Trial Inclusion criteria Exclusion criteria
Luchetti severe bronchiolitis , vented for 24 h not reported
1998 without significant improvement
PaO2/FiO2 60 on
admission and at 24h
PaCO2>5.6 kpa
PIP >35
Willson clinical and radiographic evidence of chronic lung disease
1999 diffuse parenchymal lung injury status asthmaticus
less than 24 hours mechanical vented cardiogenic pulmonary edema or
oxygenation index >7 congestive heart failure or uncorrected
term infants >1 day to 18 yrs congenital heart disease
lethal brain injury
Tibby infants neuromuscular disease
2000 RSV induced respiratory failure uncorrected congenital heart disease
pneumothorax
ventilation >24h
oxygenation index 40 terminal disease
PIP >35 on CMV at PEEP =0 chronic lung disease
preexisting airway disease
congenital heart diseases
neuromuscular diseases
Moller ARDS Consensus Conference criteria NO, HFO, ECMO, liquid ventilation or
2003 lung injury score at least 2 steroids for ARDS
ventilation between 12 and 120 hrs prostaglandins
age between 44th postconceptual chronic lung disease
week and 14 years participation in other clinical trials
admission for at least 4 hours except treatment protocols and trials
no echocardiographically detectable for oncological diseases
left heart failure severe hypoxemia
PaO2/FiO2 ratio 7 ongoing cardiopulmonary resuscitation
limitation of life support
significant airway disease that may
delay extubation
uncorrected congenital heart disease
preexisting myocardial dysfunction
cardiogenic pulmonary edema
RSV: Respiratory Syncytial Virus
ARDS: Acute Respiratory Distress Syndrome
HFO: High Frequency Oscillatory ventilation
ECMO: Extracorporeal Membrane Oxygenation
PaO2 : Arterial oxygen tension
FiO2: Fractional inspired oxygen