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Catherine Theresa Santai, Ph.D. EDUCATION 2006 Ph.D., Chemistry with Biochemistry concentration Dissertation title: “In vitro Condensation of Mixed-Stranded DNA” Georgia Institute of Technology, Atlanta, GA 2001 M.S., Chemistry with Biochemistry concentration Georgetown University, Washington, DC 1996 B.A. summa cum laude, Chemistry, minors-Biology and Physics College of Notre Dame of MD, Baltimore, MD 1992 diploma with honors, Tri-Valley High School, Valley View, PA HONORS 2006 Stanley C. Israel American Chemical Society Regional Award for AND AWARDS Enhancing Diversity in Chemistry Award earned as member of the Women Chemists committee at GA Institute of Technology that organized and planned a day long symposium bringing together professionals from academia, industry, and government to speak on the state of women and their unique career challenges in the sciences. This conference was nationally the first of its kind organized solely by graduate students. 2005-2006 GAANN Research Fellowship for Drug Design, Processing and Delivery Proposal title: Influence of ssDNA on in vitro DNA condensation 2005 Undergraduate Research Scholar (URS) Graduate Advisor Research supply and travel funds awarded Proposal title: The Influence of Bent-by-Triplex DNA Structures on DNA Condensation 2003-2004 GAANN Research Fellowship for Drug Design, Processing and Delivery Proposal title: ssDNA Condensation for Improving DNA Vaccine Delivery 2003 Georgia Institute of Technology, Chemistry and Biochemistry Dept. Teaching Assistantship 2000-2001 Achievement Rewards for College Scientists (ARCS) Research Fellowship 1996-1997 Georgetown University Chemistry Dept. Teaching Assistantship 1995 MD Section of American Chemical Society Student Award 1994 College of Notre Dame of MD Chemistry Achievement Award 1993 American Chemical Society Freshman Chemistry Achievement Award 1993 Named to National Dean’s List 1992-1996 College of Notre Dame of MD Dean’s List 1992-1996 College of Notre Dame of MD Academic Achievement Scholarship 1992 Tri-Valley High School Award for Excellence in English upon Graduation PROFESSIONAL 2006, 2007 Attended the Pennsylvania Academy of Science meeting with Wilson ACTIVITIES College students 2004-2005 Member of committee that organized and planned the 1st Women in Chemistry Symposium at GA Tech which brought together undergraduates, graduate students, and professional chemists from academia, government, and industry to discuss the state of women and their advancements in these fields. The symposium is the first of its kind organized solely by graduate students. 2005 Committee member that organized a summer lunch series for Women in Science in collaboration with the Women’s Resource Center at GA Tech. 2005 Attended the Women’s Leadership Conference at GA Tech 2005 Panelist for the Women’s Leadership Conference Session: When is Best?: Deciding when to have a child in academia. AFFILIATIONS 2008-present Member of PA Academy of Science 2007-present Member of American Chemical Society 2006-present Member of American Association for the Advancement of Science (AAAS) 2003-2006 Student Member of Biophysical Society 1998-2001 Student Member of Biophysical Society 1995-1996 Delta Epsilon Sigma National Honor Society 1994-1996 Student Member of American Chemical Society 1993-1996 Tri-Beta National Biological Honor Society PUBLICATIONS Catherine T. Santai and Nicholas V. Hud. “Mixed-Stranded DNA Condensation” in progress Sarkar, T., Conwell, C.C., Harvey, L.C., Santai, C.T., Hud, N.V. “Condensation of oligonucleotides assembled into nicked and gapped duplexes: potential structures for oligonucleotide delivery.” Nucleic Acids Research 2005 Jan 07,33(1):143-51. Persil O, Santai CT, Jain SS, Hud NV. “Assembly of an antiparallel homo-adenine DNA duplex by small-molecule binding.” J Am Chem Soc. 2004, Jul 21;126(28):8644-5. Ricketts KM, Santai CT, France JA, Graziosi AM, Doyel TD, Gazaway MY, Casillas RP. “Inflammatory cytokine response in sulfur mustard-exposed mouse skin.” J Appl Toxicol. 2000 Dec;20(S1):S73. Santai C.T., Fritz, F., and Roepe, P.D. "Effects of Ion Gradients on H+ Transport Mediated by Human MDR1 Protein.” Biochemistry 1999, 38, 4227-4234. ABSTRACTS Amanda Frankford*, Ginger Fisher, and Catherine Santai “Optimal Foraging in Squirrels” PA Academy of Sciences Annual Meeting, April 2007 *student oral presentation Yanfeng Chen, Catherine T. Santai, Nicholas V. Hud, and Thomas Orlando. “Investigating low-energy electron-induced DNA damage using single photon ionization mass spectrometry” American Chemical Society National Meeting, March 2006 Benedetta Carlotti, Catherine T. Santai, Nicholas V. Hud, Lawrence A. Bottomley. "Does the elasticity of DNA depend upon its orientation?" South East Regional Meeting of the American Chemical Society, November 2006 Catherine T. Santai, Christine C. Conwell, and Nicholas V. Hud. “Investigation of Single-Stranded DNA Condensation with Poly-L-Lysine.” South East Regional Meeting of the American Chemical Society, November 2003. Santai C.T. and Roepe, P.D. "Probing the Ion Transport Function of Human MDR1 Protein Expressed in S. cerevisiae Secretory Vesicles." Biophysical Society, February 16, 2001 Santai, C.T., Fritz, F., and Roepe, P.D. "Effects of Ion Gradients on H+ Transport Mediated by Human MDR1 Protein.” Biophysical Society, Feb. 14, 1999. Casillas, R.P., C.T. Santai, A.M. Graziosi, and T.D. Doyel. "In vivo stimulation of inflammatory cytokines in sulfur mustard exposed hairless mouse skin." Fund. Appl. Toxicol. 1997, 36:190. Casillas, R.P., C.T. Santai and J. France. "Cytokines as Potential Biomarkers of Cutaneous Vesicant Injury." 1996 FASEB 10:A421. TEACHING Wilson College EXPERIENCE Chambersburg, PA Dates: Spring 2007 - present Position: Tenure-track Assistant Professor of Chemistry Duties: I teach undergraduate General Chemistry I and II, Fundamentals of Chemistry for non majors, Biochemistry, Physical Chemistry – Quantum mechanics, Molecular Spectroscopy, and Kinetics. Wilson College Chambersburg, PA Dates: Fall 2006 Position: General Chemistry Lecturer Duties: I taught undergraduate General Chemistry I which involved three 50-minute lectures and three laboratory sections (each 3 hours) per week. I taught part-time this semester to allow time to finish writing and defend my dissertation. Georgia Institute of Technology Atlanta, GA Dates: Spring 2003 Position: Biochemistry Teaching Assistant Duties: I prepared microbiological cultures, solutions and set up equipment weekly for 25 senior-level undergraduate students to perform biochemistry experiments. I taught laboratory sessions as needed. Georgetown University Washington, DC Dates: Fall 1999 Position: Experimental Methods in Biochemistry (Graduate Level Course) Teaching Assistant Duties: I wrote the lab protocols, designed experiments and the final exam (lab practical), prepared for the experiments, troubleshot student problems with experiments, supervised students in lab (5 hrs one day a week), and advised students for a course designed to introduce first year graduate students to the experimental techniques used in a biochemistry research lab. Georgetown University Washington, DC Dates: 1996-1997 Position: General Chemistry Teaching Assistant Duties: I taught a one hour general chemistry recitation section that met two days a week in which problems were solved, questions were answered, and quizzes written by me or the primary instructor were given. I also taught a general chemistry laboratory section that met two days a week for three hours each session. RESEARCH Georgia Institute of Technology EXPERIENCE Atlanta, GA Dates: 2003-present Position: graduate student researcher Duties: My research involved the study of in vitro DNA condensation. My research examined how different secondary structures, single stranded DNA (ssDNA), mixtures of single and double stranded DNA (mixed-stranded DNA), and triplex-induced bends in DNA, affected the morphology and size of DNA when compacted with different cationic condensing agents under various solution conditions. Techniques employed included molecular biology and wet biochemistry techniques, ssDNA and dsRNA virus propagation, titering, and purification, polyacrylamide and agarose gel electrophoresis, DNA extraction and purification, ultracentrifugation, UV-Vis Spectroscopy, atomic force microscopy (AFM), and transmission electron microscopy (TEM). U.S. Food and Drug Administration (FDA) Atlanta, GA Dates: Feb 2002-Jan 2003 Position: Regulatory/Analytical Chemist Duties: As a chemist in the Atlanta Center for Nutrient Analysis, I worked as an analytical regulatory chemist performing analyses for any or all nutrients declared on the nutrition label of any food, medical food, infant formula, or dietary supplement consumed in the United States. Duties included nutritional label reviews, report and SOP writing, as well as analytical experiments to ensure federal guidelines are followed. Work involved microbiological analysis to quantitate water-soluble vitamins, ICP atomic absorption (AA) to quantitate Ca, P, K, Na, Mg, Mn, Cu, Zn, and Fe, hydride generator AA to quantitate Se, and gas chromatography to quantitate lipids. I was also involved in US total diet study for folic acid. PolyOne, Inc. Suwanee, GA Dates: Sept. 2001-Feb. 2002 Position: Raw Material and Formulation Controller Duties: I was responsible for the input of chemical formulas for polymer color additives produced by the company in multiple plants across the U.S. Georgetown University Chemistry Department Washington, DC Dates: 1997-2001 Position: Graduate research assistant Project: I expressed wild-type and mutant forms of the human multidrug resistant (MDR1) protein in different strains of Saccharomyces cerevisiae to elucidate its possible endogenous function as an ion transporter/antiporter and involvement in internal pH and membrane potential regulation. The goal was to partially purify the protein in order to measure protein function. The work involved molecular biology techniques, PCR, E.coli and yeast growth, transformation and strain maintenance, yeast membrane preparations, agarose and SDS-PAGE gel electrophoresis, Western blotting, fluorescence spectroscopy, ATPase activity assays, protein assays, HPLC, mammalian cell culture, static light scattering, and various biochemical techniques. As the most senior graduate student in the research group, my other responsibilities included experimental design, running the lab on a day-to-day basis (ordering supplies, fixing equipment, and safety compliance), troubleshooting and advising the experiments and projects of four other graduate and two undergraduate students. This work resulted in two poster presentations and a publication. U.S. Army Medical Research Institute of Chemical Defense (USAMRICD) Aberdeen, MD Dates: Summer 1995-Summer 1996 Position: Undergraduate research assistant / intern Project: I determined the levels of cytokines (IL-6, IL-1, TNF), prostaglandins (PGE2, PGE2), and protein in mouse skin following cutaneous exposure to sulfur mustard gas. Experimentally, ELISA assays were performed. A potential biological marker for sulfur mustard-induced injury was identified through my work. This work resulted in a poster presentation and a publication.
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