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Catherine T

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									               Catherine Theresa Santai, Ph.D.


EDUCATION    2006        Ph.D., Chemistry with Biochemistry concentration
                         Dissertation title: “In vitro Condensation of Mixed-Stranded DNA”
                         Georgia Institute of Technology, Atlanta, GA
             2001        M.S., Chemistry with Biochemistry concentration
                         Georgetown University, Washington, DC
             1996        B.A. summa cum laude, Chemistry, minors-Biology and Physics
                         College of Notre Dame of MD, Baltimore, MD
             1992        diploma with honors, Tri-Valley High School, Valley View, PA


HONORS       2006        Stanley C. Israel American Chemical Society Regional Award for
AND AWARDS               Enhancing Diversity in Chemistry
                         Award earned as member of the Women Chemists committee at
                         GA Institute of Technology that organized and planned a day long
                         symposium bringing together professionals from academia, industry,
                         and government to speak on the state of women and their unique career
                         challenges in the sciences. This conference was nationally the first of
                         its kind organized solely by graduate students.
             2005-2006   GAANN Research Fellowship for Drug Design, Processing and
                         Delivery
                         Proposal title: Influence of ssDNA on in vitro DNA condensation
             2005        Undergraduate Research Scholar (URS) Graduate Advisor
                         Research supply and travel funds awarded
                         Proposal title: The Influence of Bent-by-Triplex DNA Structures on
                         DNA Condensation
             2003-2004   GAANN Research Fellowship for Drug Design, Processing and
                         Delivery
                         Proposal title: ssDNA Condensation for Improving DNA Vaccine
                         Delivery
             2003        Georgia Institute of Technology, Chemistry and Biochemistry Dept.
                         Teaching Assistantship
             2000-2001   Achievement Rewards for College Scientists (ARCS) Research
                         Fellowship
             1996-1997   Georgetown University Chemistry Dept. Teaching Assistantship
             1995        MD Section of American Chemical Society Student Award
             1994        College of Notre Dame of MD Chemistry Achievement Award
             1993        American Chemical Society Freshman Chemistry Achievement Award
             1993        Named to National Dean’s List
             1992-1996   College of Notre Dame of MD Dean’s List
             1992-1996   College of Notre Dame of MD Academic Achievement Scholarship
               1992          Tri-Valley High School Award for Excellence in English upon
                             Graduation


PROFESSIONAL   2006, 2007 Attended the Pennsylvania Academy of Science meeting with Wilson
ACTIVITIES                College students
               2004-2005 Member of committee that organized and planned the 1st Women in
                          Chemistry Symposium at GA Tech which brought together
                          undergraduates, graduate students, and professional chemists from
                          academia, government, and industry to discuss the state of women and
                          their advancements in these fields. The symposium is the first of its kind
                          organized solely by graduate students.
               2005       Committee member that organized a summer lunch series for Women in
                          Science in collaboration with the Women’s Resource Center at GA Tech.
               2005       Attended the Women’s Leadership Conference at GA Tech
               2005       Panelist for the Women’s Leadership Conference Session: When is Best?:
                          Deciding when to have a child in academia.


AFFILIATIONS   2008-present Member of PA Academy of Science
               2007-present Member of American Chemical Society
               2006-present Member of American Association for the Advancement of Science
                            (AAAS)
               2003-2006    Student Member of Biophysical Society
               1998-2001    Student Member of Biophysical Society
               1995-1996    Delta Epsilon Sigma National Honor Society
               1994-1996    Student Member of American Chemical Society
               1993-1996    Tri-Beta National Biological Honor Society


PUBLICATIONS   Catherine T. Santai and Nicholas V. Hud. “Mixed-Stranded DNA Condensation”
               in progress

               Sarkar, T., Conwell, C.C., Harvey, L.C., Santai, C.T., Hud, N.V. “Condensation of
               oligonucleotides assembled into nicked and gapped duplexes: potential structures for
               oligonucleotide delivery.” Nucleic Acids Research 2005 Jan 07,33(1):143-51.

               Persil O, Santai CT, Jain SS, Hud NV. “Assembly of an antiparallel homo-adenine
               DNA duplex by small-molecule binding.” J Am Chem Soc. 2004, Jul
               21;126(28):8644-5.

               Ricketts KM, Santai CT, France JA, Graziosi AM, Doyel TD, Gazaway MY,
               Casillas RP. “Inflammatory cytokine response in sulfur mustard-exposed mouse
               skin.” J Appl Toxicol. 2000 Dec;20(S1):S73.
             Santai C.T., Fritz, F., and Roepe, P.D. "Effects of Ion Gradients on H+ Transport
             Mediated by Human MDR1 Protein.” Biochemistry 1999, 38, 4227-4234.


ABSTRACTS    Amanda Frankford*, Ginger Fisher, and Catherine Santai “Optimal Foraging in
             Squirrels” PA Academy of Sciences Annual Meeting, April 2007
             *student oral presentation

             Yanfeng Chen, Catherine T. Santai, Nicholas V. Hud, and Thomas Orlando.
             “Investigating low-energy electron-induced DNA damage using single photon
             ionization mass spectrometry” American Chemical Society National Meeting, March
             2006

             Benedetta Carlotti, Catherine T. Santai, Nicholas V. Hud, Lawrence A. Bottomley.
             "Does the elasticity of DNA depend upon its orientation?" South East Regional
             Meeting of the American Chemical Society, November 2006

             Catherine T. Santai, Christine C. Conwell, and Nicholas V. Hud. “Investigation of
             Single-Stranded DNA Condensation with Poly-L-Lysine.” South East Regional
             Meeting of the American Chemical Society, November 2003.

             Santai C.T. and Roepe, P.D. "Probing the Ion Transport Function of Human
             MDR1 Protein Expressed in S. cerevisiae Secretory Vesicles." Biophysical
             Society, February 16, 2001

             Santai, C.T., Fritz, F., and Roepe, P.D. "Effects of Ion Gradients on H+
             Transport Mediated by Human MDR1 Protein.” Biophysical Society, Feb. 14,
             1999.

             Casillas, R.P., C.T. Santai, A.M. Graziosi, and T.D. Doyel. "In vivo stimulation
             of inflammatory cytokines in sulfur mustard exposed hairless mouse skin." Fund.
              Appl. Toxicol. 1997, 36:190.

             Casillas, R.P., C.T. Santai and J. France. "Cytokines as Potential Biomarkers of
             Cutaneous Vesicant Injury." 1996 FASEB 10:A421.



TEACHING     Wilson College
EXPERIENCE   Chambersburg, PA
             Dates: Spring 2007 - present
             Position: Tenure-track Assistant Professor of Chemistry
             Duties: I teach undergraduate General Chemistry I and II, Fundamentals of Chemistry
             for non majors, Biochemistry, Physical Chemistry – Quantum mechanics, Molecular
             Spectroscopy, and Kinetics.
             Wilson College
             Chambersburg, PA
             Dates: Fall 2006
             Position: General Chemistry Lecturer
             Duties: I taught undergraduate General Chemistry I which involved three 50-minute
             lectures and three laboratory sections (each 3 hours) per week. I taught part-time this
             semester to allow time to finish writing and defend my dissertation.

             Georgia Institute of Technology
             Atlanta, GA
             Dates: Spring 2003
             Position: Biochemistry Teaching Assistant
             Duties: I prepared microbiological cultures, solutions and set up equipment
             weekly for 25 senior-level undergraduate students to perform biochemistry
             experiments. I taught laboratory sessions as needed.

             Georgetown University
             Washington, DC
             Dates: Fall 1999
             Position: Experimental Methods in Biochemistry (Graduate Level Course)
                  Teaching Assistant
             Duties: I wrote the lab protocols, designed experiments and the final exam (lab
             practical), prepared for the experiments, troubleshot student problems with
             experiments, supervised students in lab (5 hrs one day a week), and advised students
             for a course designed to introduce first year graduate students to the experimental
             techniques used in a biochemistry research lab.

             Georgetown University
             Washington, DC
             Dates: 1996-1997
             Position: General Chemistry Teaching Assistant
             Duties: I taught a one hour general chemistry recitation section that met two days a
             week in which problems were solved, questions were answered, and quizzes written by
             me or the primary instructor were given. I also taught a general chemistry laboratory
             section that met two days a week for three hours each session.


RESEARCH     Georgia Institute of Technology
EXPERIENCE   Atlanta, GA
             Dates: 2003-present
             Position: graduate student researcher
             Duties: My research involved the study of in vitro DNA condensation. My research
             examined how different secondary structures, single stranded DNA (ssDNA), mixtures
            of single and double stranded DNA (mixed-stranded DNA), and triplex-induced bends
            in DNA, affected the morphology and size of DNA when compacted with different
            cationic condensing agents under various solution conditions. Techniques employed
            included molecular biology and wet biochemistry techniques, ssDNA and dsRNA
            virus propagation, titering, and purification, polyacrylamide and agarose gel
            electrophoresis, DNA extraction and purification, ultracentrifugation, UV-Vis
            Spectroscopy, atomic force microscopy (AFM), and transmission electron microscopy
            (TEM).

            U.S. Food and Drug Administration (FDA)
            Atlanta, GA
            Dates: Feb 2002-Jan 2003
            Position: Regulatory/Analytical Chemist
            Duties: As a chemist in the Atlanta Center for Nutrient Analysis, I worked as an
            analytical regulatory chemist performing analyses for any or all nutrients declared on
            the nutrition label of any food, medical food, infant formula, or dietary supplement
            consumed in the United States. Duties included nutritional label reviews, report and
            SOP writing, as well as analytical experiments to ensure federal guidelines are
followed.
            Work involved microbiological analysis to quantitate water-soluble vitamins, ICP
            atomic absorption (AA) to quantitate Ca, P, K, Na, Mg, Mn, Cu, Zn, and Fe, hydride
            generator AA to quantitate Se, and gas chromatography to quantitate lipids. I was also
            involved in US total diet study for folic acid.

            PolyOne, Inc.
            Suwanee, GA
            Dates: Sept. 2001-Feb. 2002
            Position: Raw Material and Formulation Controller
            Duties: I was responsible for the input of chemical formulas for polymer color
additives
            produced by the company in multiple plants across the U.S.

            Georgetown University Chemistry Department
            Washington, DC
            Dates: 1997-2001
            Position: Graduate research assistant
            Project: I expressed wild-type and mutant forms of the human multidrug resistant
            (MDR1) protein in different strains of Saccharomyces cerevisiae to elucidate its
            possible endogenous function as an ion transporter/antiporter and involvement in
            internal pH and membrane potential regulation. The goal was to partially purify the
            protein in order to measure protein function. The work involved molecular biology
            techniques, PCR, E.coli and yeast growth, transformation and strain maintenance,
            yeast membrane preparations, agarose and SDS-PAGE gel electrophoresis, Western
            blotting, fluorescence spectroscopy, ATPase activity assays, protein assays, HPLC,
            mammalian cell culture, static light scattering, and various biochemical techniques. As
the most senior graduate student in the research group, my other responsibilities
included experimental design, running the lab on a day-to-day basis (ordering supplies,
fixing equipment, and safety compliance), troubleshooting and advising the
experiments and projects of four other graduate and two undergraduate students.
This work resulted in two poster presentations and a publication.

U.S. Army Medical Research Institute of Chemical Defense (USAMRICD)
Aberdeen, MD
Dates: Summer 1995-Summer 1996
Position: Undergraduate research assistant / intern
Project: I determined the levels of cytokines (IL-6, IL-1, TNF), prostaglandins
(PGE2, PGE2), and protein in mouse skin following cutaneous exposure to sulfur
mustard gas. Experimentally, ELISA assays were performed. A potential biological
marker for sulfur mustard-induced injury was identified through my work. This work
resulted in a poster presentation and a publication.

								
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