Once daily dose of gentamicin found effective as thrice

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GLIMPSE December 2006

Once daily dose of gentamicin found effective as thrice daily dose
ICDDR,B scientist Dr Ali Miraj Khan and his co-workers have, for the first time, reported that the efficacy of one daily dose of gentamicin with ceftriaxone is as effective and safe as the conventional dose of three times a day for the treatment of diarrhoea and pneumonia in malnourished children. The extended interval between intakes of intra-muscular injection will substantially reduce the treatment cost and is expected to be the best strategy for use of this injectable antimicrobial in resource-poor settings. Immediately after the publication of their article in the June issue of the Journal of Tropical Pediatrics, Reuters Health Information 2006 highlighted the importance of this new finding. Dr Khan and co-workers conducted their study on 310 randomly-selected children, aged 6 months to five years, Dr Ali Miraj Khan admitted with complications of diarrhoea, pneumonia, and malnutrition in the Dhaka Hospital of ICDDR,B at Mohakhali. They divided these children into two groups. One group received 5 mg of gentamicin per kg body-weight of the patient once daily injection; the same dose was equally divided and administered three times a day to the children of the other group. Each of the patients in both the groups received 75 mg of ceftriaxone per kg body-weight. The investigators found no difference in the clinical outcomes between patients in the two groups, showing that once daily dose of gentamicin is as effective and safe as the conventional dose of three times a day. The authors recommended widespread implementation of this new regimen of gentamicin in resourcepoor countries because it reduces the cost of intramuscular administration, and resource-constrained countries are less likely to have volutrols, which are recommended for safe administration of intravenous medications in young children, especially infants.

The Centre recently bade farewell to two distinguished members of the senior management staff: Dr AN Alam and Ms Vanessa Brooks. Dr Alam was working as Consultant Physician and Head of Training and Education Unit, ICDDR,B and Ms Vanessa as Grants and Contracts Administrator. While bidding farewell, Executive Director Professor David Sack commented: both of them were among the best-known ICDDR,B
Dr AN Alam and Prof David Sack

personnel around the world because Dr

Alam was exposed to the trainees from across the globe, who come to our Centre to update their knowledge with the latest findings of medical research, and Ms Vanessa was exposed to a huge number of people in the global donor community. We wish them a happy and a prosperous life.
8 Ms Vanessa and Prof David Sack