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Effect of Calcitonin Gene-Related Peptide on Lymphatic Vessels V. A. Akopyan, N. V. Balashov, and G. F. Khanipov Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia Received August 4, 1997 AbstractThe effects of human α-calcitonin gene-related peptide (CGRP) on collecting lymphat- ic vessels of the rat small intestine mesentery and on an isolated preparation of the thoracic part of the rat thoracic duct were investigated. The effect of α-CGRP on the lymphatic vessels was shown to be dose-dependent. This peptide at concentrations of 100 nmole/ml in vivo and 1 µmol/ml in vitro stimulates the motor activity of lymphatic vessels, increasing phasic and tonic contrac- tions.
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