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Samples of Rural Development Research Thesis Topics - PowerPoint by vlp17176

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									       DGIS -ITG
IMT A. von HUMBOLDT
        (IMTAvH)
       Lima, Peru
Institutional strengthening
     & collaboration
                  Lima & UPCH
• Lima, massive rural immigration
 in 1970-1980: 2 10 M
• Universidad Peruana Cayetano Heredia
 National General Hospital (4th line)
 Northern Lima, 3 million inhabitants
               UNIVERSIDAD PERUANA
                CAYETANO HEREDIA
                     Facultades
             Facultad de Medicina “Alberto Hurtado”
                  Facultad de Ciencias y Filisofía
                    Facultad de Estomatología
                Facultad de Veterinaria y Zootecnia
                      Facultad de Educación
                      Facultad de Enfermería
Facultad de Salud Pública y Administración “Carlos Vidal Layseca”
                       Facultad de Psicología

      - Private University, founded 1962
      - 8 Facs, 6.500 students
      - Hospital: 420 beds, training in 28
        medical specialities, 900 students
      - 3 Research Institutes,
        including IMT AvH
                     IMTAvH (1968)
•Clinics for Tropical and Infectious Diseases
 150 consultations /day, 36 beds,
  9 infectiologists, 3 dermatologists
• 7 labs
• 9 courses, pre- & post-graduate incl. Gorgas Course
     Instituto de Medicina Tropical Alexander von Humboldt

   Founded 1968, German Foundation von Humboldt
   Support PNUD / WB / WHO / TDR
   Link with National Institute of Health, MOH Peru for epidemiology
   2 poles of excellence, clinical and biological resulting from academic
    (University) and medical (Fac Med + National Hospital) environment

Constraints

   80's: international cooperations pulled off by lack of confidence in
    democracy of current regime
   90's: Fujimori stopped governmental funding to private Universities
                   IMTAvH- ITG

1987 Spin-off from DGIS/IMTA cooperation with Bolivia
         joint research project EC-STD (INCO)
Leishmaniases
1988 Collaboration for Mycobacterioses
        Françoise Portaels / Humberto Guerra
1987 Collaboration for Mycoses
        Danielle Swinne / Betty Bustamante
1989 Memorandum of Understanding (MoU)
1996 Collaboration in Malnutrition (P. Kolsteren)
         joint EC-INCO project Antwerp -Lima - Cochabamba
1996 MoU expanded + Nutrition, Public Health, STD
1998 Framework Programme DGIS-ITG-IMTAvH
        "International Strenthening & Collaboration"
                             COLLABORATION

5 topics                  12 partners             4 ITMA departments
Leishmaniases             *Jorge Arevalo             Parasitology
cut., muco-cut.            Alejandro Llanos-
                             Cuentas, MD
                          *Jean-Claude Dujardin,
                                   D Sc
•Mycobacterioses           Humberto Guerra, MD         Microbiology
TB, MDR-TB, Buruli         Françoise Portaels, D Sc
Mycoses                    Betty Bustamante, MD       Clinical Sciences &
Sporotrichosis             Danielle Swinne, D Sc      Institute of Public
                                                      Health Brussels
•Malnutrition              Iris Pecho                 Public Health
Micronutrients,            Anna Prada
co-infections              Patrick Kolsteren
•Clinical Research         Eduardo Gotuzzo            Clinical Sciences
(since 2000)              Tine Verdonck
HIV/TB, skin ulcer
* Coordination: 2 local coordinators (JA/Lima, JDC/Antwerp) + 1 promotor
(DLR/Antwerp)
SYNERGY BETWEEN TOPICS

    Clinical epidemiology of HIV/TB and skin ulcer
    Molecular tools for diagnosis and epidemiology

INSTITUTIONAL STRENGTHENING

    Human Resources: tech training, M Sc, PhD
    Centralized equipment for cryobanking &
    molecular biology
    Computerized management of reference collections:
    clinical specimens, pathogens, sera
    Distance Learning: CD- ROM Trop. Med. cfr Erwin
    Van den Ende
             DGIS INPUT, BUDGETARY

                                14,0
15,0                    12,4

10,0
                7,0
                                        BUDGET M BEF
       4,2
 5,0


-
        1998     1999    2000    2001
              BREAKDOWN 2000
                  BUDGET 12 M 4

                                  EQUIPMENT
       9%
                    19%           CONSUMABLES
 13%
                                  PERSONNEL


                          18%     TRAINING GRANTS
14%

                                  TRAVELS & STAYS

            27%                   ADMINISTRATION
                                  COSTS
                    QUALITY CONTROL

2001    Administrative management: 2nd back-up site visit
                                         (LS + JVL)
        External evaluation: 1 Lat-Am + 1 EU experts

2002    New 5-yr Master Plan to be identified by IMTAvH
          institutional priorities
          QC indicators
          sustainability

                    DGIS PROGRAMME

        Strengthens institutional sustainability
          reference and teaching capacity
                 competitivity in research fund raising:
          EC-INCO, WHO/TDR, NIH…
Major achievements (equipment)
• Improvement of basic laboratory facilities
• Common facilities for sample storage (-70°C)
•Bio-Safety
•Common laboratory facilities for molecular
 biology
    Major achievements (training)
• Clinical research: 2 MDs
• Leishmania: 2 PhD, 4 MSc, 2 MSc
• Mycology: 1 MSc
• Mycobacteriology: 5 Medical students, 1
  MSc
• Nutrition: 2 experts, multidisciplinary team
• Common activities: management biological
  samples
    Major achievements (science)
Clinical research:
• TB: many patients with MDR, frequent co-infection PCP-
  TB
• Skin ulcer (differential diagnosis): predictive value of
  clinical and epidemiological information; mostly due to
  Leishmania, PCR without biopsy (scrap)
• Translation of CD-Rom on Tropical Medicine in spanish
  (+/- 75% achieved)
    Major achievements (science)

Leishmania:
• PCR identification of Leishmania species directly in
  biopsies (first in the world): prognosis and epidemiological
  surveillance
• Development of methodologies for analysis of differential
  gene expression (virulence, drug resistance)
• Opening of a research line on the influence of vit A on
  disease progress
   Major achievements (science)
Mycobacteriology:
• Implementation of phage-based methodology for
  identification of Mycobact. infection and determination of
  drug-resistance
• Detection of resistance to second line drugs in the general
  population of TB patients and in patients with MDR-TB
  (16% kanamycin, 10% ofloxacin)
• Detection of autochtonous cases of Buruli ulcer
   Major achievements (science)
Mycology:
• possibility to be regional/national reference centre
• initiation of studies on molecular epidemiology of fungi


Nutrition:
• 71% anemia < 5 years: despite good quality of iron-
  enriched bread, this is not provided to children; search for
  alternative strategies.
• Effect of nutritional supplements on parasitoses
        Output (publications)
• Leishmania: 1 PhD thesis, 1 MSc thesis, 3
  papers
• Mycology: 3 papers
• Mycobacteriology: 1 manual, 1 paper, 5
  abstracts in proceedings
• Nutrition: reports, papers in the pipeline
• Clinical research: 1 paper in preparation
          Output (projects)
• Leishmania: 2 TDR, 1 INCO-Dev (Drug
  resistance), 1 QOL (epidemiological
  surveillance)
• Mycology: 2 clinical trials
• Mycobacteriology: 1 INCO-Dev (concerted
  action), 1 submission to TDR
• Nutrition: 1 INCO-Dev, 1 USAID
• Clinical research: 2 submissions to TDR
                    Synergy

Clinical research                  Ref. Sample
                                   collection

          Tropical and Infectious diseases
                   Leishmaniases
                      Mycoses
                 Mycobacterioses
                     HIV/AIDS

Role of nutritional               Molecular diagnosis
status                            and epidemiology
                Prospects
• Clinical trials
• Reference centre for molecular diagnosis
  and epidemiology of pathogens (inter-
  regional course)
• Immunology (starting from
  HTLV/Strongyloides)?
• …(Cysticercose, neuro-)
                DGIS

     Institutional strengthening

Stability, continuity, pilot studies for
  competitivity in research projects
   (EC-INCO, WHO-TDR, NIH..)

								
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