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Hanson-UniqueEcologicalHostsForChoclo

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					  Unique Ecological Hosts for Choclo
 Virus in Panama and Maporal Virus in
Venezuela: Evidence They Are Distinct
               Species
                     or
      When a mouse isn’t just a mouse.
   J. Delton Hanson*, Charles F. Fulhorst,
               Antonio Utera
              Hantaviruses
• RNA viruses
  – Small
  – Medium
  – Large (think Goldilocks)
• Old World – Hemorrhagic fever w/Renal
  Syndrome (1950’s)
              Hantaviruses
• New World – Hantavirus Cardiopulmonary
  Syndrome (HPS)
  – Sin Nombre (1993)
  – Others identified
  – Not all cause HPS
  – Not all HPS’s fatal
             Hantaviruses
• Host - Virus
• 1:1 Long-term relationships
  – Requirement for species recognition
                   Hantaviruses
• Large distribution follows host




   Peromyscus maniculatus      Peromyscus leucopus
               Hantaviruses
• Large distribution follows host
               Hantaviruses
• Large distribution follows host
                                       Hantaviruses
    • Large distribution follows host

                                                                              *

    Rio mamore virus
    Oligoryzomys microtis                                                                     *
                                                                                             * *
                                                                                                      *
                                                            0           500
                                                                Kilometers




Richter, Hanson, Cajimat, Milazzo, and Fulhorst. Geographical range of Rio Mamoré virus (family Bunyaviridae, genus
Hantavirus) in association with the small-eared pygmy rice rat (Oligoryzomys microtis). Vector-Borne and Zoonotic
Diseases.
             Hantaviruses
• Closely related viruses w/closely related
  hosts
  – Oryzomys sp w/ Bayou and Catacamas
    viruses
             Hantaviruses
• Closely related viruses w/closely related
  hosts
  – Sigmodon sp w/ Muleshoe and Blackcreek
    Canal
Hantaviruses




               Bradley et al. 2008
Hantaviruses




               Bradley et al. 2008
             Hantaviruses
• 2000 – Choclo virus – HPS
  – Panama
  – Oligoryzomys fulvescens (fulvous pygmy rice
    rat)
• 2004 – Maporal virus – no HPS?
  – Venezuela
  – Oligoryzomys fulvescens (fulvous pygmy rice
    rat)
• Violates 1:1 assumption
             Oligoryzomys
• Small, long tailed

• Grass adapted (Reithrodontomys)

• Peri-domestic
Oligoryzomys fulvescens
                                               ?



Oligoryzomys fulvescens

Rogers, D. S., D. K. Hardy, J. D. Hanson, E. A. Arellano, N. Lewis-Rogers and F. X. González-Cózatl. 2009. Molecular
phylogenetics of Oligoryzomys fulvescens based on cytochrome b gene sequences, with comments on the evolution of the
genus Oligoryzomys.
Miranda, GB, Oliveira, LFB, Andrades-Miranda, J, Langguth, A, et al. Phylogenetic and phylogeographic patterns in
sigmodontine rodents of the genus Oligoryzomys.
             TPMV-VRC 66412-Ind
        THAIV-Thai749-Tha
        SEOV-80·39-SKor
       HTNV-76·118-SKor
      DOBV-Ano·Poroia-Gre
          KHAV-MF·43-Rus
          TOPV-Ls136v-Rus
          PUUV-Sotkamo-Fin
          PHV-PH·1-USA
         TULV-Moravia/5302v/95-CzeR
           CADV-VHV·574-Ven
            ANDV-Chile·9717869-Chi
             LANV-510B-Par
            RIOMV-HTN·007-Per
            MAPV-HV·97021050-Ven
           CHOV-588-Pan
          BAYV-Hu_La-USA
           CATV-HV·C1280001-Hon
          BCCV-USA
         NYV-RI·1-USA
         SNV-Convict Creek 107-USA
        ELMCV-RM·97-USA

0.3
      Outgroup
             O. messorius
            O. delicatus

                  O. moojeni
              O. destructor
            O. longicaudatus
            O. andinus
              O. flavescens

                O. nigripes
               O. stramineus
             O. chacoensis
            O. costaricensis
             O. vegetus

             O. fulvescens

              O. fornesi
          O. sp1
0.1            O. microtis
      Outgroup
             O. messorius
            O. delicatus

                  O. moojeni
              O. destructor
            O. longicaudatus
            O. andinus
              O. flavescens    8.99%
                               9.73%
                O. nigripes
               O. stramineus
             O. chacoensis
            O. costaricensis
             O. vegetus
                                   11.06%
             O. fulvescens

              O. fornesi
          O. sp1
0.1            O. microtis
      Outgroup
             O. messorius
            O. delicatus       1.99%
                  O. moojeni
              O. destructor
            O. longicaudatus
            O. andinus
              O. flavescens

                O. nigripes
               O. stramineus
             O. chacoensis
            O. costaricensis   1.25%
             O. vegetus

             O. fulvescens
                                1.74%
              O. fornesi
          O. sp1
0.1            O. microtis
             TPMV-VRC 66412-Ind
        THAIV-Thai749-Tha
        SEOV-80·39-SKor
       HTNV-76·118-SKor
      DOBV-Ano·Poroia-Gre
          KHAV-MF·43-Rus
          TOPV-Ls136v-Rus
          PUUV-Sotkamo-Fin
          PHV-PH·1-USA
         TULV-Moravia/5302v/95-CzeR
           CADV-VHV·574-Ven
            ANDV-Chile·9717869-Chi
             LANV-510B-Par
            RIOMV-HTN·007-Per
            MAPV-HV·97021050-Ven
           CHOV-588-Pan
          BAYV-Hu_La-USA
           CATV-HV·C1280001-Hon
          BCCV-USA
         NYV-RI·1-USA
         SNV-Convict Creek 107-USA
        ELMCV-RM·97-USA

0.3
     Take Home Conclusions
i.e. why should you care about mice in Central
                   America
      Take Home Conclusions
 i.e. why should you care about mice in Central
                    America
• A mouse is not a mouse
                                  palustris




couesi




                        O. species 2


         O. species 1
            texensis
                                                    palustris




                  couesi




mexicanus


                                          O. species 2


                           O. species 1
       Take Home Conclusions
  i.e. why should you care about mice in Central
                     America
• A virus is not a virus
  – HPS vs non HPS
  – Fatal vs un-noticeable
      Take Home Conclusions
 i.e. why should you care about mice in Central
                    America
• You know what they say about
  assuming…
     Take Home Conclusions
i.e. why should you care about mice in Central
                   America




          Photo by Michael Patrikeev
                      Take Home Conclusions
       i.e. why should you care about mice in Central
                          America




Photo by Michael Patrikeev
     Take Home Conclusions
i.e. why should you care about mice in Central
                   America




          Photo by Michael Patrikeev
       Take Home Conclusions
  i.e. why should you care about mice in Central
                     America
• Deposit vouchers!!!
                  Acknowledgments
•   Abilene Christian University Natural   •   Museo de Historia Natural La Salle
    History Collections – Tom Lee          •   Museo Nacional de Historia Natural –
•   American Museum of Natural History –       Guillermo D’Elia
    Rob Voss, Marcelo Weksler              •   Museum of Southwestern Biology –
•   Angelo State University – Loren            Jon Dunnum, Cheryl Parameter
    Ammerman, Robert Dowler                •   Museum of Vertebrate Zoology –
•   Carnegie Museum of Natural History –       James Patton, Chris Conroy
    Sue McLaren                            •   Royal Ontario Museum – Mark
•   Monte L. Bean Life Science Museum –        Engstrom, Burton Lim
    Duke Rogers                            •   Texas Tech University – Robert J.
•   Museu Nacional Rio de Janerio –            Baker, Heath Garner, Kathy
    Cibele Bonvincino, Jaoa Oliveria           MacDonald
•   Field Museum of Natural History –      •   National Museum of Natural History –
    Bruce Patterson                            Jeremy Jacobs, Michael Carleton
•   Instituto de Cienceias Naturales       •   Robert Owen, Jane Indorf
•   University of Kansas Natural History
    Museum – Bob Timm

				
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