1:1000 1:1000 1:5000 1:250 1:2500
The activator protein transcription The erythroid anion exchanger (AE
Proteins that associate with cyclin KAP3 (kinesin superfamily-associa
The two step process of importing
1:500 1:250 1:250 1:250 1:2500 1:5000 1:500 1:500
The ability of the kinesin superfam The ability of the kinesin superfam The ability of the kinesin superfam The ability of the kinesin superfam Human chromosome 21 has been Several gene regulatory proteins c DNA-dependent protein kinase (D DNA-dependent protein kinase (D
1:500 1:500 1:1000 1:250 1:250 1:5000 1:250 1:2500
Mammalian mitochondria synthesi La was first found to bind autoanti The nuclear envelope (NE) is a sp The basal lamina contains Collage Lysosomes are digestive compartm
A specialized extension of the ER, Engagement of the T cell receptor Caldesmon is a protein componen
1:2500 1:5000 1:1000 1:1000 1:500 1:500
Sphingolipid biosynthesis is initiate TNFa (Tumor Necrosis Factor a) is The low-density lipoprotein recepto Drugs that selectively attack dividi LSF (aCP2 or LBP-1c) is a transcr Proteins of the nuclear hormone re
D B C C A A B D B B D D A A C E A B D C C D C C D D A D A A B D A B C C C B A E A B B D D D B A D E D B C
6 L05620 Lyn 56 11 M14820 M33-51KD 55 M33-55KD 55 5 H57520 MAD2 24 32 M15820 MAD2B/Rev7 26 9 M41420 MAP2B 280 14 M32220 MAPKAPK-5 54 31 M60920 MCC-103KD 100 24 M14520 MCM4 100 8 M14020 MCM5 90 15 M13120 MCM6 105 4 M17020 MEK1 45 1 M24520 MEK2 46 8 M58320 Mena-85KD 140/88/80 Mena-94KD 140/88/80 21 E93220 mEPHX 46 21 M16020 Metaxin-36KD 35 24 M75920 Mint1 120 10 M85420 MKK3b 37 15 M66720 MKP2 43 34 M99920 MnSOD 25 4 M36820 Moesin 78 20 M92920 Mre11 81 24 M34520 MSH2 102 23 G70220 MSH6 160 11 M77120 MST1 56 12 M77320 MST3 52 3 M32320 Munc-18 68 3 M51920 Mxi-1 26 29 M38420 MYPT1 130 26 N69920 Na,K ATPase beta 2-54KD 45 4 N61020 NAT1 100 22 N10720 NBS1 95 27 C70320 N-Cadherin 130 2 N15920 NCK-43KD 47 NCK-45KD 47 35 N77920 NDP52 52 28 N95520 Nedd4 110 5 N52120 Nek2-42KD 46 Nek2-47KD 46 17 N17220 Nestin 220 3 N35120 Neuronal Pentraxin 47 24 N41320 Neurotensin Receptor 3-107KD 95 35 N98720 Nexilin 97 9 N67620 NF-kappa B p65 65 28 N12520 NHE-1-90KD 92 NHE-1-97KD 92 39 N16420 Nicastrin 110 19 N62820 Ninjurin 22 16 N79420 Nip1 26 3 N25720 Nm23 17 7 N31020 nNOS/NOS Type I 155 29 N83420 No55 55 32 N14920 NSF-79KD 82 3 N42420 NTF2 15 8 N43620 Nucleoporin p62 62 32 N13920 NUDT5 40
61 51 55 22 23 250 60 103 115 90 104 50 50 85 94 46 36 128 39 48 23 71 91 103 158 65 57 75 31 133 54 99 106 130 43 45 56 116 42 45 227 47 107 91 69 91 97 118 20 30 20 193 60 79 18 65 34
3026 2288 1193 6728 829 176 1082 589 226 2761 6365 16955 7471 5267 5791 1116 6008 659 224 1191 1278 6908 2945 7169 9939 2772 8717 628 1507 5749 377 1077 369 649 3132 9261 1636 3068 685 846 937 4037 10649 3432 767 2648 1309 1230 5708 2173 16766 1679 4010 4148 15190 15148 7525
2559 1919 1044 7477 924 1039 703 516 1192 1732 4936 15974 12250 8633 9144 967 4326 213 657 2114 1200 10698 3333 8079 11601 2387 10442 1194 1707 4988 430 979 993 579 2671 9145 1619 2351 475 852 929 4665 8890 2508 675 2590 739 1294 4010 2169 14658 1964 3100 3420 11497 16518 7399
2793 2104 1119 7103 876 608 893 552 709 2247 5650 16465 9860 6950 7468 1042 5167 436 441 1653 1239 8803 3139 7624 10770 2580 9579 911 1607 5368 404 1028 681 614 2902 9203 1627 2710 580 849 933 4351 9769 2970 721 2619 1024 1262 4859 2171 15712 1822 3555 3784 13343 15833 7462
1:250 1:250 1:1000 1:1000 1:2500 1:250 1:500 1:250 1:1000 1:1000 1:1000 1:2500 1:250 1:250 1:1000 1:250 1:250 1:500 1:1000 1:5000 1:500 1:250 1:500 1:500 1:250 1:5000 1:250 1:500 1:500 1:500 1:1000 1:2500 1:1000 1:250 1:1000 1:250 1:500 1:1000 1:250 1:250 1:250 1:250 1:500 1:250 1:250 1:5000 1:2500 1:500 1:5000 1:1000 1:1000 1:5000
Lyn is a 56 kDa cytosolic tyrosine Genetic analysis in Drosophila ide
Progression of the mammalian cel Progression of the mammalian cel Microtubule-associated proteins (M Many different extracellular stimuli The Mutated in Colorectal Cancer Mini-chromosome maintenance (M Minichromosome maintenance (M Mcm proteins are nuclear proteins MEK1 (MapK/ERK Kinase 1) is a 4 MEK2 (MAP Kinase Kinase 2 or E Abl and Disabled (Dab) are essen
Microsomal epoxide hydrolase (mE The metaxin (Mtx) gene is closely Neuronal communication via neuro Mitogen activated protein (MAP) k The mitogen activated protein (MA Superoxide dismutase (SOD), cata Moesin belongs to a family of prote Originally identified in S. cerevisia DNA mismatch repair in bacteria is DNA mismatch repair in bacteria is Ste20 is a S. cerevisiae Ser/Thr pr Ste20 is a S. cerevisiae Ser/Thr pr There are two Munc-18 isoforms: M The myc protein, one of the most w Protein phosphatase-1 (PP1) is a Na+,K+-ATPase is an integral plas eIF-4 proteins are required for rec Nijmegen breakage syndrome (NB Cadherins are a family of Ca2+-de NCK is a 47 kDa protein that belon
Nuclear domain refers to discrete Regulated protein degradation inv Reversible protein phosphorylation
The cytoskeleton consists primaril Neuronal pentraxin (NP) is a poten Neurotensin (NT) is a neuropeptid Adherens junctions are actin filam NF-kB is a ubiquitously expressed The extrusion of H+ in exchange fo
Amyloid precursor protein (APP) g Ninjurin is a protein whose expres Apoptosis, a selective process of g The Nm23 is a potential metastasi Nitric oxide synthase (NOS), a cel Patients with interstitial cystitis (IC Eukaryotic protein trafficking involv Sorting of cytosolic proteins into th The nuclear pore complex (NPC) a Nudix hydrolases are a family of e
D B B A B D B D B D B B A A A C C D C A A B C B C C C B B C
A C B E B A C C D C D B C D D D
29 N83220 Nurr-74KD 72 Nurr-80KD 72 25 O84720 Oct4-45KD 46 11 O92020 OXA1Hs 42 7 P18420 p115 115 33 R79520 p116Rip 125 10 P27820 p130 Cas-133KD 130 26 P41920 p150Glued 150 25 P79320 p160-166KD 160 p160-180KD 160 3 G19020 p190 190 28 G11420 p190-B 195 22 P46020 p19Skp1 19 11 A15220 p21-Arc 21 27 P26420 p23 23 28 P11920 p24 24 2 P46220 p36 36 16 P39520 p38 alpha/SAPK2a 42 12 P98120 p38 alpha/SAPK2a 42 32 E14720 p43/EMAP II precursor-39KD 43/21 36 P77820 p45/SUG1 45 12 P68620 p47A 50/47 14 P69120 p47A-48KD 50/47 3 P21020 p53 53 14 N88520 p54nrb-50KD 60 p54nrb-55KD 60 6 P65620 p62 lck ligand 62 35 P69820 p67phox 67 35 P69820 p67phox-64KD 67 37 S87620 p70s6k 70 12 P95220 PAF53 53 8 P30620 PAI-1 47 22 E17120 pan ERK-40KD 42_85 pan ERK-46KD 42_85 pan ERK-52KD 42_85 pan ERK-69KD 42_85 pan ERK-88KD 42_85 13 M54920 pan-JNK/SAPK1 49 8 P76420 PARP 113 27 P54320 Paxillin 68 18 P49620 Paxillin-65KD 68 Paxillin-69KD 68 38 P39820 PBK 41 16 P62620 PCMT-I/II-23KD 25 PCMT-I/II-24KD 25 2 P56720 PCNA 36 10 P71720 PDI 55 31 P10020 PEX1 143 29 P10420 PEX5 90 36 P35820 Phosphatase Methylesterase-1 44 31 550747 Phospho-Akt 59 37 C26020 Phospho-Cdc2 (Y15) 34 34 F25020 Phospho-FAK (Y397) 125 15 P33820 Phospholipase C delta 1-84KD 87 Phospholipase C delta 1-92KD 87 6 P12220 Phospholipase C gamma 1-152KD 148 Phospholipase C gamma 1-172KD 148
74 80 45 41 117 119 133 153 166 181 186 195 21 21 22 30 37 39 40 39 46 48 48 53 50 55 60 71 64 63 52 51 40 46 52 69 88 45 113 65 66 69 40 23 25 32 56 157 84 47 57 33 126 84 92 153 172
2173 2236 6341 154 1293 714 10147 3866 2014 5520 4327 1818 4735 1185 2411 647 7269 3745 3208 15900 6787 11624 1153 4393 10840 8363 1165 13825 2714 961 1479 6314 8621 6114 4545 4628 16447 1403 5475 350 10742 6695 462 1290 1998 3736 1076 664 402 3257 898 1549 952 1360 2450 13564 30141
3195 4097 4987 235 900 270 9376 2277 1262 6227 2827 2186 3519 595 2187 480 10240 4494 3745 17845 5537 11372 887 3957 5172 10228 942 15833 2313 937 1193 4659 9622 8577 7556 8231 17456 1112 4872 436 15924 8402 675 37 1264 3534 795 445 555 2196 1066 1653 860 1450 2311 12212 32103
2684 3167 5664 195 1096 492 9762 3072 1638 5874 3577 2002 4127 890 2299 563 8754 4119 3476 16872 6162 11498 1020 4175 8006 9295 1054 14829 2514 949 1336 5487 9122 7345 6051 6430 16952 1258 5173 393 13333 7549 569 663 1631 3635 936 554 479 2727 982 1601 906 1405 2380 12888 31122
1:1000 1:1000 1:1000 1:2500 1:250 1:1000 1:250 1:250 1:500 1:250 1:5000 1:1000 1:1000 1:250 1:1000 1:5000 1:2500 1:2500 1:500 1:250 1:250 1:500 1:2500 1:500 1:500 1:1000 1:1000 1:2500 1:5000
Dopamine is a catecholamine neu
Development of a multicellular org The terminal complex in the mitoc Maturation and post translational m Neuronal cell morphology is regula p47v-crk (v-Crk) is the product of a p150glued was identified as a poly The c-Myb transcription factor part
GTPase activating proteins (GAPs GTPase activating proteins (GAPs In normal cells, Cyclin A and Cdk2 Cellular morphology, adhesion, an Molecular chaperones are a divers The microtubule (MT) cytoskeleton Regulation of the cell cycle by cyc Activation of the immune and infla Activation of the immune and infla The aminoacyl-tRNA synthetase fa The 26S proteasome, a eukaryotic Sorting of integral membrane prote Sorting of integral membrane prote The p53 protein is critical to regula Splicing, the removal of introns fro
p62 lck ligand (zeta-interacting pro The neutrophil respiratory burst ox
Increased protein synthesis, an ob Mammalian ribosomal DNA transc Fibrinolysis is regulated by the pla The family of serine/threonine kina
1:250 1:500 1:1000 1:1000 1:1000 1:250 1:5000 1:250 1:250 1:250 1:250 1:250 1:1000 1:250 1:250
The Ras signaling pathway links th Poly(ADP-ribose) polymerase (PA Paxillin, a focal adhesion protein, i Paxillin, a focal adhesion protein, i
Mitogen activated protein (MAP) k PCMT-II (protein carboxyl methyltr
Progression of the mammalian cel The ER is the site of translation of Peroxisomes, ubiquitous organelle Pex genes encode proteins called Protein phosphatases of the type 2 The product is phospho-specific. I Progression of the mammalian cel Focal Adhesion Kinase (FAK) is a Phospholipase C (PLC) hydrolyze
The Phospholipase C (PLC) isozy
C B A D C A C D A B B A A B B B D B A A A B B C D D C D A D A E C D A A B A C C B D A A A D C D
19 17 32 4 19 32 20 13 27 25 3 22
P19820 P21520 P27320 P13020 P94520 P76820 P14420 P88320 P82120 P75720 P73420 P53620
18 P19920 1 P45320 21 29 21 25 18 6 10 1 2 5 2 25 P54720 P67220 P65920 P16520 P17720 P36520 P14820 P20520 P22520 P15120 P62220 P44120
13 P24620 32 P17920 24 P35220 2 24 10 1 23 38 29 37 27 18 2 8 27 17 12 5 P47720 P75520 P33420 P57920 P63720 P42220 P83620 P96520 P18020 P17320 P54420 P47120 R56320 R38620 R52320 R68520
5 R60020 1 R66320 1 R78620
Phospho-p38MAPK (T180/Y182) 42 Phospho-p38MAPK (T180/Y182)-41KD 42 PI31 31 PI3-Kinase 85 PI3-Kinase p110 alpha 110 PI3-Kinase p170 170 PI4-Kinase beta 110 pICln-34KD 37/42 pICln-42KD 37/42 PIP5K gamma 87/90 PITP alpha 32 PKA C 40 PKA RI alpha-50KD 49 PKA RI alpha-55KD 49 PKA RI-51KD 48 PKA RI-56KD 48 PKA RII alpha-50KD 51 PKA RII alpha-53KD 51 PKA RII beta 53 PKB alpha/Akt 59 PKB alpha/Akt 59 PKC alpha 82 PKC beta 80 PKC delta 78 PKC epsilon 90 PKC iota-70KD 74 PKC iota-76KD 74 PKC lambda 74 PKC theta 79 PKR 68 Pleckstrin-45KD 47 Pleckstrin-47KD 47 PMF-1 23 pp120 120 PP1-37KD 36 PP1-39KD 36 PP2A Catalytic alpha 36 PP5/PPT 58 Prenylcysteine Lyase-50KD 58 PRK1 120 PRK2 140 Prostasin 40 Psme3 36 PTEN 47 PTP1B-49KD 50 PTP1B-52KD 50 PTP1C/SHP1 68 PTP1D/SHP2 72 PYK2/CAK beta 116 Rab11 24 Rab24 23 Rab27 25 Rab4-25KD 25 Rab4-29KD 25 Rab5 25 Rab8-22KD 24 Rabaptin-5-118KD 117
40 41 33 87 104 183 98 34 42 84 34 40 51 55 51 56 50 53 52 62 63 83 81 82 96 70 76 76 68 76 45 47 24 119 37 39 41 61 50 117 141 42 33 45 49 52 62 65 109 25 23 27 25 29 28 22 118
1796 1601 840 9180 606 905 17513 5096 44211 1830 2835 2364 1517 2734 3361 1740 3079 2075 1449 2547 2606 2872 2588 3228 1296 4914 17811 3839 1119 3300 1597 2863 335 5567 4601 12793 23094 1436 855 842 2238 1443 29426 32599 1178 7902 1236 1006 1064 8300 762 18764 1115 724 10940 2220 3304
1164 1170 461 10495 279 571 13440 2955 51935 1413 3081 2759 1414 2669 3239 1761 2285 6061 617 1956 565 3085 3336 2607 615 4186 17929 4437 484 4945 1369 1613 420 12942 3904 9487 19850 792 1351 679 3300 1631 20259 20351 229 2599 1282 1337 1308 6440 61 20231 1253 426 12664 2468 4739
1480 1385 650 9838 442 738 15476 4025 48073 1622 2958 2562 1466 2701 3300 1750 2682 4068 1033 2252 1585 2978 2962 2917 955 4550 17870 4138 801 4123 1483 2238 377 9254 4252 11140 21472 1114 1103 761 2769 1537 24843 26475 703 5250 1259 1172 1186 7370 412 19498 1184 575 11802 2344 4021
1:2500 1:2500 1:250 1:2500 1:250 1:250 1:10,000 1:1000 1:250 1:500 1:1000 1:250 1:250 1:1000 1:1000 1:500 1:250 1:1000 1:250 1:500 1:1000 1:250 1:250 1:250 1:1000 1:1000 1:1000 1:1000
Activation of the immune and infla Activation of the immune and infla The 20S proteasome is the major PI3-kinase phosphorylates the D-3 Phosphatidylinositol 3 (PI3) -kinas PI3-kinase phosphorylates the D-3 Phosphoinositide turnover is a we pICln (I = current, Cl = chloride, n
Phosphoinositide turnover is a we PITP (phosphatidylinositol transfer cAMP-dependent Protein Kinase ( cAMP-dependent Protein Kinase (
cAMP-dependent Protein Kinase (
cAMP-dependent Protein Kinase (
cAMP-dependent Protein Kinase ( Rac (Related to the A and C kinas Rac (Related to the A and C kinas The Protein Kinase C (PKC) family The Protein Kinase C (PKC) family The Protein Kinase C (PKC) family The Protein Kinase C (PKC) family The Protein Kinase C (PKC) family
The Protein Kinase C (PKC) family The Protein Kinase C (PKC) family Double stranded RNA (dsRNA) ge Pleckstrin was identified in platele
Polyamines are required for growt The membrane associated protein
1:5000 1:500 1:5000 1:1000 1:1000 1:250 1:1000 1:250 1:2500 1:500 1:2500 1:1000 1:1000 1:5000 1:250 1:1000 1:500 1:1000 1:500
Protein phosphatases of the type 2 Phosphorylation and dephosphory Covalent modification of proteins w Members of the Protein Kinase C The Protein Kinase C (PKC) family Prostasin is a serine protease exp The 20S proteasome is the major Mutations in the tumor suppressor PTP1B is a member of the class o
PTP1C (SH-PTP1, SHP-1, or HCP PTP1D (Syp or SH-PTP2) is a me Protein Tyrosine Kinase 2 (PYK2, The Rab proteins are small GTP-b The Rab proteins are small GTP-b Rab27, member of the low molecu The Rab proteins are small GTP-b
Rab5 is a low molecular weight GT The members of the Ras superfam The Rab proteins are small GTP-b
A C A C D C B B D B D D C C C A B
B B C B E
D C A A D D D D C C B C
A
A A
B
8 R56220 Rac1-21KD Rac1-23KD 1 R20620 RACK1 24 R81320 RAFT1/FRAP-227KD 12 R23520 Ral A 1 R32620 Ran 31 R61720 RanBP1 22 R33620 RanBP3-74KD 29 R22020 Rap1 6 R23020 Rap2-22KD Rap2-23KD 12 R37920 RAP30 4 R02120 Ras-22KD Ras-25KD 3 G12920 Ras-GAP 6 R68320 Rb 5 R27020 Rb2-127KD Rb2-142KD 3 R43320 RBBP-46KD RBBP-50KD 2 C38020 R-Cadherin 34 R35420 RCC1-41KD RCC1-43KD RCC1-48KD 5 R64820 Ref-1 13 R90220 Reps1 3 R73920 Rho 3 R26320 RhoGDI 9 R32820 Rin1-44KD Rin1-49KD Rin1-56KD Rin1-59KD 12 R41220 RIP 15 R92420 RNase HI 16 R94920 Roaz 21 R81520 ROCK-I/ROK beta 27 R61120 Ron alpha-40KD Ron alpha-42KD 3 R23820 Rsk-93KD 10 P20120 Sam68 38 S34220 SCAMP1 35 S86120 SCP3 10 R56420 Sec8 21 S57320 SGT1-38KD SGT1-41KD 31 S68020 SHC-44KD SHC-50KD SHC-55KD SHC-69KD 8 S55720 ShcC-54KD ShcC-60KD ShcC-74KD 20 S96320 SHPS-1-118KD 29 S88220 sigma 3A-19KD sigma 3A-21KD sigma 3A-23KD 32 S84820 SII/TFIIS-36KD
21 21 36 245 24 25 29 80/100 21 21 21 30 21 21 120 110 130 130 48 48 100 45 45 45 36 73 21 28 90 90 90 90 74 36 190 160 40 40 90 68 36 34/37 110 45 45 66/52/46 66/52/46 66/52/46 66/52/46 69/55 69/55 69/55 100 22 22 22 38
21 23 30 227 23 29 27 74 22 22 23 28 22 25 137 111 127 142 46 51 107 41 43 48 36 75 21 24 44 50 56 59 85 31 197 164 40 42 93 74 37 35 104 38 41 44 50 55 69 54 60 74 118 19 21 23 36
2066 12959 6890 1921 6766 19560 1297 15652 1071 12501 6302 628 1576 626 4096 1363 1775 1546 1889 7172 3400 435 667 1200 1198 564 1835 23699 1756 19809 24459 27277 2909 1197 2725 1327 5331 2779 14799 2344 1449 411 9063 7044 2895 782 3536 3893 2979 5818 6517 5811 2471 1514 1062 1965 3892
2657 22447 6134 819 7811 20778 1699 13308 863 11899 8648 666 1238 1727 3852 1170 806 1003 3895 6803 2357 481 605 1117 760 1872 2741 27576 1405 42124 32793 36840 1425 1150 1880 1131 7600 6292 10248 2894 842 334 7860 5872 1813 883 2896 3468 3411 4824 6082 3545 2571 1667 821 2130 2339
2362 17703 6512 1370 7289 20169 1498 14480 967 12200 7475 647 1407 1176 3974 1267 1290 1275 2892 6987 2879 458 636 1159 979 1218 2288 25638 1580 30966 28626 32059 2167 1174 2302 1229 6465 4536 12524 2619 1146 373 8461 6458 2354 833 3216 3680 3195 5321 6300 4678 2521 1591 941 2048 3116
1:1000 1:2500 1:250 1:5000 1:5000 1:250 1:2500 1:500 1:2500 1:1000 1:500 1:1000 1:250 1:1000 1:1000 1:500 1:250
Rac1 is a member of the expandin
Several proteins which specifically Immunosuppressive agents such a Ral is a low molecular weight GTP Ran is a highly conserved GTPase Ran is a highly conserved GTPase Ran is a highly conserved GTPase Rap1 is a member of the large Ra Rap2 is a member of the Ras supe
Synthesis of all messenger RNA in Ras and related proteins of the Ra
Ras-GAP, a protein of approximat The retinoblastoma gene (Rb) pro The pRb2 protein shows a high de
The retinoblastoma gene product,
R-Cadherin was first isolated from RCC1 (Regulator of Chromosome
1:250 1:250 1:250 1:5000 1:250
The AP-1 transcription factor cons Tyrosine kinase signaling pathway Members of the Ras superfamily o RhoGDI inhibits guanine nucleotid Rin1 is identified as the protein en
1:1000 1:500 1:1000 1:250 1:250 1:1000 1:10,000 1:500 1:500 1:1000 1:1000 1:1000
Binding or cross linking of the Fas RNases H specifically degrade the Rat Olf-1/EBF-associated zinc fing ROCK-I is a Rho-associated serin RON (recepteur d'origine Nantaise
The p90rsk (Rsk) and p70s6k kina Sam68 (Src-associated in mitosis Secretory carrier membrane prote Division of haploid germ cells durin Signal transmission between neur Maintenance of cellular function re
The mammalian SHC proteins, wh
1:5000
Mammalian ShcA is expressed as
1:1000 1:250
Protein-tyrosine kinases and phos Protein trafficking between organe
1:1000
RNA polymerase II-mediated trans
B B B A A D C B A C B A D
11 6 10 15 14 6 17 33 35 1 17
S87420 S11120 S11320 S66220 S71120 S55920 S95620 S90020 S10120 S71420 S78120
32 S80620 6 S21120
A B C C D B E C D A C C D B C D E A C A A D D B B A A A D C C D C C E
12 G16920 24 S21220 1 8 19 32 20 15 1 36 22 8 38 2 7 11 23 37 6 7 28 4 3 3 13 16 2 6 26 6 26 20 19 38 38 S21320 S70720 S21520 S12820 S89120 M82020 S65720 S91920 S66020 S55820 S10320 S40220 S55420 S92220 T33920 T93020 T10120 T57120 T38020 T70420 T41520 B71520 T81920 T69020 T97620 T33520 T94720 T73620 T85720 T36120 T93820 T31820 T15620
SII/TFIIS-38KD SIP1 Smac/DIABLO Smac/DIABLO Smad2/3 Smad4/DPC4 SMN-39KD SMN-42KD SNX1 SNX2 SQS-50KD SRP54 SRPK1-92KD SRPK1-99KD SRPK2 Stat1 (C-terminus)-108KD Stat1 (C-terminus)-87KD Stat1 (C-terminus)-95KD Stat1 (N-terminus)-83KD Stat1 (N-terminus)-94KD Stat2-90KD Stat2-99KD Stat3 Stat4 Stat5 Stat5A Stat6 Stathmin/Metablastin STI1-64KD STI1-71KD STRAP Striatin Symplekin Syndapin I Syntaxin 4 Syntaxin 6 Syntaxin 8 TAFII135 TAO1 TAP-68KD Tau-58KD TCBP49-53KD TEF-1 TFIIB TFII-I-127KD TFII-I-129KD TGN38 Thrombin Receptor/PAR1 TIAR-42KD TIAR-46KD TIEG2 TIF2 Tim23 TIP120 TLS TNIK TOK-1-49KD
38 32 22 22 58 60 40 40 74 72 48 54 92 92 115 91/84 91/84 91/84 91/84 91/84 113 113 92 89 92 92 100 19 62 62 39 110 150 52 32 31 27 135 116 70 50_68 49 53 33 135/140 135/140 85-95 47 50/42 50/42 72 160 23 120 65 150 45/50
38 32 22 21 65 72 39 42 68 74 50 52 92 99 117 108 87 95 83 94 90 99 92 68 98 97 100 18 64 71 40 104 139 54 34 31 29 140 124 68 58 53 60 38 126 129 88 47 42 46 69 160 22 138 68 175 49
7461 868 10118 3375 1806 906 2669 26885 1618 1724 245 933 6211 14369 4536 3663 3719 0 18454 965 1720 2529 7819 1283 845 1008 9364 12840 1639 4116 2045 11983 1390 644 5146 1419 3974 1251 830 1245 13359 1430 2057 9085 3213 1209 487 2750 2887 10858 3729 3252 1607 2254 6213 1259 15414
10753 534 10804 10118 2439 797 2889 28981 1329 1689 524 1222 3504 11873 3744 4294 4044 1493 5995 5382 1586 464 8536 1690 1317 504 6175 12557 5974 8349 2701 13769 1479 594 3999 1985 7085 837 673 1417 15870 4315 1677 8578 2911 1456 234 2293 2171 17122 3456 3523 1328 2755 5236 3946 7688
9107 701 10461 6746 2123 852 2779 27933 1474 1707 384 1077 4858 13121 4140 3978 3881 1493 12225 3174 1653 1497 8177 1486 1081 756 7770 12698 3806 6232 2373 12876 1434 619 4572 1702 5530 1044 752 1331 14615 2873 1867 8831 3062 1332 361 2521 2529 13990 3592 3387 1468 2505 5724 2603 11551
1:250 1:500 1:1000 1:500 1:250 1:5000 1:1000 1:500 1:1000 1:1000 1:1000 1:1000 1:1000
Spinal muscular atrophy (SMA), a Apoptosis is a genetically program Apoptosis is a genetically program The transforming growth factor b ( The transforming growth factor b ( SMN (survival motor neuron) was
Biological processes such as trans Biological processes such as trans Squalene synthase (SQS) conden Ribosomes that exist freely in the Mammalian cell pre-mRNA splicin
Mammalian cell pre-mRNA splicin The Stat proteins function as both
1:250 1:250 1:2500 1:250 1:250 1:250 1:500 1:250 1:250 1:500 1:1000 1:1000 1:250 1:5000 1:5000 1:1000 1:250 1:250 1:250 1:1000 1:1000 1:250 1:250 1:1000 1:250 1:250 1:250 1:1000 1:500 1:250 1:2500 1:2500 1:250 1:250 1:1000
ISGF3 (interferon-stimulated gene
The Stat proteins function as both
The Stat proteins function as both The Stat proteins function as both Mammary gland factor (MGF) has The Stat proteins function both as Interleukin-4 (IL-4) is a major imm The regulation of microtubule (MT Progression of the mammalian cel
The transforming growth factor b ( Signal transmission between neur Tight junctions or zonula occluden Dynamin is a brain specific GTPas Signal transmission between neur Signal transmission between cells Eukaryotic protein trafficking involv Tightly associated factors (TAFs) p Mitogen activated protein kinases Nuclear export of cellular mRNAs In addition to tubulin, microtubules Taipoxin is a lethal snake venom t TEF-1 (transcription enhancer fact TFIIB is a ubiquitous factor require General transcription factor II-I (GT General transcription factor II-I (GT Newly synthesized proteins exit th Thrombin is a Ser protease that re TIAR is an RNA-binding protein re
Sp1-like transcription factors are c Nuclear receptors (NRs) are a fam Mitochondria, the site of cellular en Originally identified as the DNA-bi Chromosomal translocations in leu Ste20 is a S. cerevisiae Ser/Thr pr Cell cycle progression is tightly reg
C B D D C A B C B B B C B D D B D B B A A C A B B C A C D B E C
36 T19520 14 T90920 14 T96120 7 19 31 31 16 34 18 32 37 8 26 24 22 31 38 31 1 10 2 30 33 17 21 10 11 35 16 22 7 T57720 T92520 T28920 T87920 T11520 T20220 U10820 U61320 U85520 U66820 U95420 U15420 U24020 V11220 V39420 V40620 V39620 V10720 V47020 V85620 V94820 X96820 Y24420 Y35320 Z24820 Z91420 Z10420 Z34720 Z72720
TOK-1-51KD Tom20 Topo II alpha- 174KD Topo II alpha-166KD Topo II beta-186KD Topo II beta-206KD Transportin TRAX-30KD TREX1 TRP32 TTF-I tyk2 UBA2-94KD Ubc9-19KD UbcH6-17KD UbcH6-19KD UbcH7 UBE3A Ufd1L Ufd2/E4 V-1/myotrophin VAP33 VASP VCP-108KD Vesl-1L-54KD VHR Vti1a Vti1b-23KD Vti1b-26KD XRCC4-52KD YAP Yes ZAP70 Kinase ZBP-89 ZFP-37-66KD ZIP Kinase ZO-1
45/50 18 170 170 180 180 101 33 32 32 140 135 95 18 21 21 18 100 40 146 11 33 46 97 45 20 29 27 27 55 74 62 70 74 67 52 220
51 17 174 166 186 206 106 30 36 36 124 132 94 19 17 19 19 108 42 136 17 30 47 108 54 21 27 23 26 52 68 65 68 74 66 54 220
3818 3151 2061 1065 1971 4412 3476 9796 1261 21989 592 1439 1251 41173 20353 1457 6670 3311 1821 1560 23208 806 6646 1428 1899 1657 1841 6464 3899 9995 4721 2609 1716 2126 369 1000 1692
2334 3218 12823 1556 2756 3768 3329 7307 1052 31458 427 1888 759 45269 19424 1561 4031 2383 2109 1048 13557 1345 6786 2620 1903 1443 1399 5850 4097 4719 4635 2355 1530 2041 898 842 2285
3076 3185 7442 1310 2364 4090 3402 8552 1157 26724 509 1663 1005 43221 19889 1509 5351 2847 1965 1304 18382 1075 6716 2024 1901 1550 1620 6157 3998 7357 4678 2482 1623 2084 634 921 1988
1:5000 1:500 1:500 1:5000 1:1000 1:2500 1:1000 1:5000 1:1000 1:1000 1:250 1:1000 1:250 1:500 1:1000 1:500 1:250 1:500 1:500 1:250 1:1000 1:250 1:2500 1:1000 1:250 1:1000 1:5000 1:5000 1:1000 1:250 1:250 1:250
Many mitochondrial proteins are e Eukaryotic DNA topoisomerase II,
Eukaryotic DNA topoisomerase II,
Nucleocytoplasmic transport occu RNA-binding proteins, such as Tra DNA replication, repair, and recom Thioredoxin (Trx) is a ubiquitously Ribosomal precursor RNA is synth Tyk2 is a widely expressed protein Protein ubiquitination is the produc Progression of the mammalian cel Maintenance of cellular function re
Progression of the mammalian cel Protein ubiquitination is the end pr Microdeletions of the chromosoma Maintenance of cellular function re V-1 (myotrophin) was identified in In eukaryotic cells, trafficking of m Vasodilator-stimulated phosphopro ATPases that belong to the ATPas The Vesl (VASP/Ena-related gene Protein tyrosine phosphatases (PT Eukaryotic protein trafficking involv Eukaryotic protein trafficking involv
DNA double-strand breaks (DSBs) Yes is a member of the Src family Yes is a member of the Src family ZAP70 is a protein tyrosine kinase The Cys-Cys-His-His family of zinc The family of nucleic acid-binding ZIP kinase (DAP kinase 3) is a me Tight junctions (zonulae occludens
Locus linkSwiss Prot 7531 P42655 55948 6520 7159 240 5589 2316 29 43 11771 163 11765 4301 8202 114592 18571 64553 8165 216 18570 8775 1495 29219 83803 301 302 307 309 310 11744 316 1173 317 81641 348 8883 8604 377 10096 13196 445 624 5525 12015 20587 83797 2246 Q9S928 P08195 Q13625 P09917 P14314 P21333 Q12979 P22303 P17426 P21851 O43747 P55196 Q9Y6Q9 O55099 O88695 O88884 Q92667 P00352 P12815 P54920 P26231 P37377 P80386 P46193 P07355 P09525 J03578 P20073 P97384 Q06278 P20172 O14727 P15684 P02649 Q13564 O75746 P16587 P32391 Q9QWY8 P00966 P30411 Q15172 Q61337 Q9ZOH3 P70384 P09038
581 Q07812
598 Q07817 598 O35147 8678 Q14457 29631 Q62896 25387 P29066 12387 1605 12122 3309 Q02248 Q14118 P70444 P11021
4171 P49736 660 29459 9774 695 9184 20318 821 12317 117059 171140 60341 P51813 O88350 Q14673 Q06187 O43684 Q61112 P27824 P14211 P47728 P11275 Q64572
1434 P55060 1454 P49674 116549 P19139 29647 841 12365 835 Q62915 Q14790 O89094 P42575
12367 836 840 1509 857 857 958 994 996 11140 998 392 983 1017 1020 1022 2064
Q96KP2 Q96KP2 P55210 P07339 Q03135 Q03135 P25942 O43550 P30260 Q16543 P21181 Q07960 P06493 P24941 Q00535 P50613 P04626
1107 Q12873 50883 54241 7461 29264 8161 1312 24392 23186 29527 7187 1398 13007 64019 13016 13017 10664 26965 8453 890 896 1612 7818 8449 2039 1676 1719 1739 9229 1760 5424 5426 7150 1796 3609 8562 6829 10540 140694 25751 13527 13527 13555 22919 22924 Q9Z265 P11442 O55156 P18760 P38432 O88587 P08050 Q9UKL0 P35355 P04049 P46108 P97315 P32577 Q91W16 P56546 P49711 Q9WTX6 Q13617 P20248 P30281 P53355 P51398 O60231 Q08495 O00273 P00376 Q12959 O35303 Q09013 P28340 Q07864 P11387 Q99704 Q12906 O43583 O43279 Q13561 P21575 Q9QXL9 Q9D2N4 Q9D2N4 Q61501 Q15691 Q9UPY8
9368 O14745 586 999 7706 3832 P54687 P12830 Q14258 P52732
1977 1983 1984 3692 13803
P29338 P55010 P10159 P56537 O14682
2022 117041 24326 13838 51474
P17813 P42676 P26684 Q03137 Q9UHB6
13860 Q08509 3028 Q99714
2067 P07992 50689 Q63538 50689 Q63538 116590 P27703 9601 7514 7430 11198 8772 5747 P13667 O14980 Q96CU8 Q920B9 Q13158 Q00944
356 P48023 2194 P49327 8880 2237 5496 10133 2280 14229 8468 241 14251 Q96AE4 P39749 Q61074 Q96CV9 P20071 Q64378 Q61576 O70323 O08917
2319 Q14254 2339 2342 9513 2534 2780 2783 10146 2571 3728 25597 P49354 P49356 P51116 P06241 P08239 P04901 Q13283 P18088 Q15151 Q63713
2978 P43080 23582 Q9NYH3
2674 Q62997 2934 P06396 2670 23163 83709 2908 2752 64528 9321 9950 2888 81504 84016 54400 9570 94189 2932 2950 10456 8841 3301 5275 10403 3163 5887 3091 405 331 9785 51362 5883 7178 3299 5000 15505 3301 3301 P14136 Q9NZ52 Q9Z272 P04150 P15104 Q62839 O15154 O95287 Q14449 P29354 P97879 O35152 O14653 Q62931 P18266 P09211 O00165 O15379 P31689 Q9UIV8 O14777 P30519 P54727 Q16665 P27540 P98170 Q92620 O60508 Q96C41 P13693 Q9ULV5 O43929 Q60446 P25685 P25685
3329 P10809 3303 P08107 3320 23640 4792 4794 6795 P08238 O95351 P25963 O00221 O35624
29128 8518 3551 16151
Q9P115 O95163 O14920 O88522
3611 Q13418 5504 P41236 3673 P17301 3710 8826 3654 10987 3716 50848 Q14573 P46940 P51617 O15386 P23458 Q9Y624
6416 P45983 16476 P05627 22950 O54716 1033 Q16667 16579 P70188 3838 P52292
16560 16563 11127 16569 8209 21849 14375 7520
P33173 P28740 Q9Y496 O15066 P30042 Q62318 P23475 P13010
6146 6741 4000 3915 3916
P35268 P05455 Q969I8 P11047 P11279
25359 Q62733 27040 O43561 800 Q05682
10558 9516 6653 9961 7024 10062
O35704 Q99732 Q92673 Q14764 Q9UD77 Q13133
4067 P07948 12416 P30658 4085 10459 4133 8550 4163 17217 4174 4175 5604 5605 13800 2052 17827 83589 5606 60587 20656 4478 4361 4436 2956 6789 8428 25558 4601 116670 482 1982 4683 1000 4690 Q13257 Q9UI95 P11137 O60491 P23508 P49717 P33992 Q14566 Q02750 P36506 M58320 P07099 P47802 O35430 P97293 Q62767 P09671 P26038 P49959 P43246 P52701 Q13043 O00506 Q99PV2 P50539 0 P14415 P78344 O60934 P15116 P16333
10241 Q13137 4734 O08758 4751 P51955 10763 25487 6272 246172 5970 24782 23385 4814 662 4831 4842 10609 4905 10204 23636 53893 P21263 P47971 Q99523 Q9Z2J4 Q04206 P26431 Q92542 Q92982 Q8VHI8 P15531 P29475 Q92791 P46459 P13662 P37198 Q99KM4
18227 Q06219 18999 5018 56042 10928 9564 29167 10514 394 394 6500 10094 56351 22360 17420 1432 1432 13722 5705 171126 171126 7157 4841 P20263 Q15070 P41542 P97434 Q63767 P28023 O35851 Q13017 Q13017 P34991 O15145 Q9R0Q7 P97799 P51949 Q16539 Q16539 P31230 P47210 P53676 P53676 P13481 Q15233
8878 Q13501 4688 O70145 83840 64424 5054 24338 P21425 Q62034 P05121 P27703
5602 142 5829 5829
P53779 P09874 P49024 P49024
55872 Q9NPD9 5110 P22061 5111 64714 5189 19305 51400 207 983 5747 5333 P12004 P05307 O43933 O09012 Q9Y570 P31749 P06493 Q05397 P51178
5336 P08487
1432 1432 9491 5295 5290 18704 5298 1207 18717 5306 5566 5566
Q16539 Q16539 Q92530 P27986 P42336 Q61182 P78405 P54105 O70161 Q00169 P17612 P17612
19084 P10644 5576 P13861 5577 207 207 5578 5579 5580 18755 5584 5583 5588 5610 5341 P31323 P31749 P31749 P17252 P05771 Q05655 Q02156 P41743 P41743 Q04759 P19525 P08567
11243 Q9UBQ3 1500 P30999
5515 65179 51449 5585 5586 5652 10197 5728 5770 5777 5781 50646 8766 19336 5873 5867
P05323 P53042 Q9UHG3 Q16512 Q16513 Q16651 Q12920 O00633 P18031 P29350 Q06124 P70600 P24410 P35290 P51159 P20338
5868 P20339 4218 P24407 9135 Q15276
207 P15154 10399 56718 5898 5901 5902 8498 54386 5911 P25388 P42346 P11233 P17080 P43487 O75759 Q9NYB0 P10114
2963 P13984 5921 P0116 5921 P20936 19645 P13405 5934 Q08999 5928 Q09028 12561 P39038 1104 P18754
328 19707 387 397 9610
P27695 O54916 P03749 P52566 Q13671
8737 10535 94188 19877 4486 6195 10657 9522 25561 116654 10910
Q13546 O75792 O08961 P70335 Q04912 Q15418 Q07666 O15126 Q63520 Q62824 Q9Y2Z0
6464 P29353
20418 Q61120
25528 P97710 11777 O88670
6917 P23193
8487 56616 56616 17126 4089 6606 6642 6643 14137 6729 6732
O14893 Q9NR28 Q9NR28 Q62432 Q13485 Q16637 Q13596 O60749 P53798 P13624 Q96SB4
6733 P78362 6772 A46159
6772 P42224 6773 P52630 6774 6775 6776 6776 6778 3925 10963 20901 29149 8189 29704 6810 60562 55943 6874 9344 10482 4137 26611 7008 2959 2969 2969 2959 2149 7073 8462 10499 54312 117152 2521 10293 56647 P52631 Q14765 P42231 P42229 P42226 P16949 P31948 Q9Z122 P70483 Q92797 Q9Z0W5 Q12846 Q63635 O88983 O00268 O88664 Q9UBU9 P10636 Q14257 P28347 Q00403 Q9UHL9 Q9UHL9 P19814 P25116 Q01085 O14901 Q15596 O35093 P97536 P35637 Q9UKE5 Q9P288
9804 Q15388 7153 P11388 7155 QU2880 3842 7257 22040 9352 7270 7297 10054 7329 7324 7332 2245 22230 10277 94351 30960 7408 22331 65137 1845 53611 53612 7518 10413 7525 7535 58820 22696 1613 7082 Q92973 Q99598 Q91XB0 O43396 Q15361 P29597 O950605 P50550 P51965 P51966 Q9Z283 P70362 O95155 P80144 Q9UB22 P0552 P54609 O88800 P51452 O89116 O88384 Q13426 P46937 P07947 P43403 Q62806 P17141 O43293 Q07157
GelType
Lane 2 3 3 3 4 4 4 4 5 5 6 8 9 10 11 11 12 13 13 14 14 16 17 17 18 18 18 19 19 20 20 20 20
Band 2 1 2 3 1 2 3 4 2 3 1 2 3 2 2 4 2 1 2 1 3 2 1 2 2 3 4 1 2 1 2 3 4
ProteinName
Abbrev
Epitope
~MW 88 78 37 24 41 39 37 25 132 120 36 34 32 68 46 38 32 76 40 225 40 30 88 45 54 44 39 79 51 77 38 37 33
Rel. Qty 23.3 28.7 31.8 1.9 9.7 28.8 16.6 7.5 3.9 46.6 6.1 16.2 60.6 8.7 10.5 26.9 14.9 72.0 3.9 9.1 13.6 52.1 10.1 17.2 14.7 21.1 12.7 58.0 5.7 4.3 17.6 33.1 16.7
Trace Qty 3051 5930 6555 384 1981 5862 3385 1533 1131 13514 1411 2258 29913 618 1608 4120 2143 31838 1720 2190 3281 5680 431 735 1640 2351 1417 21651 2144 1937 8015 15037 7583
KPKS1.2 A
KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A KPKS-1.2A v-raf murine sarcoma viral oncogene homolog B1 RafB PSTK Protein kinase C Beta1 PKCb1 PSTK p38 Hog MAP kinase p38a MAPK PSTK Cyclin-dependent kinase 5 CDK5 PSTK Extracellular regulated kinase 1 (41) ERK1 PSTK Extracellular regulated kinase 1 (40) ERK1 PSTK Extracellular regulated kinase 2 (37) ERK2 PSTK Cyclin-dependent kinase 1 (cdc2) CDK1 PSTK Protein kinase C mu (120) PKCm PSTK Protein kinase C mu (110) PKCm PSTK Extracellular regulated kinase 2 (37) ERK2 PSTK Cyclin-dependent kinase 7 CDK7 PSTK Cyclin-dependent kinase 9 CDK9 PSTK Protein kinase C delta PKCd PSTK Stress activated protein kinase (JNK) (45) NK (SAPK) PSTK J Stress activated protein kinase (JNK) (38) NK (SAPK) PSTK J v-mos Moloney murine sarcoma viral oncogene homolog 1 Mos PSTK Protein kinase C zeta (78) PKCz PSTK MAP Kinase kinase 1 (MKK1) MEK1 PTYK DNA-activated protein kinase DNA-PK PSTK MAP kinase kinase 2 (MKK2) MEK2 PTYK MAP Kinase kinase 6 MEK6 PTYK IKKbeta IKKb PSTK Aurora2 Aurora 2 PSTK S6 Kinase p70 (59) S6Ka p70 PSTK Glycogen synthase kinase 3 alpha (44) GSK3a PSTK Glycogen synthase kinase 3 beta (40) GSK3b PSTK Ribosomal S6 kinase 1 (78) RSK1 PSTK Cancer Osaka thyroid oncogene (Tpl2) COT PSTK Ribosomal S6 kinase 2 (78) RSK2 PSTK Casein kinase 2 (39) CK2a PSTK Casein kinase 2 (37) CK2a PSTK Casein kinase 2 (35) CK2a PSTK
KPKS 1.2 B
KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B KPKS-1.2B 3 4 5 7 9 11 14 14 15 16 17 18 19 2 1 1 3 2 1 1 2 2 1 1 1 1 Inhibitor NF kB kinase alpha IKKa Bone marrow X kinase BMX (Etk) Death associated protein kinase 1 DAPK Oncogene SRC Src Casein kinase 1 epsilon CK1e Calmodulin-dependent kinase 1 CaMK1 Oncogene Raf 1 (73) Raf1 Oncogene Raf 1 (69) Raf1 Protein kinase A (cAMP-dependent protein kinase) PKA Focal adhesion kinase FAK G protein-coupled receptor kinase 2 (BARK2) GRK2 ZIP kinase (death associated protein kinase 3) (45) ZIPK Janus kinase 1 JAK1 PSTK PSTK PSTK PYK PSTK PSTK PSTK PSTK PSTK PYK PSTK PSTK PTK 77 67 171 47 37 42 71 64 38 113 70 47 117 31.1 10.4 58.4 15.5 19.6 7.5 14.8 21.5 4.9 45.2 33.5 9.6 1.3 3131 690 2762 526 1140 855 2172 3157 236 4945 2086 5139 1309
KPPS 1.2
KPPS-1.2 KPPS-1.2 2 5 1 Protein phosphatase 2A - A PP2A/A ab 2 Protein phosphatase 2A - catalytic subunit PP2A/C a PSTP PSTP 47 32 62.3 38.6 19817 18658
KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2 KPPS-1.2
8 9 9 10 10 10 12 13 14 15 16 16 17 18 20
1 2 3 1 3 5 1 1 1 1 1 2 2 2 1
MAP kinase phosphatase 1 MKP-1 PTYP Protein tyrosine phosphatase 1D PTP1D PYP Protein tyrosine phosphatase 1B PTP1B PYP LCA antigen-related (LAR) transmembrane tyrosine phosphatase LAR PYP Protein phosphatase 5 - catalytic subunit PP5 (PPT) PSTP Protein phosphatase 1 - catalytic subunit - a isoform PP1/C a PSTP Protein phosphatase 1 - catalytic subunit-beta isoform PP1/C b PSTP MAP kinase phosphatase 2 MKP-2 PTYP Protein phosphatase 1 - catalytic subunit-gamma isoform PSTP PP1/C g Protein tyrosine phosphatase 1C PTP1C PYP Protein phosphatase 2X - catalytic subunit PP2X/C PSTP Dual specificity phosphatase 3 VHR PYP Dual specificity phosphatase Cdc25C Cdc25C PSTYP Protein phosphatase V - catalytic (30) PPV/C PSTP Protein phosphatase X - regulatory subunit PPX/A’2 PSTP
36 66 43 160 48 33 33 39 33 56 33 17 53 31 116
6.5 33.6 26.2 2.5 14.5 39.5 49.5 14.4 21.9 21.4 32.0 13.5 39.6 52.0 14.0
177 1988 1550 245 1403 3819 3336 572 676 603 1991 839 7331 5869 243
KPSS 3.1
GelType KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 KPSS-3.1 Lane 2 3 3 4 4 4 5 7 8 10 11 11 13 13 14 15 16 16 18 18 19 20 Band ProteinName Abbrev Epitope 1 MAP Kinase Kinase 2 (T394) (human) MEK2 human T394 1 Oncogene SRC (Y418) Src Y418 4 Eukaryotic Translation Initiation Factor 2 alpha (S52) eIF-2a S52 1 Paxillin (Y31) Pax Y31 2 MAP Kinase Kinase 1 (S298) MEK1 S298 3 Cyclin-dependent kinase 1 (T14/Y15) CDK1 T14/Y15 1 Retinoblastoma protein (T826) Rb T826 1 Oncogene SRC (Y529) Src Y529 1 MAP Kinase Kinase 1 (T292) MEK1 T292 1 Retinoblastoma protein (T356) Rb T356 2 Glycogen Synthase Kinase-3 alpha (Y279) GSK3a Y279 3 Glycogen Synthase Kinase-3 beta (Y216) GSK3b Y216 1 Extracellular signal-regulated kinase 1 (T202/Y204) T202/Y204 ERK1 2 Extracellular signal-regulated kinase 2 (T185/Y187) T185/Y187 ERK2 1 Paxillin (Y118) Pax Y118 1 Signal Transducer and Activator of Transcription 3 (S727)S727 STAT3 2 Focal Adhesion Kinase (Y576) FAK Y576 3 Lck (Y505) Lck Y505 1 Retinoblastoma protein (S807) Rb S807 2 Signal Transducer and Activator of Transcription 1 (S727)S727 STAT1 1 p21-activated kinase 1/2/3 (S141)(54) PAK1/2/3 S141 1 Retinoblastoma protein (T821) Rb T821 ~MW 41 47 34 68 41 27 136 48 42 136 45 40 41 39 64 77 108 45 128 80 53 138 Rel. Qty 37.1 17.1 16.3 11.7 17.2 40.5 10.4 58.5 30.2 18.0 9.8 2.3 4.6 14.7 22.2 12.7 22.2 9.1 25.1 8.1 18.8 12.6 Trace Qty 10473 4974 4727 6117 8972 21141 3697 24608 10770 5339 11527 2694 2132 6860 7867 9547 3160 1288 8848 2871 8128 5379
CPM 915 1779 1967 115 594 1759 1016 460 339 4054 423 677 8974 185 482 1236 643 9551 516 657 984 1704 129 221 492 705 425 6495 643 581 2405 4511 2275
Norm. CPM 915 1779 1967 115 594 1759 1016 460 339 4054 423 677 8974 185 482 1236 643 9551 516 657 984 1704 129 221 492 705 425 6495 643 581 2405 4511 2275
939 207 829 158 342 257 652 947 71 1484 626 1542 393
939 207 829 158 342 257 652 947 71 1484 626 1542 393
4954 4664
4954 4664
44 497 388 61 351 955 834 143 169 151 498 210 1833 1467 61
44 497 388 61 351 955 834 143 169 151 498 210 1833 1467 61
CPM Norm. CPM 3142 3142 1492 1492 1418 1418 1835 1835 2691 2691 6342 6342 1109 1109 7382 7382 3231 3231 1602 1602 3458 3458 808 808 640 640 2058 2058 2360 2360 2864 2864 948 948 386 386 2654 2654 861 861 2438 2438 1614 1614
Template Lane Catalog D 12 F20120 D 15 14101A A 34 A73820 B 4 A29220 C 31 A24520 A 21 A12820 A 14 M61420 B 12 A91020 C 39 A30320 A 25 A22220 A 1 A58920 C 18 A97420 D 9 A31320 B 37 A99120 C 34 A74220 A 28 A81420 C 39 M35020 A 1 A59420 C 17 A14120 A 3 A41820 D 4 A94620 B 28 R14320 A 35 A59120 C 18 A93520 D 34 A98020 B 20 R10820 D 23 B32120 A 6 B46620 D 32 B13020 A 4 C49020 D 22 P15820 B 15 E84420 A 4 N68720 A 22 67381A C 26 B19720 C 38 B10020 A 15 B67020 D 11 B22020 A 33 B68820 B 2 B36320 D 29 B84220 C 11 C74720 B 27 C26120 D 8 C67120 A 1 C26920 D 34 C16420 C 12 C28420 D 26 C45220 E 30 C36820 A 25 C61820 C 6 C67520 A 25 C40420 B 22 C78820 C 24 C37120 D 24 C36220 B 9 C57820
Name 4.1N Abl Acetylcholine Receptor alpha Acetylcholine Receptor beta Acid Ceramidase Acrp30/Adiponectin ADAM9/MDC9 Adaptin delta Adaptin epsilon AFAP AKAP220 AKAP450 AKAP79 AKAP82 AKAP95 AKAP-KL alpha-Methylacyl-CoA Racemase Amphiphysin Annexin II Light Chain AP180 ApoB-100 A-Raf Arginase I Ataxin-2 Attractin BAG-1 BART Bcl-2 BERP beta 1-Calcium Channel beta PIX beta-Enolase/ENO-3 beta-NAP Bik BMPR-II BPntase BRAMP2 BRCA1 Brevican Brm BRUCE CA150 Cadherin-5 CAF-1 p150 Calcineurin Calsequestrin CaM Kinase IV CAPS Carbonic Anhydrase XIV Carboxypeptidase E CART1-51KD Casein Kinase II beta Cathepsin L Caveolin 1 Caveolin 1 Caveolin 2
Mol. Wt. WB Dil. BackgroundLocusLink SwissProt ID ID 135/100 1:5000 The erythrocyte membraneQ9Z2H5 13821 cytoskeletal protein, 4.1R, 11350 P00520 49 1:250 Acetylcholine is an amine neurotransmitter at the neur 79557 P25108 55 1:1000 The acetylcholine receptor (AChR) is a 250kDa pentam 24261 P25109 13 1:1000 Ceramide is a sphingolipid that exhibits a wide variety 427 Q13510 30 1:500 Adipocytes express a variety of proteins that function i 9370 Q60994 84 1:250 MDC9 (metalloprotease/disintegrin/cysteine-rich protei 8754 Q13443 160 1:500 Sorting of integral8943 membrane proteins at various stage O14617 127 1:250 Sorting of integral membrane proteins is mediated by v 23431 Q9UPM8 110 1:250 Chicken embryo 60312 fibroblastsQ9HBY1 (CEF) which are transform 220 1:250 The type II cAMP-dependent Protein Kinase (PKA) is c 25228 Q62924 450 1:250 Compartmentalization of the type II cAMP-dependent p 10142 Q99996 79 1:250 The type II cAMP-dependent Protein Kinase (PKA) is c 9495 P24588 82 1:5000 The cAMP-dependent Protein Kinase (PKA) is compar 11643 Q9Z263 95 1:250 Induction of cAMP results in the activation of the cAMP 10270 O43823 105-130 1:1000 Cyclic AMP (cAMP) is a common second messenger f 11641 O54931 42 1:250 a-methylacyl-CoA Racemase (AMACR) catalyzes the r 23600 Q9UHK6 125 1:10,000 Amphiphysin was 273 originally P49418 in chicken brain described 11 1:5000 Annexin II often exists as a P07355 6281 heterotetramer complexed 180 1:250 AP180 (also known as AP-3, F1-20, NP185, and pp15 65178 Q05140 540 1:500 Low density lipoprotein (LDL) particles are produced fr 338 P04114 68 1:1000 A-Raf, a proto-oncogene that encodes a 68kDa serine 64363 P04627 35 1:1000 Arginase converts383 arginine into urea plus ornithine, the P05089 150 1:250 The hereditary ataxias are neurodegenerative disorder 6311 Q99700 175 1:250 Interactions between cell adhesion molecules and extr 8455 O75882 50/46/33 1:15,000 Members of the Bcl-2 protein family function to inhibit ( 573 Q99933 19 1:1000 The ADP-ribosylation factors (ARFs) are a family of sm 23568 Q9Y2Y0 26 1:500 Human hematopoietic malignancies are often characte 596 P10415 82 1:250 Proteins with RING finger Zn2+-binding motifs are invo 83616 O70277 58 1:250 Calcium, a universal second messenger, is involved in 782 Q02641 78 1:250 The activity of PAK family kinases is regulated through 114559 O55043 47 1:500 Enolases are glycolytic enzymes that interconvert 2-ph 2027 P13929 145 1:500 Sorting of integral8120 membrane proteins at various stage Q13367 638 Q13323 130 1:250 The transforming12168 factor b (TGFb)/activin/BMP f growth O35607 43 1:2500 Sulfation reactions involve transfer of a sulfate group f 23827 Q91XB9 96/89 1:1000 BRAMP2 (Brain form of amphiphysin 2) was cloned fro 30948 O08539 220 1:250 Breast cancer susceptibilty P38398 672 genes (BRCA1 and BRCA2 145 1:1000 Neural tissue expresses a variety of cell surface hepar 25393 P55068 180 1:250 Several of the SNF and SWI genes of Saccharomyces 6595 P25439 528 1:250 Selective proteolysis is essential for the modulation of 12211 O88738 150 1:250 Human immunodeficiency virus type 1 (HIV-1) promote 10915 O14776 130 1:250 Cadherins are a family of transmembrane glycoprotein 1003 P33151 150 1:250 CAF-1 (Chromatin assembly factor 1) is a multimeric p 10036 Q13111 61 1:250 Calcineurin is a Ca2+/calmodulin-dependent protein ph 5530 Q08209 55 1:250 Calsequestrin, a 12373O09161,O09165is located in the Ca2+-binding protein, 60 1:5000 CaM-kinase IV (Ca2+/calmodulin-dependent protein ki 814 Q16566 145 1:500 Synaptic vesicles are organelles situated at the distal t 26989 Q62717 51 1:1000 Carbonic anhydrases (CA) Q9ULX7 23831 are zinc-binding metallopro 50 1:2500 Carboxypeptidase E (CPE),P16870 1363 also known as carboxypep 53 1:250 CART1 gene, located on q11-q12 region of the chromo 9618 Q14848 25 1:250 Casein Kinase II (CKII) is a P13862 1460 serine/threonine protein kin 43 1:250 Cathepsin L is a major lysosomal cysteine protease th 1514 P07711 22 1:1000 Identified as a tyrosine phosphorylated protein in Rous 857 Q03135 22 1:5000 Identified as a tyrosine phosphorylated protein in Rous 857 Q03135 20 1:250 Identified as a tyrosine phosphorylated protein in Rous 858 P51636
C A C A E B D C D B C C D B A B A D B D B C B E A B D A C A A C D D A B D A B A A D C C C E A B C D A C B D D D A
22 13 9 6 2 39 26 2 31 7 22 36 17 37 13 22 28 38 27 24 5 6 16 22 3 9 8 32 17 24 36 5 28 39 19 9 8 35 4 6 14 28 18 21 7 25 39 18 11 11 18 27 25 33 19 18 37
C38320 C44920 C40320 C57020 556367 C80420 C92720 C27220 C10020 C25820 C18720 C81120 C38920 C95920 C96420 C82320 C21120 C15720 C24420 K24620 C68220 N93320 C11020 C34120 C60320 C50920 P13320 C14020 C93420 C34520 C25520 C23420 14821C C26520 D97520 D84920 D71820 C98320 D28120 D37920 D70920 P41620 D30120 D20320 D64220 D31520 D10020 66201A D38220 D57220 E16820 C37020 E41120 E10020 E12020 E12120 E46520
Caveolin 3 CBF beta c-Cbl CD100 CD3 zeta CD38 CD40 CD45 CD54/ICAM-1 CDC34 Cdk4 Cellugyrin CENP-H Ceruloplasmin cGB-PDE Chk1 Chromogranin A Chromogranin B Cip1/WAF1 c-Kit CLA-1 C-Nap1 Collagen VII alpha 1 Collybistin Complexin 2 Contactin Cortactin CPG16/CaM Kinase VI CRIK CRP2 CUL-3 Cyclin B Cyclin D2 Cypher1 DARPP-32 DDX1 DEK delta-Catenin Desmoglein DGK iota DGK theta Disabled-2/p96 DLC-1 DNA Ligase III DNA-PKcs/p350 Dok2/p56 dok2 Doublecortin DP-1 DP103/Gemin3 Dyrk EAAT2 E-Cadherin EEA1 eEF-2 Kinase EGF Receptor EGF Receptor (activated form) eIF-4 gamma
Identified as a tyrosine phosphorylated protein in Rous 29161 P51638 Core-binding factor (CBF) is a multimeric protein comp 12400 Q08024 cbl was identified in the genome of a transforming retro 23624 P22681 CD100 was originally described as a 150kDa surface T 10507 Q92854 12503 P20963 46 1:250 Lymphocyte trafficking is essential for efficient immune 952 P28907 44 1:2500 CD40, a member of the TNF receptor family, contains 958 P25942 180–220 1:500 CD45 (also known as leukocyte common antigen, GP1 5788 P08575 90-115 1:250 The migration of T cells through lymph nodes and their 3383 P05362 40 1:1000 The human homologue of the Saccharomyces cerevis 997 P49427 33 1:250 The Cdk4 kinase94201 cycle-regulated cyclin-depen is a cell P35426 29 1:250 Neurotransmitter89815 is O54980 by the synaptic v release mediated 33 1:250 Two complex macromolecular assemblies found at opp 26886 Q9QYM8 150 1:250 Ceruloplasmin (CP) is a copper-containing glycoprotei 12870 Q61147 95 1:500 cGMP is involved in nitric oxide signaling, as well as ce 171115 O54735 54 1:500 The cell cycle is regulated by multiple checkpoints that 1111 O14757 86 1:5000 Chromogranins are a familyP10354 24258 of regulated secretory pro 105 1:5000 Chromogranins are a family of proteins (Chromogranin 1114 O35314 21 1:500 Cip1 (p21) was identified asP38936 1026 an inhibitor of cdk activity 145 1:1000 c-Kit, a type III tyrosine kinase receptor, binding of stem 3815 P10721 80 1:500 CLA-1 (CD36 and949 LIMPII Analogous-1) is member of a Q14016 320 1:250 Centrosome structure and function is regulated in a ce 11190 O60588 290 1:250 Epidermal basement membrane of the skin is attached 1294 Q02388 62 1:2500 Members of the Ras superfamily of GTPases are dista 66013 Q9QX73 19 1:500 Release of neurotransmitters from neurons is regulate 10814 Q13329 135 1:250 Contactin (Gp135), the human homologue of chicken F 1272 Q12860 85/80 1:1000 Cortactin is a protein which Q14247 2017 is represented by two struc 48/96 1:500 Central nervous system plasticity is essential to the pro 83825 O08875 240 1:500 Citron was identified by its interactions with activated R 11113 O88938 23 1:1000 Cysteine-rich proteins (CRP1, CRP2, and CRP3/MLP) 29317 P36201 89 1:10,000 The cullins are a family of proteins that are integral to c 8452 Q13618 62 1:1000 The B-type cyclins serve asP14635 of the major mito 891 subunits 894 P30279 80 1:5000 The PDZ-LIM family of proteins (Enigma/LMP-1, ENH, 24131 Q9WVH2 32 1:250 Dopaminergic signaling in midbrain neurons is essenti 5503 Q9UD71 82 1:250 DEAD box proteins, a family of putative RNA helicases 1653 Q92499 43 1:500 The (6;9) chromosomal translocation is associated with 7913 P35659 160 1:250 The catenins (a, 18163 p120ctn) are cytoplasmic pro b, g, d, O35927 165 1:1000 Desmoglein (Dsg1) is a transmembrane glycoprotein f 1828 Q02413 117 1:1000 The protein kinase C pathway is a major signal transdu 9162 O75912 110 1:250 The protein kinase C pathway is a major signal transdu 1609 P52824 96 1:1000 CSF-1 is a growth factor that stimulates the growth and 13132 P98082 123 1:250 Members of the Ras superfamily of GTPases are dista 10395 O43199 103 1:10,000 Cells have evolved DNA repair pathways that are dedi 3980 P49916 350 1:250 DNA-PK is a trimeric enzyme that is composed of a ca 5591 P78527 56 1:250 p62dok (downstream of tyrosine kinases) was identifie 13449 O70469 41 1:250 The cerebral cortex is composed of multiple layers of n 13193 O88809 7027 Q14186 103 1:500 DEAD box proteins, a family of putative RNA helicases 11218 Q9UHI6 100 1:250 Eukaryotic protein phosphorylation is a major regulato 25255 Q63470 66 1:500 Electrogenic-coupled (Na+ and K+) glutamate transpo 6506 P43004 120 1:250 E-Cadherin is a 120kDa transmembrane glycoprotein t 999 P12830 180 1:2500 Early endosomes8411a major cytoplasmic sorting com are Q14221 100 1:1000 The eukaryotic elongation factor-2 (eEF-2) is required 25435 P70531 180 1:2500 Epidermal Growth Factor (EGF) elicits a variety of cellu 1956 P00533 180 1:1000 Epidermal Growth Factor (EGF) elicits a variety of cellu 1956 P00533 220 1:250 eIF-4 proteins are required Q04637 recognition and 26965 for mRNA
18 22 120 150
1:5000 1:250 1:5000 1:2500
D B B A D B C C A D C C A D D A C A C D B C C A A D D C B A D A A D D C C A B E E B A B B D A D C D D E C A B C A
5 23 28 9 2 39 27 14 25 8 17 11 34 35 1 29 2 36 17 22 15 37 25 10 3 24 16 39 39 33 38 39 23 14 18 33 39 29 3 26 27 38 21 14 29 36 18 39 17 21 22 8 32 22 1 9 18
S61920 N30020 N38620 E64320 E19420 E78320 E16320 E59020 E99620 E17520 E95720 F22120 F10020 F10520 F14420 F84020 F71620 G12020 M96020 G13520 G35720 G38120 G51620 G74820 G72120 G95320 G64520 G34320 G96620 G87120 G22020 H89720 H28520 K95820 C13020 H59320 H16820 H82420 H59520 H22520 H20020 H35920 H69220 H88820 H46720 H11020 I71920 I96720 I68120 N52920 N32020 N39120 I16620 V76720 I55220 L65320 C75120
Elongin C/SIII p15 eNOS/NOS Type III eNOS/NOS Type III eps15 erbB2 erg2 ERK3 ERP ESE-1 espin Exportin-t Fas/CD95/APO-1 FEZ1 FHIT Fibronectin Frabin FYB/SLAP-130 GABA B R2 GADS/Mona GAGE GBF1 GCF2 Gephyrin GluR delta 2 GOK/Stim1 gp91phox GPI-Phospholipase D GRASP55 GRIFIN GSPT2 Guanylate Kinase HAP1 Hck hcKrox hCNK1 Heme Oxygenase 1 Heparanase Hic-5 hILP/XIAP HIP1 HIP1 Hip1R HNF-1 hPrp18 HS1 Hsp10 IGF2R IGFBP-3 IGTP iNOS/NOS Type II iNOS/NOS Type II iNOS/NOS Type II Insulin Receptor beta Integrin alpha 3/VLA-3 Integrin alpha 5 Integrin alpha L/LFA-1 Integrin alpha v
15 1:250 SIII p15 is one of 6921 polypeptides that comprise the three 140 1:2500 Nitric oxide synthase (NOS), a cell-type specific enzym 4846 P29474 140 1:1000 Nitric oxide synthase (NOS), a cell-type specific enzym 4846 P29474 145 1:250 The eps15 (EGF receptor pathway substrate clone num 2060 P42566 185 1:2500 ErbB2 (Neu or Her-2) is a member of the erbB family o 2064 P06494 130 1:250 Drosophila and mammals contain a family of three rela 116745 O54853 62 1:250 The family of serine/threonine kinases known as ERKs 58840 P27704 45 1:250 ERP (ets-related13713 also named Net, is a membe protein), P41971 140/200 1:500 ESE-1 (epithelium-specific,Q9Z0R4 16443 EH domain and SH3 doma 110 1:5000 Actin-binding proteins regulate the polymerization and 56227 Q63618 110 1:250 Processing of pre-tRNA to mature tRNA involves remo 11260 O43592 45 1:5000 The Fas antigen (Apo-1, CD95) is a member of a famil 5783 P25445 75 1:250 The development9638 of cancerQ99689 is a multi-step process inv 17 1:250 Multiple tumor-derived cell lines have homozygous del 14198 O89106 240 1:10,000 The 240kDa dimeric fibronectin protein exists in two fo 2335 P02751 105 1:500 Cellular morphology, adhesion, and motility occur throu 246174 O88387 130 1:250 Engagement of the T cell receptor (TcR) results in the 2533 O15117 130 1:500 GABA receptors230142 both type-A ligand-gated and include O88871 38 1:1000 SH2 and SH3 domain-containing adaptor proteins inte 17444 O89100 24 1:250 Human melanoma cells express antigens that are reco 2543 Q13065 206 1:1000 The Golgi apparatus is a complex and dynamic organe 8729 Q92538 160 1:250 Regulation of transcription is mediated by transcription 8141 O75799 93 1:250 The sub-membraneous region of the postsynaptic neu 64845 Q03555 111 1:250 Glutamate is a major excitatory neurotransmitter of the 14804 O43424 84 1:250 The human chromosomal region 11p15 has undergone 6786 Q13586 58 1:1000 Although dormant in restingQ61093 13058 granulocytes, macrophage 110 1:250 Glycosylphosphatidylinositol (GPI)-anchored proteins a 2822 P80108 55 1:1000 Maturation and post translational modification of protei 113961 Q9R064 16 1:5000 Galectin-related-inter-fiber protein (GRIFIN) was identi 117130 O88644 88/90 1:250 Cell cycle progression is regulated by multiple genes a 14853 O88180 22 1:1000 cGMP is involved in nitric oxide signaling and signaling 14923 Q64520 85/98 1:250 Huntington's disease (HD) is an autosomal dominant n 29430 O35636 59/56 1:1000 The hematopoietic cell kinase (Hck), a member of the 3055 Q95M30 75 1:250 Human cKrox (hcKrox) is a O15156 51043 Zn2+ finger-containing tran 100/79 1:250 Proteins of the Ras superfamily play critical roles in the 10256 O95381 32 1:250 Heme oxygenases 1 and 2 P09601HO-2) cleave the he 3162 (HO-1, 72 1:250 Matrix metalloproteinases and hydrolases are enzyme 10855 Q9UL39 50 1:250 Focal adhesions 21804 structures terminal to the acti are cell Q62219 57 1:250 Apoptosis is a genetically programmed, selective proc 331 P98170 116 1:1000 Huntingtin disease (HD) is an inherited neurodegenera 3092 O00291 116 1:500 Huntingtin disease (HD) is an inherited neurodegenera 3092 O00291 120 1:250 Clathrin is the major proteinO75146 29816 component in the coat form 92 1:250 HNF-1 (Hepatocyte NuclearP22361 1), a POU-homeod 21405 Factor 42 1:250 Splicing, the removal of introns from pre-mRNA, is me 8559 Q99633 75 1:250 HS1 (lck-binding protein 1 (lckBP1)) is a protein of 486 3059 P14317 10 1:5000 Heat shock proteins (Hsp) are a set of highly conserve 15528 Q04984 273 1:250 Insulin-like growth factors (IGF) I and II exhibit extensiv 25151 Q63002 40/44 1:250 Insulin-like growth factors (IGF) I and II are peptide ho 3486 P17936 48 1:250 IGTP (Inducibly expressed Q9DCE9 is regulated by IF 16145 GTPase) 130 1:250 Nitric oxide synthase (NOS), a cell-type specific enzym 4843 P29477 130 1:2500 Nitric oxide synthase (NOS), a cell-type specific enzym 4843 P29477 130 1:10,000 Nitric oxide synthase (NOS), a cell-type specific enzym 4843 P29477 95 1:250 Insulin Receptor (IR) is a transmembrane receptor tyro 3643 P06213 135 1:250 Integrins are a family of dimeric proteins that mediate c 3675 Q62470 150 1:5000 Integrins are membrane receptors that mediate cell-ce 3678 P08648 180 1:500 Integrin aL, or LFA-1 (lymphocyte function-associated 3683 P20701 125 1:250 Integrins are a family of proteins that mediate intercellu 3685 P06756
D D D E C E B C B B E A A A B C D B B C C C C D C B B D D D C C A B D C B B A D A A E C C D D A B C C A A D C A A
9 17 13 20 36 32 24 37 33 33 31 8 17 30 24 2 7 8 5 29 3 14 36 7 2 37 15 39 31 9 38 5 34 10 21 38 3 35 19 22 19 36 21 30 9 39 32 31 4 25 39 4 31 11 38 35 33
I41720 I81720 I86220 I33220 I94320 I17820 I29320 I84520 Jxxx20 J27520 J11720 M66420 M86920 K87020 K38420 K48020 K95120 K72820 K25020 K99720 L30220 L73120 L78220 L33420 L15620 L16120 L10020 Labc20 L13020 L60620 L86020 M75820 C79620 M85020 M54020 M17520 M62720 M72220 M79820 M21720 M72620 67391A M76120 M93620 M62420 M89520 M16520 M10020 M94120 M68420 M30220 M98820 M11220 N74120 N91220 C10220 N99820
Integrin beta 1 Integrin beta 3 Integrin beta 4 IRF1 IRS-1 IRS-1 ISGF3 gamma Itch Jagged 2 Jagged1 JIP-1 JNKK1/MKK4 JNKK2/MKK7 K Channel alpha Kalinin B1 Karyopherin beta Katanin p80 Ki-67 Kip1/p27 KSR-1 L1 LAIR-1 LAP1 LAR lck LDLB LEDGF LFB3 LIMK1 LSP-1 Lysophospholipase MAP4 M-Cadherin MCAM Mcl-1 MCM MEF2D MEK5 MEKK3 Melusin mGluR1 MGMT Mint2 Mint3-65KD Mitosin MKBP MNK MRCK alpha MSH3 mSin3A MTP MUPP1 Myosin Vb/Myr6 Na,K ATPase beta 3 NABC1 N-Copine NCS-1
130 104 200 48 180 180 48 113 175 130 112 44 52 125 140 97 80 395 27 115 200 32 55 150 56 110 52/75 72 52 60 200-220 130 113 42/40 83 70 50 71 38 133 120 61 357 22 190 190 127 150 97 219 214 42 110 62 21
1:2500 1:2500 1:250 1:500 1:1000 1:250 1:250 1:500 1:250 1:250 1:500 1:1000 1:250 1:1000 1:1000 1:1000 1:250 1:2500 1:500 1:5000 1:250 1:5000 1:250 1:5000 1:250 1:1000 1:250 1:250 1:2500 1:1000 1:250 1:1000 1:1000 1:2500 1:2500 1:1000 1:500 1:1000 1:2500 1:1000 1:250 1:1000 1:250 1:2500 1:250 1:250 1:250 1:2500 1:250 1:250 1:500 1:500 1:1000 1:500
Integrins are membrane receptors that mediate cell-ce 3688 P05556 Integrins are heterodimeric P05106 3690 transmembrane receptors Cell adhesion to extracellular matrix components or to 3691 P16144 Cytokine function3659 is critical for both innate and adaptiv P10914 The IRS (Insulin 25467 substrate) proteins IRS-1, IR receptor P35570 IRS-1 (Insulin receptor substrate-1) is a major substrat 25467 P35570 ISGF3g is a nuclear DNA-binding protein. ISGF3 (inter 10379 Q00978 Maintenance of cellular function requires timely and se 16396 O08759 3714 The Notch signaling pathway is integral to the appropr 3714 Q9Y219 The JNK group of MAPKs is activated by a variety of in 19099 Q9WV19 The Ras signaling pathway P45985 signals from grow 6416 links the The transduction26400 of signals O35406 from extracellular stimuli vi Cellular excitability is modulated by the precise functio 3778 Q12917 Kalinin is an epithelial cell laminin. It is a structural com 3914 Q13751 Using nuclear import assays, several cytosolic proteins 24917 P52296 Microtubules (MTs), composed of a/b-tubulin dimers, a 10300 O60620 Cellular proliferation is a complex multi-faceted proces 4288 P46013 Kip1 is a cyclin-dependent kinase (cdk) inhibitor that w 12576 P46414 Proteins of the Ras superfamily play critical roles in the 16706 Q61097 L1 is a developmentally regulated cell adhesion molec 3897 P32004 Natural killer (NK) cells are a lymphocyte subpopulatio 3903 The nuclear envelope (NE) Q62754 81641 is a specialized extension o The leukocyte common antigen-related (LAR) receptor 5792 P10586 The p56lck protein kinase is a member of the src famil 3932 P06239 Glycoproteins, proteoglycans, and glycolipids are proc 16834 Q9Z160 p52/p75 proteins 9090 first identified through their inter were Q9NZI3 6928 P35680 Two LIM motif-containing protein kinases (LIMK) have 3984 P53667 LSP-1 (lymphocyte-specific P33241 is expressed in 4046 protein-1) Several enzymes are known to be involved in fatty acid 25514 O88202 The microtubule (MT) cytoskeleton functions in cytopla 4134 P27816 Cadherins are a 12555 of transmembrane glycoprotein family P10287 Tumor metastasis is determined by the metastatic cap 4162 P43121 Differentiated cells lose their proliferative capacity, but 4170 Q07820 Methylmalonyl-CoA mutaseP22033 is an adenosylcoba 4594 (MCM) MEF2D is a member of the Q63943 17261 MEF2 (myocyte-specific en The mitogen-activated protein (MAP) kinase cascade p 5607 Q13163 The Ras signaling pathway Q99759 4215 links signals from growth fa Integrins are membrane receptors that mediate cell-ce 26549 Q3R000 Glutamate is a major excitatory neurotransmitter and fu 24414 P23385 4255 P16455 Neuronal communication via neurotransmitter release 83610 O35431 Munc18-1-interacting proteins, Mint1, Mint2, and Mint3 9546 O88888 Mitosin, a nuclear1063 protein ofP49454 3113 amino acids, contain Myotonic dystrophy (DM), characterized by myotonia a 3316 Q16082 Copper (Cu2+) is essential Q64430 11977 for the function of enzymes p21 Rho family members (Rho, Rac, and Cdc42) are s 114116 O54874 Bacterial mismatch DNA repair involves the MutL, Mut 4437 P20585 The myc proto-oncogene family is involved in the contr 20466 Q60520 The microsomal 17777 triglycerideO08601 protein (MTP) cat transfer The postsynaptic29365 protein PSD-95 interacts with density O55164 Myosins are proteins that form oligomers consisting of 25132 P70569 Na+,K+-ATPase is an integral plasma membrane prote 483 P54709 Several studies have suggested that amplification of g 8537 O75363 The copines (copine I, copine III, copine VII, N-copine) 12891 Q9Z140 Ca2+-signaling pathways are critical for a variety of ce 65153 P36610
C D C A A D D A A D C C E B A D B E A C B E B B A C B D C C A A A B D D A A D A D A D C B C A B A E E D B E E C B
11 33 38 20 38 39 35 4 13 36 14 17 24 38 12 14 14 7 5 16 24 23 7 20 22 24 13 5 32 8 38 4 39 26 2 27 27 34 33 39 29 31 12 30 20 8 31 36 33 26 27 27 34 14 15 35 20
N65420 N10020 N13320 N79020 N38920 N11420 N15720 N63520 N73720 N87720 N58820 N12920 N74320 N17320 N38120 N89620 N90120 N41520 N33320 N91820 N34920 N32720 N48120 N22220 O79120 P66520 G88620 P72020 P33720 C86720 P94020 P93120 M74420 P67320 C24120 P16920 P15320 P81620 P14120 P34620 P10620 P24120 C91520 C24720 F25420 G15420 P70520 P98520 P23520 S38320 S37620 S12220 S99220 P11120 P39020 P75220 P91720
Ndr-53KD Nek3 NES1 Neurabin Neurabin II Neurexin I Neurexin IV/Caspr1 Neurogenin 3 Neuroglycan C Neuropilin-2 NFAT-1 NHE-3 NKT NMDAR2A NMDAR2B NMT-1 NMT-2 nNOS Nogo-A NPAT NSP1 Ntk NuMA Nup88 Occludin p140mDia p230 trans Golgi p38 delta/SAPK4 p47phox p55Cdc p95PKL PACS-1a panMunc13 Pax-5 P-Cadherin PDGF Receptor beta PECI Per2 Pericentrin Peroxiredoxin V PEX19 PhLP Phospho-Caveolin (Y14) Phospho-c-Cbl (Y700) Phospho-FAK (Y397) Phospho-GSK-3 beta (Y216) phospholipase C beta 1 Phospholipase C beta 4 Phospho-Paxillin (Y118) Phospho-Stat1 (Y701) Phospho-Stat1 (Y701) Phospho-Stat5 (Y694) Phospho-Stat6 (Y641) Phosphotyrosine-PY20 Phosphotyrosine-PY69 PI3-K p110 delta PI3-Kinase C2 beta
55 1:250 Protein phosphorylation is a common mechanism used 11329 Q9NBK5 56 1:2500 Reversible protein phosphorylation is critical for progre 23954 Q9R0A5 30 1:250 Normal epithelial 5655 cell-specific 1 (NES1) was identified O43240 180 1:250 The precise navigation of axons to their targets in the d 84685 O35867 140 1:500 Actin cytoskeleton is essential for maintaining cell mor 84686 O35274 165 1:250 Neurexins are a family of neuron-specific cell surface p 60391 Q63372 190 1:250 Neurexins are a family of neuron-specific cell surface p 84008 P97846 23 1:500 Neurogenins are11925 ofP70661 a family atonal-related bHLH (basi 120-150 1:500 Proteoglycans consist of core glycoproteins covalently 50568 Q62831 104 1:250 The precise navigation of axons to their targets in the d 81527 O35276 120 1:2500 T cells are activated and induced to proliferate followin 4773 Q13469 80 1:250 The extrusion of 24784exchange for extracellular Na+ H+ in P26433 60 1:1000 The kidneys function to excrete end products of bodily 18399 Q61185 180 1:500 The majority of synapses inP35436 14811 the central nervous system 180 1:250 The majority of synapses inQ00960 24410 the central nervous system 49-68 1:250 Myristoylation is an essential cotranslational modificati 4836 P30419 65 1:1000 Myristoylation is an essential cotranslational modificati 9397 O60551 155 1:2500 Nitric oxide synthase (NOS)P29476 4842 is a cell-type specific enzy 220 1:1000 During neural development, many axons must travel lo 83765 Q9JK11 280 1:250 Cyclins regulate transitions Q13632 cell cycle phases 4863 between 72 1:250 Proteins that contain Src homology 2 (SH2) domains m 10045 Q9Y2X4 56 1:500 The cytoplasmic 17179 tyrosine kinase (PTK) p50csk protein P41242 238 1:250 NuMA (Nuclear Mitotic Apparatus protein) is a 2115 am 4926 Q14980 88 1:2500 Nucleocytoplasmic transport involves the binding and i 4927 Q99567 65 1:250 Tight junctions (zonulae occludens) are critical to the m 18260 Q61146 140 1:500 GTPases like Ras, Rho, cdc42Hs, and Rac modulate a 13367 O08808 230 1:250 The Golgi apparatus is a very complex and dynamic or 2803 Q13439 42 1:500 Mitogen activated5603 protein kinases (MAPKs) are critical O15264 47 1:500 The neutrophil respiratory burst oxidase (NADPH-oxida 4687 P14598 55 1:1000 In order for proper991 chromosomal separation to occur d Q9BW56 95 1:500 Paxillin is involved in the integration of growth factor- a 28964 120 1:250 Clathrin-coated vesicles are involved in endocytosis an 171444 O88588 196 1:250 Release of neurotransmitters at the synaptic junction is 64829 Q62768 50 1:250 There are at least5079 members of the paired box (Pa nine Q02548 120 1:250 Cadherins are a family of transmembrane glycoprotein 1001 P22223 180 1:50 Platelet-derived growth factor (PDGF) is a potent mitog 5159 P09619 39 1:250 Peroxisomes, ubiquitous organelles of eukaryotic cells 10455 O75521 105 1:1000 Circadian rhythms are behavioral or physiological rhyth 18627 O54943 220 1:500 Centrosomes and other microtubule-organizing center 18541 P48725 15 1:10,000 Peroxisomes, ubiquitous organelles of eukaryotic cells 113898 Q9R063 38 1:250 Peroxisomes, ubiquitous organelles of eukaryotic cells 5824 P40855 45 1:500 G-protein regulatory proteins interact with G-protein a, 64013 Q63737 22 1:1000 Caveolin (VIP21) localizes to non-clathrin membrane in 857 Q03135 120 1:500 cbl was identified in the genome of a transforming retro 867 P22681 125 1:1000 Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine 5747 Q05397 46 1:1000 Glycogen Synthase Kinase-3b (GSK-3b) is a serine/th 79257 P18266 150 1:1000 PLC hydrolyzes inositol phospholipids into diacylglycer 23236 P10687 130 1:250 Phospholipase C 5332 hydrolyzes inositol phospholip (PLC) Q15147 68 1:250 A number of cytoskeletal proteins are tyrosine phosph 5829 P49024 84/91 1:1000 The Stat proteins 6772 function both as cytoplasmic signal t P42224 84/91 1:1000 The Stat proteins 6722 function both as cytoplasmic signal t P42224 92 1:500 Mammary gland factor (MGF) has been shown to play 6776 P42231 100 1:250 Interleukin-4 (IL-4), a major P42226 10617 immunoregulatory cytokine 1:1000 Phosphorylation of specific tyrosine residues is the res 1:1000 Phosphorylation of specific tyrosine residues is the res 110 1:500 Phosphoinositide 3-kinase (PI3-Kinase) phosphorylate 18707 O35904 165 1:1000 Phosphatidylinositol (PtdIns) (3) kinase phosphorylate 5287 O00750
A D A D C A D D B B A A B D A A B C A D A A A C D C C D D A A C C D D C E B C E D D B A C B C B C A C D B C D A A
8 23 28 19 26 30 25 2 14 18 26 17 19 4 24 33 39 29 9 36 3 10 23 14 16 32 23 14 13 10 31 13 3 9 34 16 13 18 37 12 30 37 35 19 16 12 8 6 19 7 22 37 6 34 38 13 11
P60220 P23720 P67920 P78020 P64720 P82820 P97220 P62220 P63420 P92020 P47920 P71020 P32520 P77520 P35220 P90620 P76020 P19620 P43520 P87520 R35520 R28720 R44520 R75020 13981A R66120 R24720 R97120 R86820 R69420 R79220 R33220 R20720 S29820 S30520 S83720 S13820 S34420 S59220 S33820 S97820 S91320 S81220 S74920 S86420 S98420 S60720 S11120 S93920 S35020 S15520 S85320 13931A S10520 S94220 S56820 S52520
PIN Pit-1 PKB alpha/Akt PKB Kinase PKC eta PKC gamma PKR PKR-66KD Plakophilin 2a Plectin PLK-1 PMCA2 PMS2 PNUTS PP1 PP2C delta PPEF-2 long form ProSAP1/CortBP1 PSD-95 PTRF Rab3 Rab5 Rabphilin-3A Rad50 Raf Ras-GRF2 RBP RECK RIG-G Rim RNCAM RPTP alpha RPTP beta S100L/A S100P SATB1 SCAR-1/WAVE-1 Selenocysteine Lyase Selenoprotein P Serine Racemase SH2-B SHIP-1/p150Ship Sin SIRP alpha 1 SKAP55 Skb1Hs SLP-76 Smac/DIABLO SMRT SNAP-25 Sos1 SPA-1 Spi Spot 14 Synapsin I Synapsin IIa Synaptogyrin
10 33 59 63 82 80 58 68 100 400/500 68 129-133 96 110 36 48 97 180 95 60 25 25 75 154 135 21 110 58 173 125/94 130 250 10 11 106 80 47 57/45 38 100 150 95 90 55 72 76 22 340 25 170 130 17 80 74 29
PIN (protein inhibitor of nNOS) is a small protein of 89 58945 Q15701 Pit-1, a 31–33 kDa pituitary-specific transcription facto 5449 P10037 Rac (Related to the A and C kinases) protein kinase sh 207 P31749 Protein Kinase B81745 is downstream of phosphoinos (PKB) O55173 The Protein Kinase C (PKC) family of homologous ser 18755 P23298 The Protein Kinase C (PKC) family of homologous ser 18752 P05129 The double stranded RNA (dsRNA)-dependent, Ser/Th 54287 Q03963 Double stranded RNA (dsRNA) generated by most viru 5610 P19525 Plakophilin 2 is a 5318 desmosomal plaque protein that belo Q99959 Plectin is an intermediate filament-binding protein that 5339 Q15149 Polo–like kinase (PLK-1) is P53350 Ser/Thr kinase w 5347 a human Depolarization of24215 the plasma membrane during neurot P11506 Mismatch DNA repair in bacteria is carried out by the M 5395 P54278 Many aspects of 65045 physiology are influenced by cellular O55000 Protein phosphatase 1 (PP1) is a protein serine/threon 5499 P08129 The PP2C subfamily of Ser/Thr protein phosphatases 64538 Q9Z1Z6 PPEF-2 (protein phosphatase with EF hand-2) is one o 5470 O14830 In the nervous system, synapses between neurons con 171093 Q9WUV9 Postsynaptic density (PSD) P31016 a dense region of 116681 refers to Eukaryotic transcription is carried out by three classes 19285 O54724 The Rab proteins are small P05713 25531 GTP-binding molecules tha Rab5 is a low molecular weight GTP-binding protein th 5868 P20339 GTP-binding proteins, like Rab3A, play a key role durin 171039 P47709 DNA double-strand breaks (DSBs) are generated durin 10111 Q92878 5894 P04049 1:250 There are a number of protein regulators of Ras activit 19418 P70392 1:1000 Retinol, a metabolic precursor of retinal and retinoic ac 19660 P09455 1:250 Reversion-inducing-cysteine-rich protein with Kazal mo 8434 O95980 1:250 Acute promyelocytic leukemia (APL) is characterized b 3437 O14879 1:1000 Neuronal communication depends, in large part, on the 84556 O35168 1:250 The precise navigation of axons to their targets in the d 17968 O35136 1:500 Receptor-like protein tyrosine phosphatases (RPTPs) 5786 P18433 1:250 Receptor-type protein-tyrosine phosphatase b (RPTPb 5800 Q16827 1:1000 A Ca2+–binding protein of low molecular weight (~10k 6273 P10462 1:250 The S100 multigene family consists of a number of sm 6286 P25815 1:250 Packaging of fully6304 functional eukaryotic chromosomal D Q01826 1:500 Cellular morphology, adhesion, and motility occur throu 8936 Q92558 1:1000 Selenocysteine residue is co-translationally incorporat 50880 Q9JL16 1:1000 Selenocysteine is6414 amino acid in which cysteine a rare P49908 1:500 The majority of synapses in the central nervous system 27364 Q9QZY7 1:500 Receptor tyrosine kinase ligation induces autophospho 89817 Q62985 1:250 Tyrosine kinase receptors control the growth, survival, 16331 Q9ES52 1:500 Src tyrosine kinase contains N-terminal SH2 and SH3 13644 Q64355 1:250 Protein tyrosine 140885 phosphatases participate in the intrace P78324 1:1000 Immediately following T cellO15268 (TcR) ligation, cy 8631 receptor 1:500 p21Cdc42/Rac-activated kinases (PAKs) bind and are 10419 O14744 1:250 SLP-76 (SH2 domain-containing Leukocyte Protein) is 3937 Q13094 1:500 Apoptosis is a genetically programmed, selective proc 56616 Q9NR28 1:250 Steroid nuclear hormone receptors regulate physiologi 9612 Q9Y618 1:1000 Release of neurotransmitters from neurons is regulate 20614 P13795 1:250 The Sos (son of sevenless)Q62245 originally identifi 20663 gene was 1:250 Trafficking of immune cells Q96FS4 6494 is essential for the develop 6667 P08047 1:250 Regulation of lipid metabolism requires transcription fa 7069 Q92746 1:25,000 Synapsins (Ia & Ib, IIa & IIb, and IIIa) are a group of re 24949 P09951 1:5000 Synapsins are a 29179 of four related proteins (Synaps group Q63537 1:250 Synaptic vesicles (Sv) are organelles situated at the di 29205 Q62876
1:250 1:1000 1:250 1:250 1:250 1:1000 1:500 1:1000 1:250 1:250 1:250 1:250 1:250 1:250 1:1000 1:250 1:250 1:250 1:250 1:250 1:2500 1:250 1:5000 1:250
A E A E A D C E C C A D D C C B C A C A C C C A D A B B C B E A C D D D C E A C E C
23 29 11 26 31 34 34 28 26 32 15 27 21 27 31 35 38 21 21 6 8 7 16 11 23 38 34 18 23 35 22 30 33 29 33 25 27 30 36 30 33 15
S12520 S31620 S39520 S17420 S25120 S88720 T77420 T27720 T39720 T26820 J55020 T13820 T70120 T82220 T66920 N10320 T31820 T89420 T10620 T60820 T50320 T37220 T84620 T16020 T21820 T34120 T20720 U10820 U68920 V84120 V20920 V83320 V34420 W82920 X97720 556453 X98220 X37320 Z98920 Z37520 Z61220 Z45420
Synaptojanin 1 Synaptophysin Synaptotagmin Synaptotagmin V Syntaphilin Syntaxin 11 TAF-172 Tat-SF1 TBP Telethonin Tenascin-R/Janusin Tensin Thrombospondin-1 Thrombospondin-2 TLP1 tNASP TNIK Tomosyn TopBP1 Tpl-2 TRADD Transferrin Receptor TRF2 trk B TRP-1 Tubby Tyrosine Hydroxylase UBA2 Utrophin VAP-1 Veli Vesl-1L Villin WRN Xin XPA XPD XPF ZO-2 ZPR1 ZRP-1/TRIP6 Zyxin
140 1:500 Phosphoinositide turnover is a mechanism of intracellu 85238 Q62910 33 1:25,000 Synaptophysin is24804 integral membrane glycoprot a major P07825 65 1:1000 Synaptotagmin (p65) is an abundant synaptic vesicle p 6857 P21579 48 1:1000 Synaptotagmin I 54309 toP47861 of C2 domain con belongs a family 68 1:500 Synaptic vesicles9751 are organelles situated at the distal t O15079 40 1:2500 Eukaryotic protein trafficking involves the packaging of 8676 O75558 172 1:250 TATA binding protein (TBP), along with several TBP-a 9044 O14981 140 1:500 Tat protein is expressed early in the viral life cycle of th 27336 Q99730 37 1:250 Originally identified as the DNA-binding subunit of the 6908 P20226 19 1:1000 Autosomal recessive limb-girdle muscular dystrophy (A 21393 O70548 180/160 1:1000 Originally identified as the oligodendrocyte-specific gly 7112 Q92752 215 1:250 A number of cytoskeletal proteins are phosphorylated 7145 Q04205 190 1:250 Thrombospondin-1 (TSP-1)P07996 21825 is a trimeric 450kDa glyco 200 1:250 Cell adhesion interactions involve large extracellular gl 7058 P35442 240/230 1:500 Somatic cells lose terminal O08653 repetitive DNA w 64523 telomeric 150 1:250 Early in spermatogenesis, mammalian somatic histone 50927 O35499 150 1:250 Ste20 is a S. cerevisiae Ser/Thr protein kinase that fun 10293 Q9UKE5 130 1:250 Neuronal signal transmission and neurotransmitter rele 81022 Q9WU70 161 1:250 Eukaryotic DNA topoisomerase II, a ubiquitous ATP-de 11073 Q92547 60 1:1000 Tpl-2 is an oncogenic serine-threonine protein kinase. 116596 Q63562 34 1:250 TNFa (Tumor Necrosis Factor) stimulates programmed 8717 Q15628 85 1:1000 Iron acquisition is7037 a prerequisite for cell proliferation. T P02786 66 1:250 Telomeres, the physical ends of eukaryotic chromosom 7014 Q15554 145/95 1:1000 The trk B gene encodes a 145kDa glycosylated transm 4915 Q16620 70 1:2500 The normal synthesis and distribution of melanin is a h 7306 P17643 64 1:250 Tubby is an autosomal recessive syndrome characteri 22141 P50586 58 1:5000 Dopamine and its metabolic products norepinephrine a 25085 P04177 95 1:1000 Protein ubiquitination is the product of a multienzyme c 10054 O950605 400 1:250 Utrophin is an autosomal homolog of dystrophin locate 22288 O08614 110/220 1:250 A fundamental element of the immune response is the 11754 O70423 26-32 1:500 The initial step in 8825 synaptic vesicle exocytosis is the doc O14910 45 1:250 The Vesl (VASP/Ena-related gene up-regulated during 65137 Q9QUJ8 95 1:1000 The isolated intestinal microvillus cytoskeleton (core) c 22349 P31976 162 1:250 Werner Syndrome (WS) is an autosomal recessive dis 7486 Q14191 182 1:500 Normal cardiac morphogenesis requires a number of t 22437 7507 P23025 87 1:1000 DNA lesions caused by chemical mutagens or radiatio 13871 O08811 115 1:250 DNA lesions caused by chemical mutagens or radiatio 2072 Q92889 160 1:250 Tight junctions (zonulae occludens) are critical to the m 21873 Q9Z0U1 51 1:500 ZPR1 is a zinc finger protein identifed through its intera 22687 Q62384 51 1:250 Zyxin is an 82kDa zinc-binding metalloprotein found in 7705 Q15654 83 1:2500 Zyxin is an 82kDa zinc-binding metalloprotein found in 7791 Q04584
KPSS 3.1
18
eIF-2Bε eIF-4E ERK5/BMK1 GRK2 JNK MEK1 MET MET
S540 S209 T218+Y220 S670 T183+Y185 T291 Y1003 Y1230+Y1234+Y1235
Euraryotic translation initiation factor 2B, epsilon subun Eukaryotic translation initiation factor 4 Extracellular signal-regulated kinase 5/Big MAP kinase G protein-coupled receptor kinase-2 Jun-N-terminus/stress-activated protein kinase (SAPK MAP kinase kinase 1 Met receptor tyrosine kinase Met receptor tyrosine kinase
MLK3 p38 MAPK p53 PKC δ PKR PYK2 RB RB SHC SRC
T277+S281 T180+Y182 S392 Y313 T451 Y579 S612 T821 Y349+Y350 Y529
Mixed-lineage kinase 3 p38 alpha MAP kinase Tumor suppressor p53 Protein kinase C delta Protein kinase R Protein tyrosine kinase-2 Retinoblastoma protein Retinoblastoma protein SH2 domain-containing transforming protein 1 Src tyrosine kinase
KPKS 1.2
37
BTK CaMK4 CaMKK CDK2 CDK4 CDK6 CK1δ CSK eEF2K ERK3 ERK6 FYN GCK HPK1 JAK2 KSR1 LCK LYN MEK4 MNK2 MST1 PAK1 PAK3 PDK1 PKB α PKC α PKC ε PKC γ PKC λ PKC θ PKG1 PKR PYK2 ROK α SYK YES1 ZAP70
PYK PSTK PSTK PSTK PSTK PSTK PSTK PYK PSTK PSTK PSTK PYK PSTK PSTK PYK PSTK PYK PYK PSTK PSTK PYK PSTK PSTK PSTK PSTK PSTK PSTK PSTK PSTK PSTK PSTK PSTK PYK PYK PYK PYK PYK
Bruton agammaglobulinemia tyrosine kinase Calmodulin-dependent kinase 4 Calmodulin-dependent kinase kinase Cyclin-dependent kinase 2 PSTK Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Casein kinase 1 delta Src tyrosine kinase Elongation factor-2 kinase Extracellular regulated kinase 3 Extracellular-regulated kinase 6 Fyn Germinal centre kinase Hematopoietic progenitor kinase 1 Janus kinase 2 Kinase suppressor of Ras 1 Lymphocyte-specific protein-tyrosine kinase Lyn MAP kinase kinase 4 (MKK4) MAP kinase interacting kinase 2 Mammalian sterile 20-like 1 p21 activated kinase 1 (PAK alpha) p21 activated Kinase 3 (PAK beta) 3-phosphoinositide-dependent protein kinase 1 (PKB k Protein kinase B alpha (Akt1) Protein kinase C alpha Protein kinase C epsilon Protein kinase C gamma Protein kinase C lambda Protein kinase C theta Protein kinase G1 (cGMP-dependent protein kinase) Doubled stranded RNA-dependent protein kinase Protein tyrosine kinase 2 RhoA kinase alpha Spleen tyrosine kinase Yamaguchi sarcoma viral oncogene homolog 1 Zeta-chain (TCR) associated protein kinase
KPPS 1.2
12
CD45 Cdc25B KAP PAC1
PYP PSTYP PSYP PTYP
Leukocyte common antigen CD45 transmembrane pho Cell division cycle 25B Cyclin-dependent kinase associated phosphatase MAP kinase phosphatase PAC1
PP2A/C-β PP2B/A-α PP2C/α PP2C/β PP2C/δ PTEN PTP-PEST SIRPa1
PSTP PSTYP PSTP PSTP PSTP PSTYP PYP PYPsub
Protein phosphatase 2A - catalytic subunit - beta isofo Protein phosphatase 2B - catalytic subunit - alpha isof Protein phosphatase 2C - catalytic subunit - alpha isof Protein phosphatase 2C - catalytic subunit - beta isofo Protein phosphatase 2C - catalytic subunit - delta isofo Phosphatidylinositol 3’-phosphate and protein phospha Protein tyrosine phosphatase with PEST sequences Signal regulatory protein substrate of PTP1D phospha
15
SHC PTEN PTP-PEST PP2C/α PP2C/β PP2C/δ PP2A/C-β PP2B/A-α ROK α RB RB PYK2 PYK2 PKR PKR
Y349+Y350 PSTYP PYP PSTP PSTP PSTP PSTP PSTYP PYK S612 T821 Y579 PYK T451 PSTK
SH2 domain-containing transforming protein 1 Phosphatidylinositol 3’-phosphate and protein phospha Protein tyrosine phosphatase with PEST sequences Protein phosphatase 2C - catalytic subunit - alpha isof Protein phosphatase 2C - catalytic subunit - beta isofo Protein phosphatase 2C - catalytic subunit - delta isofo Protein phosphatase 2A - catalytic subunit - beta isofo Protein phosphatase 2B - catalytic subunit - alpha isof RhoA kinase alpha Retinoblastoma protein Retinoblastoma protein Protein tyrosine kinase-2 Protein tyrosine kinase 2 Protein kinase R Doubled stranded RNA-dependent protein kinase
SwissProt ID
O09161,O09165
nitiation factor 2B, epsilon subunit nitiation factor 4 ulated kinase 5/Big MAP kinase 1
activated protein kinase (SAPK)
g transforming protein 1
nemia tyrosine kinase kinase kinase
otein-tyrosine kinase
pendent protein kinase 1 (PKB kinase)
MP-dependent protein kinase) -dependent protein kinase
ral oncogene homolog 1 ciated protein kinase
tigen CD45 transmembrane phosphatase
se associated phosphatase
A - catalytic subunit - beta isoform B - catalytic subunit - alpha isoform C - catalytic subunit - alpha isoform C - catalytic subunit - beta isoform C - catalytic subunit - delta isoform phosphate and protein phosphatase hatase with PEST sequences n substrate of PTP1D phosphatase
g transforming protein 1 phosphate and protein phosphatase hatase with PEST sequences C - catalytic subunit - alpha isoform C - catalytic subunit - beta isoform C - catalytic subunit - delta isoform A - catalytic subunit - beta isoform B - catalytic subunit - alpha isoform
-dependent protein kinase