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ARDS and Sepsis

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					Usually, kidney failure from sepsis is a
temporary problem. If treatment for the
                                                ARDS Foundation offers information
infection is successful, the kidneys usually    and support to patients and families
recover and dialysis can be stopped.            who are dealing with a loved one in
Intravenous fluids and medications that         crisis or after the crisis is over.
increase the blood pressure are used to                                                      ARDS FOUNDATION
prevent dangerously low blood pressure that                                               3100 DUNDEE RD. STE. 402
can lead to irreversible brain injury. If the                                              NORTHBROOK, IL 60062
source the infection can be removed from the
                                                ·   Information and Support to Patients     WWW.ARDSUSA.ORG
body (ie; appendicitis or abscess), surgery         and their families.
may be an important part of the treatment
                                                ·   Resources
plan.
                                                ·   ARDS Stories
Is there a difference among people              ·   How to “Make a Difference” in the
that have recovered from ARDS that                  fight against ARDS
resulted from sepsis and those in               ·   Prayer Circle
whom ARDS is attributed to other
causes?
There is limited information in this area.
Only a single study to date has considered
                                                ·   Message Board
                                                                                          ARDS
the outcome of patients that recovered from     And More!
ARDS with/due to sepsis to those that
recovered from ARDS due to trauma. This
study suggested that physical function,         ARDS Foundation is constantly adding
                                                                                           and
general health, and “vitality” among those      information, resources and stories, so
that recover from ARDS with sepsis, were
best among the patients in whom ARDS and
sepsis resulted from trauma
                                                check back often!
                                                                                          Sepsis
For more information about Sepsis:
http://www.sepsis.com/
                                                            ARDS FOUNDATION
                                                         3100 DUNDEE RD. STE. 402
                                                          NORTHBROOK, IL 60062
For more information about ARDS:
                                                           WWW.ARDSUSA.ORG
http://www.ardsnet.org/                                        (312) 749‐7047
                                                             FAX‐(847) 272‐5499


                                                    EILEEN RUBIN ZACHARIAS‐PRESIDENT
                                                           EILEEN@ARDSUSA.ORG

                                                     PAULA J. BLONSKI‐VICE PRESIDENT
                                                         PAULA@ARDSUSA.ORG
     ARDS AND SEPSIS

What is ARDS?                                    Other common findings in patients with sepsis        half of all patients with ARDS also have sepsis.
                                                 include shaking chills, low blood pressure,          The second leading cause of ARDS is sepsis
Acute respiratory distress syndrome (ARDS)       alterations in mental status (confusion or           caused by an infection in some other part of the
occurs when there is extensive inflammation      sleepiness), decreased urine output, and skin        body, such as a urinary tract infection or an
in the lungs. This can be caused by several      that is dusky or mottled and cool to the touch.      infection in the skin (cellulitis). These infections
different diseases, including pneumonia and                                                           are responsible for approximately one­third of
sepsis. Regardless of what causes ARDS, lung                                                          all patients with ARDS. Individuals who
function is severely reduced, leading to                                                              develop ARDS from an infection in the lung and
                                                 What are common causes of sepsis?
shortness of breath and difficulty getting                                                            who also develop the sepsis syndrome usually
oxygen into the blood and removing carbon        Sepsis is most frequently the result of an           have a worse outcome (only 60% survive) than
dioxide. Older patients and those with           overwhelming bacterial or fungal infection.          those with ARDS from other causes such as
chronic diseases such as cirrhosis, renal        Responsible organisms usually get into the blood     trauma (76% survive). Mortality from ARDS
failure, and those with poor baseline lung       stream from the lungs, intestinal tract, urinary     increases with age.
function, tend to have a harder time with        system, or skin. Once in the blood, these
ARDS.                                            organisms trigger the body­wide inflammatory
                                                 response described above.
                                                                                                      Does sepsis have adverse effects on
                                                 Sepsis may not always begin with an infection.       organ systems other than the lungs?
What is Sepsis?                                  Other common causes of sepsis are the same
                                                 things that can also cause ARDS. These include       Sepsis can disrupt the normal function of most
Sepsis is what happens when a severe                                                                  major organs in the body. Organs of note are
infection affects the entire body. Germs         the aspiration of gastric contents into the lung,
                                                 severe body trauma, pancreatitis, and the            the heart, kidneys, liver, and intestines. In
(bacteria, viruses, and fungi) and harmful                                                            severe cases of sepsis, mental status is also
germ substances (endotoxin) may be               transfusion of blood products.
                                                                                                      altered. As more organs are affected by
released into the bloodstream from an                                                                 sepsis, the likelihood of survival decreases.
infection that was previously localized to a                                                          For example, persons with sepsis and single
part of the body, such as infected skin of the   Are there different levels of sepsis?                organ dysfunction have an 80% chance of
leg. Doctor’s say a patient has sepsis when                                                           surviving, whereas persons in which four
                                                 Sepsis can progress from a relatively mild
there is a known or suspected infection and                                                           organs are affected have only a 20% chance of
                                                 condition that responds quickly to antibiotics and
the patient has two or more of the following                                                          surviving their acute illness.
                                                 intravenous fluids, to severe sepsis in which
signs that indicate the infection is spreading
                                                 organs such as the kidneys, liver, and heart are
to the rest of the body:
                                                 adversely affected. Even more serious is septic
                                                 shock, in which intravenous fluids and special       How is sepsis treated?
                                                 medications that typically increase the blood fail
1.      Temperature > 38 C (ie; 100° F) or <                                                          The treatment of sepsis is directed at
                                                 to do so. Patients in this last group may not
        36 C (ie; 97° F)                                                                              (1) identifying and treating the responsible
                                                 survive.
                                                                                                      infection with antibiotics and antifungals, and
2.      Heart rate > 90 beats/minute
                                                                                                      (2) supporting patient with failing organs until
3.      Respiratory rate > 20 breaths/minute                                                          the associate systemic inflammatory response
                                                 What is the relationship between sepsis              is controlled. In patient in whom the lungs are
4.      High white blood cell count (> 12,000    and ARDS?                                            affected, a breathing machine may be used
        cell/microliter of blood) or low white
                                                 The most common cause of ARDS is sepsis from a       until the lungs recover and are capable of
        blood cell count (< 4000
                                                 lung infection, also known as pneumonia. Almost      working on their own. Dialysis can be used for
        cells/microliter of blood)
                                                                                                      patients in whom the kidneys have failed.

				
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posted:8/8/2011
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