ADVANCED HUMAN NUTRITION

NuFS 109                                                                Instructor: Clarie Hollenbeck, Ph.D.
Fall 2006                                                               Office: CCB 107
MW 9:00 to 10:15                                                        Phone: 924-3106
Room: CCB 102                                                           email:

Office Hours:     M & W 10:30 – 11:30, T & R 11:00 – 12:00, F 9:00 – 10:00, or by appointment

Prerequisites: NuFS 106A, Bio 66, Chem 132, 132L, Stat 95 or HS 167, or Bus 90

Course Description: Advanced studies of vitamins and minerals. Evaluation and interpretation of nutritional
research methodology and findings. (Lecture & Discussion: 3 hours) 3 Units

Broad Goals:

1.       To learn the chemical structures, chemical properties, antagonist, food sources, dietary requirements and
         toxicities of vitamin and minerals

2.       To learn the absorption, transport and storage of vitamins and minerals.

3.       To study the biochemical and physiological functions of vitamins and minerals.

4.       To understand metabolic pathways and related clinical symptoms of vitamin and mineral deficiencies and

5.       To become acquainted with nutrition research literature: abstracts, journals, and reviews.

6.       To write, report and evaluate nutritional research findings and methodology.


Upon completion of this course, the students should be able to:

1.       Describe the specific metabolic functions of the various vitamins and minerals, including difference
         resulting from differences in structure and/or charge

2.       Describe the biochemical mechanism(s) underlying symptoms of deficiency and/or toxicity

3.       Explain the processes of digestion, absorption and transport of the various vitamins and minerals

4.       Describe any interactions that occur among vitamins and minerals that affect their absorption, disposition
         or functions in the body

Active Learning: As an advanced nutrition course, you are all expected to be an active learner and critical thinker.
Active learning, and critical analysis are incorporated and introduced into the content throughout the course. Thought
provoking issues will be presented to you that will require critical thinking and analysis drawing from several related
academic disciplines you have mastered in your courses thus far. It is critical to your success in this course that in
evaluating the scientific content of the material that you apply critical thinking and writing skills.
Course Honor Code: An honor code is a code of conduct and honesty which is adopted by all students that,
individually and collectively they will not give or receive unpermitted aid in class work, in the preparation of
reports, projects, papers. or in any other work that is to be used as a basis for grading. This includes copying
from another’s examination paper or allowing another to copy from one’s own paper, unpermitted
collaboration, plagiarism, revising and resubmitting a quiz, examination or assignment for grading without
the instructor’s knowledge and consent. Representing as one’s own work, the work of another, giving or
receiving aid on an academic assignment under circumstances in which a reasonable person should have
known that such aid was not permitted will be considered violation of this code. Any student registered in,
and taking this class for a grade agrees to abide by this code as a condition of their taking the class and
receiving a grade.


Primary Text:
Course Reader NuFS 109 Fall 2006 (available at the SJSU Print shop)

Secondary Text: (The following are acceptable texts that can be used to supplement the course reader for those
students who desire more complete or additional information).

Shils, Olson, Shihe & Ross. Modern Nutrition in Health and Disease. 9th edition. Williams & Saunders Press. 1999

Stipanuk, Martha H. ed. Biochemical and Physiological Aspects of Human Nutrition . W.B. Saunders Co.
Philadelphia: 2000

Examinations / Term Paper:

          Exams: There will be four midterm exams. Each midterm will be worth 200 points. Examinations will
consist of two sections. The first will be knowledge questions and require concise, specific and direct answers. The
second section will consist of understanding questions, and will be based on those knowledge areas addressed in
section I. The understanding questions will be essay questions in which I will expect an overall explanation
supported by specific examples. Illustrations or figures may be used to support your explanation but will not serve in
lieu of a written explanation. You will need to score well in both sections to get an A grade.

         Exam I            Esentiality, Bioavailability, DRI’s, Vitamins A, D, E, and K
         Exam II           Thiamin, Riboflavin, Niacin, Pantothenate, Biotin and Pyridoxine
         Exam III          Folate, Cobalamine, Ascorbate, Calcium, Phosphorus and Magnesium,
         Exam IV           Electrolytes, Iron, Iodine, Selenium, Zinc, Copper, Chromium, Fluoride,
                           and Non-vitamin Phytochemicals

         Annotated Bibliography / Term Paper: Select one of the major nutrients that will be covered in the
class. You need to then go on line to the DRI’s and read the section in the appropriate report that pertains
specifically to your nutrient. Links to the various reports can be found at:


This assignment will be written and turned in three parts. You will turn in the assignment each time in a double-
sided folder (I will show you an example in class). When you turn in material for the first time, it will be placed in
the right side of the folder. I will return it to you in the left side. Each time you turn in the folder all previous
submissions need to be included (those already turned in on the left and the new submission on the right). You need
to put your name, NuFS 109, and Fall 2006 on the outside of the folder in the upper right hand corner using a
permanent ink (please print).

1. You should outline the information, rationale and any important considerations presented or discussed in the
report. This will help you understand the articles you will be reading and needs to be incorporated into the final
discussion paper that you will write. This will be submitted along with a list of at least 3 references you will be using
as the bases of your Term Paper. The length should be just long enough to briefly summarize the nutrient discussion
in the DRI’s. (10 pts) – Due 9/13
2. Compile an annotated bibliography of recent publications (after 2000, but as recent as possible) of important
original articles, which provide new information in regard to that particular nutrient (to some extent this will be
governed by the nutrient chosen, but at least 3 articles would be necessary). The annotated bibliography should be
a detailed abstract of the article with as much detailed information as needed to reconstruct the nature of the study. It
should include an objective description of the author’s rationale, study design and methods, results, discussion and
overall conclusions (these should be the authors ideas not yours). This abstract should be followed by a short critical
critique of the study (These should be your ideas, criticisms and conclusions. In other words, how well was the study
done, what do you think were the strong points, the weak points, etc.). (20 pts) – Due 10/23

3. After compiling the bibliography, you will write a short 3 - 4 page summary and discussion paper of the nutrient
including the important points or concerns discussed, any new scientific information provided, how this supports,
clarifies, or alters what we already know about this nutrient, as well as what was discussed in the DRI report for that
nutrient. (70 pts) – Due 11/22

Student Evaluations:


                           Exam I                                         200 pts
                           Exam II                                        200 pts
                           Exam III                                       200 pts
                           Exam IV                                        200 pts


                           Annotated Bibliography/Term Paper              100 pts

                  Total Points:                                           900 pts

Graduate Credit: If you are a graduate student you can have this course included in your graduate program,
provided you receive an overall grade of B for the course. Graduate students are not graded any differently than
undergraduate students, and will not receive any special considerations because they are a graduate student. Those
students who wish to receive graduate credit for the course must fill out a Graduate Credit Request Form. To obtain
graduate credit you need to develop your Term Paper to a much greater extent. You will need to include at least 8 -
10 original research articles on your topic and provide a much greater level of critical thinking and discussion. If the
paper is not written at a graduate level, you will not receive graduate credit for the course. You will not receive a
grade on the extra work done for graduate credit, and the term paper will not be graded differently than the
undergraduate students because you have done extra work. If you have any specific questions regarding graduate
credit for the course please see me during my office hours.

University Drop Policy:

Dropping a course after the 2nd week through the 13th week of instruction is permissible only for
serious and compelling reasons, submitted in writing. Unsatisfactory performance in course work is
not a serious and compelling reason in itself for requesting permission to drop.
                               TENTATIVE CLASS SCHEDULE

Date              Topic
8/23    Introduction / Expectations
8/28    Essentiality / RDA / Bioavailability / Precursors - Provitamins - Vitamins
8/30    Fat Soluble Vitamins / Vitamin A
9/4     Labor Day No Class
9/6     Vitamin A / Vitamin D
9/11    No Class – Work on your Term Paper
9/13    Vitamin D – DRI Nutrient Summary and References Due (part #1)
9/18    No Class ADA Meetings
9/20    No Class ADA Meetings
9/25    Vitamin E
9/27    Vitamin K
10/2    Thiamin
10/4    Exam I
10/9    Riboflavin
10/11   Niacin
10/16   Panothenic Acid / Biotin
10/18   Pyridoxine
10/23   Exam II / Annotated Bibliography for Term Paper Due (part #2)
10/25   Folate / B12
10/30   Ascorbate
11/1    Mineral Interactions / Calcium
11/6    Calcium
11/8    Phosphorus / Magnesium
11/13   Exam III
11/15   Water / Electrolytes
11/20   Iron
11/22   Iodine / Selenium / Term Papers Due (part #3)
11/27   Zinc / Copper
11/29   Chromium / Fluoride / Choline / Taurine
12/4    Non-Vitamin A Carotinoids: β carotene / Lycopene / Lutein
12/6    Free Radicals / Antioxidant Systems / Antioxidant Vitamins & Minerals
12/12   7:15 – 9:30 Exam IV

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